8DJM

HMGCR-UBIAD1 Complex State 1

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0004659	molecular_function	prenyltransferase activity
B	0016020	cellular_component	membrane
B	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
C	0005506	molecular_function	iron ion binding
C	0009055	molecular_function	electron transfer activity
C	0020037	molecular_function	heme binding
C	0022900	biological_process	electron transport chain
C	0042597	cellular_component	periplasmic space
C	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
H	TYR220-HIS226
L	TYR211-HIS217

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: axial binding residue

Chain	Residue	Details
C	TRP273
C	ILE368
A	TYR90-LEU114
A	ALA124-SER149
A	GLY160-VAL187
A	ILE192-LEU220
A	PRO249-ALA275
A	MET315-PHE339

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site_id	SWS_FT_FI2
Number of Residues	27
Details	TOPO_DOM: Lumenal => ECO:0000305|PubMed:1374417

Chain	Residue	Details
A	ASN40-ASP56
A	ASP115-GLU123
A	ARG188-GLU191

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site_id	SWS_FT_FI3
Number of Residues	19
Details	TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:1374417

Chain	Residue	Details
A	GLN79-ARG89
A	GLN150-ARG159

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site_id	SWS_FT_FI4
Number of Residues	27
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:1374417

Chain	Residue	Details
A	GLU221-ARG248

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site_id	SWS_FT_FI5
Number of Residues	38
Details	TOPO_DOM: Lumenal => ECO:0000269|PubMed:1374417

Chain	Residue	Details
A	ASP276-LYS314

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site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN281

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site_id	SWS_FT_FI7
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:14563840, ECO:0000269|PubMed:15247208

Chain	Residue	Details
A	ARG89
A	ARG248

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