8CHS

Human heparan sulfate N-deacetylase-N-sulfotransferase 1 in complex with calcium, 3'-phosphoadenosine-5'-phosphosulfate and nanobody nAb13 (composite map and model).

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0000271	biological_process	polysaccharide biosynthetic process
A	0003279	biological_process	cardiac septum development
A	0005515	molecular_function	protein binding
A	0005794	cellular_component	Golgi apparatus
A	0006954	biological_process	inflammatory response
A	0007507	biological_process	heart development
A	0007585	biological_process	respiratory gaseous exchange by respiratory system
A	0008146	molecular_function	sulfotransferase activity
A	0008283	biological_process	cell population proliferation
A	0008543	biological_process	fibroblast growth factor receptor signaling pathway
A	0009887	biological_process	animal organ morphogenesis
A	0015012	biological_process	heparan sulfate proteoglycan biosynthetic process
A	0015014	biological_process	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
A	0015015	biological_process	heparan sulfate proteoglycan biosynthetic process, enzymatic modification
A	0015016	molecular_function	[heparan sulfate]-glucosamine N-sulfotransferase activity
A	0016020	cellular_component	membrane
A	0016740	molecular_function	transferase activity
A	0016787	molecular_function	hydrolase activity
A	0019213	molecular_function	deacetylase activity
A	0030203	biological_process	glycosaminoglycan metabolic process
A	0030210	biological_process	heparin biosynthetic process
A	0030900	biological_process	forebrain development
A	0030901	biological_process	midbrain development
A	0032588	cellular_component	trans-Golgi network membrane
A	0035904	biological_process	aorta development
A	0043410	biological_process	positive regulation of MAPK cascade
A	0045880	biological_process	positive regulation of smoothened signaling pathway
A	0048702	biological_process	embryonic neurocranium morphogenesis
A	0048703	biological_process	embryonic viscerocranium morphogenesis
A	0050119	molecular_function	N-acetylglucosamine deacetylase activity
A	0060976	biological_process	coronary vasculature development
A	0102140	molecular_function	heparan sulfate N-deacetylase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: For sulfotransferase activity => ECO:0000305|PubMed:9744796

Chain	Residue	Details
A	LYS614

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:10196134, ECO:0007744|PDB:1NST

Chain	Residue	Details
A	LYS614
A	SER712
A	TRP817
A	LYS833

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site_id	SWS_FT_FI3
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN231
A	ASN351
A	ASN401
A	ASN667

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