Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8DNO

Human Brain Aldehyde Dehydrogenase 1 family, member A1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001523	biological_process	retinoid metabolic process
A	0001758	molecular_function	retinal dehydrogenase activity
A	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
A	0005096	molecular_function	GTPase activator activity
A	0005497	molecular_function	androgen binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006081	biological_process	cellular aldehyde metabolic process
A	0006629	biological_process	lipid metabolic process
A	0009449	biological_process	gamma-aminobutyric acid biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A	0018479	molecular_function	benzaldehyde dehydrogenase (NAD+) activity
A	0019145	molecular_function	aminobutyraldehyde dehydrogenase (NAD+) activity
A	0030392	biological_process	fructosamine catabolic process
A	0030424	cellular_component	axon
A	0036438	biological_process	maintenance of lens transparency
A	0042572	biological_process	retinol metabolic process
A	0042995	cellular_component	cell projection
A	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
A	0045202	cellular_component	synapse
A	0051287	molecular_function	NAD binding
A	0070062	cellular_component	extracellular exosome
A	0106373	molecular_function	3-deoxyglucosone dehydrogenase activity
A	0110095	biological_process	cellular detoxification of aldehyde
A	0120163	biological_process	negative regulation of cold-induced thermogenesis
B	0000166	molecular_function	nucleotide binding
B	0001523	biological_process	retinoid metabolic process
B	0001758	molecular_function	retinal dehydrogenase activity
B	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
B	0005096	molecular_function	GTPase activator activity
B	0005497	molecular_function	androgen binding
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006081	biological_process	cellular aldehyde metabolic process
B	0006629	biological_process	lipid metabolic process
B	0009449	biological_process	gamma-aminobutyric acid biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0018479	molecular_function	benzaldehyde dehydrogenase (NAD+) activity
B	0019145	molecular_function	aminobutyraldehyde dehydrogenase (NAD+) activity
B	0030392	biological_process	fructosamine catabolic process
B	0030424	cellular_component	axon
B	0036438	biological_process	maintenance of lens transparency
B	0042572	biological_process	retinol metabolic process
B	0042995	cellular_component	cell projection
B	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
B	0045202	cellular_component	synapse
B	0051287	molecular_function	NAD binding
B	0070062	cellular_component	extracellular exosome
B	0106373	molecular_function	3-deoxyglucosone dehydrogenase activity
B	0110095	biological_process	cellular detoxification of aldehyde
B	0120163	biological_process	negative regulation of cold-induced thermogenesis
C	0000166	molecular_function	nucleotide binding
C	0001523	biological_process	retinoid metabolic process
C	0001758	molecular_function	retinal dehydrogenase activity
C	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
C	0005096	molecular_function	GTPase activator activity
C	0005497	molecular_function	androgen binding
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006081	biological_process	cellular aldehyde metabolic process
C	0006629	biological_process	lipid metabolic process
C	0009449	biological_process	gamma-aminobutyric acid biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0018479	molecular_function	benzaldehyde dehydrogenase (NAD+) activity
C	0019145	molecular_function	aminobutyraldehyde dehydrogenase (NAD+) activity
C	0030392	biological_process	fructosamine catabolic process
C	0030424	cellular_component	axon
C	0036438	biological_process	maintenance of lens transparency
C	0042572	biological_process	retinol metabolic process
C	0042995	cellular_component	cell projection
C	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
C	0045202	cellular_component	synapse
C	0051287	molecular_function	NAD binding
C	0070062	cellular_component	extracellular exosome
C	0106373	molecular_function	3-deoxyglucosone dehydrogenase activity
C	0110095	biological_process	cellular detoxification of aldehyde
C	0120163	biological_process	negative regulation of cold-induced thermogenesis
D	0000166	molecular_function	nucleotide binding
D	0001523	biological_process	retinoid metabolic process
D	0001758	molecular_function	retinal dehydrogenase activity
D	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
D	0005096	molecular_function	GTPase activator activity
D	0005497	molecular_function	androgen binding
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006081	biological_process	cellular aldehyde metabolic process
D	0006629	biological_process	lipid metabolic process
D	0009449	biological_process	gamma-aminobutyric acid biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D	0018479	molecular_function	benzaldehyde dehydrogenase (NAD+) activity
D	0019145	molecular_function	aminobutyraldehyde dehydrogenase (NAD+) activity
D	0030392	biological_process	fructosamine catabolic process
D	0030424	cellular_component	axon
D	0036438	biological_process	maintenance of lens transparency
D	0042572	biological_process	retinol metabolic process
D	0042995	cellular_component	cell projection
D	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
D	0045202	cellular_component	synapse
D	0051287	molecular_function	NAD binding
D	0070062	cellular_component	extracellular exosome
D	0106373	molecular_function	3-deoxyglucosone dehydrogenase activity
D	0110095	biological_process	cellular detoxification of aldehyde
D	0120163	biological_process	negative regulation of cold-induced thermogenesis

