8CXI

Structures of Zika Virus in Complex with Antibodies Targeting E Dimer Epitopes and Basis for Neutralization Efficacy

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0046983	molecular_function	protein dimerization activity
B	0046983	molecular_function	protein dimerization activity
C	0046983	molecular_function	protein dimerization activity
D	0000166	molecular_function	nucleotide binding
D	0001172	biological_process	RNA-templated transcription
D	0003723	molecular_function	RNA binding
D	0003724	molecular_function	RNA helicase activity
D	0003725	molecular_function	double-stranded RNA binding
D	0003968	molecular_function	RNA-directed RNA polymerase activity
D	0004252	molecular_function	serine-type endopeptidase activity
D	0004386	molecular_function	helicase activity
D	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
D	0004483	molecular_function	methyltransferase cap1 activity
D	0005198	molecular_function	structural molecule activity
D	0005524	molecular_function	ATP binding
D	0005525	molecular_function	GTP binding
D	0005576	cellular_component	extracellular region
D	0005813	cellular_component	centrosome
D	0006370	biological_process	7-methylguanosine mRNA capping
D	0006397	biological_process	mRNA processing
D	0006508	biological_process	proteolysis
D	0008168	molecular_function	methyltransferase activity
D	0008233	molecular_function	peptidase activity
D	0008236	molecular_function	serine-type peptidase activity
D	0008289	molecular_function	lipid binding
D	0010498	biological_process	proteasomal protein catabolic process
D	0016020	cellular_component	membrane
D	0016032	biological_process	viral process
D	0016070	biological_process	RNA metabolic process
D	0016740	molecular_function	transferase activity
D	0016779	molecular_function	nucleotidyltransferase activity
D	0016787	molecular_function	hydrolase activity
D	0016817	molecular_function	hydrolase activity, acting on acid anhydrides
D	0016887	molecular_function	ATP hydrolysis activity
D	0017111	molecular_function	ribonucleoside triphosphate phosphatase activity
D	0019028	cellular_component	viral capsid
D	0019031	cellular_component	viral envelope
D	0019058	biological_process	viral life cycle
D	0019062	biological_process	virion attachment to host cell
D	0030430	cellular_component	host cell cytoplasm
D	0032259	biological_process	methylation
D	0033644	cellular_component	host cell membrane
D	0034062	molecular_function	5'-3' RNA polymerase activity
D	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
D	0039520	biological_process	symbiont-mediated activation of host autophagy
D	0039563	biological_process	symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity
D	0039564	biological_process	symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity
D	0039574	biological_process	symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity
D	0039654	biological_process	fusion of virus membrane with host endosome membrane
D	0039663	biological_process	membrane fusion involved in viral entry into host cell
D	0039694	biological_process	viral RNA genome replication
D	0042025	cellular_component	host cell nucleus
D	0044165	cellular_component	host cell endoplasmic reticulum
D	0044167	cellular_component	host cell endoplasmic reticulum membrane
D	0044220	cellular_component	host cell perinuclear region of cytoplasm
D	0044423	cellular_component	virion component
D	0045087	biological_process	innate immune response
D	0045824	biological_process	negative regulation of innate immune response
D	0046718	biological_process	symbiont entry into host cell
D	0046872	molecular_function	metal ion binding
D	0046983	molecular_function	protein dimerization activity
D	0051536	molecular_function	iron-sulfur cluster binding
D	0051539	molecular_function	4 iron, 4 sulfur cluster binding
D	0052170	biological_process	symbiont-mediated suppression of host innate immune response
D	0055036	cellular_component	virion membrane
D	0060090	molecular_function	molecular adaptor activity
