8D4D

gamma-Arf1 mediated dimeric assembly of AP-1, Arf1, Nef complex within lattice on MHC-I lipopeptide incorporated narrow membrane tubes

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0001822	biological_process	kidney development
A	0005515	molecular_function	protein binding
A	0005765	cellular_component	lysosomal membrane
A	0005769	cellular_component	early endosome
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0006886	biological_process	intracellular protein transport
A	0007368	biological_process	determination of left/right symmetry
A	0007507	biological_process	heart development
A	0008021	cellular_component	synaptic vesicle
A	0012505	cellular_component	endomembrane system
A	0015031	biological_process	protein transport
A	0016020	cellular_component	membrane
A	0016192	biological_process	vesicle-mediated transport
A	0019901	molecular_function	protein kinase binding
A	0030117	cellular_component	membrane coat
A	0030121	cellular_component	AP-1 adaptor complex
A	0030131	cellular_component	clathrin adaptor complex
A	0030276	molecular_function	clathrin binding
A	0030659	cellular_component	cytoplasmic vesicle membrane
A	0030665	cellular_component	clathrin-coated vesicle membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0032588	cellular_component	trans-Golgi network membrane
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0060155	biological_process	platelet dense granule organization
A	0110010	biological_process	basolateral protein secretion
A	1903232	biological_process	melanosome assembly
B	0000139	cellular_component	Golgi membrane
B	0001822	biological_process	kidney development
B	0005515	molecular_function	protein binding
B	0005765	cellular_component	lysosomal membrane
B	0005769	cellular_component	early endosome
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0006886	biological_process	intracellular protein transport
B	0007368	biological_process	determination of left/right symmetry
B	0007507	biological_process	heart development
B	0008021	cellular_component	synaptic vesicle
B	0012505	cellular_component	endomembrane system
B	0015031	biological_process	protein transport
B	0016020	cellular_component	membrane
B	0016192	biological_process	vesicle-mediated transport
B	0019901	molecular_function	protein kinase binding
B	0030117	cellular_component	membrane coat
B	0030121	cellular_component	AP-1 adaptor complex
B	0030131	cellular_component	clathrin adaptor complex
B	0030276	molecular_function	clathrin binding
B	0030659	cellular_component	cytoplasmic vesicle membrane
B	0030665	cellular_component	clathrin-coated vesicle membrane
B	0031410	cellular_component	cytoplasmic vesicle
B	0032588	cellular_component	trans-Golgi network membrane
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0060155	biological_process	platelet dense granule organization
B	0110010	biological_process	basolateral protein secretion
B	1903232	biological_process	melanosome assembly
C	0000139	cellular_component	Golgi membrane
C	0000287	molecular_function	magnesium ion binding
C	0002090	biological_process	regulation of receptor internalization
C	0003723	molecular_function	RNA binding
C	0003924	molecular_function	GTPase activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005794	cellular_component	Golgi apparatus
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0005925	cellular_component	focal adhesion
C	0006878	biological_process	intracellular copper ion homeostasis
C	0006886	biological_process	intracellular protein transport
C	0012505	cellular_component	endomembrane system
C	0014069	cellular_component	postsynaptic density
C	0015031	biological_process	protein transport
C	0016020	cellular_component	membrane
C	0016192	biological_process	vesicle-mediated transport
C	0016787	molecular_function	hydrolase activity
C	0019904	molecular_function	protein domain specific binding
C	0030017	cellular_component	sarcomere
C	0031252	cellular_component	cell leading edge
C	0032991	cellular_component	protein-containing complex
C	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
C	0043005	cellular_component	neuron projection
C	0045202	cellular_component	synapse
C	0060292	biological_process	long-term synaptic depression
C	0070062	cellular_component	extracellular exosome
C	0097061	biological_process	dendritic spine organization
C	0098586	biological_process	cellular response to virus
C	1990386	biological_process	mitotic cleavage furrow ingression
D	0000139	cellular_component	Golgi membrane
D	0000287	molecular_function	magnesium ion binding
D	0002090	biological_process	regulation of receptor internalization
D	0003723	molecular_function	RNA binding
D	0003924	molecular_function	GTPase activity
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005794	cellular_component	Golgi apparatus
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0005925	cellular_component	focal adhesion
D	0006878	biological_process	intracellular copper ion homeostasis
