8DJA

Cryo-EM structure of mouse PrP23-144 amyloid fibrils (polymorph 1)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016020	cellular_component	membrane
A	0051260	biological_process	protein homooligomerization
B	0016020	cellular_component	membrane
B	0051260	biological_process	protein homooligomerization
C	0016020	cellular_component	membrane
C	0051260	biological_process	protein homooligomerization
D	0016020	cellular_component	membrane
D	0051260	biological_process	protein homooligomerization
E	0016020	cellular_component	membrane
E	0051260	biological_process	protein homooligomerization
F	0016020	cellular_component	membrane
F	0051260	biological_process	protein homooligomerization
G	0016020	cellular_component	membrane
G	0051260	biological_process	protein homooligomerization
H	0016020	cellular_component	membrane
H	0051260	biological_process	protein homooligomerization
I	0016020	cellular_component	membrane
I	0051260	biological_process	protein homooligomerization
J	0016020	cellular_component	membrane
J	0051260	biological_process	protein homooligomerization
K	0016020	cellular_component	membrane
K	0051260	biological_process	protein homooligomerization
L	0016020	cellular_component	membrane
L	0051260	biological_process	protein homooligomerization
M	0016020	cellular_component	membrane
M	0051260	biological_process	protein homooligomerization
N	0016020	cellular_component	membrane
N	0051260	biological_process	protein homooligomerization
O	0016020	cellular_component	membrane
O	0051260	biological_process	protein homooligomerization
P	0016020	cellular_component	membrane
P	0051260	biological_process	protein homooligomerization
Q	0016020	cellular_component	membrane
Q	0051260	biological_process	protein homooligomerization
R	0016020	cellular_component	membrane
R	0051260	biological_process	protein homooligomerization
S	0016020	cellular_component	membrane
S	0051260	biological_process	protein homooligomerization
T	0016020	cellular_component	membrane
T	0051260	biological_process	protein homooligomerization

Functional Information from PROSITE/UniProt

site_id	PS00291
Number of Residues	16
Details	PRION_1 Prion protein signature 1. AGAAAAGAVVGGLGGY

Chain	Residue	Details
A	ALA113-TYR128

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	240
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P04156

Chain	Residue	Details
A	HIS61
A	HIS85
D	HIS69
D	GLY70
D	GLY71
D	HIS77
D	GLY78
D	GLY79
D	HIS85
D	GLY86
D	GLY87
H	HIS61
A	GLY86
H	GLY62
H	GLY63
H	HIS69
H	GLY70
H	GLY71
H	HIS77
H	GLY78
H	GLY79
H	HIS85
H	GLY86
A	GLY87
H	GLY87
M	HIS61
M	GLY62
M	GLY63
M	HIS69
M	GLY70
M	GLY71
M	HIS77
M	GLY78
M	GLY79
B	HIS61
M	HIS85
M	GLY86
M	GLY87
R	HIS61
R	GLY62
R	GLY63
R	HIS69
R	GLY70
R	GLY71
R	HIS77
B	GLY62
R	GLY78
R	GLY79
R	HIS85
R	GLY86
R	GLY87
E	HIS61
E	GLY62
E	GLY63
E	HIS69
E	GLY70
B	GLY63
E	GLY71
E	HIS77
E	GLY78
E	GLY79
E	HIS85
E	GLY86
E	GLY87
I	HIS61
I	GLY62
I	GLY63
B	HIS69
I	HIS69
I	GLY70
I	GLY71
I	HIS77
I	GLY78
I	GLY79
I	HIS85
I	GLY86
I	GLY87
N	HIS61
B	GLY70
N	GLY62
N	GLY63
N	HIS69
N	GLY70
N	GLY71
N	HIS77
N	GLY78
N	GLY79
N	HIS85
N	GLY86
B	GLY71
N	GLY87
S	HIS61
S	GLY62
S	GLY63
S	HIS69
S	GLY70
S	GLY71
S	HIS77
S	GLY78
S	GLY79
B	HIS77
S	HIS85
S	GLY86
S	GLY87
F	HIS61
F	GLY62
F	GLY63
F	HIS69
F	GLY70
F	GLY71
F	HIS77
A	GLY62
B	GLY78
F	GLY78
F	GLY79
F	HIS85
F	GLY86
F	GLY87
J	HIS61
J	GLY62
J	GLY63
J	HIS69
J	GLY70
B	GLY79
J	GLY71
J	HIS77
J	GLY78
J	GLY79
J	HIS85
J	GLY86
J	GLY87
O	HIS61
O	GLY62
O	GLY63
B	HIS85
O	HIS69
O	GLY70
O	GLY71
O	HIS77
O	GLY78
O	GLY79
O	HIS85
O	GLY86
O	GLY87
T	HIS61
B	GLY86
T	GLY62
T	GLY63
T	HIS69
T	GLY70
T	GLY71
T	HIS77
T	GLY78
T	GLY79
T	HIS85
T	GLY86
B	GLY87
T	GLY87
K	HIS61
K	GLY62
K	GLY63
K	HIS69
K	GLY70
A	GLY63
K	GLY71
K	HIS77
K	GLY78
K	GLY79
K	HIS85
K	GLY86
K	GLY87
P	HIS61
P	GLY62
P	GLY63
A	HIS69
P	HIS69
P	GLY70
P	GLY71
P	HIS77
P	GLY78
P	GLY79
P	HIS85
P	GLY86
P	GLY87
C	HIS61
A	GLY70
C	GLY62
C	GLY63
C	HIS69
C	GLY70
C	GLY71
C	HIS77
C	GLY78
C	GLY79
C	HIS85
C	GLY86
A	GLY71
C	GLY87
G	HIS61
G	GLY62
G	GLY63
G	HIS69
G	GLY70
G	GLY71
G	HIS77
G	GLY78
G	GLY79
A	HIS77
G	HIS85
G	GLY86
G	GLY87
L	HIS61
L	GLY62
L	GLY63
L	HIS69
L	GLY70
L	GLY71
L	HIS77
A	GLY78
L	GLY78
L	GLY79
L	HIS85
L	GLY86
L	GLY87
Q	HIS61
Q	GLY62
Q	GLY63
Q	HIS69
Q	GLY70
A	GLY79
Q	GLY71
Q	HIS77
Q	GLY78
Q	GLY79
Q	HIS85
Q	GLY86
Q	GLY87
D	HIS61
D	GLY62
D	GLY63

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	MOD_RES: Hydroxyproline => ECO:0000269|PubMed:11032800

Chain	Residue	Details
A	PRO45
H	PRO45
M	PRO45
R	PRO45
E	PRO45
I	PRO45
N	PRO45
S	PRO45
F	PRO45
J	PRO45
O	PRO45
B	PRO45
T	PRO45
K	PRO45
P	PRO45
C	PRO45
G	PRO45
L	PRO45
Q	PRO45
D	PRO45

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