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8CV2

Human excitatory amino acid transporter 3 (EAAT3) in an outward facing sodium-bound state

Functional Information from GO Data
ChainGOidnamespacecontents
A0001662biological_processbehavioral fear response
A0001932biological_processregulation of protein phosphorylation
A0001975biological_processresponse to amphetamine
A0002027biological_processregulation of heart rate
A0005253molecular_functionmonoatomic anion channel activity
A0005313molecular_functionL-glutamate transmembrane transporter activity
A0005314molecular_functionhigh-affinity L-glutamate transmembrane transporter activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005783cellular_componentendoplasmic reticulum
A0005886cellular_componentplasma membrane
A0006749biological_processglutathione metabolic process
A0006750biological_processglutathione biosynthetic process
A0006801biological_processsuperoxide metabolic process
A0006811biological_processmonoatomic ion transport
A0006836biological_processneurotransmitter transport
A0006865biological_processamino acid transport
A0006882biological_processintracellular zinc ion homeostasis
A0007212biological_processG protein-coupled dopamine receptor signaling pathway
A0007215biological_processglutamate receptor signaling pathway
A0007268biological_processchemical synaptic transmission
A0007420biological_processbrain development
A0007611biological_processlearning or memory
A0007613biological_processmemory
A0007625biological_processgrooming behavior
A0007626biological_processlocomotory behavior
A0009410biological_processresponse to xenobiotic stimulus
A0009986cellular_componentcell surface
A0010460biological_processpositive regulation of heart rate
A0010467biological_processgene expression
A0010842biological_processretina layer formation
A0015108molecular_functionchloride transmembrane transporter activity
A0015179molecular_functionL-amino acid transmembrane transporter activity
A0015183molecular_functionL-aspartate transmembrane transporter activity
A0015293molecular_functionsymporter activity
A0015501molecular_functionglutamate:sodium symporter activity
A0015813biological_processL-glutamate transmembrane transport
A0016020cellular_componentmembrane
A0016324cellular_componentapical plasma membrane
A0016595molecular_functionglutamate binding
A0019221biological_processcytokine-mediated signaling pathway
A0022008biological_processneurogenesis
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0030534biological_processadult behavior
A0031901cellular_componentearly endosome membrane
A0031902cellular_componentlate endosome membrane
A0031982cellular_componentvesicle
A0032279cellular_componentasymmetric synapse
A0033229molecular_functioncysteine transmembrane transporter activity
A0034599biological_processcellular response to oxidative stress
A0035633biological_processmaintenance of blood-brain barrier
A0036293biological_processresponse to decreased oxygen levels
A0042417biological_processdopamine metabolic process
A0042802molecular_functionidentical protein binding
A0042883biological_processcysteine transport
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0043083cellular_componentsynaptic cleft
A0043197cellular_componentdendritic spine
A0043198cellular_componentdendritic shaft
A0043204cellular_componentperikaryon
A0043278biological_processresponse to morphine
A0043524biological_processnegative regulation of neuron apoptotic process
A0043679cellular_componentaxon terminus
A0045121cellular_componentmembrane raft
A0045184biological_processestablishment of protein localization
A0045202cellular_componentsynapse
A0046872molecular_functionmetal ion binding
A0048514biological_processblood vessel morphogenesis
A0048678biological_processresponse to axon injury
A0050808biological_processsynapse organization
A0051402biological_processneuron apoptotic process
A0051938biological_processL-glutamate import
A0055037cellular_componentrecycling endosome
A0055038cellular_componentrecycling endosome membrane
A0060013biological_processrighting reflex
A0060041biological_processretina development in camera-type eye
A0060047biological_processheart contraction
A0060291biological_processlong-term synaptic potentiation
A0061744biological_processmotor behavior
A0070062cellular_componentextracellular exosome
A0070633biological_processtransepithelial transport
A0070777biological_processD-aspartate transmembrane transport
A0070778biological_processL-aspartate transmembrane transport
A0070779biological_processD-aspartate import across plasma membrane