D	0006886	biological_process	intracellular protein transport
D	0012505	cellular_component	endomembrane system
D	0014069	cellular_component	postsynaptic density
D	0015031	biological_process	protein transport
D	0016020	cellular_component	membrane
D	0016192	biological_process	vesicle-mediated transport
D	0016787	molecular_function	hydrolase activity
D	0019904	molecular_function	protein domain specific binding
D	0030017	cellular_component	sarcomere
D	0031252	cellular_component	cell leading edge
D	0032991	cellular_component	protein-containing complex
D	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
D	0043005	cellular_component	neuron projection
D	0045202	cellular_component	synapse
D	0060292	biological_process	long-term synaptic depression
D	0070062	cellular_component	extracellular exosome
D	0097061	biological_process	dendritic spine organization
D	0098586	biological_process	cellular response to virus
D	1990386	biological_process	mitotic cleavage furrow ingression
E	0006886	biological_process	intracellular protein transport
E	0016192	biological_process	vesicle-mediated transport
E	0030117	cellular_component	membrane coat
F	0000139	cellular_component	Golgi membrane
F	0000287	molecular_function	magnesium ion binding
F	0002090	biological_process	regulation of receptor internalization
F	0003723	molecular_function	RNA binding
F	0003924	molecular_function	GTPase activity
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005794	cellular_component	Golgi apparatus
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0005925	cellular_component	focal adhesion
F	0006878	biological_process	intracellular copper ion homeostasis
F	0006886	biological_process	intracellular protein transport
F	0012505	cellular_component	endomembrane system
F	0014069	cellular_component	postsynaptic density
F	0015031	biological_process	protein transport
F	0016020	cellular_component	membrane
F	0016192	biological_process	vesicle-mediated transport
F	0016787	molecular_function	hydrolase activity
F	0019904	molecular_function	protein domain specific binding
F	0030017	cellular_component	sarcomere
F	0031252	cellular_component	cell leading edge
F	0032991	cellular_component	protein-containing complex
F	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
F	0043005	cellular_component	neuron projection
F	0045202	cellular_component	synapse
F	0060292	biological_process	long-term synaptic depression
F	0070062	cellular_component	extracellular exosome
F	0097061	biological_process	dendritic spine organization
F	0098586	biological_process	cellular response to virus
F	1990386	biological_process	mitotic cleavage furrow ingression
G	0006886	biological_process	intracellular protein transport
G	0016192	biological_process	vesicle-mediated transport
G	0030117	cellular_component	membrane coat
H	0000139	cellular_component	Golgi membrane
H	0000287	molecular_function	magnesium ion binding
H	0002090	biological_process	regulation of receptor internalization
H	0003723	molecular_function	RNA binding
H	0003924	molecular_function	GTPase activity
H	0005515	molecular_function	protein binding
H	0005525	molecular_function	GTP binding
H	0005794	cellular_component	Golgi apparatus
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0005925	cellular_component	focal adhesion
H	0006878	biological_process	intracellular copper ion homeostasis
H	0006886	biological_process	intracellular protein transport
H	0012505	cellular_component	endomembrane system
H	0014069	cellular_component	postsynaptic density
H	0015031	biological_process	protein transport
H	0016020	cellular_component	membrane
H	0016192	biological_process	vesicle-mediated transport
H	0016787	molecular_function	hydrolase activity
H	0019904	molecular_function	protein domain specific binding
H	0030017	cellular_component	sarcomere
H	0031252	cellular_component	cell leading edge
H	0032991	cellular_component	protein-containing complex
H	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
H	0043005	cellular_component	neuron projection
H	0045202	cellular_component	synapse
H	0060292	biological_process	long-term synaptic depression
H	0070062	cellular_component	extracellular exosome
H	0097061	biological_process	dendritic spine organization
H	0098586	biological_process	cellular response to virus
H	1990386	biological_process	mitotic cleavage furrow ingression
I	0005102	molecular_function	signaling receptor binding
I	0005515	molecular_function	protein binding
I	0005525	molecular_function	GTP binding
I	0005576	cellular_component	extracellular region
I	0016020	cellular_component	membrane
I	0017124	molecular_function	SH3 domain binding
I	0019049	biological_process	virus-mediated perturbation of host defense response
I	0019058	biological_process	viral life cycle
I	0019901	molecular_function	protein kinase binding
I	0020002	cellular_component	host cell plasma membrane
I	0031996	molecular_function	thioesterase binding
