8DS1

Structure of SARS-CoV-2 Mpro in complex with nsp12-nsp13 (C12) cut site sequence

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008233	molecular_function	peptidase activity
A	0019082	biological_process	viral protein processing
B	0008233	molecular_function	peptidase activity
B	0019082	biological_process	viral protein processing
C	0008233	molecular_function	peptidase activity
C	0019082	biological_process	viral protein processing
D	0008233	molecular_function	peptidase activity
D	0019082	biological_process	viral protein processing
E	0008233	molecular_function	peptidase activity
E	0019082	biological_process	viral protein processing
F	0008233	molecular_function	peptidase activity
F	0019082	biological_process	viral protein processing
G	0008233	molecular_function	peptidase activity
G	0019082	biological_process	viral protein processing
H	0008233	molecular_function	peptidase activity
H	0019082	biological_process	viral protein processing
I	0008233	molecular_function	peptidase activity
I	0019082	biological_process	viral protein processing
J	0008233	molecular_function	peptidase activity
J	0019082	biological_process	viral protein processing
K	0008233	molecular_function	peptidase activity
K	0019082	biological_process	viral protein processing
L	0008233	molecular_function	peptidase activity
L	0019082	biological_process	viral protein processing

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000305|PubMed:32198291

Chain	Residue	Details
A	HIS41
J	HIS41
K	HIS41
L	HIS41
B	HIS41
C	HIS41
D	HIS41
E	HIS41
F	HIS41
G	HIS41
H	HIS41
I	HIS41

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site_id	SWS_FT_FI2
Number of Residues	12
Details	ACT_SITE: Nucleophile; for 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000269|PubMed:32198291

Chain	Residue	Details
A	CYS145
J	CYS145
K	CYS145
L	CYS145
B	CYS145
C	CYS145
D	CYS145
E	CYS145
F	CYS145
G	CYS145
H	CYS145
I	CYS145

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