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8E0H

Crystal structure of human Sar1aD104/D140A double mutant

Functional Information from GO Data
ChainGOidnamespacecontents
A0003400biological_processregulation of COPII vesicle coating
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0006886biological_processintracellular protein transport
A0006888biological_processendoplasmic reticulum to Golgi vesicle-mediated transport
A0015031biological_processprotein transport
A0016020cellular_componentmembrane
A0016050biological_processvesicle organization
A0016192biological_processvesicle-mediated transport
A0016787molecular_functionhydrolase activity
A0030127cellular_componentCOPII vesicle coat
A0032580cellular_componentGolgi cisterna membrane
A0042953biological_processlipoprotein transport
A0048208biological_processCOPII vesicle coating
A0061024biological_processmembrane organization
A0070971cellular_componentendoplasmic reticulum exit site
A0090110biological_processCOPII-coated vesicle cargo loading
A0140785molecular_functionamino acid sensor activity
A1903432biological_processregulation of TORC1 signaling
A1904262biological_processnegative regulation of TORC1 signaling
A1990253biological_processcellular response to leucine starvation
B0003400biological_processregulation of COPII vesicle coating
B0003924molecular_functionGTPase activity
B0003925molecular_functionG protein activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005737cellular_componentcytoplasm
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0006886biological_processintracellular protein transport
B0006888biological_processendoplasmic reticulum to Golgi vesicle-mediated transport
B0015031biological_processprotein transport
B0016020cellular_componentmembrane
B0016050biological_processvesicle organization
B0016192biological_processvesicle-mediated transport
B0016787molecular_functionhydrolase activity
B0030127cellular_componentCOPII vesicle coat
B0032580cellular_componentGolgi cisterna membrane
B0042953biological_processlipoprotein transport
B0048208biological_processCOPII vesicle coating
B0061024biological_processmembrane organization
B0070971cellular_componentendoplasmic reticulum exit site
B0090110biological_processCOPII-coated vesicle cargo loading
B0140785molecular_functionamino acid sensor activity
B1903432biological_processregulation of TORC1 signaling
B1904262biological_processnegative regulation of TORC1 signaling
B1990253biological_processcellular response to leucine starvation
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:36369712, ECO:0007744|PDB:8DZO, ECO:0007744|PDB:8DZT
ChainResidueDetails
AASP34
AASP75
BASP34
BASP75

site_idSWS_FT_FI2
Number of Residues20
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q9Y6B6
ChainResidueDetails
AASN35
ALEU181
BASN35
BGLY37
BLYS38
BTHR39
BTHR40
BASN134
BLYS135
BASP137
BVAL180
AGLY37
BLEU181
ALYS38
ATHR39
ATHR40
AASN134
ALYS135
AASP137
AVAL180

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:36369712, ECO:0007744|PDB:8DZN
ChainResidueDetails
AALA36
BALA36

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
ATHR139
BTHR139

227344

PDB entries from 2024-11-13

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