I	0033668	biological_process	symbiont-mediated suppression of host apoptosis
I	0039505	biological_process	symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class II
I	0039521	biological_process	suppression by virus of host autophagy
I	0042288	molecular_function	MHC class I protein binding
I	0042609	molecular_function	CD4 receptor binding
I	0044177	cellular_component	host cell Golgi apparatus
I	0044178	cellular_component	host cell Golgi membrane
I	0044423	cellular_component	virion component
I	0045225	biological_process	negative regulation of CD4 production
I	0046776	biological_process	symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I
I	0050848	biological_process	regulation of calcium-mediated signaling
I	0051117	molecular_function	ATPase binding
I	0070206	biological_process	protein trimerization
I	0075528	biological_process	perturbation by virus of host immune response
J	0005515	molecular_function	protein binding
J	0005765	cellular_component	lysosomal membrane
J	0005769	cellular_component	early endosome
J	0005794	cellular_component	Golgi apparatus
J	0005802	cellular_component	trans-Golgi network
J	0005829	cellular_component	cytosol
J	0006886	biological_process	intracellular protein transport
J	0015031	biological_process	protein transport
J	0016020	cellular_component	membrane
J	0016192	biological_process	vesicle-mediated transport
J	0030121	cellular_component	AP-1 adaptor complex
J	0030131	cellular_component	clathrin adaptor complex
J	0030665	cellular_component	clathrin-coated vesicle membrane
J	0031410	cellular_component	cytoplasmic vesicle
J	0032438	biological_process	melanosome organization
J	0032588	cellular_component	trans-Golgi network membrane
J	0035646	biological_process	endosome to melanosome transport
J	0043231	cellular_component	intracellular membrane-bounded organelle
J	0045202	cellular_component	synapse
J	0060155	biological_process	platelet dense granule organization
J	1903232	biological_process	melanosome assembly
K	0005102	molecular_function	signaling receptor binding
K	0005515	molecular_function	protein binding
K	0005525	molecular_function	GTP binding
K	0005576	cellular_component	extracellular region
K	0016020	cellular_component	membrane
K	0017124	molecular_function	SH3 domain binding
K	0019049	biological_process	virus-mediated perturbation of host defense response
K	0019058	biological_process	viral life cycle
K	0019901	molecular_function	protein kinase binding
K	0020002	cellular_component	host cell plasma membrane
K	0031996	molecular_function	thioesterase binding
K	0033668	biological_process	symbiont-mediated suppression of host apoptosis
K	0039505	biological_process	symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class II
K	0039521	biological_process	suppression by virus of host autophagy
K	0042288	molecular_function	MHC class I protein binding
K	0042609	molecular_function	CD4 receptor binding
K	0044177	cellular_component	host cell Golgi apparatus
K	0044178	cellular_component	host cell Golgi membrane
K	0044423	cellular_component	virion component
K	0045225	biological_process	negative regulation of CD4 production
K	0046776	biological_process	symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I
K	0050848	biological_process	regulation of calcium-mediated signaling
K	0051117	molecular_function	ATPase binding
K	0070206	biological_process	protein trimerization
K	0075528	biological_process	perturbation by virus of host immune response
L	0005102	molecular_function	signaling receptor binding
L	0005515	molecular_function	protein binding
L	0005525	molecular_function	GTP binding
L	0005576	cellular_component	extracellular region
L	0016020	cellular_component	membrane
L	0017124	molecular_function	SH3 domain binding
L	0019049	biological_process	virus-mediated perturbation of host defense response
L	0019058	biological_process	viral life cycle
L	0019901	molecular_function	protein kinase binding
L	0020002	cellular_component	host cell plasma membrane
L	0031996	molecular_function	thioesterase binding
L	0033668	biological_process	symbiont-mediated suppression of host apoptosis
L	0039505	biological_process	symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class II
L	0039521	biological_process	suppression by virus of host autophagy
L	0042288	molecular_function	MHC class I protein binding
L	0042609	molecular_function	CD4 receptor binding
L	0044177	cellular_component	host cell Golgi apparatus
L	0044178	cellular_component	host cell Golgi membrane
L	0044423	cellular_component	virion component
L	0045225	biological_process	negative regulation of CD4 production
L	0046776	biological_process	symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I
L	0050848	biological_process	regulation of calcium-mediated signaling
L	0051117	molecular_function	ATPase binding
L	0070206	biological_process	protein trimerization
L	0075528	biological_process	perturbation by virus of host immune response
