8D7E

Cryo-EM structure of human CNTFR alpha in complex with the Fab fragments of two antibodies

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0004896	molecular_function	cytokine receptor activity
C	0004897	molecular_function	ciliary neurotrophic factor receptor activity
C	0004921	molecular_function	interleukin-11 receptor activity
C	0005102	molecular_function	signaling receptor binding
C	0005125	molecular_function	cytokine activity
C	0005515	molecular_function	protein binding
C	0005615	cellular_component	extracellular space
C	0005886	cellular_component	plasma membrane
C	0007165	biological_process	signal transduction
C	0007399	biological_process	nervous system development
C	0008284	biological_process	positive regulation of cell population proliferation
C	0009897	cellular_component	external side of plasma membrane
C	0016020	cellular_component	membrane
C	0016324	cellular_component	apical plasma membrane
C	0019221	biological_process	cytokine-mediated signaling pathway
C	0019898	cellular_component	extrinsic component of membrane
C	0019955	molecular_function	cytokine binding
C	0019970	molecular_function	interleukin-11 binding
C	0032991	cellular_component	protein-containing complex
C	0038023	molecular_function	signaling receptor activity
C	0038154	biological_process	interleukin-11-mediated signaling pathway
C	0043524	biological_process	negative regulation of neuron apoptotic process
C	0070110	cellular_component	ciliary neurotrophic factor receptor complex
C	0070120	biological_process	ciliary neurotrophic factor-mediated signaling pathway
C	0070446	biological_process	negative regulation of oligodendrocyte progenitor proliferation
C	0097059	cellular_component	CNTFR-CLCF1 complex
C	0098552	cellular_component	side of membrane
C	0140597	molecular_function	protein carrier chaperone

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
G	TYR193-HIS199
E	TYR193-HIS199
F	TYR198-HIS204
D	TYR201-HIS207

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site_id	PS01354
Number of Residues	43
Details	HEMATOPO_REC_L_F3 Long hematopoietin receptor, soluble alpha chains family signature. VkPDPPenVvarpvpsnprrLevtWqtPsTWpdpes.FpLkFfL

Chain	Residue	Details
C	VAL202-LEU244

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	77
Details	Domain: {"description":"Ig-like C2-type"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	97
Details	Domain: {"description":"Fibronectin type-III 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	4
Details	Motif: {"description":"WSXWS motif"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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