D	0075509	biological_process	endocytosis involved in viral entry into host cell
D	0075512	biological_process	clathrin-dependent endocytosis of virus by host cell
D	0106005	biological_process	RNA 5'-cap (guanine-N7)-methylation
E	0000166	molecular_function	nucleotide binding
E	0001172	biological_process	RNA-templated transcription
E	0003723	molecular_function	RNA binding
E	0003724	molecular_function	RNA helicase activity
E	0003725	molecular_function	double-stranded RNA binding
E	0003968	molecular_function	RNA-directed RNA polymerase activity
E	0004252	molecular_function	serine-type endopeptidase activity
E	0004386	molecular_function	helicase activity
E	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
E	0004483	molecular_function	methyltransferase cap1 activity
E	0005198	molecular_function	structural molecule activity
E	0005524	molecular_function	ATP binding
E	0005525	molecular_function	GTP binding
E	0005576	cellular_component	extracellular region
E	0005813	cellular_component	centrosome
E	0006370	biological_process	7-methylguanosine mRNA capping
E	0006397	biological_process	mRNA processing
E	0006508	biological_process	proteolysis
E	0008168	molecular_function	methyltransferase activity
E	0008233	molecular_function	peptidase activity
E	0008236	molecular_function	serine-type peptidase activity
E	0008289	molecular_function	lipid binding
E	0010498	biological_process	proteasomal protein catabolic process
E	0016020	cellular_component	membrane
E	0016032	biological_process	viral process
E	0016070	biological_process	RNA metabolic process
E	0016740	molecular_function	transferase activity
E	0016779	molecular_function	nucleotidyltransferase activity
E	0016787	molecular_function	hydrolase activity
E	0016817	molecular_function	hydrolase activity, acting on acid anhydrides
E	0016887	molecular_function	ATP hydrolysis activity
E	0017111	molecular_function	ribonucleoside triphosphate phosphatase activity
E	0019028	cellular_component	viral capsid
E	0019031	cellular_component	viral envelope
E	0019058	biological_process	viral life cycle
E	0019062	biological_process	virion attachment to host cell
E	0030430	cellular_component	host cell cytoplasm
E	0032259	biological_process	methylation
E	0033644	cellular_component	host cell membrane
E	0034062	molecular_function	5'-3' RNA polymerase activity
E	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
E	0039520	biological_process	symbiont-mediated activation of host autophagy
E	0039563	biological_process	symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity
E	0039564	biological_process	symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity
E	0039574	biological_process	symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity
E	0039654	biological_process	fusion of virus membrane with host endosome membrane
E	0039663	biological_process	membrane fusion involved in viral entry into host cell
E	0039694	biological_process	viral RNA genome replication
E	0042025	cellular_component	host cell nucleus
E	0044165	cellular_component	host cell endoplasmic reticulum
E	0044167	cellular_component	host cell endoplasmic reticulum membrane
E	0044220	cellular_component	host cell perinuclear region of cytoplasm
E	0044423	cellular_component	virion component
E	0045087	biological_process	innate immune response
E	0045824	biological_process	negative regulation of innate immune response
E	0046718	biological_process	symbiont entry into host cell
E	0046872	molecular_function	metal ion binding
E	0046983	molecular_function	protein dimerization activity
E	0051536	molecular_function	iron-sulfur cluster binding
E	0051539	molecular_function	4 iron, 4 sulfur cluster binding
E	0052170	biological_process	symbiont-mediated suppression of host innate immune response
E	0055036	cellular_component	virion membrane
E	0060090	molecular_function	molecular adaptor activity
E	0075509	biological_process	endocytosis involved in viral entry into host cell
