8CXI
Structures of Zika Virus in Complex with Antibodies Targeting E Dimer Epitopes and Basis for Neutralization Efficacy
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0046983 | molecular_function | protein dimerization activity |
| B | 0046983 | molecular_function | protein dimerization activity |
| C | 0046983 | molecular_function | protein dimerization activity |
| D | 0001172 | biological_process | RNA-templated transcription |
| D | 0003723 | molecular_function | RNA binding |
| D | 0003724 | molecular_function | RNA helicase activity |
| D | 0003725 | molecular_function | double-stranded RNA binding |
| D | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
| D | 0004252 | molecular_function | serine-type endopeptidase activity |
| D | 0004386 | molecular_function | helicase activity |
| D | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| D | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
| D | 0005198 | molecular_function | structural molecule activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005525 | molecular_function | GTP binding |
| D | 0005576 | cellular_component | extracellular region |
| D | 0005813 | cellular_component | centrosome |
| D | 0006370 | biological_process | 7-methylguanosine mRNA capping |
| D | 0006508 | biological_process | proteolysis |
| D | 0008168 | molecular_function | methyltransferase activity |
| D | 0008236 | molecular_function | serine-type peptidase activity |
| D | 0008289 | molecular_function | lipid binding |
| D | 0016020 | cellular_component | membrane |
| D | 0016032 | biological_process | viral process |
| D | 0016070 | biological_process | RNA metabolic process |
| D | 0016817 | molecular_function | hydrolase activity, acting on acid anhydrides |
| D | 0016887 | molecular_function | ATP hydrolysis activity |
| D | 0017111 | molecular_function | ribonucleoside triphosphate phosphatase activity |
| D | 0019028 | cellular_component | viral capsid |
| D | 0019031 | cellular_component | viral envelope |
| D | 0019049 | biological_process | virus-mediated perturbation of host defense response |
| D | 0019058 | biological_process | viral life cycle |
| D | 0019062 | biological_process | virion attachment to host cell |
| D | 0030430 | cellular_component | host cell cytoplasm |
| D | 0032259 | biological_process | methylation |
| D | 0033644 | cellular_component | host cell membrane |
| D | 0034062 | molecular_function | 5'-3' RNA polymerase activity |
| D | 0039502 | biological_process | symbiont-mediated suppression of host type I interferon-mediated signaling pathway |
| D | 0039520 | biological_process | induction by virus of host autophagy |
| D | 0039563 | biological_process | symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity |
| D | 0039564 | biological_process | symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity |
| D | 0039574 | biological_process | symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity |
| D | 0039654 | biological_process | fusion of virus membrane with host endosome membrane |
| D | 0039694 | biological_process | viral RNA genome replication |
| D | 0042025 | cellular_component | host cell nucleus |
| D | 0044165 | cellular_component | host cell endoplasmic reticulum |
| D | 0044167 | cellular_component | host cell endoplasmic reticulum membrane |
| D | 0044220 | cellular_component | host cell perinuclear region of cytoplasm |
| D | 0044423 | cellular_component | virion component |
| D | 0045824 | biological_process | negative regulation of innate immune response |
| D | 0046718 | biological_process | symbiont entry into host cell |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0046983 | molecular_function | protein dimerization activity |
| D | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| D | 0055036 | cellular_component | virion membrane |
| D | 0060090 | molecular_function | molecular adaptor activity |
