Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

8D3U

Human alpha3 Na+/K+-ATPase in its Na+-occluded state

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0001540molecular_functionamyloid-beta binding
A0001917cellular_componentphotoreceptor inner segment
A0005215molecular_functiontransporter activity
A0005391molecular_functionP-type sodium:potassium-exchanging transporter activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005783cellular_componentendoplasmic reticulum
A0005794cellular_componentGolgi apparatus
A0005886cellular_componentplasma membrane
A0005890cellular_componentsodium:potassium-exchanging ATPase complex
A0006813biological_processpotassium ion transport
A0006814biological_processsodium ion transport
A0006883biological_processintracellular sodium ion homeostasis
A0008556molecular_functionP-type potassium transmembrane transporter activity
A0010248biological_processestablishment or maintenance of transmembrane electrochemical gradient
A0016020cellular_componentmembrane
A0016887molecular_functionATP hydrolysis activity
A0030007biological_processintracellular potassium ion homeostasis
A0030424cellular_componentaxon
A0031090cellular_componentorganelle membrane
A0032809cellular_componentneuronal cell body membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0036376biological_processsodium ion export across plasma membrane
A0043025cellular_componentneuronal cell body
A0045202cellular_componentsynapse
A0046872molecular_functionmetal ion binding
A0051087molecular_functionprotein-folding chaperone binding
A0060075biological_processregulation of resting membrane potential
A0060342cellular_componentphotoreceptor inner segment membrane
A0071383biological_processcellular response to steroid hormone stimulus
A0086064biological_processcell communication by electrical coupling involved in cardiac conduction
A0098984cellular_componentneuron to neuron synapse
A1902600biological_processproton transmembrane transport
A1903416biological_processresponse to glycoside
A1903561cellular_componentextracellular vesicle
A1904646biological_processcellular response to amyloid-beta
A1990239molecular_functionsteroid hormone binding
A1990535biological_processneuron projection maintenance
A1990573biological_processpotassium ion import across plasma membrane
B0001671molecular_functionATPase activator activity
B0005391molecular_functionP-type sodium:potassium-exchanging transporter activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0005890cellular_componentsodium:potassium-exchanging ATPase complex
B0006813biological_processpotassium ion transport
B0006814biological_processsodium ion transport
B0006874biological_processintracellular calcium ion homeostasis
B0006883biological_processintracellular sodium ion homeostasis
B0007155biological_processcell adhesion
B0010248biological_processestablishment or maintenance of transmembrane electrochemical gradient
B0010468biological_processregulation of gene expression
B0010882biological_processregulation of cardiac muscle contraction by calcium ion signaling
B0014704cellular_componentintercalated disc
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0016324cellular_componentapical plasma membrane
B0016328cellular_componentlateral plasma membrane
B0019901molecular_functionprotein kinase binding
B0023026molecular_functionMHC class II protein complex binding
B0030007biological_processintracellular potassium ion homeostasis
B0030315cellular_componentT-tubule
B0030674molecular_functionprotein-macromolecule adaptor activity
B0031090cellular_componentorganelle membrane
B0032781biological_processpositive regulation of ATP-dependent activity
B0035725biological_processsodium ion transmembrane transport
B0036126cellular_componentsperm flagellum
B0036376biological_processsodium ion export across plasma membrane
B0042383cellular_componentsarcolemma
B0044861biological_processprotein transport into plasma membrane raft
B0045087biological_processinnate immune response
B0046034biological_processATP metabolic process
B0046982molecular_functionprotein heterodimerization activity
B0050821biological_processprotein stabilization
B0051117molecular_functionATPase binding
B0055119biological_processrelaxation of cardiac muscle
B0060048biological_processcardiac muscle contraction
B0070062cellular_componentextracellular exosome
B0072659biological_processprotein localization to plasma membrane
B0086009biological_processmembrane repolarization
B0086013biological_processmembrane repolarization during cardiac muscle cell action potential
B0086064biological_processcell communication by electrical coupling involved in cardiac conduction
B0098655biological_processmonoatomic cation transmembrane transport
B1901018biological_processpositive regulation of potassium ion transmembrane transporter activity
B1902600biological_processproton transmembrane transport
B1903169biological_processregulation of calcium ion transmembrane transport
B1903278biological_processpositive regulation of sodium ion export across plasma membrane
B1903288biological_processpositive regulation of potassium ion import across plasma membrane
B1903408biological_processpositive regulation of P-type sodium:potassium-exchanging transporter activity
B1903561cellular_componentextracellular vesicle
B1990573biological_processpotassium ion import across plasma membrane
G0016020cellular_componentmembrane
G0043269biological_processregulation of monoatomic ion transport
G0099106molecular_functionion channel regulator activity
Functional Information from PROSITE/UniProt
site_idPS00154
Number of Residues7
DetailsATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTLT
ChainResidueDetails
AASP366-THR372

site_idPS00390
Number of Residues21
DetailsATPASE_NA_K_BETA_1 Sodium and potassium ATPases beta subunits signature 1. WkkFiWNsekkefLGRTggsW
ChainResidueDetails
BTRP12-TRP32

site_idPS00391
Number of Residues16
DetailsATPASE_NA_K_BETA_2 Sodium and potassium ATPases beta subunits signature 2. RkvCRfklewLgnCSG
ChainResidueDetails
BARG146-GLY161

site_idPS01310
Number of Residues14
DetailsFXYD FXYD family signature. DpFhYDyqTLRigG
ChainResidueDetails
GASP28-GLY41

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues16
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
GSER19-GLN35
ASER976-LYS996
ALEU122-ALA142
AGLU279-ILE298
AVAL311-ALA328
ALYS763-LEU782
AGLY793-ALA813
ALEU834-PHE856
AHIS909-LYS928
ALYS942-TYR960

site_idSWS_FT_FI2
Number of Residues21
DetailsTRANSMEM: Helical => ECO:0000269|PubMed:36075933, ECO:0007744|PDB:8D3V
ChainResidueDetails
GTHR36-LEU57
ALEU299-ALA310
APHE783-LEU792
APHE857-CYS908
ACYS961-PRO975

site_idSWS_FT_FI3
Number of Residues37
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
GSER58-ASN95
ATHR329-LEU762
ATYR814-LYS833
ATHR929-ASN941
ALEU997-TYR1013

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P07340
ChainResidueDetails
BSER11

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P14094
ChainResidueDetails
BTYR101
AASP711

site_idSWS_FT_FI6
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:19159218
ChainResidueDetails
BASN158
BASN193

site_idSWS_FT_FI7
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973
ChainResidueDetails
BASN265
ASER218
ASER265

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q6PIC6
ChainResidueDetails
ATYR548

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphoserine; by PKA => ECO:0000250
ChainResidueDetails
ASER933

222415

PDB entries from 2024-07-10

PDB statisticsPDBj update infoContact PDBjnumon