Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8CXI

Structures of Zika Virus in Complex with Antibodies Targeting E Dimer Epitopes and Basis for Neutralization Efficacy

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0046983	molecular_function	protein dimerization activity
B	0046983	molecular_function	protein dimerization activity
C	0046983	molecular_function	protein dimerization activity
D	0000166	molecular_function	nucleotide binding
D	0001172	biological_process	RNA-templated transcription
D	0003723	molecular_function	RNA binding
D	0003724	molecular_function	RNA helicase activity
D	0003725	molecular_function	double-stranded RNA binding
D	0003968	molecular_function	RNA-directed RNA polymerase activity
D	0004252	molecular_function	serine-type endopeptidase activity
D	0004386	molecular_function	helicase activity
D	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
D	0004483	molecular_function	methyltransferase cap1 activity
D	0005198	molecular_function	structural molecule activity
D	0005524	molecular_function	ATP binding
D	0005525	molecular_function	GTP binding
D	0005576	cellular_component	extracellular region
D	0005813	cellular_component	centrosome
D	0006370	biological_process	7-methylguanosine mRNA capping
D	0006397	biological_process	mRNA processing
D	0006508	biological_process	proteolysis
D	0008168	molecular_function	methyltransferase activity
D	0008233	molecular_function	peptidase activity
D	0008236	molecular_function	serine-type peptidase activity
D	0008289	molecular_function	lipid binding
D	0016032	biological_process	viral process
D	0016070	biological_process	RNA metabolic process
D	0016740	molecular_function	transferase activity
D	0016779	molecular_function	nucleotidyltransferase activity
D	0016787	molecular_function	hydrolase activity
D	0016817	molecular_function	hydrolase activity, acting on acid anhydrides
D	0016887	molecular_function	ATP hydrolysis activity
D	0017111	molecular_function	ribonucleoside triphosphate phosphatase activity
D	0019028	cellular_component	viral capsid
D	0019031	cellular_component	viral envelope
D	0019058	biological_process	viral life cycle
D	0019062	biological_process	virion attachment to host cell
D	0030430	cellular_component	host cell cytoplasm
D	0032259	biological_process	methylation
D	0034062	molecular_function	5'-3' RNA polymerase activity
D	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
D	0039520	biological_process	symbiont-mediated activation of host autophagy
D	0039563	biological_process	symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity
D	0039564	biological_process	symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity
D	0039574	biological_process	symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity
D	0039654	biological_process	fusion of virus membrane with host endosome membrane
D	0039663	biological_process	membrane fusion involved in viral entry into host cell
D	0039694	biological_process	viral RNA genome replication
D	0042025	cellular_component	host cell nucleus
D	0044167	cellular_component	host cell endoplasmic reticulum membrane
D	0044220	cellular_component	host cell perinuclear region of cytoplasm
D	0044423	cellular_component	virion component
D	0045824	biological_process	negative regulation of innate immune response
D	0046718	biological_process	symbiont entry into host cell
D	0046872	molecular_function	metal ion binding
D	0046983	molecular_function	protein dimerization activity
D	0051536	molecular_function	iron-sulfur cluster binding
D	0051539	molecular_function	4 iron, 4 sulfur cluster binding
D	0052170	biological_process	symbiont-mediated suppression of host innate immune response
D	0055036	cellular_component	virion membrane
D	0060090	molecular_function	molecular adaptor activity
D	0075509	biological_process	endocytosis involved in viral entry into host cell
D	0075512	biological_process	clathrin-dependent endocytosis of virus by host cell
D	0106005	biological_process	RNA 5'-cap (guanine-N7)-methylation
E	0000166	molecular_function	nucleotide binding
E	0001172	biological_process	RNA-templated transcription
E	0003723	molecular_function	RNA binding
E	0003724	molecular_function	RNA helicase activity
E	0003725	molecular_function	double-stranded RNA binding
E	0003968	molecular_function	RNA-directed RNA polymerase activity
E	0004252	molecular_function	serine-type endopeptidase activity
E	0004386	molecular_function	helicase activity
E	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
E	0004483	molecular_function	methyltransferase cap1 activity
E	0005198	molecular_function	structural molecule activity
E	0005524	molecular_function	ATP binding
E	0005525	molecular_function	GTP binding
E	0005576	cellular_component	extracellular region
E	0005813	cellular_component	centrosome
E	0006370	biological_process	7-methylguanosine mRNA capping
E	0006397	biological_process	mRNA processing
E	0006508	biological_process	proteolysis
E	0008168	molecular_function	methyltransferase activity
E	0008233	molecular_function	peptidase activity
E	0008236	molecular_function	serine-type peptidase activity
E	0008289	molecular_function	lipid binding
E	0016032	biological_process	viral process
E	0016070	biological_process	RNA metabolic process
E	0016740	molecular_function	transferase activity
E	0016779	molecular_function	nucleotidyltransferase activity
E	0016787	molecular_function	hydrolase activity
E	0016817	molecular_function	hydrolase activity, acting on acid anhydrides
E	0016887	molecular_function	ATP hydrolysis activity
E	0017111	molecular_function	ribonucleoside triphosphate phosphatase activity
E	0019028	cellular_component	viral capsid
E	0019031	cellular_component	viral envelope
E	0019058	biological_process	viral life cycle
E	0019062	biological_process	virion attachment to host cell
E	0030430	cellular_component	host cell cytoplasm
E	0032259	biological_process	methylation
E	0034062	molecular_function	5'-3' RNA polymerase activity