| D | 0075512 | biological_process | clathrin-dependent endocytosis of virus by host cell |
| D | 0106005 | biological_process | RNA 5'-cap (guanine-N7)-methylation |
| E | 0001172 | biological_process | RNA-templated transcription |
| E | 0003723 | molecular_function | RNA binding |
| E | 0003724 | molecular_function | RNA helicase activity |
| E | 0003725 | molecular_function | double-stranded RNA binding |
| E | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
| E | 0004252 | molecular_function | serine-type endopeptidase activity |
| E | 0004386 | molecular_function | helicase activity |
| E | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| E | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
| E | 0005198 | molecular_function | structural molecule activity |
| E | 0005524 | molecular_function | ATP binding |
| E | 0005525 | molecular_function | GTP binding |
| E | 0005576 | cellular_component | extracellular region |
| E | 0005813 | cellular_component | centrosome |
| E | 0006370 | biological_process | 7-methylguanosine mRNA capping |
| E | 0006508 | biological_process | proteolysis |
| E | 0008168 | molecular_function | methyltransferase activity |
| E | 0008236 | molecular_function | serine-type peptidase activity |
| E | 0008289 | molecular_function | lipid binding |
| E | 0016020 | cellular_component | membrane |
| E | 0016032 | biological_process | viral process |
| E | 0016070 | biological_process | RNA metabolic process |
| E | 0016817 | molecular_function | hydrolase activity, acting on acid anhydrides |
| E | 0016887 | molecular_function | ATP hydrolysis activity |
| E | 0017111 | molecular_function | ribonucleoside triphosphate phosphatase activity |
| E | 0019028 | cellular_component | viral capsid |
| E | 0019031 | cellular_component | viral envelope |
| E | 0019049 | biological_process | virus-mediated perturbation of host defense response |
| E | 0019058 | biological_process | viral life cycle |
| E | 0019062 | biological_process | virion attachment to host cell |
| E | 0030430 | cellular_component | host cell cytoplasm |
| E | 0032259 | biological_process | methylation |
| E | 0033644 | cellular_component | host cell membrane |
| E | 0034062 | molecular_function | 5'-3' RNA polymerase activity |
| E | 0039502 | biological_process | symbiont-mediated suppression of host type I interferon-mediated signaling pathway |
| E | 0039520 | biological_process | induction by virus of host autophagy |
| E | 0039563 | biological_process | symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity |
| E | 0039564 | biological_process | symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity |
| E | 0039574 | biological_process | symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity |
| E | 0039654 | biological_process | fusion of virus membrane with host endosome membrane |
| E | 0039694 | biological_process | viral RNA genome replication |
| E | 0042025 | cellular_component | host cell nucleus |
| E | 0044165 | cellular_component | host cell endoplasmic reticulum |
| E | 0044167 | cellular_component | host cell endoplasmic reticulum membrane |
| E | 0044220 | cellular_component | host cell perinuclear region of cytoplasm |
| E | 0044423 | cellular_component | virion component |
| E | 0045824 | biological_process | negative regulation of innate immune response |
| E | 0046718 | biological_process | symbiont entry into host cell |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0046983 | molecular_function | protein dimerization activity |
| E | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| E | 0055036 | cellular_component | virion membrane |
| E | 0060090 | molecular_function | molecular adaptor activity |
| E | 0075512 | biological_process | clathrin-dependent endocytosis of virus by host cell |
| E | 0106005 | biological_process | RNA 5'-cap (guanine-N7)-methylation |
