8DH6
Cryo-EM structure of Saccharomyces cerevisiae cytochrome c oxidase (Complex IV) extracted in lipid nanodiscs
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| a | 0004129 | molecular_function | cytochrome-c oxidase activity |
| a | 0005515 | molecular_function | protein binding |
| a | 0005739 | cellular_component | mitochondrion |
| a | 0005743 | cellular_component | mitochondrial inner membrane |
| a | 0006119 | biological_process | oxidative phosphorylation |
| a | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| a | 0009060 | biological_process | aerobic respiration |
| a | 0015990 | biological_process | electron transport coupled proton transport |
| a | 0016020 | cellular_component | membrane |
| a | 0020037 | molecular_function | heme binding |
| a | 0031966 | cellular_component | mitochondrial membrane |
| a | 0045277 | cellular_component | respiratory chain complex IV |
| a | 0045333 | biological_process | cellular respiration |
| a | 0046872 | molecular_function | metal ion binding |
| b | 0004129 | molecular_function | cytochrome-c oxidase activity |
| b | 0005507 | molecular_function | copper ion binding |
| b | 0005515 | molecular_function | protein binding |
| b | 0005739 | cellular_component | mitochondrion |
| b | 0005743 | cellular_component | mitochondrial inner membrane |
| b | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| b | 0009060 | biological_process | aerobic respiration |
| b | 0016020 | cellular_component | membrane |
| b | 0016491 | molecular_function | oxidoreductase activity |
| b | 0022900 | biological_process | electron transport chain |
| b | 0042773 | biological_process | ATP synthesis coupled electron transport |
| b | 0045277 | cellular_component | respiratory chain complex IV |
| b | 0046872 | molecular_function | metal ion binding |
| b | 1902600 | biological_process | proton transmembrane transport |
| c | 0004129 | molecular_function | cytochrome-c oxidase activity |
| c | 0005739 | cellular_component | mitochondrion |
| c | 0005743 | cellular_component | mitochondrial inner membrane |
| c | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| c | 0009055 | molecular_function | electron transfer activity |
| c | 0009060 | biological_process | aerobic respiration |
| c | 0016020 | cellular_component | membrane |
| c | 0019646 | biological_process | aerobic electron transport chain |
| c | 0022904 | biological_process | respiratory electron transport chain |
| c | 0031966 | cellular_component | mitochondrial membrane |
| c | 0045277 | cellular_component | respiratory chain complex IV |
| c | 0045333 | biological_process | cellular respiration |
| c | 0048039 | molecular_function | ubiquinone binding |
| c | 1902600 | biological_process | proton transmembrane transport |
| d | 0005740 | cellular_component | mitochondrial envelope |
| d | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| d | 0045277 | cellular_component | respiratory chain complex IV |
| e | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| e | 0045277 | cellular_component | respiratory chain complex IV |
| f | 0005743 | cellular_component | mitochondrial inner membrane |
| f | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| f | 0045277 | cellular_component | respiratory chain complex IV |
| g | 0004129 | molecular_function | cytochrome-c oxidase activity |
| g | 0005739 | cellular_component | mitochondrion |
| g | 0005743 | cellular_component | mitochondrial inner membrane |
| g | 0006119 | biological_process | oxidative phosphorylation |
| g | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| g | 0016491 | molecular_function | oxidoreductase activity |
| g | 0031966 | cellular_component | mitochondrial membrane |
| g | 0045277 | cellular_component | respiratory chain complex IV |
| g | 0045333 | biological_process | cellular respiration |
| g | 1902600 | biological_process | proton transmembrane transport |
| h | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| h | 0045277 | cellular_component | respiratory chain complex IV |
| i | 0004129 | molecular_function | cytochrome-c oxidase activity |
| i | 0005739 | cellular_component | mitochondrion |
| i | 0005743 | cellular_component | mitochondrial inner membrane |
| i | 0006119 | biological_process | oxidative phosphorylation |
