8CR2

Homo sapiens Get1/Get2 heterotetramer (a3' deletion variant) in complex with a Get3 dimer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0043529	cellular_component	GET complex
A	0045048	biological_process	protein insertion into ER membrane
A	0046872	molecular_function	metal ion binding
A	0070062	cellular_component	extracellular exosome
A	0071816	biological_process	tail-anchored membrane protein insertion into ER membrane
A	0140597	molecular_function	protein carrier chaperone
B	0000166	molecular_function	nucleotide binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005654	cellular_component	nucleoplasm
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0043529	cellular_component	GET complex
B	0045048	biological_process	protein insertion into ER membrane
B	0046872	molecular_function	metal ion binding
B	0070062	cellular_component	extracellular exosome
B	0071816	biological_process	tail-anchored membrane protein insertion into ER membrane
B	0140597	molecular_function	protein carrier chaperone
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0043495	molecular_function	protein-membrane adaptor activity
C	0043529	cellular_component	GET complex
C	0045048	biological_process	protein insertion into ER membrane
C	0050821	biological_process	protein stabilization
C	0071816	biological_process	tail-anchored membrane protein insertion into ER membrane
C	0090150	biological_process	establishment of protein localization to membrane
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0043495	molecular_function	protein-membrane adaptor activity
D	0043529	cellular_component	GET complex
D	0045048	biological_process	protein insertion into ER membrane
D	0050821	biological_process	protein stabilization
D	0071816	biological_process	tail-anchored membrane protein insertion into ER membrane
D	0090150	biological_process	establishment of protein localization to membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03112","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q6IQE5","evidenceCode":"ECO:0000250"},{"source":"HAMAP-Rule","id":"MF_03112","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03112","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32910895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37963916","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SO5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8CR1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8CR2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q6IQE5","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	138
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	133
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	116
Details	Region: {"description":"Interaction with GET3/TRC40"}

Chain

Residue

Details

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site_id	SWS_FT_FI8
Number of Residues	110
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI9
Number of Residues	4
Details	Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"31417168","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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