8DF1

Chi3l1 bound by antibody C59

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004568	molecular_function	chitinase activity
A	0005201	molecular_function	extracellular matrix structural constituent
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005975	biological_process	carbohydrate metabolic process
A	0006032	biological_process	chitin catabolic process
A	0006915	biological_process	apoptotic process
A	0006954	biological_process	inflammatory response
A	0007250	biological_process	activation of NF-kappaB-inducing kinase activity
A	0008061	molecular_function	chitin binding
A	0009612	biological_process	response to mechanical stimulus
A	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
A	0030246	molecular_function	carbohydrate binding
A	0030324	biological_process	lung development
A	0031012	cellular_component	extracellular matrix
A	0032757	biological_process	positive regulation of interleukin-8 production
A	0034612	biological_process	response to tumor necrosis factor
A	0035580	cellular_component	specific granule lumen
A	0045766	biological_process	positive regulation of angiogenesis
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0051216	biological_process	cartilage development
A	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0070062	cellular_component	extracellular exosome
A	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
A	0070555	biological_process	response to interleukin-1
A	0070741	biological_process	response to interleukin-6
A	0071356	biological_process	cellular response to tumor necrosis factor
B	0004568	molecular_function	chitinase activity
B	0005201	molecular_function	extracellular matrix structural constituent
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0005975	biological_process	carbohydrate metabolic process
B	0006032	biological_process	chitin catabolic process
B	0006915	biological_process	apoptotic process
B	0006954	biological_process	inflammatory response
B	0007250	biological_process	activation of NF-kappaB-inducing kinase activity
B	0008061	molecular_function	chitin binding
B	0009612	biological_process	response to mechanical stimulus
B	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
B	0030246	molecular_function	carbohydrate binding
B	0030324	biological_process	lung development
B	0031012	cellular_component	extracellular matrix
B	0032757	biological_process	positive regulation of interleukin-8 production
B	0034612	biological_process	response to tumor necrosis factor
B	0035580	cellular_component	specific granule lumen
B	0045766	biological_process	positive regulation of angiogenesis
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0051216	biological_process	cartilage development
B	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B	0070062	cellular_component	extracellular exosome
B	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
B	0070555	biological_process	response to interleukin-1
B	0070741	biological_process	response to interleukin-6
B	0071356	biological_process	cellular response to tumor necrosis factor
C	0004568	molecular_function	chitinase activity
C	0005201	molecular_function	extracellular matrix structural constituent
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005737	cellular_component	cytoplasm
C	0005783	cellular_component	endoplasmic reticulum
C	0005975	biological_process	carbohydrate metabolic process
C	0006032	biological_process	chitin catabolic process
C	0006915	biological_process	apoptotic process
C	0006954	biological_process	inflammatory response
C	0007250	biological_process	activation of NF-kappaB-inducing kinase activity
C	0008061	molecular_function	chitin binding
C	0009612	biological_process	response to mechanical stimulus
C	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
C	0030246	molecular_function	carbohydrate binding
C	0030324	biological_process	lung development
C	0031012	cellular_component	extracellular matrix
C	0032757	biological_process	positive regulation of interleukin-8 production
C	0034612	biological_process	response to tumor necrosis factor
C	0035580	cellular_component	specific granule lumen
C	0045766	biological_process	positive regulation of angiogenesis
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0051216	biological_process	cartilage development
C	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C	0070062	cellular_component	extracellular exosome
C	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
C	0070555	biological_process	response to interleukin-1
C	0070741	biological_process	response to interleukin-6
C	0071356	biological_process	cellular response to tumor necrosis factor
D	0004568	molecular_function	chitinase activity
D	0005201	molecular_function	extracellular matrix structural constituent
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005737	cellular_component	cytoplasm
D	0005783	cellular_component	endoplasmic reticulum
D	0005975	biological_process	carbohydrate metabolic process
D	0006032	biological_process	chitin catabolic process
D	0006915	biological_process	apoptotic process
