8DEA
Scaffold Hopping via Ring Opening Enables Identification of Acyclic Compounds as New Complement Factor D Inhibitors
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006508 | biological_process | proteolysis |
| A | 0006956 | biological_process | complement activation |
| A | 0006957 | biological_process | complement activation, alternative pathway |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0009617 | biological_process | response to bacterium |
| A | 0031093 | cellular_component | platelet alpha granule lumen |
| A | 0034774 | cellular_component | secretory granule lumen |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 1904813 | cellular_component | ficolin-1-rich granule lumen |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0006508 | biological_process | proteolysis |
| B | 0006956 | biological_process | complement activation |
| B | 0006957 | biological_process | complement activation, alternative pathway |
| B | 0008236 | molecular_function | serine-type peptidase activity |
| B | 0009617 | biological_process | response to bacterium |
| B | 0031093 | cellular_component | platelet alpha granule lumen |
| B | 0034774 | cellular_component | secretory granule lumen |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 1904813 | cellular_component | ficolin-1-rich granule lumen |
| C | 0004252 | molecular_function | serine-type endopeptidase activity |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005615 | cellular_component | extracellular space |
| C | 0006508 | biological_process | proteolysis |
| C | 0006956 | biological_process | complement activation |
| C | 0006957 | biological_process | complement activation, alternative pathway |
| C | 0008236 | molecular_function | serine-type peptidase activity |
| C | 0009617 | biological_process | response to bacterium |
| C | 0031093 | cellular_component | platelet alpha granule lumen |
| C | 0034774 | cellular_component | secretory granule lumen |
| C | 0070062 | cellular_component | extracellular exosome |
| C | 1904813 | cellular_component | ficolin-1-rich granule lumen |
| D | 0004252 | molecular_function | serine-type endopeptidase activity |
| D | 0005576 | cellular_component | extracellular region |
| D | 0005615 | cellular_component | extracellular space |
| D | 0006508 | biological_process | proteolysis |
| D | 0006956 | biological_process | complement activation |
| D | 0006957 | biological_process | complement activation, alternative pathway |
| D | 0008236 | molecular_function | serine-type peptidase activity |
| D | 0009617 | biological_process | response to bacterium |
| D | 0031093 | cellular_component | platelet alpha granule lumen |
| D | 0034774 | cellular_component | secretory granule lumen |
| D | 0070062 | cellular_component | extracellular exosome |
| D | 1904813 | cellular_component | ficolin-1-rich granule lumen |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | ACT_SITE: Charge relay system |
| Chain | Residue | Details |
| A | HIS41 | |
| D | HIS41 | |
| D | ASP89 | |
| D | SER183 | |
| A | ASP89 | |
| A | SER183 | |
| B | HIS41 | |
| B | ASP89 | |
| B | SER183 | |
| C | HIS41 | |
| C | ASP89 | |
| C | SER183 |
