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8CXI

Structures of Zika Virus in Complex with Antibodies Targeting E Dimer Epitopes and Basis for Neutralization Efficacy

Functional Information from GO Data
ChainGOidnamespacecontents
A0046983molecular_functionprotein dimerization activity
B0046983molecular_functionprotein dimerization activity
C0046983molecular_functionprotein dimerization activity
D0000166molecular_functionnucleotide binding
D0001172biological_processRNA-templated transcription
D0003723molecular_functionRNA binding
D0003724molecular_functionRNA helicase activity
D0003725molecular_functiondouble-stranded RNA binding
D0003968molecular_functionRNA-directed RNA polymerase activity
D0004252molecular_functionserine-type endopeptidase activity
D0004386molecular_functionhelicase activity
D0004482molecular_functionmRNA 5'-cap (guanine-N7-)-methyltransferase activity
D0004483molecular_functionmethyltransferase cap1 activity
D0005198molecular_functionstructural molecule activity
D0005524molecular_functionATP binding
D0005525molecular_functionGTP binding
D0005576cellular_componentextracellular region
D0005813cellular_componentcentrosome
D0006370biological_process7-methylguanosine mRNA capping
D0006397biological_processmRNA processing
D0006508biological_processproteolysis
D0008168molecular_functionmethyltransferase activity
D0008233molecular_functionpeptidase activity
D0008236molecular_functionserine-type peptidase activity
D0008289molecular_functionlipid binding
D0016032biological_processviral process
D0016070biological_processRNA metabolic process
D0016740molecular_functiontransferase activity
D0016779molecular_functionnucleotidyltransferase activity
D0016787molecular_functionhydrolase activity
D0016817molecular_functionhydrolase activity, acting on acid anhydrides
D0016887molecular_functionATP hydrolysis activity
D0017111molecular_functionribonucleoside triphosphate phosphatase activity
D0019028cellular_componentviral capsid
D0019031cellular_componentviral envelope
D0019058biological_processviral life cycle
D0019062biological_processvirion attachment to host cell
D0030430cellular_componenthost cell cytoplasm
D0032259biological_processmethylation
D0034062molecular_function5'-3' RNA polymerase activity
D0039502biological_processsymbiont-mediated suppression of host type I interferon-mediated signaling pathway
D0039520biological_processsymbiont-mediated activation of host autophagy
D0039563biological_processsymbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity
D0039564biological_processsymbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity
D0039574biological_processsymbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity
D0039654biological_processfusion of virus membrane with host endosome membrane
D0039663biological_processmembrane fusion involved in viral entry into host cell
D0039694biological_processviral RNA genome replication
D0042025cellular_componenthost cell nucleus
D0044167cellular_componenthost cell endoplasmic reticulum membrane
D0044220cellular_componenthost cell perinuclear region of cytoplasm
D0044423cellular_componentvirion component
D0045824biological_processnegative regulation of innate immune response
D0046718biological_processsymbiont entry into host cell
D0046872molecular_functionmetal ion binding
D0046983molecular_functionprotein dimerization activity
D0051536molecular_functioniron-sulfur cluster binding
D0051539molecular_function4 iron, 4 sulfur cluster binding
D0052170biological_processsymbiont-mediated suppression of host innate immune response
D0055036cellular_componentvirion membrane
D0060090molecular_functionmolecular adaptor activity
D0075509biological_processendocytosis involved in viral entry into host cell
D0075512biological_processclathrin-dependent endocytosis of virus by host cell
D0106005biological_processRNA 5'-cap (guanine-N7)-methylation
E0000166molecular_functionnucleotide binding
E0001172biological_processRNA-templated transcription
E0003723molecular_functionRNA binding
E0003724molecular_functionRNA helicase activity
E0003725molecular_functiondouble-stranded RNA binding
E0003968molecular_functionRNA-directed RNA polymerase activity
E0004252molecular_functionserine-type endopeptidase activity
E0004386molecular_functionhelicase activity
E0004482molecular_functionmRNA 5'-cap (guanine-N7-)-methyltransferase activity
E0004483molecular_functionmethyltransferase cap1 activity
E0005198molecular_functionstructural molecule activity
E0005524molecular_functionATP binding
E0005525molecular_functionGTP binding
E0005576cellular_componentextracellular region
E0005813cellular_componentcentrosome
E0006370biological_process7-methylguanosine mRNA capping
E0006397biological_processmRNA processing
E0006508biological_processproteolysis
E0008168molecular_functionmethyltransferase activity
E0008233molecular_functionpeptidase activity
E0008236molecular_functionserine-type peptidase activity
E0008289molecular_functionlipid binding
E0016032biological_processviral process
E0016070biological_processRNA metabolic process
E0016740molecular_functiontransferase activity
E0016779molecular_functionnucleotidyltransferase activity
E0016787molecular_functionhydrolase activity
E0016817molecular_functionhydrolase activity, acting on acid anhydrides
E0016887molecular_functionATP hydrolysis activity
E0017111molecular_functionribonucleoside triphosphate phosphatase activity
E0019028cellular_componentviral capsid
E0019031cellular_componentviral envelope
E0019058biological_processviral life cycle
E0019062biological_processvirion attachment to host cell
E0030430cellular_componenthost cell cytoplasm
E0032259biological_processmethylation
E0034062molecular_function5'-3' RNA polymerase activity
E0039502biological_processsymbiont-mediated suppression of host type I interferon-mediated signaling pathway
E0039520biological_processsymbiont-mediated activation of host autophagy