E	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
E	0039520	biological_process	symbiont-mediated activation of host autophagy
E	0039563	biological_process	symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity
E	0039564	biological_process	symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity
E	0039574	biological_process	symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity
E	0039654	biological_process	fusion of virus membrane with host endosome membrane
E	0039663	biological_process	membrane fusion involved in viral entry into host cell
E	0039694	biological_process	viral RNA genome replication
E	0042025	cellular_component	host cell nucleus
E	0044167	cellular_component	host cell endoplasmic reticulum membrane
E	0044220	cellular_component	host cell perinuclear region of cytoplasm
E	0044423	cellular_component	virion component
E	0045824	biological_process	negative regulation of innate immune response
E	0046718	biological_process	symbiont entry into host cell
E	0046872	molecular_function	metal ion binding
E	0046983	molecular_function	protein dimerization activity
E	0051536	molecular_function	iron-sulfur cluster binding
E	0051539	molecular_function	4 iron, 4 sulfur cluster binding
E	0052170	biological_process	symbiont-mediated suppression of host innate immune response
E	0055036	cellular_component	virion membrane
E	0060090	molecular_function	molecular adaptor activity
E	0075509	biological_process	endocytosis involved in viral entry into host cell
E	0075512	biological_process	clathrin-dependent endocytosis of virus by host cell
E	0106005	biological_process	RNA 5'-cap (guanine-N7)-methylation
F	0000166	molecular_function	nucleotide binding
F	0001172	biological_process	RNA-templated transcription
F	0003723	molecular_function	RNA binding
F	0003724	molecular_function	RNA helicase activity
F	0003725	molecular_function	double-stranded RNA binding
F	0003968	molecular_function	RNA-directed RNA polymerase activity
F	0004252	molecular_function	serine-type endopeptidase activity
F	0004386	molecular_function	helicase activity
F	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
F	0004483	molecular_function	methyltransferase cap1 activity
F	0005198	molecular_function	structural molecule activity
F	0005524	molecular_function	ATP binding
F	0005525	molecular_function	GTP binding
F	0005576	cellular_component	extracellular region
F	0005813	cellular_component	centrosome
F	0006370	biological_process	7-methylguanosine mRNA capping
F	0006397	biological_process	mRNA processing
F	0006508	biological_process	proteolysis
F	0008168	molecular_function	methyltransferase activity
F	0008233	molecular_function	peptidase activity
F	0008236	molecular_function	serine-type peptidase activity
F	0008289	molecular_function	lipid binding
F	0016032	biological_process	viral process
F	0016070	biological_process	RNA metabolic process
F	0016740	molecular_function	transferase activity
F	0016779	molecular_function	nucleotidyltransferase activity
F	0016787	molecular_function	hydrolase activity
F	0016817	molecular_function	hydrolase activity, acting on acid anhydrides
F	0016887	molecular_function	ATP hydrolysis activity
F	0017111	molecular_function	ribonucleoside triphosphate phosphatase activity
F	0019028	cellular_component	viral capsid
F	0019031	cellular_component	viral envelope
F	0019058	biological_process	viral life cycle
F	0019062	biological_process	virion attachment to host cell
F	0030430	cellular_component	host cell cytoplasm
F	0032259	biological_process	methylation
F	0034062	molecular_function	5'-3' RNA polymerase activity
F	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
F	0039520	biological_process	symbiont-mediated activation of host autophagy
F	0039563	biological_process	symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity
F	0039564	biological_process	symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity
F	0039574	biological_process	symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity
F	0039654	biological_process	fusion of virus membrane with host endosome membrane
F	0039663	biological_process	membrane fusion involved in viral entry into host cell
F	0039694	biological_process	viral RNA genome replication
F	0042025	cellular_component	host cell nucleus
F	0044167	cellular_component	host cell endoplasmic reticulum membrane
F	0044220	cellular_component	host cell perinuclear region of cytoplasm
F	0044423	cellular_component	virion component
F	0045824	biological_process	negative regulation of innate immune response
F	0046718	biological_process	symbiont entry into host cell
F	0046872	molecular_function	metal ion binding
F	0046983	molecular_function	protein dimerization activity
F	0051536	molecular_function	iron-sulfur cluster binding
F	0051539	molecular_function	4 iron, 4 sulfur cluster binding
F	0052170	biological_process	symbiont-mediated suppression of host innate immune response
F	0055036	cellular_component	virion membrane
F	0060090	molecular_function	molecular adaptor activity
F	0075509	biological_process	endocytosis involved in viral entry into host cell
F	0075512	biological_process	clathrin-dependent endocytosis of virus by host cell
F	0106005	biological_process	RNA 5'-cap (guanine-N7)-methylation

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1362
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	27
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	39
Details	Region: {"description":"Fusion peptide","evidences":[{"source":"UniProtKB","id":"P14336","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; by host","evidences":[{"source":"PubMed","id":"27093288","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27338953","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27882950","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29091758","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	9
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"A0A142I5B9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details