Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8E43

E. coli 50S ribosome bound to compound streptogramin A analog 3336

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
K	0000027	biological_process	ribosomal large subunit assembly
K	0002181	biological_process	cytoplasmic translation
K	0003723	molecular_function	RNA binding
K	0003735	molecular_function	structural constituent of ribosome
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005840	cellular_component	ribosome
K	0006412	biological_process	translation
K	0008270	molecular_function	zinc ion binding
K	0015934	cellular_component	large ribosomal subunit
K	0016740	molecular_function	transferase activity
K	0019843	molecular_function	rRNA binding
K	0022625	cellular_component	cytosolic large ribosomal subunit
K	0032297	biological_process	negative regulation of DNA-templated DNA replication initiation
K	1990082	cellular_component	DnaA-L2 complex
K	1990904	cellular_component	ribonucleoprotein complex
L	0002181	biological_process	cytoplasmic translation
L	0003735	molecular_function	structural constituent of ribosome
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0005840	cellular_component	ribosome
L	0006412	biological_process	translation
L	0015934	cellular_component	large ribosomal subunit
L	0019843	molecular_function	rRNA binding
L	0022625	cellular_component	cytosolic large ribosomal subunit
L	1990904	cellular_component	ribonucleoprotein complex
M	0001070	molecular_function	RNA-binding transcription regulator activity
M	0002181	biological_process	cytoplasmic translation
M	0003677	molecular_function	DNA binding
M	0003735	molecular_function	structural constituent of ribosome
M	0005515	molecular_function	protein binding
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0005840	cellular_component	ribosome
M	0006353	biological_process	DNA-templated transcription termination
M	0006412	biological_process	translation
M	0006417	biological_process	regulation of translation
M	0015934	cellular_component	large ribosomal subunit
M	0017148	biological_process	negative regulation of translation
M	0019843	molecular_function	rRNA binding
M	0022625	cellular_component	cytosolic large ribosomal subunit
M	0030371	molecular_function	translation repressor activity
M	0031555	biological_process	transcriptional attenuation
M	0042255	biological_process	ribosome assembly
M	0045892	biological_process	negative regulation of DNA-templated transcription
M	0046677	biological_process	response to antibiotic
M	0048027	molecular_function	mRNA 5'-UTR binding
M	0060698	molecular_function	endoribonuclease inhibitor activity
M	1990904	cellular_component	ribonucleoprotein complex
M	2000766	biological_process	negative regulation of cytoplasmic translation
N	0000027	biological_process	ribosomal large subunit assembly
N	0002181	biological_process	cytoplasmic translation
N	0003735	molecular_function	structural constituent of ribosome
N	0005515	molecular_function	protein binding
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0005840	cellular_component	ribosome
N	0006412	biological_process	translation
N	0019843	molecular_function	rRNA binding
N	0022625	cellular_component	cytosolic large ribosomal subunit
N	1990904	cellular_component	ribonucleoprotein complex
O	0002181	biological_process	cytoplasmic translation
O	0003729	molecular_function	mRNA binding
O	0003735	molecular_function	structural constituent of ribosome
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0005840	cellular_component	ribosome
O	0006412	biological_process	translation
O	0008270	molecular_function	zinc ion binding
O	0017148	biological_process	negative regulation of translation
O	0022625	cellular_component	cytosolic large ribosomal subunit
O	0043229	cellular_component	intracellular organelle
O	0048027	molecular_function	mRNA 5'-UTR binding
O	0070180	molecular_function	large ribosomal subunit rRNA binding
O	1990904	cellular_component	ribonucleoprotein complex
P	0002181	biological_process	cytoplasmic translation
P	0003735	molecular_function	structural constituent of ribosome
P	0005515	molecular_function	protein binding
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005840	cellular_component	ribosome
P	0006412	biological_process	translation
P	0015934	cellular_component	large ribosomal subunit
P	0019843	molecular_function	rRNA binding
P	0022625	cellular_component	cytosolic large ribosomal subunit
P	0042255	biological_process	ribosome assembly
P	0042256	biological_process	cytosolic ribosome assembly
P	0046677	biological_process	response to antibiotic
P	0070180	molecular_function	large ribosomal subunit rRNA binding
P	1902626	biological_process	assembly of large subunit precursor of preribosome
P	1990904	cellular_component	ribonucleoprotein complex
Q	0000027	biological_process	ribosomal large subunit assembly
Q	0000302	biological_process	response to reactive oxygen species
Q	0002181	biological_process	cytoplasmic translation
Q	0003735	molecular_function	structural constituent of ribosome
Q	0005515	molecular_function	protein binding
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0005840	cellular_component	ribosome
Q	0006412	biological_process	translation
Q	0009314	biological_process	response to radiation
Q	0015934	cellular_component	large ribosomal subunit
Q	0022625	cellular_component	cytosolic large ribosomal subunit
Q	1990904	cellular_component	ribonucleoprotein complex
R	0002181	biological_process	cytoplasmic translation
R	0003735	molecular_function	structural constituent of ribosome
R	0005515	molecular_function	protein binding
R	0005737	cellular_component	cytoplasm
R	0005840	cellular_component	ribosome
R	0006412	biological_process	translation
R	0022625	cellular_component	cytosolic large ribosomal subunit
R	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PROSITE/UniProt

site_id	PS00464
Number of Residues	25
Details	RIBOSOMAL_L22 Ribosomal protein L22 signature. KriMpRAkGRadrilkrtSHITVvV

Chain	Residue	Details
P	LYS83-VAL107

site_id	PS00467
Number of Residues	12
Details	RIBOSOMAL_L2 Ribosomal protein L2 signature. PtvRGTAmNPvD

Chain	Residue	Details
K	PRO218-ASP229

site_id	PS00474
Number of Residues	24
Details	RIBOSOMAL_L3 Ribosomal protein L3 signature. FadvkkvDvtGtSkGKGfaGtvkR

Chain	Residue	Details
N	PHE101-ARG124

site_id	PS00475
Number of Residues	31
Details	RIBOSOMAL_L15 Ribosomal protein L15 signature. KVILaGeVttp..VtVrglrVTkgAraaIeaaG

Chain	Residue	Details
L	LYS109-GLY139

site_id	PS00783
Number of Residues	23
Details	RIBOSOMAL_L13 Ribosomal protein L13 signature. VKGMLPkgpl.GRamfrkLkVYaG

Chain	Residue	Details
O	VAL105-GLY127

site_id	PS00784
Number of Residues	20
Details	RIBOSOMAL_L34 Ribosomal protein L34 signature. KRTFQpsvlkRnrsh.GFraR

Chain	Residue	Details
R	LYS2-ARG21

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:34403461, ECO:0000269\|PubMed:34504068, ECO:0000312\|PDB:7O19, ECO:0000312\|PDB:7O1A, ECO:0000312\|PDB:7O1C, ECO:0000312\|PDB:7OIZ, ECO:0000312\|PDB:7OJ0

Chain	Residue	Details
P	LYS90

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N5-methylglutamine => ECO:0000269\|PubMed:365579, ECO:0000305\|PubMed:331083

Chain	Residue	Details
N	GLN150

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)