E	0075512	biological_process	clathrin-dependent endocytosis of virus by host cell
E	0106005	biological_process	RNA 5'-cap (guanine-N7)-methylation
F	0000166	molecular_function	nucleotide binding
F	0001172	biological_process	RNA-templated transcription
F	0003723	molecular_function	RNA binding
F	0003724	molecular_function	RNA helicase activity
F	0003725	molecular_function	double-stranded RNA binding
F	0003968	molecular_function	RNA-directed RNA polymerase activity
F	0004252	molecular_function	serine-type endopeptidase activity
F	0004386	molecular_function	helicase activity
F	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
F	0004483	molecular_function	methyltransferase cap1 activity
F	0005198	molecular_function	structural molecule activity
F	0005524	molecular_function	ATP binding
F	0005525	molecular_function	GTP binding
F	0005576	cellular_component	extracellular region
F	0005813	cellular_component	centrosome
F	0006370	biological_process	7-methylguanosine mRNA capping
F	0006397	biological_process	mRNA processing
F	0006508	biological_process	proteolysis
F	0008168	molecular_function	methyltransferase activity
F	0008233	molecular_function	peptidase activity
F	0008236	molecular_function	serine-type peptidase activity
F	0008289	molecular_function	lipid binding
F	0010498	biological_process	proteasomal protein catabolic process
F	0016020	cellular_component	membrane
F	0016032	biological_process	viral process
F	0016070	biological_process	RNA metabolic process
F	0016740	molecular_function	transferase activity
F	0016779	molecular_function	nucleotidyltransferase activity
F	0016787	molecular_function	hydrolase activity
F	0016817	molecular_function	hydrolase activity, acting on acid anhydrides
F	0016887	molecular_function	ATP hydrolysis activity
F	0017111	molecular_function	ribonucleoside triphosphate phosphatase activity
F	0019028	cellular_component	viral capsid
F	0019031	cellular_component	viral envelope
F	0019058	biological_process	viral life cycle
F	0019062	biological_process	virion attachment to host cell
F	0030430	cellular_component	host cell cytoplasm
F	0032259	biological_process	methylation
F	0033644	cellular_component	host cell membrane
F	0034062	molecular_function	5'-3' RNA polymerase activity
F	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
F	0039520	biological_process	symbiont-mediated activation of host autophagy
F	0039563	biological_process	symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity
F	0039564	biological_process	symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity
F	0039574	biological_process	symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity
F	0039654	biological_process	fusion of virus membrane with host endosome membrane
F	0039663	biological_process	membrane fusion involved in viral entry into host cell
F	0039694	biological_process	viral RNA genome replication
F	0042025	cellular_component	host cell nucleus
F	0044165	cellular_component	host cell endoplasmic reticulum
F	0044167	cellular_component	host cell endoplasmic reticulum membrane
F	0044220	cellular_component	host cell perinuclear region of cytoplasm
F	0044423	cellular_component	virion component
F	0045087	biological_process	innate immune response
F	0045824	biological_process	negative regulation of innate immune response
F	0046718	biological_process	symbiont entry into host cell
F	0046872	molecular_function	metal ion binding
F	0046983	molecular_function	protein dimerization activity
F	0051536	molecular_function	iron-sulfur cluster binding
F	0051539	molecular_function	4 iron, 4 sulfur cluster binding
F	0052170	biological_process	symbiont-mediated suppression of host innate immune response
F	0055036	cellular_component	virion membrane
F	0060090	molecular_function	molecular adaptor activity
F	0075509	biological_process	endocytosis involved in viral entry into host cell
F	0075512	biological_process	clathrin-dependent endocytosis of virus by host cell
F	0106005	biological_process	RNA 5'-cap (guanine-N7)-methylation

