8CD0

Human heparan sulfate N-deacetylase-N-sulfotransferase 1 in complex with calcium, 3'-phosphoadenosine-5'-phosphosulfate, and nanobody nAb7 (composite map and model)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0000271	biological_process	polysaccharide biosynthetic process
A	0003279	biological_process	cardiac septum development
A	0003824	molecular_function	catalytic activity
A	0005515	molecular_function	protein binding
A	0005794	cellular_component	Golgi apparatus
A	0006954	biological_process	inflammatory response
A	0007507	biological_process	heart development
A	0007585	biological_process	respiratory gaseous exchange by respiratory system
A	0008146	molecular_function	sulfotransferase activity
A	0008283	biological_process	cell population proliferation
A	0008543	biological_process	fibroblast growth factor receptor signaling pathway
A	0009887	biological_process	animal organ morphogenesis
A	0015012	biological_process	heparan sulfate proteoglycan biosynthetic process
A	0015016	molecular_function	heparan sulfate N-sulfotransferase activity
A	0016020	cellular_component	membrane
A	0016740	molecular_function	transferase activity
A	0016787	molecular_function	hydrolase activity
A	0019213	molecular_function	deacetylase activity
A	0030203	biological_process	glycosaminoglycan metabolic process
A	0030210	biological_process	heparin proteoglycan biosynthetic process
A	0030900	biological_process	forebrain development
A	0030901	biological_process	midbrain development
A	0032588	cellular_component	trans-Golgi network membrane
A	0035904	biological_process	aorta development
A	0043410	biological_process	positive regulation of MAPK cascade
A	0045880	biological_process	positive regulation of smoothened signaling pathway
A	0048702	biological_process	embryonic neurocranium morphogenesis
A	0048703	biological_process	embryonic viscerocranium morphogenesis
A	0050119	molecular_function	N-acetylglucosamine deacetylase activity
A	0060976	biological_process	coronary vasculature development
A	0102140	molecular_function	heparan sulfate N-deacetylase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"For sulfotransferase activity","evidences":[{"source":"PubMed","id":"9744796","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10196134","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1NST","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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