| F | 0001172 | biological_process | RNA-templated transcription |
| F | 0003723 | molecular_function | RNA binding |
| F | 0003724 | molecular_function | RNA helicase activity |
| F | 0003725 | molecular_function | double-stranded RNA binding |
| F | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
| F | 0004252 | molecular_function | serine-type endopeptidase activity |
| F | 0004386 | molecular_function | helicase activity |
| F | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| F | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
| F | 0005198 | molecular_function | structural molecule activity |
| F | 0005524 | molecular_function | ATP binding |
| F | 0005525 | molecular_function | GTP binding |
| F | 0005576 | cellular_component | extracellular region |
| F | 0005813 | cellular_component | centrosome |
| F | 0006370 | biological_process | 7-methylguanosine mRNA capping |
| F | 0006508 | biological_process | proteolysis |
| F | 0008168 | molecular_function | methyltransferase activity |
| F | 0008236 | molecular_function | serine-type peptidase activity |
| F | 0008289 | molecular_function | lipid binding |
| F | 0016020 | cellular_component | membrane |
| F | 0016032 | biological_process | viral process |
| F | 0016070 | biological_process | RNA metabolic process |
| F | 0016817 | molecular_function | hydrolase activity, acting on acid anhydrides |
| F | 0016887 | molecular_function | ATP hydrolysis activity |
| F | 0017111 | molecular_function | ribonucleoside triphosphate phosphatase activity |
| F | 0019028 | cellular_component | viral capsid |
| F | 0019031 | cellular_component | viral envelope |
| F | 0019049 | biological_process | virus-mediated perturbation of host defense response |
| F | 0019058 | biological_process | viral life cycle |
| F | 0019062 | biological_process | virion attachment to host cell |
| F | 0030430 | cellular_component | host cell cytoplasm |
| F | 0032259 | biological_process | methylation |
| F | 0033644 | cellular_component | host cell membrane |
| F | 0034062 | molecular_function | 5'-3' RNA polymerase activity |
| F | 0039502 | biological_process | symbiont-mediated suppression of host type I interferon-mediated signaling pathway |
| F | 0039520 | biological_process | induction by virus of host autophagy |
| F | 0039563 | biological_process | symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity |
| F | 0039564 | biological_process | symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity |
| F | 0039574 | biological_process | symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity |
| F | 0039654 | biological_process | fusion of virus membrane with host endosome membrane |
| F | 0039694 | biological_process | viral RNA genome replication |
| F | 0042025 | cellular_component | host cell nucleus |
| F | 0044165 | cellular_component | host cell endoplasmic reticulum |
| F | 0044167 | cellular_component | host cell endoplasmic reticulum membrane |
| F | 0044220 | cellular_component | host cell perinuclear region of cytoplasm |
| F | 0044423 | cellular_component | virion component |
| F | 0045824 | biological_process | negative regulation of innate immune response |
| F | 0046718 | biological_process | symbiont entry into host cell |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0046983 | molecular_function | protein dimerization activity |
| F | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| F | 0055036 | cellular_component | virion membrane |
| F | 0060090 | molecular_function | molecular adaptor activity |
| F | 0075512 | biological_process | clathrin-dependent endocytosis of virus by host cell |
| F | 0106005 | biological_process | RNA 5'-cap (guanine-N7)-methylation |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3495 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| D | MET-214-ARG-111 | |
| D | GLU2248-LEU3208 | |
| E | MET-214-ARG-111 | |