M	0005515	molecular_function	protein binding
M	0005765	cellular_component	lysosomal membrane
M	0005769	cellular_component	early endosome
M	0005794	cellular_component	Golgi apparatus
M	0005802	cellular_component	trans-Golgi network
M	0005829	cellular_component	cytosol
M	0006886	biological_process	intracellular protein transport
M	0015031	biological_process	protein transport
M	0016020	cellular_component	membrane
M	0016192	biological_process	vesicle-mediated transport
M	0030121	cellular_component	AP-1 adaptor complex
M	0030131	cellular_component	clathrin adaptor complex
M	0030665	cellular_component	clathrin-coated vesicle membrane
M	0031410	cellular_component	cytoplasmic vesicle
M	0032438	biological_process	melanosome organization
M	0032588	cellular_component	trans-Golgi network membrane
M	0035646	biological_process	endosome to melanosome transport
M	0043231	cellular_component	intracellular membrane-bounded organelle
M	0045202	cellular_component	synapse
M	0060155	biological_process	platelet dense granule organization
M	1903232	biological_process	melanosome assembly
N	0005102	molecular_function	signaling receptor binding
N	0005515	molecular_function	protein binding
N	0005525	molecular_function	GTP binding
N	0005576	cellular_component	extracellular region
N	0016020	cellular_component	membrane
N	0017124	molecular_function	SH3 domain binding
N	0019049	biological_process	virus-mediated perturbation of host defense response
N	0019058	biological_process	viral life cycle
N	0019901	molecular_function	protein kinase binding
N	0020002	cellular_component	host cell plasma membrane
N	0031996	molecular_function	thioesterase binding
N	0033668	biological_process	symbiont-mediated suppression of host apoptosis
N	0039505	biological_process	symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class II
N	0039521	biological_process	suppression by virus of host autophagy
N	0042288	molecular_function	MHC class I protein binding
N	0042609	molecular_function	CD4 receptor binding
N	0044177	cellular_component	host cell Golgi apparatus
N	0044178	cellular_component	host cell Golgi membrane
N	0044423	cellular_component	virion component
N	0045225	biological_process	negative regulation of CD4 production
N	0046776	biological_process	symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I
N	0050848	biological_process	regulation of calcium-mediated signaling
N	0051117	molecular_function	ATPase binding
N	0070206	biological_process	protein trimerization
N	0075528	biological_process	perturbation by virus of host immune response
O	0000139	cellular_component	Golgi membrane
O	0005515	molecular_function	protein binding
O	0005737	cellular_component	cytoplasm
O	0005765	cellular_component	lysosomal membrane
O	0005769	cellular_component	early endosome
O	0005794	cellular_component	Golgi apparatus
O	0005829	cellular_component	cytosol
O	0005905	cellular_component	clathrin-coated pit
O	0006605	biological_process	protein targeting
O	0006886	biological_process	intracellular protein transport
O	0015031	biological_process	protein transport
O	0016192	biological_process	vesicle-mediated transport
O	0030117	cellular_component	membrane coat
O	0030121	cellular_component	AP-1 adaptor complex
O	0030659	cellular_component	cytoplasmic vesicle membrane
O	0031410	cellular_component	cytoplasmic vesicle
O	0032588	cellular_component	trans-Golgi network membrane
O	0035615	molecular_function	clathrin adaptor activity
O	0043231	cellular_component	intracellular membrane-bounded organelle
O	0060155	biological_process	platelet dense granule organization
O	1903232	biological_process	melanosome assembly
P	0006955	biological_process	immune response
P	0019882	biological_process	antigen processing and presentation
S	0000139	cellular_component	Golgi membrane
S	0005515	molecular_function	protein binding
S	0005737	cellular_component	cytoplasm
S	0005765	cellular_component	lysosomal membrane
S	0005769	cellular_component	early endosome
S	0005794	cellular_component	Golgi apparatus
S	0005829	cellular_component	cytosol
S	0005905	cellular_component	clathrin-coated pit
S	0006605	biological_process	protein targeting
S	0006886	biological_process	intracellular protein transport
S	0015031	biological_process	protein transport
S	0016192	biological_process	vesicle-mediated transport
S	0030117	cellular_component	membrane coat
S	0030121	cellular_component	AP-1 adaptor complex
S	0030659	cellular_component	cytoplasmic vesicle membrane
S	0031410	cellular_component	cytoplasmic vesicle
S	0032588	cellular_component	trans-Golgi network membrane
S	0035615	molecular_function	clathrin adaptor activity
S	0043231	cellular_component	intracellular membrane-bounded organelle
S	0060155	biological_process	platelet dense granule organization
S	1903232	biological_process	melanosome assembly
Y	0006955	biological_process	immune response
Y	0019882	biological_process	antigen processing and presentation

