8CEF

Asymmetric Dimerization in a Transcription Factor Superfamily is Promoted by Allosteric Interactions with DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0006355	biological_process	regulation of DNA-templated transcription
C	0008270	molecular_function	zinc ion binding
C	0043565	molecular_function	sequence-specific DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0006355	biological_process	regulation of DNA-templated transcription
D	0008270	molecular_function	zinc ion binding
D	0043565	molecular_function	sequence-specific DNA binding
G	0003700	molecular_function	DNA-binding transcription factor activity
G	0006355	biological_process	regulation of DNA-templated transcription
G	0008270	molecular_function	zinc ion binding
G	0043565	molecular_function	sequence-specific DNA binding
H	0003700	molecular_function	DNA-binding transcription factor activity
H	0006355	biological_process	regulation of DNA-templated transcription
H	0008270	molecular_function	zinc ion binding
H	0043565	molecular_function	sequence-specific DNA binding
J	0003700	molecular_function	DNA-binding transcription factor activity
J	0006355	biological_process	regulation of DNA-templated transcription
J	0008270	molecular_function	zinc ion binding
J	0043565	molecular_function	sequence-specific DNA binding
K	0003700	molecular_function	DNA-binding transcription factor activity
K	0006355	biological_process	regulation of DNA-templated transcription
K	0008270	molecular_function	zinc ion binding
K	0043565	molecular_function	sequence-specific DNA binding

Functional Information from PROSITE/UniProt

site_id	PS00031
Number of Residues	27
Details	NUCLEAR_REC_DBD_1 Nuclear hormones receptors DNA-binding region signature. ClvCg.Dvasgy.HYgvasCeaCkaFFkR

Chain	Residue	Details
C	CYS79-ARG105

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	450
Details	DNA_BIND: Nuclear receptor => ECO:0000255\|PROSITE-ProRule:PRU00407

site_id	SWS_FT_FI2
Number of Residues	234
Details	ZN_FING: NR C4-type => ECO:0000255\|PROSITE-ProRule:PRU00407

site_id	SWS_FT_FI3
Number of Residues	6
Details	SITE: Required for DNA-dependent dimerization => ECO:0000250

site_id	SWS_FT_FI4
Number of Residues	24
Details	MOD_RES: N6-acetyllysine; by PCAF/KAT2B => ECO:0000250\|UniProtKB:P11474