| i | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| i | 0016491 | molecular_function | oxidoreductase activity |
| i | 0045277 | cellular_component | respiratory chain complex IV |
| i | 1902600 | biological_process | proton transmembrane transport |
Functional Information from PROSITE/UniProt
| site_id | PS00077 |
| Number of Residues | 55 |
| Details | COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyiliipgfgiishvvstyskkpvfgeismvyamasigllgflvws..HH |
| Chain | Residue | Details |
| a | TRP237-HIS291 |
| site_id | PS00078 |
| Number of Residues | 49 |
| Details | COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. ViHdfaipslgikvdatpgrlnqvsaliqregvfyga......CselCgtgHanM |
| Chain | Residue | Details |
| b | VAL184-MET232 |
| site_id | PS00848 |
| Number of Residues | 23 |
| Details | COX5B_1 Cytochrome c oxidase subunit Vb, zinc binding region signature. IMWlkptvnevarCweCGsvYKL |
| Chain | Residue | Details |
| d | ILE121-LEU143 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | TOPO_DOM: Mitochondrial matrix => ECO:0000269|PubMed:30598554 |
| Chain | Residue | Details |
| i | THR2-GLY8 | |
| d | HIS119 | |
| d | CYS134 | |
| d | CYS137 | |
| a | HIS328-ALA335 | |
| a | LEU401-ASN406 | |
| a | GLN475-SER534 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 35 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:30598554 |
| Chain | Residue | Details |
| i | THR9-ARG44 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 11 |
| Details | TOPO_DOM: Mitochondrial intermembrane => ECO:0000269|PubMed:30598554 |
| Chain | Residue | Details |
| i | GLU45-LYS56 | |
| c | SER115-LEU137 | |
| c | TYR189-TYR201 | |
| c | TRP266-VAL269 | |
| a | ALA359-THR370 | |
| a | GLY432-GLY449 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:30598554 |
| Chain | Residue | Details |
| c | ASN49-ALA73 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 33 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:30598554 |
| Chain | Residue | Details |
| c | MET81-MET114 | |
| b | CYS221 | |
| b | CYS225 | |
| b | MET232 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:30598554 |
| Chain | Residue | Details |
| c | PRO138-ALA161 | |
| b | HIS229 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:30598554 |
| Chain | Residue | Details |
| c | ASN165-GLU188 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 28 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:30598554 |
| Chain | Residue | Details |
| c | GLY202-MET230 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 16 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:30598554 |
| Chain | Residue | Details |
| c | TYR249-TYR265 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 28 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:30598554 |
| Chain | Residue | Details |
| a | ALA299-ILE327 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:30598554 |
| Chain | Residue | Details |
| a | THR336-LEU358 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 29 |
| Details | TRANSMEM: Helical; Name=10 => ECO:0000269|PubMed:30598554 |
| Chain | Residue | Details |
| a | TYR371-ILE400 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000269|PubMed:30598554 |
| Chain | Residue | Details |
| a | GLU407-LEU431 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0000269|PubMed:30598554 |
| Chain | Residue | Details |
| a | TRP450-ASP474 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 9 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:30598554, ECO:0000269|PubMed:30598556 |
| Chain | Residue | Details |
| a | GLU39 | |
| a | ALA42 | |
| a | GLY44 | |
| a | HIS241 | |
| a | HIS290 | |
| a | HIS291 | |
| a | HIS368 | |
| a | ASP369 | |
| a | PRO441 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | BINDING: axial binding residue => ECO:0000269|PubMed:30598554, ECO:0000269|PubMed:30598556 |
| Chain | Residue | Details |
| a | HIS62 | |
| a | HIS378 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P00396 |
| Chain | Residue | Details |
| a | TYR245 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 1 |
| Details | BINDING: axial binding residue => ECO:0000269|PubMed:30598554 |
| Chain | Residue | Details |
| a | HIS376 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 2 |
| Details | CROSSLNK: 1'-histidyl-3'-tyrosine (His-Tyr) => ECO:0000269|PubMed:30598554 |
| Chain | Residue | Details |
| a | HIS241 | |
| a | TYR245 |