| E | SER55-GLN59 | |
| E | ASN553-SER558 | |
| E | ASP984-VAL1005 | |
| E | ARG1077-ASN1080 | |
| E | THR1152-SER1158 | |
| E | LYS1204-LYS1257 | |
| E | SER2002-GLU2003 | |
| E | MET2151-PRO2160 | |
| D | SER55-GLN59 | |
| E | GLU2248-LEU3208 | |
| F | MET-214-ARG-111 | |
| F | SER55-GLN59 | |
| F | ASN553-SER558 | |
| F | ASP984-VAL1005 | |
| F | ARG1077-ASN1080 | |
| F | THR1152-SER1158 | |
| F | LYS1204-LYS1257 | |
| F | SER2002-GLU2003 | |
| F | MET2151-PRO2160 | |
| D | ASN553-SER558 | |
| F | GLU2248-LEU3208 | |
| D | ASP984-VAL1005 | |
| D | ARG1077-ASN1080 | |
| D | THR1152-SER1158 | |
| D | LYS1204-LYS1257 | |
| D | SER2002-GLU2003 | |
| D | MET2151-PRO2160 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 960 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| D | GLY-110-VAL-90 | |
| D | TRP1159-ALA1179 | |
| D | ILE1183-GLY1203 | |
| D | LEU1956-LEU1976 | |
| D | ILE2004-ILE2024 | |
| D | VAL2130-LEU2150 | |
| D | LEU2161-LEU2181 | |
| D | VAL2227-GLY2247 | |
| E | GLY-110-VAL-90 | |
| E | TRP35-GLY54 | |
| E | LEU531-LEU552 | |
| D | TRP35-GLY54 | |
| E | ILE559-ALA579 | |
| E | ILE963-SER983 | |
| E | ALA1006-PHE1026 | |
| E | LEU1056-PRO1076 | |
| E | ILE1081-TRP1101 | |
| E | ALA1131-LEU1151 | |
| E | TRP1159-ALA1179 | |
| E | ILE1183-GLY1203 | |
| E | LEU1956-LEU1976 | |
| E | ILE2004-ILE2024 | |
| D | LEU531-LEU552 | |
| E | VAL2130-LEU2150 | |
| E | LEU2161-LEU2181 | |
| E | VAL2227-GLY2247 | |
| F | GLY-110-VAL-90 | |
| F | TRP35-GLY54 | |
| F | LEU531-LEU552 | |
| F | ILE559-ALA579 | |
| F | ILE963-SER983 | |
| F | ALA1006-PHE1026 | |
| F | LEU1056-PRO1076 | |
| D | ILE559-ALA579 | |
| F | ILE1081-TRP1101 | |
| F | ALA1131-LEU1151 | |
| F | TRP1159-ALA1179 | |
| F | ILE1183-GLY1203 | |
| F | LEU1956-LEU1976 | |
| F | ILE2004-ILE2024 | |
| F | VAL2130-LEU2150 | |
| F | LEU2161-LEU2181 | |
| F | VAL2227-GLY2247 | |
| D | ILE963-SER983 | |
| D | ALA1006-PHE1026 | |
| D | LEU1056-PRO1076 | |
| D | ILE1081-TRP1101 | |
| D | ALA1131-LEU1151 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1731 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| D | THR-89-ASN34 | |
| D | ILE76-SER530 | |
| E | THR-89-ASN34 | |
| E | ILE76-SER530 | |
| F | THR-89-ASN34 | |
| F | ILE76-SER530 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 45 |
| Details | TRANSMEM: Helical => ECO:0000305 |
| Chain | Residue | Details |
| D | LYS60-SER75 | |
| E | LYS60-SER75 | |
| F | LYS60-SER75 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3687 |
| Details | TOPO_DOM: Lumenal => ECO:0000305 |
| Chain | Residue | Details |
| D | ASP580-LYS962 | |
| D | GLN2182-GLN2226 | |
| E | ASP580-LYS962 | |
| E | ARG1027-ASP1055 | |
| E | ARG1102-MET1130 | |
| E | LYS1180-ASP1182 | |
| E | TYR1279-THR1955 | |
| E | MET1977-LYS1980 | |
| E | PRO2025-ALA2039 | |
| E | ASN2055-SER2092 | |
| E | THR2114-GLY2129 | |
| D | ARG1027-ASP1055 | |
| E | GLN2182-GLN2226 | |
| F | ASP580-LYS962 | |
| F | ARG1027-ASP1055 | |
| F | ARG1102-MET1130 | |
| F | LYS1180-ASP1182 | |
| F | TYR1279-THR1955 | |
| F | MET1977-LYS1980 | |
| F | PRO2025-ALA2039 | |
| F | ASN2055-SER2092 | |
| F | THR2114-GLY2129 | |
| D | ARG1102-MET1130 | |
| F | GLN2182-GLN2226 | |
| D | LYS1180-ASP1182 | |
| D | TYR1279-THR1955 | |
| D | MET1977-LYS1980 | |
| D | PRO2025-ALA2039 | |
| D | ASN2055-SER2092 | |
| D | THR2114-GLY2129 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 180 |
| Details | INTRAMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| D | VAL1258-TRP1278 | |
| D | GLY1981-LEU2001 | |
| D | ALA2093-THR2113 | |
| E | VAL1258-TRP1278 | |
| E | GLY1981-LEU2001 | |
| E | ALA2093-THR2113 | |
| F | VAL1258-TRP1278 | |
| F | GLY1981-LEU2001 | |
| F | ALA2093-THR2113 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 42 |
| Details | INTRAMEM: Helical; Note=Signal for NS4B => ECO:0000305 |
| Chain | Residue | Details |
| D | ILE2040-ALA2054 | |
| E | ILE2040-ALA2054 | |
