8E5B
Human L-type voltage-gated calcium channel Cav1.3 in the presence of Amiodarone and Sofosbuvir at 3.3 Angstrom resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005245 | molecular_function | voltage-gated calcium channel activity |
| A | 0005262 | molecular_function | calcium channel activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005891 | cellular_component | voltage-gated calcium channel complex |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006816 | biological_process | calcium ion transport |
| A | 0007188 | biological_process | adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| A | 0007605 | biological_process | sensory perception of sound |
| A | 0008331 | molecular_function | high voltage-gated calcium channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0030018 | cellular_component | Z disc |
| A | 0030506 | molecular_function | ankyrin binding |
| A | 0034702 | cellular_component | monoatomic ion channel complex |
| A | 0045762 | biological_process | positive regulation of adenylate cyclase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051393 | molecular_function | alpha-actinin binding |
| A | 0051928 | biological_process | positive regulation of calcium ion transport |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0060372 | biological_process | regulation of atrial cardiac muscle cell membrane repolarization |
| A | 0070509 | biological_process | calcium ion import |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0086002 | biological_process | cardiac muscle cell action potential involved in contraction |
| A | 0086007 | molecular_function | voltage-gated calcium channel activity involved in cardiac muscle cell action potential |
| A | 0086012 | biological_process | membrane depolarization during cardiac muscle cell action potential |
| A | 0086046 | biological_process | membrane depolarization during SA node cell action potential |
| A | 0086059 | molecular_function | voltage-gated calcium channel activity involved SA node cell action potential |
| A | 0086091 | biological_process | regulation of heart rate by cardiac conduction |
| A | 0098703 | biological_process | calcium ion import across plasma membrane |
| A | 1901016 | biological_process | regulation of potassium ion transmembrane transporter activity |
| A | 1901379 | biological_process | regulation of potassium ion transmembrane transport |
| A | 1990454 | cellular_component | L-type voltage-gated calcium channel complex |
| C | 0005245 | molecular_function | voltage-gated calcium channel activity |
| C | 0005246 | molecular_function | calcium channel regulator activity |
| C | 0005262 | molecular_function | calcium channel activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0005891 | cellular_component | voltage-gated calcium channel complex |
| C | 0006816 | biological_process | calcium ion transport |
| C | 0007268 | biological_process | chemical synaptic transmission |
| C | 0007528 | biological_process | neuromuscular junction development |
| C | 0008331 | molecular_function | high voltage-gated calcium channel activity |
| C | 0016020 | cellular_component | membrane |
| C | 0034702 | cellular_component | monoatomic ion channel complex |
| C | 0045202 | cellular_component | synapse |
| C | 0050852 | biological_process | T cell receptor signaling pathway |
| C | 0060402 | biological_process | calcium ion transport into cytosol |
| C | 0061577 | biological_process | calcium ion transmembrane transport via high voltage-gated calcium channel |
| C | 0070588 | biological_process | calcium ion transmembrane transport |
| C | 0072659 | biological_process | protein localization to plasma membrane |
| C | 0098903 | biological_process | regulation of membrane repolarization during action potential |
| C | 1901843 | biological_process | positive regulation of high voltage-gated calcium channel activity |
| C | 1990454 | cellular_component | L-type voltage-gated calcium channel complex |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P54287 |
| Chain | Residue | Details |
| C | SER152 | |
| A | GLY1149-SER1205 | |
| A | LYS1260-SER1266 | |
| A | GLU1334-TYR1352 | |
| A | ASP1465-LEU2161 | |
| C | SER393 | |
| A | PRO255-HIS273 | |
| A | GLY407-VAL523 | |
| A | GLY578-SER585 | |
| A | THR634-SER652 | |
| A | ASP753-HIS886 | |
| A | GLY942-ASN953 | |
| A | LYS999-ASN1017 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| D | VAL1074-LEU1094 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| D | VAL1095-LEU1103 | |
| A | GLN1225-ILE1239 | |
| A | ALA1289-ILE1313 | |
| A | GLY1373-PHE1439 | |
| A | GLU215-ASP235 | |
| A | ILE294-LEU381 | |
| A | HIS544-ALA558 | |
| A | VAL605-GLY614 | |
| A | GLY674-ILE727 | |
| A | GLU906-TYR921 | |
| A | GLN973-SER978 | |
| A | LYS1038-GLU1127 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| D | ASP259 | |
| D | SER261 | |
| D | SER263 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P54290 |
| Chain | Residue | Details |
| D | SER119 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 7 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:34234349, ECO:0007744|PDB:7MIX, ECO:0007744|PDB:7MIY |
| Chain | Residue | Details |
| D | ASN92 | |
| D | ASN184 | |
| D | ASN348 | |
| D | ASN468 | |
| D | ASN613 | |
| D | ASN781 | |
| D | ASN895 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 9 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| D | ASN136 | |
| D | ASN324 | |
| D | ASN475 | |
| D | ASN604 | |
| D | ASN675 | |
| D | ASN824 | |
| D | ASN888 | |
| D | ASN985 | |
| D | ASN998 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=S6 of repeat I => ECO:0000255 |
| Chain | Residue | Details |
| A | PRO382-SER406 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S1 of repeat II => ECO:0000255 |
| Chain | Residue | Details |
| A | THR524-GLU543 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S2 of repeat II => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN559-LEU577 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S3 of repeat II => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU586-LEU604 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S4 of repeat II => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE615-TRP633 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S5 of repeat II => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU653-GLY673 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=S6 of repeat II => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL728-VAL752 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S1 of repeat III => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE887-ALA905 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S2 of repeat III => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE922-PHE941 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S3 of repeat III => ECO:0000255 |
| Chain | Residue | Details |
| A | TYR954-ILE972 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S4 of repeat III => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL979-ALA998 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S5 of repeat III => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE1018-PHE1037 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S6 of repeat III => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE1128-VAL1148 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S1 of repeat IV => ECO:0000255 |
| Chain | Residue | Details |
| A | PRO1206-MET1224 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S2 of repeat IV => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU1240-PHE1259 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=S3 of repeat IV => ECO:0000255 |
| Chain | Residue | Details |
| A | ASP1267-GLU1288 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S4 of repeat IV => ECO:0000255 |
| Chain | Residue | Details |
| A | SER1314-GLY1333 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S5 of repeat IV => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL1353-PHE1372 |
| site_id | SWS_FT_FI26 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=S6 of repeat IV => ECO:0000255 |
| Chain | Residue | Details |
| A | ALA1440-MET1464 |
| site_id | SWS_FT_FI27 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P07293 |
| Chain | Residue | Details |
| A | GLU364 | |
| A | GLU705 | |
| A | GLU1101 |
| site_id | SWS_FT_FI28 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN155 | |
| A | ASN225 | |
| A | ASN329 |
