8DDU
cryo-EM structure of TRPM3 ion channel in the presence of PIP2, state3
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0051262 | biological_process | protein tetramerization |
| A | 0055085 | biological_process | transmembrane transport |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0051262 | biological_process | protein tetramerization |
| B | 0055085 | biological_process | transmembrane transport |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0051262 | biological_process | protein tetramerization |
| C | 0055085 | biological_process | transmembrane transport |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0051262 | biological_process | protein tetramerization |
| D | 0055085 | biological_process | transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3688 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | MET1-LEU894 | |
| D | MET1-LEU894 | |
| D | ILE949-ASP964 | |
| D | VAL1014-ARG1028 | |
| A | ILE949-ASP964 | |
| A | VAL1014-ARG1028 | |
| B | MET1-LEU894 | |
| B | ILE949-ASP964 | |
| B | VAL1014-ARG1028 | |
| C | MET1-LEU894 | |
| C | ILE949-ASP964 | |
| C | VAL1014-ARG1028 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 92 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:36283409 |
| Chain | Residue | Details |
| A | VAL895-GLU918 | |
| B | VAL895-GLU918 | |
| C | VAL895-GLU918 | |
| D | VAL895-GLU918 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 136 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| A | LYS919-MET925 | |
| C | LEU986-ILE989 | |
| C | GLU1057-ARG1073 | |
| C | ALA1102-ILE1111 | |
| D | LYS919-MET925 | |
| D | LEU986-ILE989 | |
| D | GLU1057-ARG1073 | |
| D | ALA1102-ILE1111 | |
| A | LEU986-ILE989 | |
| A | GLU1057-ARG1073 | |
| A | ALA1102-ILE1111 | |
| B | LYS919-MET925 | |
| B | LEU986-ILE989 | |
| B | GLU1057-ARG1073 | |
| B | ALA1102-ILE1111 | |
| C | LYS919-MET925 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 88 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:36283409 |
| Chain | Residue | Details |
| A | SER926-LEU948 | |
| B | SER926-LEU948 | |
| C | SER926-LEU948 | |
| D | SER926-LEU948 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:36283409 |
| Chain | Residue | Details |
| A | GLN965-ARG985 | |
| B | GLN965-ARG985 | |
| C | GLN965-ARG985 | |
| D | GLN965-ARG985 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 92 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:36283409 |
| Chain | Residue | Details |
| A | PHE990-PHE1013 | |
| B | PHE990-PHE1013 | |
| C | PHE990-PHE1013 | |
| D | PHE990-PHE1013 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 108 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:36283409 |
| Chain | Residue | Details |
| A | GLN1029-GLY1056 | |
| B | GLN1029-GLY1056 | |
| C | GLN1029-GLY1056 | |
| D | GLN1029-GLY1056 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 108 |
| Details | INTRAMEM: Pore-forming => ECO:0000305|PubMed:32780479 |
| Chain | Residue | Details |
| A | GLU1074-VAL1101 | |
| B | GLU1074-VAL1101 | |
| C | GLU1074-VAL1101 | |
| D | GLU1074-VAL1101 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 100 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:36283409 |
| Chain | Residue | Details |
| A | ALA1112-ILE1137 | |
| B | ALA1112-ILE1137 | |
| C | ALA1112-ILE1137 | |
| D | ALA1112-ILE1137 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:36283409, ECO:0007744|PDB:8DDU |
| Chain | Residue | Details |
| A | ASP796 | |
| B | ASP796 | |
| C | ASP796 | |
| D | ASP796 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:36283409, ECO:0007744|PDB:8DDT, ECO:0007744|PDB:8DDU |
| Chain | Residue | Details |
| A | MET1017 | |
| A | LEU1018 | |
| B | MET1017 | |
| B | LEU1018 | |
| C | MET1017 | |
| C | LEU1018 | |
| D | MET1017 | |
| D | LEU1018 |