| F | ILE2040-ALA2054 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 9 |
| Details | ACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU00860 |
| Chain | Residue | Details |
| D | HIS1338 | |
| D | ASP1362 | |
| D | SER1422 | |
| E | HIS1338 | |
| E | ASP1362 | |
| E | SER1422 | |
| F | HIS1338 | |
| F | ASP1362 | |
| F | SER1422 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 12 |
| Details | ACT_SITE: For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 |
| Chain | Residue | Details |
| D | LYS2366 | |
| F | ASP2451 | |
| F | LYS2487 | |
| F | GLU2523 | |
| D | ASP2451 | |
| D | LYS2487 | |
| D | GLU2523 | |
| E | LYS2366 | |
| E | ASP2451 | |
| E | LYS2487 | |
| E | GLU2523 | |
| F | LYS2366 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00541 |
| Chain | Residue | Details |
| D | LEU1481 | |
| E | LEU1481 | |
| F | LEU1481 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 9 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27866982 |
| Chain | Residue | Details |
| D | LYS2318 | |
| D | GLU2454 | |
| D | ARG2518 | |
| E | LYS2318 | |
| E | GLU2454 | |
| E | ARG2518 | |
| F | LYS2318 | |
| F | GLU2454 | |
| F | ARG2518 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27866982 |
| Chain | Residue | Details |
| D | SER2361 | |
| D | THR2409 | |
| E | SER2361 | |
| E | THR2409 | |
| F | SER2361 | |
| F | THR2409 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 15 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 |
| Chain | Residue | Details |
| D | GLY2391 | |
| E | VAL2437 | |
| F | GLY2391 | |
| F | TRP2392 | |
| F | LYS2410 | |
| F | ASP2436 | |
| F | VAL2437 | |
| D | TRP2392 | |
| D | LYS2410 | |
| D | ASP2436 | |
| D | VAL2437 | |
| E | GLY2391 | |
| E | TRP2392 | |
| E | LYS2410 | |
| E | ASP2436 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 9 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359 |
| Chain | Residue | Details |
| D | HIS2415 | |
| D | GLU2416 | |
| D | ASP2451 | |
| E | HIS2415 | |
| E | GLU2416 | |
| E | ASP2451 | |
| F | HIS2415 | |
| F | GLU2416 | |
| F | ASP2451 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 |
| Chain | Residue | Details |
| D | ILE2452 | |
| D | TYR2525 | |
| E | ILE2452 | |
| E | TYR2525 | |
| F | ILE2452 | |
| F | TYR2525 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 18 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q32ZE1 |
| Chain | Residue | Details |
| D | GLU2744 | |
| E | CYS2756 | |
| E | HIS3019 | |
| E | CYS3035 | |
| F | GLU2744 | |
| F | HIS2748 | |
| F | CYS2753 | |
| F | CYS2756 | |
| F | HIS3019 | |
| F | CYS3035 | |
| D | HIS2748 | |
| D | CYS2753 | |
| D | CYS2756 | |
| D | HIS3019 | |
| D | CYS3035 | |
| E | GLU2744 | |
| E | HIS2748 | |
| E | CYS2753 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P14335 |
| Chain | Residue | Details |
| D | CYS3154 | |
| E | CYS3154 | |
| F | CYS3154 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 3 |
| Details | SITE: Cleavage; by viral protease NS3 => ECO:0000250|UniProtKB:Q32ZE1 |
| Chain | Residue | Details |
| D | ARG-111 | |
| E | ARG-111 | |
| F | ARG-111 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 3 |
| Details | SITE: Cleavage; by host signal peptidase => ECO:0000250|UniProtKB:Q32ZE1 |
| Chain | Residue | Details |
| D | ALA-93 | |
| E | ALA-93 | |
| F | ALA-93 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 3 |
| Details | SITE: Fetal microcephaly |
| Chain | Residue | Details |
| D | ASN-76 | |
| E | ASN-76 | |
| F | ASN-76 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 3 |
| Details | SITE: Cleavage; by host furin => ECO:0000250|UniProtKB:Q32ZE1 |
| Chain | Residue | Details |
| D | ARG0 | |
| E | ARG0 | |
| F | ARG0 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 9 |
| Details | SITE: Cleavage; by host signal peptidase => ECO:0000250|UniProtKB:P06935 |
| Chain | Residue | Details |
| D | SER75 | |