A0071242biological_processcellular response to ammonium ion
A0071288biological_processcellular response to mercury ion
A0071314biological_processcellular response to cocaine
A0071407biological_processcellular response to organic cyclic compound
A0071577biological_processzinc ion transmembrane transport
A0071944cellular_componentcell periphery
A0072347biological_processresponse to anesthetic
A0090313biological_processregulation of protein targeting to membrane
A0090461biological_processintracellular glutamate homeostasis
A0097049biological_processmotor neuron apoptotic process
A0097386cellular_componentglial cell projection
A0097440cellular_componentapical dendrite
A0098685cellular_componentSchaffer collateral - CA1 synapse
A0098712biological_processL-glutamate import across plasma membrane
A0098793cellular_componentpresynapse
A0098877biological_processneurotransmitter receptor transport to plasma membrane
A0099170biological_processpostsynaptic modulation of chemical synaptic transmission
A0099544cellular_componentperisynaptic space
A0140009biological_processL-aspartate import across plasma membrane
A0140010molecular_functionD-aspartate transmembrane transporter activity
A0150002cellular_componentdistal dendrite
A0150104biological_processtransport across blood-brain barrier
A1902476biological_processchloride transmembrane transport
A1903712biological_processcysteine transmembrane transport
A1903926biological_processcellular response to bisphenol A
A1990635cellular_componentproximal dendrite
A1990708biological_processconditioned place preference
B0001662biological_processbehavioral fear response
B0001932biological_processregulation of protein phosphorylation
B0001975biological_processresponse to amphetamine
B0002027biological_processregulation of heart rate
B0005253molecular_functionmonoatomic anion channel activity
B0005313molecular_functionL-glutamate transmembrane transporter activity
B0005314molecular_functionhigh-affinity L-glutamate transmembrane transporter activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005768cellular_componentendosome
B0005783cellular_componentendoplasmic reticulum
B0005886cellular_componentplasma membrane
B0006749biological_processglutathione metabolic process
B0006750biological_processglutathione biosynthetic process
B0006801biological_processsuperoxide metabolic process
B0006811biological_processmonoatomic ion transport
B0006836biological_processneurotransmitter transport
B0006865biological_processamino acid transport
B0006882biological_processintracellular zinc ion homeostasis
B0007212biological_processG protein-coupled dopamine receptor signaling pathway
B0007215biological_processglutamate receptor signaling pathway
B0007268biological_processchemical synaptic transmission
B0007420biological_processbrain development
B0007611biological_processlearning or memory
B0007613biological_processmemory
B0007625biological_processgrooming behavior
B0007626biological_processlocomotory behavior
B0009410biological_processresponse to xenobiotic stimulus
B0009986cellular_componentcell surface
B0010460biological_processpositive regulation of heart rate
B0010467biological_processgene expression
B0010842biological_processretina layer formation
B0015108molecular_functionchloride transmembrane transporter activity
B0015179molecular_functionL-amino acid transmembrane transporter activity
B0015183molecular_functionL-aspartate transmembrane transporter activity
B0015293molecular_functionsymporter activity
B0015501molecular_functionglutamate:sodium symporter activity
B0015813biological_processL-glutamate transmembrane transport
B0016020cellular_componentmembrane
B0016324cellular_componentapical plasma membrane
B0016595molecular_functionglutamate binding
B0019221biological_processcytokine-mediated signaling pathway
B0022008biological_processneurogenesis
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0030534biological_processadult behavior
B0031901cellular_componentearly endosome membrane
B0031902cellular_componentlate endosome membrane
B0031982cellular_componentvesicle
B0032279cellular_componentasymmetric synapse
B0033229molecular_functioncysteine transmembrane transporter activity
B0034599biological_processcellular response to oxidative stress
B0035633biological_processmaintenance of blood-brain barrier
B0036293biological_processresponse to decreased oxygen levels
B0042417biological_processdopamine metabolic process
B0042802molecular_functionidentical protein binding
B0042883biological_processcysteine transport
B0043005cellular_componentneuron projection
B0043025cellular_componentneuronal cell body
