8CN0

Crystal structure of CREBBP-Y1482N histone acetyltransferase domain in complex with Coenzyme A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004402	molecular_function	histone acetyltransferase activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0008270	molecular_function	zinc ion binding

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. SlpFrqpvDpqllgipDYFdiVknpMdlstIkrkldtgq..Yqepwqyvddvwl.MfnNAwlY

Chain	Residue	Details
A	SER1108-TYR1167

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site_id	PS01357
Number of Residues	26
Details	ZF_ZZ_1 Zinc finger ZZ-type signature. CneCkhhvet..RWhCtv...CeDYdLCinC

Chain	Residue	Details
A	CYS1707-CYS1732

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	ZN_FING: ZZ-type => ECO:0000255|PROSITE-ProRule:PRU00228

Chain	Residue	Details
A	ARG1702-ASP1750

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site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q09472

Chain	Residue	Details
A	LEU1434
A	ARG1446
A	ILE1493
A	ARG1498
A	TRP1502

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site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00228

Chain	Residue	Details
A	CYS1707
A	CYS1710
A	CYS1720
A	CYS1723
A	CYS1729
A	CYS1732
A	HIS1738
A	HIS1740

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:23806337

Chain	Residue	Details
A	LYS1216
A	LYS1744

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site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine; by IKKA => ECO:0000250|UniProtKB:Q92793

Chain	Residue	Details
A	SER1382
A	SER1386

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q92793

Chain	Residue	Details
A	LYS1741

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