8E6S
Human TRPM2 ion channel in 1 mM dADPR and Ca2+
Functional Information from PROSITE/UniProt
site_id | PS01095 |
Number of Residues | 9 |
Details | GH18_1 Glycosyl hydrolases family 18 (GH18) active site signature. IDGVNFNpE |
Chain | Residue | Details |
A | ILE986-GLU994 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4972 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
Chain | Residue | Details |
A | MET1-GLY752 | |
B | LYS918-ARG929 | |
B | ILE1045-ALA1079 | |
B | LEU1099-TYR1503 | |
C | MET1-GLY752 | |
C | LEU770-PRO795 | |
C | TYR849-PHE867 | |
C | LYS918-ARG929 | |
C | ILE1045-ALA1079 | |
C | LEU1099-TYR1503 | |
D | MET1-GLY752 | |
A | LEU770-PRO795 | |
D | LEU770-PRO795 | |
D | TYR849-PHE867 | |
D | LYS918-ARG929 | |
D | ILE1045-ALA1079 | |
D | LEU1099-TYR1503 | |
A | TYR849-PHE867 | |
A | LYS918-ARG929 | |
A | ILE1045-ALA1079 | |
A | LEU1099-TYR1503 | |
B | MET1-GLY752 | |
B | LEU770-PRO795 | |
B | TYR849-PHE867 |
site_id | SWS_FT_FI2 |
Number of Residues | 136 |
Details | INTRAMEM: INTRAMEM => ECO:0000269|PubMed:30467180 |
Chain | Residue | Details |
A | LEU753-GLY769 | |
A | ALA1080-VAL1098 | |
B | LEU753-GLY769 | |
B | ALA1080-VAL1098 | |
C | LEU753-GLY769 | |
C | ALA1080-VAL1098 | |
D | LEU753-GLY769 | |
D | ALA1080-VAL1098 |
site_id | SWS_FT_FI3 |
Number of Residues | 484 |
Details | TRANSMEM: Helical => ECO:0000269|PubMed:30467180 |
Chain | Residue | Details |
A | VAL796-VAL816 | |
B | VAL897-SER917 | |
B | MET930-VAL950 | |
B | TRP1023-LEU1044 | |
C | VAL796-VAL816 | |
C | CYS828-PHE848 | |
C | TRP868-ILE888 | |
C | VAL897-SER917 | |
C | MET930-VAL950 | |
C | TRP1023-LEU1044 | |
D | VAL796-VAL816 | |
A | CYS828-PHE848 | |
D | CYS828-PHE848 | |
D | TRP868-ILE888 | |
D | VAL897-SER917 | |
D | MET930-VAL950 | |
D | TRP1023-LEU1044 | |
A | TRP868-ILE888 | |
A | VAL897-SER917 | |
A | MET930-VAL950 | |
A | TRP1023-LEU1044 | |
B | VAL796-VAL816 | |
B | CYS828-PHE848 | |
B | TRP868-ILE888 |
site_id | SWS_FT_FI4 |
Number of Residues | 288 |
Details | TOPO_DOM: Extracellular => ECO:0000305 |
Chain | Residue | Details |
A | LEU817-TRP827 | |
C | PRO889-ARG896 | |
C | ALA951-ALA970 | |
C | ILE986-GLU1022 | |
D | LEU817-TRP827 | |
D | PRO889-ARG896 | |
D | ALA951-ALA970 | |
D | ILE986-GLU1022 | |
A | PRO889-ARG896 | |
A | ALA951-ALA970 | |
A | ILE986-GLU1022 | |
B | LEU817-TRP827 | |
B | PRO889-ARG896 | |
B | ALA951-ALA970 | |
B | ILE986-GLU1022 | |
C | LEU817-TRP827 |
site_id | SWS_FT_FI5 |
Number of Residues | 56 |
Details | INTRAMEM: Pore-forming => ECO:0000269|PubMed:30467180 |
Chain | Residue | Details |
A | VAL971-TYR985 | |
B | VAL971-TYR985 | |
C | VAL971-TYR985 | |
D | VAL971-TYR985 |
site_id | SWS_FT_FI6 |
Number of Residues | 16 |
Details | BINDING: BINDING => ECO:0000305|PubMed:30467180 |
Chain | Residue | Details |
A | GLU843 | |
C | GLN846 | |
C | ASN869 | |
C | GLU1073 | |
D | GLU843 | |
D | GLN846 | |
D | ASN869 | |
D | GLU1073 | |
A | GLN846 | |
A | ASN869 | |
A | GLU1073 | |
B | GLU843 | |
B | GLN846 | |
B | ASN869 | |
B | GLU1073 | |
C | GLU843 |