Functional Information from PROSITE/UniProt

site_id	PS00070
Number of Residues	12
Details	ALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. FyHQGQCCIAAS

Chain	Residue	Details
A	PHE296-SER307

site_id	PS00687
Number of Residues	8
Details	ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. LELGGKSP

Chain	Residue	Details
A	LEU268-PRO275

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255\|PROSITE-ProRule:PRU10007, ECO:0000255\|PROSITE-ProRule:PRU10008, ECO:0000269\|PubMed:3676276

Chain	Residue	Details
A	GLU269
B	GLU269
C	GLU269
D	GLU269

site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Nucleophile => ECO:0000255\|PROSITE-ProRule:PRU10007, ECO:0000255\|PROSITE-ProRule:PRU10008, ECO:0000269\|PubMed:3676276

Chain	Residue	Details
A	CYS303
B	CYS303
C	CYS303
D	CYS303

site_id	SWS_FT_FI3
Number of Residues	28
Details	BINDING: BINDING => ECO:0000269\|PubMed:25450233, ECO:0000269\|PubMed:25634381, ECO:0007744\|PDB:4WB9, ECO:0007744\|PDB:4X4L

Chain	Residue	Details
A	ILE167
B	GLY226
B	GLY246
B	GLU269
B	GLU349
B	GLU400
C	ILE167
C	LYS193
C	GLY226
C	GLY246
C	GLU269
A	LYS193
C	GLU349
C	GLU400
D	ILE167
D	LYS193
D	GLY226
D	GLY246
D	GLU269
D	GLU349
D	GLU400
A	GLY226
A	GLY246
A	GLU269
A	GLU349
A	GLU400
B	ILE167
B	LYS193

site_id	SWS_FT_FI4
Number of Residues	4
Details	SITE: Transition state stabilizer => ECO:0000250\|UniProtKB:P20000

Chain	Residue	Details
A	ASN170
B	ASN170
C	ASN170
D	ASN170

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: N-acetylserine => ECO:0000269\|PubMed:6723659, ECO:0007744\|PubMed:22223895

Chain	Residue	Details
A	SER2
B	SER2
C	SER2
D	SER2

site_id	SWS_FT_FI6
Number of Residues	36
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	LYS91
B	LYS91
B	LYS128
B	LYS252
B	LYS353
B	LYS367
B	LYS410
B	LYS419
B	LYS435
B	LYS495
C	LYS91
A	LYS128
C	LYS128
C	LYS252
C	LYS353
C	LYS367
C	LYS410
C	LYS419
C	LYS435
C	LYS495
D	LYS91
D	LYS128
A	LYS252
D	LYS252
D	LYS353
D	LYS367
D	LYS410
D	LYS419
D	LYS435
D	LYS495
A	LYS353
A	LYS367
A	LYS410
A	LYS419
A	LYS435
A	LYS495

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	THR337
B	THR337
C	THR337
D	THR337

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER413
B	SER413
C	SER413
D	SER413

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)