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3495
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
D	MET-214-ARG-111
D	GLU2248-LEU3208
E	MET-214-ARG-111
E	SER55-GLN59
E	ASN553-SER558
E	ASP984-VAL1005
E	ARG1077-ASN1080
E	THR1152-SER1158
E	LYS1204-LYS1257
E	SER2002-GLU2003
E	MET2151-PRO2160
D	SER55-GLN59
E	GLU2248-LEU3208
F	MET-214-ARG-111
F	SER55-GLN59
F	ASN553-SER558
F	ASP984-VAL1005
F	ARG1077-ASN1080
F	THR1152-SER1158
F	LYS1204-LYS1257
F	SER2002-GLU2003
F	MET2151-PRO2160
D	ASN553-SER558
F	GLU2248-LEU3208
D	ASP984-VAL1005
D	ARG1077-ASN1080
D	THR1152-SER1158
D	LYS1204-LYS1257
D	SER2002-GLU2003
D	MET2151-PRO2160

---

site_id	SWS_FT_FI2
Number of Residues	960
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
D	GLY-110-VAL-90
D	TRP1159-ALA1179
D	ILE1183-GLY1203
D	LEU1956-LEU1976
D	ILE2004-ILE2024
D	VAL2130-LEU2150
D	LEU2161-LEU2181
D	VAL2227-GLY2247
E	GLY-110-VAL-90
E	TRP35-GLY54
E	LEU531-LEU552
D	TRP35-GLY54
E	ILE559-ALA579
E	ILE963-SER983
E	ALA1006-PHE1026
E	LEU1056-PRO1076
E	ILE1081-TRP1101
E	ALA1131-LEU1151
E	TRP1159-ALA1179
E	ILE1183-GLY1203
E	LEU1956-LEU1976
E	ILE2004-ILE2024
D	LEU531-LEU552
E	VAL2130-LEU2150
E	LEU2161-LEU2181
E	VAL2227-GLY2247
F	GLY-110-VAL-90
F	TRP35-GLY54
F	LEU531-LEU552
F	ILE559-ALA579
F	ILE963-SER983
F	ALA1006-PHE1026
F	LEU1056-PRO1076
D	ILE559-ALA579
F	ILE1081-TRP1101
F	ALA1131-LEU1151
F	TRP1159-ALA1179
F	ILE1183-GLY1203
F	LEU1956-LEU1976
F	ILE2004-ILE2024
F	VAL2130-LEU2150
F	LEU2161-LEU2181
F	VAL2227-GLY2247
D	ILE963-SER983
D	ALA1006-PHE1026
D	LEU1056-PRO1076
D	ILE1081-TRP1101
D	ALA1131-LEU1151

---

site_id	SWS_FT_FI3
Number of Residues	1731
Details	TOPO_DOM: Extracellular => ECO:0000305

Chain	Residue	Details
D	THR-89-ASN34
D	ILE76-SER530
E	THR-89-ASN34
E	ILE76-SER530
F	THR-89-ASN34
F	ILE76-SER530

---

site_id	SWS_FT_FI4
Number of Residues	45
Details	TRANSMEM: Helical => ECO:0000305

Chain	Residue	Details
D	LYS60-SER75
E	LYS60-SER75
F	LYS60-SER75

---

site_id	SWS_FT_FI5
Number of Residues	3687
Details	TOPO_DOM: Lumenal => ECO:0000305

Chain	Residue	Details
D	ASP580-LYS962
D	GLN2182-GLN2226
E	ASP580-LYS962
E	ARG1027-ASP1055
E	ARG1102-MET1130
E	LYS1180-ASP1182
E	TYR1279-THR1955
E	MET1977-LYS1980
E	PRO2025-ALA2039
E	ASN2055-SER2092
E	THR2114-GLY2129
D	ARG1027-ASP1055
E	GLN2182-GLN2226
F	ASP580-LYS962
F	ARG1027-ASP1055
F	ARG1102-MET1130
F	LYS1180-ASP1182
F	TYR1279-THR1955
F	MET1977-LYS1980
F	PRO2025-ALA2039
F	ASN2055-SER2092
F	THR2114-GLY2129
D	ARG1102-MET1130
F	GLN2182-GLN2226
D	LYS1180-ASP1182
D	TYR1279-THR1955
D	MET1977-LYS1980
D	PRO2025-ALA2039
D	ASN2055-SER2092
D	THR2114-GLY2129

---

site_id	SWS_FT_FI6
Number of Residues	180
Details	INTRAMEM: Helical => ECO:0000255

Chain	Residue	Details
D	VAL1258-TRP1278
D	GLY1981-LEU2001
D	ALA2093-THR2113
E	VAL1258-TRP1278
E	GLY1981-LEU2001
E	ALA2093-THR2113
F	VAL1258-TRP1278
F	GLY1981-LEU2001
F	ALA2093-THR2113

---

site_id	SWS_FT_FI7
Number of Residues	42
Details	INTRAMEM: Helical; Note=Signal for NS4B => ECO:0000305

Chain	Residue	Details
D	ILE2040-ALA2054
E	ILE2040-ALA2054
F	ILE2040-ALA2054

---

site_id	SWS_FT_FI8
Number of Residues	9
Details	ACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU00860

