8D85
Cryo-EM structure of human IL-27 signaling complex: model containing the interaction core region
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0004896 | molecular_function | cytokine receptor activity |
| B | 0016020 | cellular_component | membrane |
| C | 0004896 | molecular_function | cytokine receptor activity |
| C | 0005125 | molecular_function | cytokine activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005615 | cellular_component | extracellular space |
| C | 0005788 | cellular_component | endoplasmic reticulum lumen |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006959 | biological_process | humoral immune response |
| C | 0009897 | cellular_component | external side of plasma membrane |
| C | 0016020 | cellular_component | membrane |
| C | 0019221 | biological_process | cytokine-mediated signaling pathway |
| C | 0019955 | molecular_function | cytokine binding |
| C | 0032729 | biological_process | positive regulation of type II interferon production |
| C | 0042088 | biological_process | T-helper 1 type immune response |
| C | 0042098 | biological_process | T cell proliferation |
| C | 0043235 | cellular_component | receptor complex |
| C | 0045523 | molecular_function | interleukin-27 receptor binding |
| C | 0046641 | biological_process | positive regulation of alpha-beta T cell proliferation |
| D | 0002230 | biological_process | positive regulation of defense response to virus by host |
| D | 0005102 | molecular_function | signaling receptor binding |
| D | 0005125 | molecular_function | cytokine activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005576 | cellular_component | extracellular region |
| D | 0005615 | cellular_component | extracellular space |
| D | 0005788 | cellular_component | endoplasmic reticulum lumen |
| D | 0005829 | cellular_component | cytosol |
| D | 0006954 | biological_process | inflammatory response |
| D | 0007165 | biological_process | signal transduction |
| D | 0009617 | biological_process | response to bacterium |
| D | 0009986 | cellular_component | cell surface |
| D | 0032729 | biological_process | positive regulation of type II interferon production |
| D | 0042129 | biological_process | regulation of T cell proliferation |
| D | 0045087 | biological_process | innate immune response |
| D | 0045523 | molecular_function | interleukin-27 receptor binding |
| D | 0045625 | biological_process | regulation of T-helper 1 cell differentiation |
| D | 0050688 | biological_process | regulation of defense response to virus |
| D | 0140459 | biological_process | response to Gram-positive bacterium |
Functional Information from PROSITE/UniProt
| site_id | PS01353 |
| Number of Residues | 54 |
| Details | HEMATOPO_REC_L_F2 Long hematopoietin receptor, gp130 family signature. NlvgkSdaavltipacdfqathpvmdlkafpkdnmlw....VeWtt.Presvkk...Yi.LeW |
| Chain | Residue | Details |
| B | ASN404-TRP457 |
| site_id | PS01354 |
| Number of Residues | 41 |
| Details | HEMATOPO_REC_L_F3 Long hematopoietin receptor, soluble alpha chains family signature. IkPDPPegVrlsplaerq..LqvqWepPgSWpfpei.FsLkYwI |
| Chain | Residue | Details |
| C | ILE127-ILE167 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 596 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| B | GLU23-GLU619 | |
| C | ASN105 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11098061, ECO:0000269|PubMed:20489211 |
| Chain | Residue | Details |
| B | ASN43 | |
| B | ASN83 | |
| B | ASN553 | |
| A | ASN311 | |
| A | ASN374 | |
| A | ASN382 | |
| A | ASN467 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11098061 |
| Chain | Residue | Details |
| B | ASN131 | |
| B | ASN157 | |
| B | ASN564 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11098061, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:20489211 |
| Chain | Residue | Details |
| B | ASN227 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11098061, ECO:0000269|PubMed:16335952 |
| Chain | Residue | Details |
| B | ASN379 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11098061, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:20489211 |
| Chain | Residue | Details |
| B | ASN383 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218 |
| Chain | Residue | Details |
| B | ASN390 |
