8DBJ

Human PRPS1 with Phosphate, ATP, and R5P; Filament Interface

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004749	molecular_function	ribose phosphate diphosphokinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006015	biological_process	5-phosphoribose 1-diphosphate biosynthetic process
A	0006144	biological_process	purine nucleobase metabolic process
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006796	biological_process	phosphate-containing compound metabolic process
A	0007399	biological_process	nervous system development
A	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
A	0009165	biological_process	nucleotide biosynthetic process
A	0016301	molecular_function	kinase activity
A	0034418	biological_process	urate biosynthetic process
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0044249	biological_process	obsolete cellular biosynthetic process
A	0046101	biological_process	hypoxanthine biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0090407	biological_process	organophosphate biosynthetic process
B	0000287	molecular_function	magnesium ion binding
B	0004749	molecular_function	ribose phosphate diphosphokinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006015	biological_process	5-phosphoribose 1-diphosphate biosynthetic process
B	0006144	biological_process	purine nucleobase metabolic process
B	0006164	biological_process	purine nucleotide biosynthetic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006796	biological_process	phosphate-containing compound metabolic process
B	0007399	biological_process	nervous system development
B	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
B	0009165	biological_process	nucleotide biosynthetic process
B	0016301	molecular_function	kinase activity
B	0034418	biological_process	urate biosynthetic process
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0044249	biological_process	obsolete cellular biosynthetic process
B	0046101	biological_process	hypoxanthine biosynthetic process
B	0046872	molecular_function	metal ion binding
B	0090407	biological_process	organophosphate biosynthetic process
C	0000287	molecular_function	magnesium ion binding
C	0004749	molecular_function	ribose phosphate diphosphokinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006015	biological_process	5-phosphoribose 1-diphosphate biosynthetic process
C	0006144	biological_process	purine nucleobase metabolic process
C	0006164	biological_process	purine nucleotide biosynthetic process
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006796	biological_process	phosphate-containing compound metabolic process
C	0007399	biological_process	nervous system development
C	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
C	0009165	biological_process	nucleotide biosynthetic process
C	0016301	molecular_function	kinase activity
C	0034418	biological_process	urate biosynthetic process
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0044249	biological_process	obsolete cellular biosynthetic process
C	0046101	biological_process	hypoxanthine biosynthetic process
C	0046872	molecular_function	metal ion binding
C	0090407	biological_process	organophosphate biosynthetic process
D	0000287	molecular_function	magnesium ion binding
D	0004749	molecular_function	ribose phosphate diphosphokinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006015	biological_process	5-phosphoribose 1-diphosphate biosynthetic process
D	0006144	biological_process	purine nucleobase metabolic process
D	0006164	biological_process	purine nucleotide biosynthetic process
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0006796	biological_process	phosphate-containing compound metabolic process
D	0007399	biological_process	nervous system development
D	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
D	0009165	biological_process	nucleotide biosynthetic process
D	0016301	molecular_function	kinase activity
D	0034418	biological_process	urate biosynthetic process
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0044249	biological_process	obsolete cellular biosynthetic process
D	0046101	biological_process	hypoxanthine biosynthetic process
D	0046872	molecular_function	metal ion binding
D	0090407	biological_process	organophosphate biosynthetic process
E	0000287	molecular_function	magnesium ion binding
E	0004749	molecular_function	ribose phosphate diphosphokinase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006015	biological_process	5-phosphoribose 1-diphosphate biosynthetic process
E	0006144	biological_process	purine nucleobase metabolic process
E	0006164	biological_process	purine nucleotide biosynthetic process
E	0006221	biological_process	pyrimidine nucleotide biosynthetic process
E	0006796	biological_process	phosphate-containing compound metabolic process
