Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004866 | molecular_function | endopeptidase inhibitor activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006954 | biological_process | inflammatory response |
| A | 0006956 | biological_process | complement activation |
| B | 0004866 | molecular_function | endopeptidase inhibitor activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0006954 | biological_process | inflammatory response |
| B | 0006956 | biological_process | complement activation |
| E | 0004866 | molecular_function | endopeptidase inhibitor activity |
| F | 0004866 | molecular_function | endopeptidase inhibitor activity |
Functional Information from PROSITE/UniProt
| site_id | PS00477 |
| Number of Residues | 9 |
| Details | ALPHA_2_MACROGLOBULIN Alpha-2-macroglobulin family thiolester region signature. PsGCGEQnM |
| Chain | Residue | Details |
| A | PRO1006-MET1014 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by carboxypeptidases => ECO:0000250 |
| Chain | Residue | Details |
| A | ALA745 | |
| B | ALA745 | |
| F | SER38 | |
| F | SER70 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by C3 convertase => ECO:0000250 |
| Chain | Residue | Details |
| A | ARG746 | |
| B | ARG746 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | SITE: Cleavage; by factor I => ECO:0000250 |
| Chain | Residue | Details |
| A | GLN953 | |
| A | ARG1302 | |
| A | ARG1319 | |
| B | GLN953 | |
| B | ARG1302 | |
| B | ARG1319 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Coordinates Mg2+ for interaction with Complement factor B Bb fragment => ECO:0000250|UniProtKB:P01024 |
| Chain | Residue | Details |
| A | ASN1661 | |
| B | ASN1661 | |
| Chain | Residue | Details |
| A | SER670 | |
| A | SER967 | |
| A | SER1320 | |
| A | SER1571 | |
| B | SER670 | |
| B | SER967 | |
| B | SER1320 | |
| B | SER1571 | |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN938 | |
| A | ASN1649 | |
| B | ASN938 | |
| B | ASN1649 | |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | CROSSLNK: Isoglutamyl cysteine thioester (Cys-Gln) => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS1009 | |
| A | GLN1012 | |
| B | CYS1009 | |
| B | GLN1012 | |
