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8CR1

Homo sapiens Get1/Get2 heterotetramer in complex with a Get3 dimer

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0015105molecular_functionarsenite transmembrane transporter activity
A0015700biological_processarsenite transport
A0016787molecular_functionhydrolase activity
A0016887molecular_functionATP hydrolysis activity
A0032977molecular_functionmembrane insertase activity
A0043529cellular_componentGET complex
A0045048biological_processprotein insertion into ER membrane
A0046872molecular_functionmetal ion binding
A0070062cellular_componentextracellular exosome
A0071816biological_processtail-anchored membrane protein insertion into ER membrane
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0015105molecular_functionarsenite transmembrane transporter activity
B0015700biological_processarsenite transport
B0016787molecular_functionhydrolase activity
B0016887molecular_functionATP hydrolysis activity
B0032977molecular_functionmembrane insertase activity
B0043529cellular_componentGET complex
B0045048biological_processprotein insertion into ER membrane
B0046872molecular_functionmetal ion binding
B0070062cellular_componentextracellular exosome
B0071816biological_processtail-anchored membrane protein insertion into ER membrane
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0016020cellular_componentmembrane
C0043495molecular_functionprotein-membrane adaptor activity
C0043529cellular_componentGET complex
C0045048biological_processprotein insertion into ER membrane
C0050821biological_processprotein stabilization
C0071816biological_processtail-anchored membrane protein insertion into ER membrane
C0090150biological_processestablishment of protein localization to membrane
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0016020cellular_componentmembrane
D0043495molecular_functionprotein-membrane adaptor activity
D0043529cellular_componentGET complex
D0045048biological_processprotein insertion into ER membrane
D0050821biological_processprotein stabilization
D0071816biological_processtail-anchored membrane protein insertion into ER membrane
D0090150biological_processestablishment of protein localization to membrane
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues226
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
CILE190-VAL207
DTRP1009-PRO1029
DILE1100-ILE1120
DVAL1149-VAL1169
CILE213-PHE231
CVAL270-LEU288
DILE190-VAL207
DILE213-PHE231
DVAL270-LEU288
CTRP1009-PRO1029
CILE1100-ILE1120
CVAL1149-VAL1169

site_idSWS_FT_FI2
Number of Residues22
DetailsTOPO_DOM: Lumenal => ECO:0000305|PubMed:31417168
ChainResidueDetails
CCYS208-SER212
BCYS292
CASP289-PRO296
DCYS208-SER212
DASP289-PRO296
ACYS292
BLYS45
BGLU251
BASN278
BCYS289

site_idSWS_FT_FI3
Number of Residues74
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:31417168
ChainResidueDetails
CPRO232-GLU269
DPRO232-GLU269

site_idSWS_FT_FI4
Number of Residues68
DetailsTOPO_DOM: Lumenal => ECO:0000255
ChainResidueDetails
CMET1001-HIS1008
CTRP1121-ARG1148
DMET1001-HIS1008
DTRP1121-ARG1148

site_idSWS_FT_FI5
Number of Residues146
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
CSER1030-LYS1099
CLEU1170-SER1174
DSER1030-LYS1099
DLEU1170-SER1174

227344

PDB entries from 2024-11-13

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