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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8D9D

Human DNA polymerase-alpha/primase elongation complex II bound to primer/template

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0000428cellular_componentDNA-directed RNA polymerase complex
A0003899molecular_functionDNA-directed RNA polymerase activity
A0005515molecular_functionprotein binding
A0005654cellular_componentnucleoplasm
A0005658cellular_componentalpha DNA polymerase:primase complex
A0006260biological_processDNA replication
A0006269biological_processDNA replication, synthesis of primer
A0006270biological_processDNA replication initiation
A0008270molecular_functionzinc ion binding
A0016020cellular_componentmembrane
A0016740molecular_functiontransferase activity
A0016779molecular_functionnucleotidyltransferase activity
A0032553molecular_functionribonucleotide binding
A0046872molecular_functionmetal ion binding
B0003677molecular_functionDNA binding
B0003899molecular_functionDNA-directed RNA polymerase activity
B0005515molecular_functionprotein binding
B0005654cellular_componentnucleoplasm
B0005658cellular_componentalpha DNA polymerase:primase complex
B0006260biological_processDNA replication
B0006269biological_processDNA replication, synthesis of primer
B0006270biological_processDNA replication initiation
B0046872molecular_functionmetal ion binding
B0051536molecular_functioniron-sulfur cluster binding
B0051539molecular_function4 iron, 4 sulfur cluster binding
B0071667molecular_functionDNA/RNA hybrid binding
C0000166molecular_functionnucleotide binding
C0000731biological_processDNA synthesis involved in DNA repair
C0000785cellular_componentchromatin
C0003676molecular_functionnucleic acid binding
C0003677molecular_functionDNA binding
C0003682molecular_functionchromatin binding
C0003688molecular_functionDNA replication origin binding
C0003697molecular_functionsingle-stranded DNA binding
C0003887molecular_functionDNA-directed DNA polymerase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005635cellular_componentnuclear envelope
C0005654cellular_componentnucleoplasm
C0005658cellular_componentalpha DNA polymerase:primase complex
C0005730cellular_componentnucleolus
C0005829cellular_componentcytosol
C0006260biological_processDNA replication
C0006261biological_processDNA-templated DNA replication
C0006269biological_processDNA replication, synthesis of primer
C0006270biological_processDNA replication initiation
C0006271biological_processDNA strand elongation involved in DNA replication
C0006272biological_processleading strand elongation
C0006273biological_processlagging strand elongation
C0006281biological_processDNA repair
C0006289biological_processnucleotide-excision repair
C0006303biological_processdouble-strand break repair via nonhomologous end joining
C0008270molecular_functionzinc ion binding
C0016363cellular_componentnuclear matrix
C0016740molecular_functiontransferase activity
C0016779molecular_functionnucleotidyltransferase activity
C0019901molecular_functionprotein kinase binding
C0032479biological_processregulation of type I interferon production
C0034061molecular_functionDNA polymerase activity
C0046872molecular_functionmetal ion binding
C1902975biological_processmitotic DNA replication initiation
C1904161biological_processDNA synthesis involved in UV-damage excision repair
D0003677molecular_functionDNA binding
D0006260biological_processDNA replication
Functional Information from PROSITE/UniProt
site_idPS00116
Number of Residues9
DetailsDNA_POLYMERASE_B DNA polymerase family B signature. YGDTDSIMI
ChainResidueDetails
CTYR1000-ILE1008
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues10
DetailsMotif: {"description":"Zinc knuckle motif","evidences":[{"source":"PubMed","id":"24043831","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25550159","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26975377","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues3
DetailsActive site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues5
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"24043831","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31479243","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31479243","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6R4S","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"24043831","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25550159","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26975377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31479243","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"24043831","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24239947","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31479243","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31479243","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues142
DetailsRegion: {"description":"RNA:DNA duplex-binding","evidences":[{"source":"PubMed","id":"26975377","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"17893144","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25550159","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26975377","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"17893144","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25550159","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues35
DetailsZinc finger: {"description":"CysA-type","evidences":[{"source":"UniProtKB","id":"P15436","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues26
DetailsMotif: {"description":"CysB motif","evidences":[{"source":"UniProtKB","id":"P15436","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"26975377","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5EXR","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues1
DetailsModified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P33609","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

244693

PDB entries from 2025-11-12

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