Chain	Residue	Details
D	HIS1338
D	ASP1362
D	SER1422
E	HIS1338
E	ASP1362
E	SER1422
F	HIS1338
F	ASP1362
F	SER1422

---

site_id	SWS_FT_FI9
Number of Residues	12
Details	ACT_SITE: For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4

Chain	Residue	Details
D	LYS2366
F	ASP2451
F	LYS2487
F	GLU2523
D	ASP2451
D	LYS2487
D	GLU2523
E	LYS2366
E	ASP2451
E	LYS2487
E	GLU2523
F	LYS2366

---

site_id	SWS_FT_FI10
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00541

Chain	Residue	Details
D	LEU1481
E	LEU1481
F	LEU1481

---

site_id	SWS_FT_FI11
Number of Residues	9
Details	BINDING: BINDING => ECO:0000269|PubMed:27866982

Chain	Residue	Details
D	LYS2318
D	GLU2454
D	ARG2518
E	LYS2318
E	GLU2454
E	ARG2518
F	LYS2318
F	GLU2454
F	ARG2518

---

site_id	SWS_FT_FI12
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27866982

Chain	Residue	Details
D	SER2361
D	THR2409
E	SER2361
E	THR2409
F	SER2361
F	THR2409

---

site_id	SWS_FT_FI13
Number of Residues	15
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359

Chain	Residue	Details
D	GLY2391
E	VAL2437
F	GLY2391
F	TRP2392
F	LYS2410
F	ASP2436
F	VAL2437
D	TRP2392
D	LYS2410
D	ASP2436
D	VAL2437
E	GLY2391
E	TRP2392
E	LYS2410
E	ASP2436

---

site_id	SWS_FT_FI14
Number of Residues	9
Details	BINDING: BINDING => ECO:0000269|PubMed:27633330, ECO:0000269|PubMed:27866982, ECO:0000269|PubMed:28031359

Chain	Residue	Details
D	HIS2415
D	GLU2416
D	ASP2451
E	HIS2415
E	GLU2416
E	ASP2451
F	HIS2415
F	GLU2416
F	ASP2451

---

site_id	SWS_FT_FI15
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00924

Chain	Residue	Details
D	ILE2452
D	TYR2525
E	ILE2452
E	TYR2525
F	ILE2452
F	TYR2525

---

site_id	SWS_FT_FI16
Number of Residues	18
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q32ZE1

Chain	Residue	Details
D	GLU2744
E	CYS2756
E	HIS3019
E	CYS3035
F	GLU2744
F	HIS2748
F	CYS2753
F	CYS2756
F	HIS3019
F	CYS3035
D	HIS2748
D	CYS2753
D	CYS2756
D	HIS3019
D	CYS3035
E	GLU2744
E	HIS2748
E	CYS2753

---

site_id	SWS_FT_FI17
Number of Residues	3
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P14335

Chain	Residue	Details
D	CYS3154
E	CYS3154
F	CYS3154

---

site_id	SWS_FT_FI18
Number of Residues	3
Details	SITE: Cleavage; by viral protease NS3 => ECO:0000250|UniProtKB:Q32ZE1

Chain	Residue	Details
D	ARG-111
E	ARG-111
F	ARG-111

---

site_id	SWS_FT_FI19
Number of Residues	3
Details	SITE: Cleavage; by host signal peptidase => ECO:0000250|UniProtKB:Q32ZE1

Chain	Residue	Details
D	ALA-93
E	ALA-93
F	ALA-93

---

site_id	SWS_FT_FI20
Number of Residues	3
Details	SITE: Fetal microcephaly

Chain	Residue	Details
D	ASN-76
E	ASN-76
F	ASN-76

---

site_id	SWS_FT_FI21
Number of Residues	3
Details	SITE: Cleavage; by host furin => ECO:0000250|UniProtKB:Q32ZE1

Chain	Residue	Details
D	ARG0
E	ARG0
F	ARG0

---

site_id	SWS_FT_FI22
Number of Residues	9
Details	SITE: Cleavage; by host signal peptidase => ECO:0000250|UniProtKB:P06935

