8D7H

Cryo-EM structure of human CLCF1 in complex with CRLF1 and CNTFR alpha

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001657	biological_process	ureteric bud development
A	0004896	molecular_function	cytokine receptor activity
A	0005125	molecular_function	cytokine activity
A	0005127	molecular_function	ciliary neurotrophic factor receptor binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005829	cellular_component	cytosol
A	0008284	biological_process	positive regulation of cell population proliferation
A	0009897	cellular_component	external side of plasma membrane
A	0019221	biological_process	cytokine-mediated signaling pathway
A	0019955	molecular_function	cytokine binding
A	0043235	cellular_component	receptor complex
A	0043524	biological_process	negative regulation of neuron apoptotic process
A	0097058	cellular_component	CRLF-CLCF1 complex
A	0097696	biological_process	cell surface receptor signaling pathway via STAT
A	2000672	biological_process	negative regulation of motor neuron apoptotic process
C	0001967	biological_process	suckling behavior
C	0003360	biological_process	brainstem development
C	0004896	molecular_function	cytokine receptor activity
C	0004897	molecular_function	ciliary neurotrophic factor receptor activity
C	0005102	molecular_function	signaling receptor binding
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0007165	biological_process	signal transduction
C	0007399	biological_process	nervous system development
C	0007548	biological_process	sex differentiation
C	0008284	biological_process	positive regulation of cell population proliferation
C	0009897	cellular_component	external side of plasma membrane
C	0016020	cellular_component	membrane
C	0016324	cellular_component	apical plasma membrane
C	0019898	cellular_component	extrinsic component of membrane
C	0019955	molecular_function	cytokine binding
C	0043524	biological_process	negative regulation of neuron apoptotic process
C	0060538	biological_process	skeletal muscle organ development
C	0070110	cellular_component	ciliary neurotrophic factor receptor complex
C	0070120	biological_process	ciliary neurotrophic factor-mediated signaling pathway
C	0097049	biological_process	motor neuron apoptotic process
C	0097059	cellular_component	CNTFR-CLCF1 complex
C	0098552	cellular_component	side of membrane
C	2000672	biological_process	negative regulation of motor neuron apoptotic process
D	0002639	biological_process	positive regulation of immunoglobulin production
D	0005102	molecular_function	signaling receptor binding
D	0005125	molecular_function	cytokine activity
D	0005127	molecular_function	ciliary neurotrophic factor receptor binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0007166	biological_process	cell surface receptor signaling pathway
D	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
D	0008083	molecular_function	growth factor activity
D	0008284	biological_process	positive regulation of cell population proliferation
D	0019221	biological_process	cytokine-mediated signaling pathway
D	0030183	biological_process	B cell differentiation
D	0030890	biological_process	positive regulation of B cell proliferation
D	0043524	biological_process	negative regulation of neuron apoptotic process
D	0048295	biological_process	positive regulation of isotype switching to IgE isotypes
D	0048711	biological_process	positive regulation of astrocyte differentiation
D	0097058	cellular_component	CRLF-CLCF1 complex
D	0097059	cellular_component	CNTFR-CLCF1 complex
D	0097696	biological_process	cell surface receptor signaling pathway via STAT
E	0001657	biological_process	ureteric bud development
E	0004896	molecular_function	cytokine receptor activity
E	0005125	molecular_function	cytokine activity
E	0005127	molecular_function	ciliary neurotrophic factor receptor binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005829	cellular_component	cytosol
E	0008284	biological_process	positive regulation of cell population proliferation
E	0009897	cellular_component	external side of plasma membrane
E	0019221	biological_process	cytokine-mediated signaling pathway
E	0019955	molecular_function	cytokine binding
E	0043235	cellular_component	receptor complex
E	0043524	biological_process	negative regulation of neuron apoptotic process
E	0097058	cellular_component	CRLF-CLCF1 complex
E	0097696	biological_process	cell surface receptor signaling pathway via STAT
E	2000672	biological_process	negative regulation of motor neuron apoptotic process
G	0001967	biological_process	suckling behavior
G	0003360	biological_process	brainstem development
G	0004896	molecular_function	cytokine receptor activity
G	0004897	molecular_function	ciliary neurotrophic factor receptor activity
G	0005102	molecular_function	signaling receptor binding
G	0005515	molecular_function	protein binding
G	0005886	cellular_component	plasma membrane
G	0007165	biological_process	signal transduction
G	0007399	biological_process	nervous system development
G	0007548	biological_process	sex differentiation
G	0008284	biological_process	positive regulation of cell population proliferation
G	0009897	cellular_component	external side of plasma membrane
G	0016020	cellular_component	membrane
G	0016324	cellular_component	apical plasma membrane
G	0019898	cellular_component	extrinsic component of membrane
G	0019955	molecular_function	cytokine binding
G	0043524	biological_process	negative regulation of neuron apoptotic process
G	0060538	biological_process	skeletal muscle organ development
G	0070110	cellular_component	ciliary neurotrophic factor receptor complex
G	0070120	biological_process	ciliary neurotrophic factor-mediated signaling pathway
G	0097049	biological_process	motor neuron apoptotic process
G	0097059	cellular_component	CNTFR-CLCF1 complex
G	0098552	cellular_component	side of membrane
G	2000672	biological_process	negative regulation of motor neuron apoptotic process
H	0002639	biological_process	positive regulation of immunoglobulin production
H	0005102	molecular_function	signaling receptor binding
H	0005125	molecular_function	cytokine activity
H	0005127	molecular_function	ciliary neurotrophic factor receptor binding
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0007166	biological_process	cell surface receptor signaling pathway
H	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
H	0008083	molecular_function	growth factor activity
H	0008284	biological_process	positive regulation of cell population proliferation
H	0019221	biological_process	cytokine-mediated signaling pathway
H	0030183	biological_process	B cell differentiation
H	0030890	biological_process	positive regulation of B cell proliferation
H	0043524	biological_process	negative regulation of neuron apoptotic process
H	0048295	biological_process	positive regulation of isotype switching to IgE isotypes
H	0048711	biological_process	positive regulation of astrocyte differentiation
H	0097058	cellular_component	CRLF-CLCF1 complex
H	0097059	cellular_component	CNTFR-CLCF1 complex
H	0097696	biological_process	cell surface receptor signaling pathway via STAT

Functional Information from PROSITE/UniProt

site_id	PS01354
Number of Residues	43
Details	HEMATOPO_REC_L_F3 Long hematopoietin receptor, soluble alpha chains family signature. VkPDPPenVvarpvpsnprrLevtWqtPsTWpdpes.FpLkFfL

Chain	Residue	Details
C	VAL202-LEU244

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9JM58

Chain	Residue	Details
A	SER219
E	SER219

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site_id	SWS_FT_FI2
Number of Residues	12
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN92
E	ASN168
E	ASN292
E	ASN382
A	ASN104
A	ASN140
A	ASN168
A	ASN292
A	ASN382
E	ASN92
E	ASN104
E	ASN140

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