E0039563biological_processsymbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity
E0039564biological_processsymbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity
E0039574biological_processsymbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity
E0039654biological_processfusion of virus membrane with host endosome membrane
E0039663biological_processmembrane fusion involved in viral entry into host cell
E0039694biological_processviral RNA genome replication
E0042025cellular_componenthost cell nucleus
E0044167cellular_componenthost cell endoplasmic reticulum membrane
E0044220cellular_componenthost cell perinuclear region of cytoplasm
E0044423cellular_componentvirion component
E0045824biological_processnegative regulation of innate immune response
E0046718biological_processsymbiont entry into host cell
E0046872molecular_functionmetal ion binding
E0046983molecular_functionprotein dimerization activity
E0051536molecular_functioniron-sulfur cluster binding
E0051539molecular_function4 iron, 4 sulfur cluster binding
E0052170biological_processsymbiont-mediated suppression of host innate immune response
E0055036cellular_componentvirion membrane
E0060090molecular_functionmolecular adaptor activity
E0075509biological_processendocytosis involved in viral entry into host cell
E0075512biological_processclathrin-dependent endocytosis of virus by host cell
E0106005biological_processRNA 5'-cap (guanine-N7)-methylation
F0000166molecular_functionnucleotide binding
F0001172biological_processRNA-templated transcription
F0003723molecular_functionRNA binding
F0003724molecular_functionRNA helicase activity
F0003725molecular_functiondouble-stranded RNA binding
F0003968molecular_functionRNA-directed RNA polymerase activity
F0004252molecular_functionserine-type endopeptidase activity
F0004386molecular_functionhelicase activity
F0004482molecular_functionmRNA 5'-cap (guanine-N7-)-methyltransferase activity
F0004483molecular_functionmethyltransferase cap1 activity
F0005198molecular_functionstructural molecule activity
F0005524molecular_functionATP binding
F0005525molecular_functionGTP binding
F0005576cellular_componentextracellular region
F0005813cellular_componentcentrosome
F0006370biological_process7-methylguanosine mRNA capping
F0006397biological_processmRNA processing
F0006508biological_processproteolysis
F0008168molecular_functionmethyltransferase activity
F0008233molecular_functionpeptidase activity
F0008236molecular_functionserine-type peptidase activity
F0008289molecular_functionlipid binding
F0016032biological_processviral process
F0016070biological_processRNA metabolic process
F0016740molecular_functiontransferase activity
F0016779molecular_functionnucleotidyltransferase activity
F0016787molecular_functionhydrolase activity
F0016817molecular_functionhydrolase activity, acting on acid anhydrides
F0016887molecular_functionATP hydrolysis activity
F0017111molecular_functionribonucleoside triphosphate phosphatase activity
F0019028cellular_componentviral capsid
F0019031cellular_componentviral envelope
F0019058biological_processviral life cycle
F0019062biological_processvirion attachment to host cell
F0030430cellular_componenthost cell cytoplasm
F0032259biological_processmethylation
F0034062molecular_function5'-3' RNA polymerase activity
F0039502biological_processsymbiont-mediated suppression of host type I interferon-mediated signaling pathway
F0039520biological_processsymbiont-mediated activation of host autophagy
F0039563biological_processsymbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity
F0039564biological_processsymbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity
F0039574biological_processsymbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity
F0039654biological_processfusion of virus membrane with host endosome membrane
F0039663biological_processmembrane fusion involved in viral entry into host cell
F0039694biological_processviral RNA genome replication
F0042025cellular_componenthost cell nucleus
F0044167cellular_componenthost cell endoplasmic reticulum membrane
F0044220cellular_componenthost cell perinuclear region of cytoplasm
F0044423cellular_componentvirion component
F0045824biological_processnegative regulation of innate immune response
F0046718biological_processsymbiont entry into host cell
F0046872molecular_functionmetal ion binding
F0046983molecular_functionprotein dimerization activity
F0051536molecular_functioniron-sulfur cluster binding
F0051539molecular_function4 iron, 4 sulfur cluster binding
F0052170biological_processsymbiont-mediated suppression of host innate immune response
F0055036cellular_componentvirion membrane
F0060090molecular_functionmolecular adaptor activity
F0075509biological_processendocytosis involved in viral entry into host cell
F0075512biological_processclathrin-dependent endocytosis of virus by host cell
F0106005biological_processRNA 5'-cap (guanine-N7)-methylation
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1362
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues27
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues39
DetailsRegion: {"description":"Fusion peptide","evidences":[{"source":"UniProtKB","id":"P14336","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues3
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine; by host","evidences":[{"source":"PubMed","id":"27093288","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27338953","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27882950","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29091758","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues9
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"A0A142I5B9","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues57
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues45
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

243531

PDB entries from 2025-10-22

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