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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8DXQ

Structure of LRRC8C-LRRC8A(IL125) Chimera, Class 4

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues161
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"30095067","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"30127360","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5ZSU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DJB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues126
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"30095067","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"30127360","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5ZSU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DJB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues147
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"36897307","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8DXN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXR","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues203
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"36897307","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8DXN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXR","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues168
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"36897307","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8DXN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXR","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues7
DetailsSite: {"description":"Required for anion selectivity","evidences":[{"source":"PubMed","id":"30095067","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues168
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"36897307","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8DXN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXR","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues133
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"36897307","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8DXN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXR","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

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PDB entries from 2025-10-22

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