8CMD
Human Leukocyte Antigen class II allotype DR1 presenting SARS-CoV-2 Spike peptide S761-775
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006955 | biological_process | immune response |
| A | 0016020 | cellular_component | membrane |
| A | 0019882 | biological_process | antigen processing and presentation |
| A | 0042613 | cellular_component | MHC class II protein complex |
| B | 0006955 | biological_process | immune response |
| B | 0016020 | cellular_component | membrane |
| B | 0019882 | biological_process | antigen processing and presentation |
| B | 0042613 | cellular_component | MHC class II protein complex |
| D | 0006955 | biological_process | immune response |
| D | 0016020 | cellular_component | membrane |
| D | 0019882 | biological_process | antigen processing and presentation |
| D | 0042613 | cellular_component | MHC class II protein complex |
| E | 0006955 | biological_process | immune response |
| E | 0016020 | cellular_component | membrane |
| E | 0019882 | biological_process | antigen processing and presentation |
| E | 0042613 | cellular_component | MHC class II protein complex |
| G | 0006955 | biological_process | immune response |
| G | 0016020 | cellular_component | membrane |
| G | 0019882 | biological_process | antigen processing and presentation |
| G | 0042613 | cellular_component | MHC class II protein complex |
| H | 0006955 | biological_process | immune response |
| H | 0016020 | cellular_component | membrane |
| H | 0019882 | biological_process | antigen processing and presentation |
| H | 0042613 | cellular_component | MHC class II protein complex |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YDCRVEH |
| Chain | Residue | Details |
| A | TYR161-HIS167 | |
| B | TYR171-HIS177 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | SITE: Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4GBX |
| Chain | Residue | Details |
| A | GLN9 | |
| D | GLN9 | |
| G | GLN9 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | SITE: Self-peptide antigen => ECO:0000269|PubMed:31619516 |
| Chain | Residue | Details |
| A | GLY49 | |
| A | ALA52 | |
| D | GLY49 | |
| D | ALA52 | |
| G | GLY49 | |
| G | ALA52 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | SITE: Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:8145819 |
| Chain | Residue | Details |
| A | PHE51 | |
| D | PHE51 | |
| G | PHE51 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | SITE: Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819 |
| Chain | Residue | Details |
| A | SER53 | |
| D | SER53 | |
| G | SER53 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | SITE: Pathogen-derived peptide antigen => ECO:0000269|PubMed:23260142, ECO:0007744|PDB:4GBX |
| Chain | Residue | Details |
| A | GLU55 | |
| D | GLU55 | |
| G | GLU55 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | SITE: Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4GBX |
| Chain | Residue | Details |
| A | ASN62 | |
| D | ASN62 | |
| G | ASN62 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | SITE: Pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX |
| Chain | Residue | Details |
| A | ASN69 | |
| D | ASN69 | |
| G | ASN69 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | SITE: Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX |
| Chain | Residue | Details |
| A | ARG76 | |
| D | ARG76 | |
| G | ARG76 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400 |
| Chain | Residue | Details |
| A | ASN78 | |
| A | ASN118 | |
| D | ASN78 | |
| D | ASN118 | |
| G | ASN78 | |
| G | ASN118 |