B0043083cellular_componentsynaptic cleft
B0043197cellular_componentdendritic spine
B0043198cellular_componentdendritic shaft
B0043204cellular_componentperikaryon
B0043278biological_processresponse to morphine
B0043524biological_processnegative regulation of neuron apoptotic process
B0043679cellular_componentaxon terminus
B0045121cellular_componentmembrane raft
B0045184biological_processestablishment of protein localization
B0045202cellular_componentsynapse
B0046872molecular_functionmetal ion binding
B0048514biological_processblood vessel morphogenesis
B0048678biological_processresponse to axon injury
B0050808biological_processsynapse organization
B0051402biological_processneuron apoptotic process
B0051938biological_processL-glutamate import
B0055037cellular_componentrecycling endosome
B0055038cellular_componentrecycling endosome membrane
B0060013biological_processrighting reflex
B0060041biological_processretina development in camera-type eye
B0060047biological_processheart contraction
B0060291biological_processlong-term synaptic potentiation
B0061744biological_processmotor behavior
B0070062cellular_componentextracellular exosome
B0070633biological_processtransepithelial transport
B0070777biological_processD-aspartate transmembrane transport
B0070778biological_processL-aspartate transmembrane transport
B0070779biological_processD-aspartate import across plasma membrane
B0071242biological_processcellular response to ammonium ion
B0071288biological_processcellular response to mercury ion
B0071314biological_processcellular response to cocaine
B0071407biological_processcellular response to organic cyclic compound
B0071577biological_processzinc ion transmembrane transport
B0071944cellular_componentcell periphery
B0072347biological_processresponse to anesthetic
B0090313biological_processregulation of protein targeting to membrane
B0090461biological_processintracellular glutamate homeostasis
B0097049biological_processmotor neuron apoptotic process
B0097386cellular_componentglial cell projection
B0097440cellular_componentapical dendrite
B0098685cellular_componentSchaffer collateral - CA1 synapse
B0098712biological_processL-glutamate import across plasma membrane
B0098793cellular_componentpresynapse
B0098877biological_processneurotransmitter receptor transport to plasma membrane
B0099170biological_processpostsynaptic modulation of chemical synaptic transmission
B0099544cellular_componentperisynaptic space
B0140009biological_processL-aspartate import across plasma membrane
B0140010molecular_functionD-aspartate transmembrane transporter activity
B0150002cellular_componentdistal dendrite
B0150104biological_processtransport across blood-brain barrier
B1902476biological_processchloride transmembrane transport
B1903712biological_processcysteine transmembrane transport
B1903926biological_processcellular response to bisphenol A
B1990635cellular_componentproximal dendrite
B1990708biological_processconditioned place preference
C0001662biological_processbehavioral fear response
C0001932biological_processregulation of protein phosphorylation
C0001975biological_processresponse to amphetamine
C0002027biological_processregulation of heart rate
C0005253molecular_functionmonoatomic anion channel activity
C0005313molecular_functionL-glutamate transmembrane transporter activity
C0005314molecular_functionhigh-affinity L-glutamate transmembrane transporter activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005768cellular_componentendosome
C0005783cellular_componentendoplasmic reticulum
C0005886cellular_componentplasma membrane
C0006749biological_processglutathione metabolic process
C0006750biological_processglutathione biosynthetic process
C0006801biological_processsuperoxide metabolic process
C0006811biological_processmonoatomic ion transport
C0006836biological_processneurotransmitter transport
C0006865biological_processamino acid transport
C0006882biological_processintracellular zinc ion homeostasis
C0007212biological_processG protein-coupled dopamine receptor signaling pathway
C0007215biological_processglutamate receptor signaling pathway
C0007268biological_processchemical synaptic transmission
C0007420biological_processbrain development
C0007611biological_processlearning or memory
C0007613biological_processmemory
C0007625biological_processgrooming behavior
C0007626biological_processlocomotory behavior
C0009410biological_processresponse to xenobiotic stimulus
C0009986cellular_componentcell surface
C0010460biological_processpositive regulation of heart rate
C0010467biological_processgene expression
C0010842biological_processretina layer formation
