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8CHF

cryo-EM Structure of Craf:14-3-3:Mek1

Functional Information from GO Data
ChainGOidnamespacecontents
A0000165biological_processMAPK cascade
A0001678biological_processintracellular glucose homeostasis
A0001934biological_processpositive regulation of protein phosphorylation
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004709molecular_functionMAP kinase kinase kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005741cellular_componentmitochondrial outer membrane
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006468biological_processprotein phosphorylation
A0006915biological_processapoptotic process
A0007165biological_processsignal transduction
A0007190biological_processactivation of adenylate cyclase activity
A0008285biological_processnegative regulation of cell population proliferation
A0008286biological_processinsulin receptor signaling pathway
A0008625biological_processextrinsic apoptotic signaling pathway via death domain receptors
A0014044biological_processSchwann cell development
A0019899molecular_functionenzyme binding
A0030154biological_processcell differentiation
A0030878biological_processthyroid gland development
A0031143cellular_componentpseudopodium
A0031267molecular_functionsmall GTPase binding
A0031333biological_processnegative regulation of protein-containing complex assembly
A0033138biological_processpositive regulation of peptidyl-serine phosphorylation
A0035019biological_processsomatic stem cell population maintenance
A0035023biological_processregulation of Rho protein signal transduction
A0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
A0035994biological_processresponse to muscle stretch
A0036211biological_processprotein modification process
A0038133biological_processERBB2-ERBB3 signaling pathway
A0042060biological_processwound healing
A0042552biological_processmyelination
A0042802molecular_functionidentical protein binding
A0042981biological_processregulation of apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
A0043410biological_processpositive regulation of MAPK cascade
A0044342biological_processtype B pancreatic cell proliferation
A0045104biological_processintermediate filament cytoskeleton organization
A0045595biological_processregulation of cell differentiation
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046872molecular_functionmetal ion binding
A0048009biological_processinsulin-like growth factor receptor signaling pathway
A0048011biological_processneurotrophin TRK receptor signaling pathway
A0048538biological_processthymus development
A0060324biological_processface development
A0060333biological_processtype II interferon-mediated signaling pathway
A0071550biological_processdeath-inducing signaling complex assembly
A0106310molecular_functionprotein serine kinase activity
A1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
A1902531biological_processregulation of intracellular signal transduction
A2000145biological_processregulation of cell motility
B0000165biological_processMAPK cascade
B0001678biological_processintracellular glucose homeostasis
B0001934biological_processpositive regulation of protein phosphorylation
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004709molecular_functionMAP kinase kinase kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005741cellular_componentmitochondrial outer membrane
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006468biological_processprotein phosphorylation
B0006915biological_processapoptotic process
B0007165biological_processsignal transduction
B0007190biological_processactivation of adenylate cyclase activity
B0008285biological_processnegative regulation of cell population proliferation
B0008286biological_processinsulin receptor signaling pathway
B0008625biological_processextrinsic apoptotic signaling pathway via death domain receptors
B0014044biological_processSchwann cell development
B0019899molecular_functionenzyme binding
B0030154biological_processcell differentiation
B0030878biological_processthyroid gland development
B0031143cellular_componentpseudopodium
B0031267molecular_functionsmall GTPase binding
B0031333biological_processnegative regulation of protein-containing complex assembly
B0033138biological_processpositive regulation of peptidyl-serine phosphorylation