E	0007399	biological_process	nervous system development
E	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
E	0009165	biological_process	nucleotide biosynthetic process
E	0016301	molecular_function	kinase activity
E	0034418	biological_process	urate biosynthetic process
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0044249	biological_process	obsolete cellular biosynthetic process
E	0046101	biological_process	hypoxanthine biosynthetic process
E	0046872	molecular_function	metal ion binding
E	0090407	biological_process	organophosphate biosynthetic process
F	0000287	molecular_function	magnesium ion binding
F	0004749	molecular_function	ribose phosphate diphosphokinase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006015	biological_process	5-phosphoribose 1-diphosphate biosynthetic process
F	0006144	biological_process	purine nucleobase metabolic process
F	0006164	biological_process	purine nucleotide biosynthetic process
F	0006221	biological_process	pyrimidine nucleotide biosynthetic process
F	0006796	biological_process	phosphate-containing compound metabolic process
F	0007399	biological_process	nervous system development
F	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
F	0009165	biological_process	nucleotide biosynthetic process
F	0016301	molecular_function	kinase activity
F	0034418	biological_process	urate biosynthetic process
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0044249	biological_process	obsolete cellular biosynthetic process
F	0046101	biological_process	hypoxanthine biosynthetic process
F	0046872	molecular_function	metal ion binding
F	0090407	biological_process	organophosphate biosynthetic process
G	0000287	molecular_function	magnesium ion binding
G	0004749	molecular_function	ribose phosphate diphosphokinase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006015	biological_process	5-phosphoribose 1-diphosphate biosynthetic process
G	0006144	biological_process	purine nucleobase metabolic process
G	0006164	biological_process	purine nucleotide biosynthetic process
G	0006221	biological_process	pyrimidine nucleotide biosynthetic process
G	0006796	biological_process	phosphate-containing compound metabolic process
G	0007399	biological_process	nervous system development
G	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
G	0009165	biological_process	nucleotide biosynthetic process
G	0016301	molecular_function	kinase activity
G	0034418	biological_process	urate biosynthetic process
G	0042802	molecular_function	identical protein binding
G	0042803	molecular_function	protein homodimerization activity
G	0044249	biological_process	obsolete cellular biosynthetic process
G	0046101	biological_process	hypoxanthine biosynthetic process
G	0046872	molecular_function	metal ion binding
G	0090407	biological_process	organophosphate biosynthetic process
H	0000287	molecular_function	magnesium ion binding
H	0004749	molecular_function	ribose phosphate diphosphokinase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006015	biological_process	5-phosphoribose 1-diphosphate biosynthetic process
H	0006144	biological_process	purine nucleobase metabolic process
H	0006164	biological_process	purine nucleotide biosynthetic process
H	0006221	biological_process	pyrimidine nucleotide biosynthetic process
H	0006796	biological_process	phosphate-containing compound metabolic process
H	0007399	biological_process	nervous system development
H	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
H	0009165	biological_process	nucleotide biosynthetic process
H	0016301	molecular_function	kinase activity
H	0034418	biological_process	urate biosynthetic process
H	0042802	molecular_function	identical protein binding
H	0042803	molecular_function	protein homodimerization activity
H	0044249	biological_process	obsolete cellular biosynthetic process
H	0046101	biological_process	hypoxanthine biosynthetic process
H	0046872	molecular_function	metal ion binding
H	0090407	biological_process	organophosphate biosynthetic process
I	0000287	molecular_function	magnesium ion binding
I	0004749	molecular_function	ribose phosphate diphosphokinase activity
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006015	biological_process	5-phosphoribose 1-diphosphate biosynthetic process
I	0006144	biological_process	purine nucleobase metabolic process
I	0006164	biological_process	purine nucleotide biosynthetic process
I	0006221	biological_process	pyrimidine nucleotide biosynthetic process
I	0006796	biological_process	phosphate-containing compound metabolic process
I	0007399	biological_process	nervous system development
I	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
I	0009165	biological_process	nucleotide biosynthetic process
I	0016301	molecular_function	kinase activity
I	0034418	biological_process	urate biosynthetic process
I	0042802	molecular_function	identical protein binding