C0015108molecular_functionchloride transmembrane transporter activity
C0015179molecular_functionL-amino acid transmembrane transporter activity
C0015183molecular_functionL-aspartate transmembrane transporter activity
C0015293molecular_functionsymporter activity
C0015501molecular_functionglutamate:sodium symporter activity
C0015813biological_processL-glutamate transmembrane transport
C0016020cellular_componentmembrane
C0016324cellular_componentapical plasma membrane
C0016595molecular_functionglutamate binding
C0019221biological_processcytokine-mediated signaling pathway
C0022008biological_processneurogenesis
C0030424cellular_componentaxon
C0030425cellular_componentdendrite
C0030534biological_processadult behavior
C0031901cellular_componentearly endosome membrane
C0031902cellular_componentlate endosome membrane
C0031982cellular_componentvesicle
C0032279cellular_componentasymmetric synapse
C0033229molecular_functioncysteine transmembrane transporter activity
C0034599biological_processcellular response to oxidative stress
C0035633biological_processmaintenance of blood-brain barrier
C0036293biological_processresponse to decreased oxygen levels
C0042417biological_processdopamine metabolic process
C0042802molecular_functionidentical protein binding
C0042883biological_processcysteine transport
C0043005cellular_componentneuron projection
C0043025cellular_componentneuronal cell body
C0043083cellular_componentsynaptic cleft
C0043197cellular_componentdendritic spine
C0043198cellular_componentdendritic shaft
C0043204cellular_componentperikaryon
C0043278biological_processresponse to morphine
C0043524biological_processnegative regulation of neuron apoptotic process
C0043679cellular_componentaxon terminus
C0045121cellular_componentmembrane raft
C0045184biological_processestablishment of protein localization
C0045202cellular_componentsynapse
C0046872molecular_functionmetal ion binding
C0048514biological_processblood vessel morphogenesis
C0048678biological_processresponse to axon injury
C0050808biological_processsynapse organization
C0051402biological_processneuron apoptotic process
C0051938biological_processL-glutamate import
C0055037cellular_componentrecycling endosome
C0055038cellular_componentrecycling endosome membrane
C0060013biological_processrighting reflex
C0060041biological_processretina development in camera-type eye
C0060047biological_processheart contraction
C0060291biological_processlong-term synaptic potentiation
C0061744biological_processmotor behavior
C0070062cellular_componentextracellular exosome
C0070633biological_processtransepithelial transport
C0070777biological_processD-aspartate transmembrane transport
C0070778biological_processL-aspartate transmembrane transport
C0070779biological_processD-aspartate import across plasma membrane
C0071242biological_processcellular response to ammonium ion
C0071288biological_processcellular response to mercury ion
C0071314biological_processcellular response to cocaine
C0071407biological_processcellular response to organic cyclic compound
C0071577biological_processzinc ion transmembrane transport
C0071944cellular_componentcell periphery
C0072347biological_processresponse to anesthetic
C0090313biological_processregulation of protein targeting to membrane
C0090461biological_processintracellular glutamate homeostasis
C0097049biological_processmotor neuron apoptotic process
C0097386cellular_componentglial cell projection
C0097440cellular_componentapical dendrite
C0098685cellular_componentSchaffer collateral - CA1 synapse
C0098712biological_processL-glutamate import across plasma membrane
C0098793cellular_componentpresynapse
C0098877biological_processneurotransmitter receptor transport to plasma membrane
C0099170biological_processpostsynaptic modulation of chemical synaptic transmission
C0099544cellular_componentperisynaptic space
C0140009biological_processL-aspartate import across plasma membrane
C0140010molecular_functionD-aspartate transmembrane transporter activity
C0150002cellular_componentdistal dendrite
C0150104biological_processtransport across blood-brain barrier
C1902476biological_processchloride transmembrane transport
C1903712biological_processcysteine transmembrane transport
C1903926biological_processcellular response to bisphenol A
C1990635cellular_componentproximal dendrite
C1990708biological_processconditioned place preference
Functional Information from PROSITE/UniProt
site_idPS00713
Number of Residues15
DetailsNA_DICARBOXYL_SYMP_1 Sodium:dicarboxylate symporter family signature 1. P.GEiLMrMLKLIIlP
ChainResidueDetails
APRO55-PRO69