B0035019biological_processsomatic stem cell population maintenance
B0035023biological_processregulation of Rho protein signal transduction
B0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
B0035994biological_processresponse to muscle stretch
B0036211biological_processprotein modification process
B0038133biological_processERBB2-ERBB3 signaling pathway
B0042060biological_processwound healing
B0042552biological_processmyelination
B0042802molecular_functionidentical protein binding
B0042981biological_processregulation of apoptotic process
B0043066biological_processnegative regulation of apoptotic process
B0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
B0043410biological_processpositive regulation of MAPK cascade
B0044342biological_processtype B pancreatic cell proliferation
B0045104biological_processintermediate filament cytoskeleton organization
B0045595biological_processregulation of cell differentiation
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046872molecular_functionmetal ion binding
B0048009biological_processinsulin-like growth factor receptor signaling pathway
B0048011biological_processneurotrophin TRK receptor signaling pathway
B0048538biological_processthymus development
B0060324biological_processface development
B0060333biological_processtype II interferon-mediated signaling pathway
B0071550biological_processdeath-inducing signaling complex assembly
B0106310molecular_functionprotein serine kinase activity
B1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
B1902531biological_processregulation of intracellular signal transduction
B2000145biological_processregulation of cell motility
C0005737cellular_componentcytoplasm
C0007165biological_processsignal transduction
D0005737cellular_componentcytoplasm
D0007165biological_processsignal transduction
E0000165biological_processMAPK cascade
E0000187biological_processobsolete activation of MAPK activity
E0004672molecular_functionprotein kinase activity
E0004674molecular_functionprotein serine/threonine kinase activity
E0004708molecular_functionMAP kinase kinase activity
E0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
E0004713molecular_functionprotein tyrosine kinase activity
E0005078molecular_functionMAP-kinase scaffold activity
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005739cellular_componentmitochondrion
E0005769cellular_componentearly endosome
E0005770cellular_componentlate endosome
E0005783cellular_componentendoplasmic reticulum
E0005794cellular_componentGolgi apparatus
E0005813cellular_componentcentrosome
E0005816cellular_componentspindle pole body
E0005829cellular_componentcytosol
E0005856cellular_componentcytoskeleton
E0005886cellular_componentplasma membrane
E0005925cellular_componentfocal adhesion
E0006468biological_processprotein phosphorylation
E0006935biological_processchemotaxis
E0007165biological_processsignal transduction
E0007507biological_processheart development
E0008285biological_processnegative regulation of cell population proliferation
E0010628biological_processpositive regulation of gene expression
E0014044biological_processSchwann cell development
E0016020cellular_componentmembrane
E0021697biological_processcerebellar cortex formation
E0030182biological_processneuron differentiation
E0030216biological_processkeratinocyte differentiation
E0030295molecular_functionprotein kinase activator activity
E0030878biological_processthyroid gland development
E0032872biological_processregulation of stress-activated MAPK cascade
E0035987biological_processendodermal cell differentiation
E0038133biological_processERBB2-ERBB3 signaling pathway
E0042552biological_processmyelination
E0043410biological_processpositive regulation of MAPK cascade
E0043539molecular_functionprotein serine/threonine kinase activator activity
E0044342biological_processtype B pancreatic cell proliferation
E0045893biological_processpositive regulation of DNA-templated transcription
E0048009biological_processinsulin-like growth factor receptor signaling pathway
E0048538biological_processthymus development
E0048679biological_processregulation of axon regeneration
E0048870biological_processcell motility
E0050772biological_processpositive regulation of axonogenesis
E0060020biological_processBergmann glial cell differentiation
E0060324biological_processface development
E0060425biological_processlung morphogenesis
