8D7E
Cryo-EM structure of human CNTFR alpha in complex with the Fab fragments of two antibodies
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| C | 0004896 | molecular_function | cytokine receptor activity |
| C | 0004897 | molecular_function | ciliary neurotrophic factor receptor activity |
| C | 0004921 | molecular_function | interleukin-11 receptor activity |
| C | 0005102 | molecular_function | signaling receptor binding |
| C | 0005125 | molecular_function | cytokine activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0007165 | biological_process | signal transduction |
| C | 0007399 | biological_process | nervous system development |
| C | 0008284 | biological_process | positive regulation of cell population proliferation |
| C | 0009897 | cellular_component | external side of plasma membrane |
| C | 0016020 | cellular_component | membrane |
| C | 0016324 | cellular_component | apical plasma membrane |
| C | 0019221 | biological_process | cytokine-mediated signaling pathway |
| C | 0019898 | cellular_component | extrinsic component of membrane |
| C | 0019955 | molecular_function | cytokine binding |
| C | 0019970 | molecular_function | interleukin-11 binding |
| C | 0032991 | cellular_component | protein-containing complex |
| C | 0038023 | molecular_function | signaling receptor activity |
| C | 0038154 | biological_process | interleukin-11-mediated signaling pathway |
| C | 0043524 | biological_process | negative regulation of neuron apoptotic process |
| C | 0070110 | cellular_component | ciliary neurotrophic factor receptor complex |
| C | 0070120 | biological_process | ciliary neurotrophic factor-mediated signaling pathway |
| C | 0070446 | biological_process | negative regulation of oligodendrocyte progenitor proliferation |
| C | 0097059 | cellular_component | CNTFR-CLCF1 complex |
| C | 0140597 | molecular_function | protein carrier activity |
| C | 7770013 | cellular_component | humanin receptor complex |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| E | TYR193-HIS199 | |
| G | TYR193-HIS199 | |
| D | TYR201-HIS207 | |
| F | TYR198-HIS204 |
| site_id | PS01354 |
| Number of Residues | 43 |
| Details | HEMATOPO_REC_L_F3 Long hematopoietin receptor, soluble alpha chains family signature. VkPDPPenVvarpvpsnprrLevtWqtPsTWpdpes.FpLkFfL |
| Chain | Residue | Details |
| C | VAL202-LEU244 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 77 |
| Details | Domain: {"description":"Ig-like C2-type"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 97 |
| Details | Domain: {"description":"Fibronectin type-III 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Motif: {"description":"WSXWS motif"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36930708","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8D74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D7R","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