site_idPS00714
Number of Residues24
DetailsNA_DICARBOXYL_SYMP_2 Sodium:dicarboxylate symporter family signature 2. PvGaTiNMDGTaLYeaVaaVFIAQ
ChainResidueDetails
APRO360-GLN383

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues324
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305
ChainResidueDetails
AMET1-ASN18
BVAL309-PRO313
BGLU345-ARG353
BGLU463-PHE524
CMET1-ASN18
CASP83-ARG93
CGLY230-ASP238
CVAL309-PRO313
CGLU345-ARG353
CGLU463-PHE524
AASP83-ARG93
AGLY230-ASP238
AVAL309-PRO313
AGLU345-ARG353
AGLU463-PHE524
BMET1-ASN18
BASP83-ARG93
BGLY230-ASP238

site_idSWS_FT_FI2
Number of Residues177
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
ATRP19-VAL38
AMET62-LEU82
AALA94-VAL114
BTRP19-VAL38
BMET62-LEU82
BALA94-VAL114
CTRP19-VAL38
CMET62-LEU82
CALA94-VAL114

site_idSWS_FT_FI3
Number of Residues465
DetailsTOPO_DOM: Extracellular => ECO:0000305
ChainResidueDetails
AARG39-ARG61
BLEU428-ASP440
CARG39-ARG61
CSER115-MET205
CALA267-MET286
CILE381-GLN393
CLEU428-ASP440
ASER115-MET205
AALA267-MET286
AILE381-GLN393
ALEU428-ASP440
BARG39-ARG61
BSER115-MET205
BALA267-MET286
BILE381-GLN393

site_idSWS_FT_FI4
Number of Residues69
DetailsTRANSMEM: Helical; Name=4 => ECO:0000250|UniProtKB:P43003
ChainResidueDetails
ATYR206-MET229
BTYR206-MET229
CTYR206-MET229

site_idSWS_FT_FI5
Number of Residues81
DetailsTRANSMEM: Helical; Name=5 => ECO:0000250|UniProtKB:P43003
ChainResidueDetails
APHE239-ILE266
BPHE239-ILE266
CPHE239-ILE266

site_idSWS_FT_FI6
Number of Residues63
DetailsTRANSMEM: Helical; Name=6 => ECO:0000250|UniProtKB:P43003
ChainResidueDetails
AALA287-VAL308
BALA287-VAL308
CALA287-VAL308

site_idSWS_FT_FI7
Number of Residues189
DetailsINTRAMEM: Discontinuously helical => ECO:0000250|UniProtKB:P43003
ChainResidueDetails
APHE314-ALA344
AILE394-GLY427
BPHE314-ALA344
BILE394-GLY427
CPHE314-ALA344
CILE394-GLY427

site_idSWS_FT_FI8
Number of Residues78
DetailsTRANSMEM: Helical; Name=7 => ECO:0000250|UniProtKB:P43003
ChainResidueDetails
AILE354-PHE380
BILE354-PHE380
CILE354-PHE380

site_idSWS_FT_FI9
Number of Residues63
DetailsTRANSMEM: Helical; Name=8 => ECO:0000250|UniProtKB:P43003
ChainResidueDetails
ACYS441-VAL462
BCYS441-VAL462
CCYS441-VAL462

site_idSWS_FT_FI10
Number of Residues39
DetailsBINDING: BINDING => ECO:0000269|PubMed:33658209, ECO:0007744|PDB:6X2Z
ChainResidueDetails
ATYR98
AALA408
ATHR448
AASN451
AASP455
BTYR98
BTHR101
BTHR102
BGLY362
BTHR364
BASN366
ATHR101
BASP368
BSER405
BILE406
BALA408
BTHR448
BASN451
BASP455
CTYR98
CTHR101
CTHR102
ATHR102
CGLY362
CTHR364
CASN366
CASP368
CSER405
CILE406
CALA408
CTHR448
CASN451
CASP455
AGLY362
ATHR364
AASN366
AASP368
ASER405
AILE406

site_idSWS_FT_FI11
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:33658209, ECO:0007744|PDB:6X2Z, ECO:0007744|PDB:6X3E
ChainResidueDetails
ASER331
CSER333
CTHR370
CARG447
ASER333
ATHR370
AARG447
BSER331
BSER333
BTHR370
BARG447
CSER331

site_idSWS_FT_FI12
Number of Residues3
DetailsBINDING: BINDING => ECO:0000269|PubMed:33658209, ECO:0007744|PDB:6X3E
ChainResidueDetails
AVAL411
BVAL411
CVAL411

site_idSWS_FT_FI13
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P51906
ChainResidueDetails
ASER517
ASER522
BSER517
BSER522
CSER517
CSER522

site_idSWS_FT_FI14
Number of Residues9
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN43
ATHR178
ATHR195
BASN43
BTHR178
BTHR195
CASN43
CTHR178
CTHR195

222415

PDB entries from 2024-07-10

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