I	0042803	molecular_function	protein homodimerization activity
I	0044249	biological_process	obsolete cellular biosynthetic process
I	0046101	biological_process	hypoxanthine biosynthetic process
I	0046872	molecular_function	metal ion binding
I	0090407	biological_process	organophosphate biosynthetic process
J	0000287	molecular_function	magnesium ion binding
J	0004749	molecular_function	ribose phosphate diphosphokinase activity
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006015	biological_process	5-phosphoribose 1-diphosphate biosynthetic process
J	0006144	biological_process	purine nucleobase metabolic process
J	0006164	biological_process	purine nucleotide biosynthetic process
J	0006221	biological_process	pyrimidine nucleotide biosynthetic process
J	0006796	biological_process	phosphate-containing compound metabolic process
J	0007399	biological_process	nervous system development
J	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
J	0009165	biological_process	nucleotide biosynthetic process
J	0016301	molecular_function	kinase activity
J	0034418	biological_process	urate biosynthetic process
J	0042802	molecular_function	identical protein binding
J	0042803	molecular_function	protein homodimerization activity
J	0044249	biological_process	obsolete cellular biosynthetic process
J	0046101	biological_process	hypoxanthine biosynthetic process
J	0046872	molecular_function	metal ion binding
J	0090407	biological_process	organophosphate biosynthetic process
K	0000287	molecular_function	magnesium ion binding
K	0004749	molecular_function	ribose phosphate diphosphokinase activity
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006015	biological_process	5-phosphoribose 1-diphosphate biosynthetic process
K	0006144	biological_process	purine nucleobase metabolic process
K	0006164	biological_process	purine nucleotide biosynthetic process
K	0006221	biological_process	pyrimidine nucleotide biosynthetic process
K	0006796	biological_process	phosphate-containing compound metabolic process
K	0007399	biological_process	nervous system development
K	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
K	0009165	biological_process	nucleotide biosynthetic process
K	0016301	molecular_function	kinase activity
K	0034418	biological_process	urate biosynthetic process
K	0042802	molecular_function	identical protein binding
K	0042803	molecular_function	protein homodimerization activity
K	0044249	biological_process	obsolete cellular biosynthetic process
K	0046101	biological_process	hypoxanthine biosynthetic process
K	0046872	molecular_function	metal ion binding
K	0090407	biological_process	organophosphate biosynthetic process
L	0000287	molecular_function	magnesium ion binding
L	0004749	molecular_function	ribose phosphate diphosphokinase activity
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006015	biological_process	5-phosphoribose 1-diphosphate biosynthetic process
L	0006144	biological_process	purine nucleobase metabolic process
L	0006164	biological_process	purine nucleotide biosynthetic process
L	0006221	biological_process	pyrimidine nucleotide biosynthetic process
L	0006796	biological_process	phosphate-containing compound metabolic process
L	0007399	biological_process	nervous system development
L	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
L	0009165	biological_process	nucleotide biosynthetic process
L	0016301	molecular_function	kinase activity
L	0034418	biological_process	urate biosynthetic process
L	0042802	molecular_function	identical protein binding
L	0042803	molecular_function	protein homodimerization activity
L	0044249	biological_process	obsolete cellular biosynthetic process
L	0046101	biological_process	hypoxanthine biosynthetic process
L	0046872	molecular_function	metal ion binding
L	0090407	biological_process	organophosphate biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00114
Number of Residues	16
Details	PRPP_SYNTHASE Phosphoribosyl pyrophosphate synthase signature. DLHAsQIQGFFdiPVD

Chain	Residue	Details
A	ASP128-ASP143

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING:

Chain	Residue	Details
A	ARG96
J	ARG96
K	ARG96
L	ARG96
B	ARG96
C	ARG96
D	ARG96
E	ARG96
F	ARG96
G	ARG96
H	ARG96
I	ARG96

---

site_id	SWS_FT_FI2
Number of Residues	48
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
A	ASP128
C	HIS130
C	ASP139
C	ASP143
D	ASP128
D	HIS130
D	ASP139
D	ASP143
E	ASP128
E	HIS130
E	ASP139
A	HIS130
E	ASP143
F	ASP128
F	HIS130
F	ASP139
F	ASP143
G	ASP128
G	HIS130
G	ASP139
G	ASP143
H	ASP128
A	ASP139
H	HIS130
H	ASP139
H	ASP143
I	ASP128
I	HIS130
I	ASP139
I	ASP143
J	ASP128
J	HIS130
J	ASP139
A	ASP143
J	ASP143
K	ASP128
K	HIS130
K	ASP139
K	ASP143
L	ASP128
L	HIS130
L	ASP139
L	ASP143
B	ASP128
B	HIS130
B	ASP139
B	ASP143
C	ASP128

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