8DYO
Cryo-EM structure of Importin-4 bound to RanGTP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000785 | cellular_component | chromatin |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006606 | biological_process | protein import into nucleus |
| A | 0006886 | biological_process | intracellular protein transport |
| A | 0008139 | molecular_function | nuclear localization sequence binding |
| A | 0015031 | biological_process | protein transport |
| A | 0016020 | cellular_component | membrane |
| A | 0031267 | molecular_function | small GTPase binding |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0034504 | biological_process | protein localization to nucleus |
| A | 0061608 | molecular_function | nuclear import signal receptor activity |
| B | 0000054 | biological_process | ribosomal subunit export from nucleus |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000467 | biological_process | exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006334 | biological_process | nucleosome assembly |
| B | 0006606 | biological_process | protein import into nucleus |
| B | 0006913 | biological_process | nucleocytoplasmic transport |
| B | 0006997 | biological_process | nucleus organization |
| B | 0015031 | biological_process | protein transport |
| B | 0016973 | biological_process | poly(A)+ mRNA export from nucleus |
| B | 0046822 | biological_process | regulation of nucleocytoplasmic transport |
| B | 1901987 | biological_process | regulation of cell cycle phase transition |
Functional Information from PROSITE/UniProt
| site_id | PS00118 |
| Number of Residues | 8 |
| Details | PA2_HIS Phospholipase A2 histidine active site. CCAlHKaC |
| Chain | Residue | Details |
| A | CYS725-CYS732 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 66 |
| Details | Domain: {"description":"Importin N-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00115","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 40 |
| Details | Repeat: {"description":"HEAT 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"HEAT 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"HEAT 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 164 |
| Details | Domain: {"description":"Small GTPase Ran-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00752","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 8 |
| Details | Region: {"description":"Switch-I","evidences":[{"source":"PROSITE-ProRule","id":"PRU00752","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 16 |
| Details | Region: {"description":"Switch-II","evidences":[{"source":"PROSITE-ProRule","id":"PRU00752","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 13 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P62825","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