Chain	Residue	Details
D	SER75
D	ALA579
D	ALA2054
E	SER75
E	ALA579
E	ALA2054
F	SER75
F	ALA579
F	ALA2054

---

site_id	SWS_FT_FI23
Number of Residues	3
Details	SITE: Cleavage; by host => ECO:0000250|UniProtKB:P06935

Chain	Residue	Details
D	ALA931
E	ALA931
F	ALA931

---

site_id	SWS_FT_FI24
Number of Residues	9
Details	SITE: Cleavage; by viral protease NS3 => ECO:0000250|UniProtKB:P06935

Chain	Residue	Details
D	ARG1157
D	ARG2031
D	ARG2305
E	ARG1157
E	ARG2031
E	ARG2305
F	ARG1157
F	ARG2031
F	ARG2305

---

site_id	SWS_FT_FI25
Number of Residues	6
Details	SITE: Cleavage; by autolysis => ECO:0000250|UniProtKB:P06935

Chain	Residue	Details
D	ARG1287
D	ARG1904
E	ARG1287
E	ARG1904
F	ARG1287
F	ARG1904

---

site_id	SWS_FT_FI26
Number of Residues	6
Details	SITE: Involved in NS3 ATPase and RTPase activities => ECO:0000250|UniProtKB:P14335

Chain	Residue	Details
D	ARG1743
D	ARG1746
E	ARG1743
E	ARG1746
F	ARG1743
F	ARG1746

---

site_id	SWS_FT_FI27
Number of Residues	21
Details	SITE: mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924

Chain	Residue	Details
D	LYS2318
E	PHE2329
E	LYS2333
E	SER2455
E	ARG2518
E	SER2520
F	LYS2318
F	ASN2322
F	PHE2329
F	LYS2333
F	SER2455
D	ASN2322
F	ARG2518
F	SER2520
D	PHE2329
D	LYS2333
D	SER2455
D	ARG2518
D	SER2520
E	LYS2318
E	ASN2322

---

site_id	SWS_FT_FI28
Number of Residues	6
Details	SITE: mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924

Chain	Residue	Details
D	LEU2321
D	MET2324
E	LEU2321
E	MET2324
F	LEU2321
F	MET2324

---

site_id	SWS_FT_FI29
Number of Residues	9
Details	SITE: Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924

Chain	Residue	Details
D	LYS2366
D	LYS2487
D	GLU2523
E	LYS2366
E	LYS2487
E	GLU2523
F	LYS2366
F	LYS2487
F	GLU2523

---

site_id	SWS_FT_FI30
Number of Residues	3
Details	SITE: Essential for 2'-O-methyltransferase and N-7 methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924

Chain	Residue	Details
D	ASP2451
E	ASP2451
F	ASP2451

---

site_id	SWS_FT_FI31
Number of Residues	3
Details	MOD_RES: N6-acetyllysine; by host => ECO:0000250|UniProtKB:Q32ZE1

Chain	Residue	Details
D	LYS1676
E	LYS1676
F	LYS1676

---

site_id	SWS_FT_FI32
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P03314

Chain	Residue	Details
D	SER2361
E	SER2361
F	SER2361

---

site_id	SWS_FT_FI33
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000255

Chain	Residue	Details
D	ASN-23
E	ASN-23
F	ASN-23

---

site_id	SWS_FT_FI34
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000269|PubMed:27093288, ECO:0000269|PubMed:27338953, ECO:0000269|PubMed:27882950, ECO:0000269|PubMed:29091758

Chain	Residue	Details
D	ASN229
E	ASN229
F	ASN229

---

site_id	SWS_FT_FI35
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000250|UniProtKB:Q32ZE1

Chain	Residue	Details
D	ASN709
D	ASN786
E	ASN709
E	ASN786
F	ASN709
F	ASN786

---

site_id	SWS_FT_FI36
Number of Residues	9
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:A0A142I5B9

Chain	Residue	Details
D	LYS113
D	LYS356
E	LYS113
E	LYS356
F	LYS113
F	LYS356

---