Functional Information from PROSITE/UniProt

site_id	PS00989
Number of Residues	11
Details	CLAT_ADAPTOR_S Clathrin adaptor complexes small chain signature. LVYKryasLYF

Chain	Residue	Details
S	LEU57-PHE67

---

site_id	PS00990
Number of Residues	21
Details	CLAT_ADAPTOR_M_1 Clathrin adaptor complexes medium chain signature 1. VSWRse.GikYrkNeVFLDVIE

Chain	Residue	Details
M	VAL157-GLU177

---

site_id	PS00991
Number of Residues	15
Details	CLAT_ADAPTOR_M_2 Clathrin adaptor complexes medium chain signature 2. IsFIPPdGeFeLmsY

Chain	Residue	Details
M	ILE253-TYR267

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: N-acetylserine => ECO:0000250|UniProtKB:Q9BXS5

Chain	Residue	Details
M	SER2
J	SER2
Y	SER350
Y	SER352
P	SER343
P	GLY349
P	SER350
P	SER352

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17242355, ECO:0007744|PubMed:21183079

Chain	Residue	Details
M	THR152
M	THR154
J	THR152
J	THR154

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q32Q06

Chain	Residue	Details
M	THR223
J	THR223
P	SER356
P	SER359

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N-acetylglycine; alternate => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895

Chain	Residue	Details
C	GLY2
H	GLY2
D	GLY2
F	GLY2

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	LIPID: N-myristoyl glycine; alternate => ECO:0000269|PubMed:20213681, ECO:0000269|PubMed:23535599, ECO:0000269|PubMed:25255805, ECO:0000269|PubMed:25807930

Chain	Residue	Details
C	GLY2
H	GLY2
D	GLY2
F	GLY2

---