E0060440biological_processtrachea formation
E0060502biological_processepithelial cell proliferation involved in lung morphogenesis
E0060674biological_processplacenta blood vessel development
E0060711biological_processlabyrinthine layer development
E0070371biological_processERK1 and ERK2 cascade
E0070374biological_processpositive regulation of ERK1 and ERK2 cascade
E0071902biological_processpositive regulation of protein serine/threonine kinase activity
E0090170biological_processregulation of Golgi inheritance
E0090398biological_processcellular senescence
E0097110molecular_functionscaffold protein binding
E0106310molecular_functionprotein serine kinase activity
E1903226biological_processpositive regulation of endodermal cell differentiation
E2000641biological_processregulation of early endosome to late endosome transport
F0000165biological_processMAPK cascade
F0000187biological_processobsolete activation of MAPK activity
F0004672molecular_functionprotein kinase activity
F0004674molecular_functionprotein serine/threonine kinase activity
F0004708molecular_functionMAP kinase kinase activity
F0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
F0004713molecular_functionprotein tyrosine kinase activity
F0005078molecular_functionMAP-kinase scaffold activity
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005769cellular_componentearly endosome
F0005770cellular_componentlate endosome
F0005783cellular_componentendoplasmic reticulum
F0005794cellular_componentGolgi apparatus
F0005813cellular_componentcentrosome
F0005816cellular_componentspindle pole body
F0005829cellular_componentcytosol
F0005856cellular_componentcytoskeleton
F0005886cellular_componentplasma membrane
F0005925cellular_componentfocal adhesion
F0006468biological_processprotein phosphorylation
F0006935biological_processchemotaxis
F0007165biological_processsignal transduction
F0007507biological_processheart development
F0008285biological_processnegative regulation of cell population proliferation
F0010628biological_processpositive regulation of gene expression
F0014044biological_processSchwann cell development
F0016020cellular_componentmembrane
F0021697biological_processcerebellar cortex formation
F0030182biological_processneuron differentiation
F0030216biological_processkeratinocyte differentiation
F0030295molecular_functionprotein kinase activator activity
F0030878biological_processthyroid gland development
F0032872biological_processregulation of stress-activated MAPK cascade
F0035987biological_processendodermal cell differentiation
F0038133biological_processERBB2-ERBB3 signaling pathway
F0042552biological_processmyelination
F0043410biological_processpositive regulation of MAPK cascade
F0043539molecular_functionprotein serine/threonine kinase activator activity
F0044342biological_processtype B pancreatic cell proliferation
F0045893biological_processpositive regulation of DNA-templated transcription
F0048009biological_processinsulin-like growth factor receptor signaling pathway
F0048538biological_processthymus development
F0048679biological_processregulation of axon regeneration
F0048870biological_processcell motility
F0050772biological_processpositive regulation of axonogenesis
F0060020biological_processBergmann glial cell differentiation
F0060324biological_processface development
F0060425biological_processlung morphogenesis
F0060440biological_processtrachea formation
F0060502biological_processepithelial cell proliferation involved in lung morphogenesis
F0060674biological_processplacenta blood vessel development
F0060711biological_processlabyrinthine layer development
F0070371biological_processERK1 and ERK2 cascade
F0070374biological_processpositive regulation of ERK1 and ERK2 cascade
F0071902biological_processpositive regulation of protein serine/threonine kinase activity
F0090170biological_processregulation of Golgi inheritance
F0090398biological_processcellular senescence
F0097110molecular_functionscaffold protein binding
F0106310molecular_functionprotein serine kinase activity
F1903226biological_processpositive regulation of endodermal cell differentiation
F2000641biological_processregulation of early endosome to late endosome transport
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGAGNGGVVFkVshkpsglv..........MARK
ChainResidueDetails
ELEU74-LYS97
AILE355-LYS375

