8D85

Cryo-EM structure of human IL-27 signaling complex: model containing the interaction core region

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0004896	molecular_function	cytokine receptor activity
B	0016020	cellular_component	membrane
C	0002376	biological_process	immune system process
C	0002826	biological_process	negative regulation of T-helper 1 type immune response
C	0004896	molecular_function	cytokine receptor activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005788	cellular_component	endoplasmic reticulum lumen
C	0005886	cellular_component	plasma membrane
C	0006959	biological_process	humoral immune response
C	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
C	0016020	cellular_component	membrane
C	0030888	biological_process	regulation of B cell proliferation
C	0032729	biological_process	positive regulation of type II interferon production
C	0032733	biological_process	positive regulation of interleukin-10 production
C	0042088	biological_process	T-helper 1 type immune response
C	0042098	biological_process	T cell proliferation
C	0042129	biological_process	regulation of T cell proliferation
C	0043066	biological_process	negative regulation of apoptotic process
C	0043410	biological_process	positive regulation of MAPK cascade
C	0045523	molecular_function	interleukin-27 receptor binding
C	0046641	biological_process	positive regulation of alpha-beta T cell proliferation
C	0070106	biological_process	interleukin-27-mediated signaling pathway
C	0070757	biological_process	interleukin-35-mediated signaling pathway
D	0005102	molecular_function	signaling receptor binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005788	cellular_component	endoplasmic reticulum lumen
D	0005829	cellular_component	cytosol
D	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
D	0009617	biological_process	response to bacterium
D	0009986	cellular_component	cell surface
D	0032729	biological_process	positive regulation of type II interferon production
D	0032733	biological_process	positive regulation of interleukin-10 production
D	0042129	biological_process	regulation of T cell proliferation
D	0043066	biological_process	negative regulation of apoptotic process
D	0043410	biological_process	positive regulation of MAPK cascade
D	0045523	molecular_function	interleukin-27 receptor binding
D	0045625	biological_process	regulation of T-helper 1 cell differentiation
D	0050863	biological_process	regulation of T cell activation
D	0070106	biological_process	interleukin-27-mediated signaling pathway
D	0140459	biological_process	response to Gram-positive bacterium

Functional Information from PROSITE/UniProt

site_id	PS01353
Number of Residues	54
Details	HEMATOPO_REC_L_F2 Long hematopoietin receptor, gp130 family signature. NlvgkSdaavltipacdfqathpvmdlkafpkdnmlw....VeWtt.Presvkk...Yi.LeW

Chain	Residue	Details
B	ASN404-TRP457

---

site_id	PS01354
Number of Residues	41
Details	HEMATOPO_REC_L_F3 Long hematopoietin receptor, soluble alpha chains family signature. IkPDPPegVrlsplaerq..LqvqWepPgSWpfpei.FsLkYwI

Chain	Residue	Details
C	ILE127-ILE167

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	96
Details	Domain: {"description":"Fibronectin type-III 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Motif: {"description":"WSXWS motif"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	94
Details	Domain: {"description":"Ig-like C2-type"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	91
Details	Domain: {"description":"Fibronectin type-III 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20489211","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20489211","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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