| D | ALA579 | |
| D | ALA2054 | |
| E | SER75 | |
| E | ALA579 | |
| E | ALA2054 | |
| F | SER75 | |
| F | ALA579 | |
| F | ALA2054 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 3 |
| Details | SITE: Cleavage; by host => ECO:0000250|UniProtKB:P06935 |
| Chain | Residue | Details |
| D | ALA931 | |
| E | ALA931 | |
| F | ALA931 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 9 |
| Details | SITE: Cleavage; by viral protease NS3 => ECO:0000250|UniProtKB:P06935 |
| Chain | Residue | Details |
| D | ARG1157 | |
| D | ARG2031 | |
| D | ARG2305 | |
| E | ARG1157 | |
| E | ARG2031 | |
| E | ARG2305 | |
| F | ARG1157 | |
| F | ARG2031 | |
| F | ARG2305 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 6 |
| Details | SITE: Cleavage; by autolysis => ECO:0000250|UniProtKB:P06935 |
| Chain | Residue | Details |
| D | ARG1287 | |
| D | ARG1904 | |
| E | ARG1287 | |
| E | ARG1904 | |
| F | ARG1287 | |
| F | ARG1904 |
| site_id | SWS_FT_FI26 |
| Number of Residues | 6 |
| Details | SITE: Involved in NS3 ATPase and RTPase activities => ECO:0000250|UniProtKB:P14335 |
| Chain | Residue | Details |
| D | ARG1743 | |
| D | ARG1746 | |
| E | ARG1743 | |
| E | ARG1746 | |
| F | ARG1743 | |
| F | ARG1746 |
| site_id | SWS_FT_FI27 |
| Number of Residues | 21 |
| Details | SITE: mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 |
| Chain | Residue | Details |
| D | LYS2318 | |
| E | PHE2329 | |
| E | LYS2333 | |
| E | SER2455 | |
| E | ARG2518 | |
| E | SER2520 | |
| F | LYS2318 | |
| F | ASN2322 | |
| F | PHE2329 | |
| F | LYS2333 | |
| F | SER2455 | |
| D | ASN2322 | |
| F | ARG2518 | |
| F | SER2520 | |
| D | PHE2329 | |
| D | LYS2333 | |
| D | SER2455 | |
| D | ARG2518 | |
| D | SER2520 | |
| E | LYS2318 | |
| E | ASN2322 |
| site_id | SWS_FT_FI28 |
| Number of Residues | 6 |
| Details | SITE: mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924 |
| Chain | Residue | Details |
| D | LEU2321 | |
| D | MET2324 | |
| E | LEU2321 | |
| E | MET2324 | |
| F | LEU2321 | |
| F | MET2324 |
| site_id | SWS_FT_FI29 |
| Number of Residues | 9 |
| Details | SITE: Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 |
| Chain | Residue | Details |
| D | LYS2366 | |
| D | LYS2487 | |
| D | GLU2523 | |
| E | LYS2366 | |
| E | LYS2487 | |
| E | GLU2523 | |
| F | LYS2366 | |
| F | LYS2487 | |
| F | GLU2523 |
| site_id | SWS_FT_FI30 |
| Number of Residues | 3 |
| Details | SITE: Essential for 2'-O-methyltransferase and N-7 methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 |
| Chain | Residue | Details |
| D | ASP2451 | |
| E | ASP2451 | |
| F | ASP2451 |
| site_id | SWS_FT_FI31 |
| Number of Residues | 3 |
| Details | MOD_RES: N6-acetyllysine; by host => ECO:0000250|UniProtKB:Q32ZE1 |
| Chain | Residue | Details |
| D | LYS1676 | |
| E | LYS1676 | |
| F | LYS1676 |
| site_id | SWS_FT_FI32 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P03314 |
| Chain | Residue | Details |
| D | SER2361 | |
| E | SER2361 | |
| F | SER2361 |
| site_id | SWS_FT_FI33 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000255 |
| Chain | Residue | Details |
| D | ASN-23 | |
| E | ASN-23 | |
| F | ASN-23 |
| site_id | SWS_FT_FI34 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000269|PubMed:27093288, ECO:0000269|PubMed:27338953, ECO:0000269|PubMed:27882950, ECO:0000269|PubMed:29091758 |
| Chain | Residue | Details |
| D | ASN229 | |
| E | ASN229 | |
| F | ASN229 |
| site_id | SWS_FT_FI35 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000250|UniProtKB:Q32ZE1 |
| Chain | Residue | Details |
| D | ASN709 | |
| D | ASN786 | |
| E | ASN709 | |
| E | ASN786 | |
| F | ASN709 | |
| F | ASN786 |
| site_id | SWS_FT_FI36 |
| Number of Residues | 9 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:A0A142I5B9 |
| Chain | Residue | Details |
| D | LYS113 | |
| D | LYS356 | |
| E | LYS113 | |
| E | LYS356 | |
| F | LYS113 | |
| F | LYS356 |