D	0006954	biological_process	inflammatory response
D	0007250	biological_process	activation of NF-kappaB-inducing kinase activity
D	0008061	molecular_function	chitin binding
D	0009612	biological_process	response to mechanical stimulus
D	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
D	0030246	molecular_function	carbohydrate binding
D	0030324	biological_process	lung development
D	0031012	cellular_component	extracellular matrix
D	0032757	biological_process	positive regulation of interleukin-8 production
D	0034612	biological_process	response to tumor necrosis factor
D	0035580	cellular_component	specific granule lumen
D	0045766	biological_process	positive regulation of angiogenesis
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0051216	biological_process	cartilage development
D	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D	0070062	cellular_component	extracellular exosome
D	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
D	0070555	biological_process	response to interleukin-1
D	0070741	biological_process	response to interleukin-6
D	0071356	biological_process	cellular response to tumor necrosis factor
E	0004568	molecular_function	chitinase activity
E	0005201	molecular_function	extracellular matrix structural constituent
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005737	cellular_component	cytoplasm
E	0005783	cellular_component	endoplasmic reticulum
E	0005975	biological_process	carbohydrate metabolic process
E	0006032	biological_process	chitin catabolic process
E	0006915	biological_process	apoptotic process
E	0006954	biological_process	inflammatory response
E	0007250	biological_process	activation of NF-kappaB-inducing kinase activity
E	0008061	molecular_function	chitin binding
E	0009612	biological_process	response to mechanical stimulus
E	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
E	0030246	molecular_function	carbohydrate binding
E	0030324	biological_process	lung development
E	0031012	cellular_component	extracellular matrix
E	0032757	biological_process	positive regulation of interleukin-8 production
E	0034612	biological_process	response to tumor necrosis factor
E	0035580	cellular_component	specific granule lumen
E	0045766	biological_process	positive regulation of angiogenesis
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0051216	biological_process	cartilage development
E	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
E	0070062	cellular_component	extracellular exosome
E	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
E	0070555	biological_process	response to interleukin-1
E	0070741	biological_process	response to interleukin-6
E	0071356	biological_process	cellular response to tumor necrosis factor
F	0004568	molecular_function	chitinase activity
F	0005201	molecular_function	extracellular matrix structural constituent
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005737	cellular_component	cytoplasm
F	0005783	cellular_component	endoplasmic reticulum
F	0005975	biological_process	carbohydrate metabolic process
F	0006032	biological_process	chitin catabolic process
F	0006915	biological_process	apoptotic process
F	0006954	biological_process	inflammatory response
F	0007250	biological_process	activation of NF-kappaB-inducing kinase activity
F	0008061	molecular_function	chitin binding
F	0009612	biological_process	response to mechanical stimulus
F	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
F	0030246	molecular_function	carbohydrate binding
F	0030324	biological_process	lung development
F	0031012	cellular_component	extracellular matrix
F	0032757	biological_process	positive regulation of interleukin-8 production
F	0034612	biological_process	response to tumor necrosis factor
F	0035580	cellular_component	specific granule lumen
F	0045766	biological_process	positive regulation of angiogenesis
F	0048471	cellular_component	perinuclear region of cytoplasm
F	0051216	biological_process	cartilage development
F	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
F	0070062	cellular_component	extracellular exosome
F	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
F	0070555	biological_process	response to interleukin-1
F	0070741	biological_process	response to interleukin-6
F	0071356	biological_process	cellular response to tumor necrosis factor

Functional Information from PROSITE/UniProt

site_id	PS00217
Number of Residues	26
Details	SUGAR_TRANSPORT_2 Sugar transport proteins signature 2. FhGAWrGTtghhsplFrgQedaspdR

Chain	Residue	Details
A	PHE213-ARG238

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2166
Details	Domain: {"description":"GH18","evidences":[{"source":"PROSITE-ProRule","id":"PRU01258","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	84
Details	Region: {"description":"Important for AKT1 activation and IL8 production","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	54
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01258","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12775711","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---