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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8CR1

Homo sapiens Get1/Get2 heterotetramer in complex with a Get3 dimer

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0016787molecular_functionhydrolase activity
A0016887molecular_functionATP hydrolysis activity
A0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
A0032977molecular_functionmembrane insertase activity
A0043529cellular_componentGET complex
A0045048biological_processprotein insertion into ER membrane
A0046872molecular_functionmetal ion binding
A0070062cellular_componentextracellular exosome
A0071816biological_processtail-anchored membrane protein insertion into ER membrane
B0000166molecular_functionnucleotide binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0016787molecular_functionhydrolase activity
B0016887molecular_functionATP hydrolysis activity
B0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
B0032977molecular_functionmembrane insertase activity
B0043529cellular_componentGET complex
B0045048biological_processprotein insertion into ER membrane
B0046872molecular_functionmetal ion binding
B0070062cellular_componentextracellular exosome
B0071816biological_processtail-anchored membrane protein insertion into ER membrane
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0006620biological_processpost-translational protein targeting to endoplasmic reticulum membrane
C0007605biological_processsensory perception of sound
C0016020cellular_componentmembrane
C0043495molecular_functionmembrane-membrane adaptor activity
C0043529cellular_componentGET complex
C0045048biological_processprotein insertion into ER membrane
C0050808biological_processsynapse organization
C0050821biological_processprotein stabilization
C0051649biological_processestablishment of localization in cell
C0071599biological_processotic vesicle development
C0071816biological_processtail-anchored membrane protein insertion into ER membrane
C0090150biological_processestablishment of protein localization to membrane
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0006620biological_processpost-translational protein targeting to endoplasmic reticulum membrane
D0007605biological_processsensory perception of sound
D0016020cellular_componentmembrane
D0043495molecular_functionmembrane-membrane adaptor activity
D0043529cellular_componentGET complex
D0045048biological_processprotein insertion into ER membrane
D0050808biological_processsynapse organization
D0050821biological_processprotein stabilization
D0051649biological_processestablishment of localization in cell
D0071599biological_processotic vesicle development
D0071816biological_processtail-anchored membrane protein insertion into ER membrane
D0090150biological_processestablishment of protein localization to membrane
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsActive site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03112","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues16
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q6IQE5","evidenceCode":"ECO:0000250"},{"source":"HAMAP-Rule","id":"MF_03112","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03112","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32910895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37963916","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SO5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8CR1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8CR2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q6IQE5","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues192
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues138
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues54
DetailsTopological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues116
DetailsRegion: {"description":"Interaction with GET3/TRC40"}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues110
DetailsCoiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues8
DetailsTopological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"31417168","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues74
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"31417168","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

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PDB entries from 2025-07-23

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