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKpsNILV
ChainResidueDetails
EILE186-VAL198
AILE464-LEU476

site_idPS00479
Number of Residues46
DetailsZF_DAG_PE_1 Zinc finger phorbol-ester/DAG-type signature. HnFarktflklaf.CdiCqkfLlngfr.....CqtCgykfHehCstkvptm..C
ChainResidueDetails
AHIS139-CYS184

site_idPS00796
Number of Residues11
Details1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV
ChainResidueDetails
CARG44-VAL54

site_idPS00797
Number of Residues20
Details1433_2 14-3-3 proteins signature 2. YKDSTLIMQLLRDNLTLWTS
ChainResidueDetails
CTYR217-SER236

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
ChainResidueDetails
EASP190
FASP190

site_idSWS_FT_FI2
Number of Residues10
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:15543157, ECO:0000269|PubMed:17880056, ECO:0000269|PubMed:18951019, ECO:0000269|PubMed:19019675, ECO:0000269|PubMed:19706763, ECO:0000269|PubMed:21310613
ChainResidueDetails
ELEU74
FASP208
EMET143
ESER150
ELYS192
EASP208
FLEU74
FMET143
FSER150
FLYS192

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:19161339, ECO:0007744|PDB:3EQH
ChainResidueDetails
ELYS97
BCYS152
BCYS155
BCYS165
BCYS168
BHIS173
BCYS176
BCYS184
FLYS97
ACYS155
ACYS165
ACYS168
AHIS173
ACYS176
ACYS184
BHIS139

site_idSWS_FT_FI4
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:19161339, ECO:0007744|PDB:3EQF
ChainResidueDetails
EGLU144
ESER194
FGLU144
FSER194

site_idSWS_FT_FI5
Number of Residues2
DetailsSITE: Cleavage; by anthrax lethal factor
ChainResidueDetails
EPRO8
FPRO8

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine; by BRAF and RAF1 => ECO:0000269|PubMed:10409742, ECO:0000269|PubMed:20956560, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:8131746
ChainResidueDetails
EALA218
FALA218

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphoserine; by BRAF and RAF1 => ECO:0000269|PubMed:20956560, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:8131746
ChainResidueDetails
EALA222
FALA222

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976
ChainResidueDetails
ETHR286
FTHR286

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by MAPK1 => ECO:0000250|UniProtKB:Q01986
ChainResidueDetails
ETHR292
FTHR292

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PAK => ECO:0000269|PubMed:16129686
ChainResidueDetails
ESER298
FSER298

site_idSWS_FT_FI11
Number of Residues2
DetailsMOD_RES: Phosphoserine; by MAPK1 => ECO:0000269|PubMed:21917714, ECO:0007744|PubMed:19690332
ChainResidueDetails
ASER289
BSER289

site_idSWS_FT_FI12
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER296
BSER296

site_idSWS_FT_FI13
Number of Residues2
DetailsMOD_RES: Phosphoserine; by MAPK1 => ECO:0000269|PubMed:21917714, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER301
BSER301

site_idSWS_FT_FI14
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PAK1, PAK2, PAK3 and PAK5 => ECO:0000269|PubMed:11733498, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:18465753, ECO:0000269|PubMed:21917714
ChainResidueDetails
ASER338
BSER338

site_idSWS_FT_FI15
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PAK1, PAK2 and PAK3 => ECO:0000269|PubMed:15849194
ChainResidueDetails
ASER339
BSER339

site_idSWS_FT_FI16
Number of Residues4
DetailsMOD_RES: Phosphotyrosine; by SRC => ECO:0000269|PubMed:16892053
ChainResidueDetails
ATYR340
AASP341
BTYR340
BASP341

site_idSWS_FT_FI17
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:16093354
ChainResidueDetails
ASER471
BSER471

site_idSWS_FT_FI18
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:11447113
ChainResidueDetails
ATHR491
BTHR491

site_idSWS_FT_FI19
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:11447113
ChainResidueDetails
ASER494
BSER494

site_idSWS_FT_FI20
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8349614
ChainResidueDetails
ASER499
BSER499

site_idSWS_FT_FI21
Number of Residues2
DetailsMOD_RES: Symmetric dimethylarginine; by PRMT5 => ECO:0000269|PubMed:21917714
ChainResidueDetails
AARG563
BARG563

site_idSWS_FT_FI22
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:10801873, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:21917714, ECO:0000269|PubMed:8349614
ChainResidueDetails
ASEP621
BSEP621

site_idSWS_FT_FI23
Number of Residues2
DetailsMOD_RES: Phosphoserine; by MAPK1 => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER642
BSER642

223166

PDB entries from 2024-07-31

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