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8D7E

Cryo-EM structure of human CNTFR alpha in complex with the Fab fragments of two antibodies

Functional Information from GO Data
ChainGOidnamespacecontents
C0001967biological_processsuckling behavior
C0003360biological_processbrainstem development
C0004896molecular_functioncytokine receptor activity
C0004897molecular_functionciliary neurotrophic factor receptor activity
C0005102molecular_functionsignaling receptor binding
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0007165biological_processsignal transduction
C0007399biological_processnervous system development
C0007548biological_processsex differentiation
C0008284biological_processpositive regulation of cell population proliferation
C0009897cellular_componentexternal side of plasma membrane
C0016020cellular_componentmembrane
C0016324cellular_componentapical plasma membrane
C0019898cellular_componentextrinsic component of membrane
C0019955molecular_functioncytokine binding
C0043524biological_processnegative regulation of neuron apoptotic process
C0060538biological_processskeletal muscle organ development
C0070110cellular_componentciliary neurotrophic factor receptor complex
C0070120biological_processciliary neurotrophic factor-mediated signaling pathway
C0097049biological_processmotor neuron apoptotic process
C0097059cellular_componentCNTFR-CLCF1 complex
C0098552cellular_componentside of membrane
C2000672biological_processnegative regulation of motor neuron apoptotic process
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
ChainResidueDetails
ETYR193-HIS199
FTYR198-HIS204
DTYR201-HIS207
GTYR193-HIS199

site_idPS01354
Number of Residues43
DetailsHEMATOPO_REC_L_F3 Long hematopoietin receptor, soluble alpha chains family signature. VkPDPPenVvarpvpsnprrLevtWqtPsTWpdpes.FpLkFfL
ChainResidueDetails
CVAL202-LEU244

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsLIPID: GPI-anchor amidated serine => ECO:0000255
ChainResidueDetails
CSER342

site_idSWS_FT_FI2
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
CASN60
CASN70
CASN142
CASN190

226262

PDB entries from 2024-10-16

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