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8CAU

human alpha7 nicotinic receptor in complex with the C4 nanobody and nicotine

Functional Information from GO Data
ChainGOidnamespacecontents
A0001540molecular_functionamyloid-beta binding
A0001666biological_processresponse to hypoxia
A0004888molecular_functiontransmembrane signaling receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
A0005262molecular_functioncalcium channel activity
A0005515molecular_functionprotein binding
A0005789cellular_componentendoplasmic reticulum membrane
A0005886cellular_componentplasma membrane
A0005892cellular_componentacetylcholine-gated channel complex
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0006874biological_processintracellular calcium ion homeostasis
A0007165biological_processsignal transduction
A0007249biological_processcanonical NF-kappaB signal transduction
A0007268biological_processchemical synaptic transmission
A0007271biological_processsynaptic transmission, cholinergic
A0007611biological_processlearning or memory
A0007613biological_processmemory
A0007614biological_processshort-term memory
A0008284biological_processpositive regulation of cell population proliferation
A0015464molecular_functionacetylcholine receptor activity
A0015643molecular_functiontoxic substance binding
A0016020cellular_componentmembrane
A0017081molecular_functionchloride channel regulator activity
A0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
A0023019biological_processsignal transduction involved in regulation of gene expression
A0030425cellular_componentdendrite
A0032720biological_processnegative regulation of tumor necrosis factor production
A0034220biological_processmonoatomic ion transmembrane transport
A0034703cellular_componentcation channel complex
A0035094biological_processresponse to nicotine
A0042166molecular_functionacetylcholine binding
A0042391biological_processregulation of membrane potential
A0042803molecular_functionprotein homodimerization activity
A0043005cellular_componentneuron projection
A0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
A0043410biological_processpositive regulation of MAPK cascade
A0044853cellular_componentplasma membrane raft
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0045766biological_processpositive regulation of angiogenesis
A0050808biological_processsynapse organization
A0050890biological_processcognition
A0050893biological_processsensory processing
A0051247biological_processpositive regulation of protein metabolic process
A0060079biological_processexcitatory postsynaptic potential
A0060084biological_processsynaptic transmission involved in micturition
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0070588biological_processcalcium ion transmembrane transport
A0095500biological_processacetylcholine receptor signaling pathway
A0097061biological_processdendritic spine organization
A0098794cellular_componentpostsynapse
A0098815biological_processmodulation of excitatory postsynaptic potential
A0098878cellular_componentneurotransmitter receptor complex
A0140059biological_processdendrite arborization
A1900016biological_processnegative regulation of cytokine production involved in inflammatory response
A1900273biological_processpositive regulation of long-term synaptic potentiation
A1902004biological_processpositive regulation of amyloid-beta formation
A1902430biological_processnegative regulation of amyloid-beta formation
A1902991biological_processregulation of amyloid precursor protein catabolic process
A1904645biological_processresponse to amyloid-beta
A1905144biological_processresponse to acetylcholine
A1905869biological_processnegative regulation of 3'-UTR-mediated mRNA stabilization
A1905906biological_processregulation of amyloid fibril formation
A1990806biological_processligand-gated ion channel signaling pathway
A2000463biological_processpositive regulation of excitatory postsynaptic potential
B0001540molecular_functionamyloid-beta binding
B0001666biological_processresponse to hypoxia
B0004888molecular_functiontransmembrane signaling receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
B0005262molecular_functioncalcium channel activity
B0005515molecular_functionprotein binding
B0005789cellular_componentendoplasmic reticulum membrane
B0005886cellular_componentplasma membrane
B0005892cellular_componentacetylcholine-gated channel complex
B0006811biological_processmonoatomic ion transport
B0006816biological_processcalcium ion transport
B0006874biological_processintracellular calcium ion homeostasis
B0007165biological_processsignal transduction
B0007249biological_processcanonical NF-kappaB signal transduction
B0007268biological_processchemical synaptic transmission
B0007271biological_processsynaptic transmission, cholinergic
B0007611biological_processlearning or memory
B0007613biological_processmemory
B0007614biological_processshort-term memory
B0008284biological_processpositive regulation of cell population proliferation
B0015464molecular_functionacetylcholine receptor activity
B0015643molecular_functiontoxic substance binding
B0016020cellular_componentmembrane
B0017081molecular_functionchloride channel regulator activity
B0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
B0023019biological_processsignal transduction involved in regulation of gene expression
B0030425cellular_componentdendrite
B0032720biological_processnegative regulation of tumor necrosis factor production
B0034220biological_processmonoatomic ion transmembrane transport
B0034703cellular_componentcation channel complex
B0035094biological_processresponse to nicotine
B0042166molecular_functionacetylcholine binding
B0042391biological_processregulation of membrane potential
B0042803molecular_functionprotein homodimerization activity
B0043005cellular_componentneuron projection
B0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
B0043410biological_processpositive regulation of MAPK cascade
B0044853cellular_componentplasma membrane raft
B0045202cellular_componentsynapse
B0045211cellular_componentpostsynaptic membrane
B0045766biological_processpositive regulation of angiogenesis
B0050808biological_processsynapse organization
B0050890biological_processcognition
B0050893biological_processsensory processing
B0051247biological_processpositive regulation of protein metabolic process
B0060079biological_processexcitatory postsynaptic potential
B0060084biological_processsynaptic transmission involved in micturition
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0070588biological_processcalcium ion transmembrane transport
B0095500biological_processacetylcholine receptor signaling pathway
B0097061biological_processdendritic spine organization
B0098794cellular_componentpostsynapse
B0098815biological_processmodulation of excitatory postsynaptic potential
B0098878cellular_componentneurotransmitter receptor complex
B0140059biological_processdendrite arborization
B1900016biological_processnegative regulation of cytokine production involved in inflammatory response
B1900273biological_processpositive regulation of long-term synaptic potentiation
B1902004biological_processpositive regulation of amyloid-beta formation
B1902430biological_processnegative regulation of amyloid-beta formation
B1902991biological_processregulation of amyloid precursor protein catabolic process
B1904645biological_processresponse to amyloid-beta
B1905144biological_processresponse to acetylcholine
B1905869biological_processnegative regulation of 3'-UTR-mediated mRNA stabilization
B1905906biological_processregulation of amyloid fibril formation
B1990806biological_processligand-gated ion channel signaling pathway
B2000463biological_processpositive regulation of excitatory postsynaptic potential
C0001540molecular_functionamyloid-beta binding
C0001666biological_processresponse to hypoxia
C0004888molecular_functiontransmembrane signaling receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
C0005262molecular_functioncalcium channel activity
C0005515molecular_functionprotein binding
C0005789cellular_componentendoplasmic reticulum membrane
C0005886cellular_componentplasma membrane
C0005892cellular_componentacetylcholine-gated channel complex
C0006811biological_processmonoatomic ion transport
C0006816biological_processcalcium ion transport
C0006874biological_processintracellular calcium ion homeostasis
C0007165biological_processsignal transduction
C0007249biological_processcanonical NF-kappaB signal transduction
C0007268biological_processchemical synaptic transmission
C0007271biological_processsynaptic transmission, cholinergic
C0007611biological_processlearning or memory
C0007613biological_processmemory
C0007614biological_processshort-term memory
C0008284biological_processpositive regulation of cell population proliferation
C0015464molecular_functionacetylcholine receptor activity
C0015643molecular_functiontoxic substance binding
C0016020cellular_componentmembrane
C0017081molecular_functionchloride channel regulator activity
C0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
C0023019biological_processsignal transduction involved in regulation of gene expression
C0030425cellular_componentdendrite
C0032720biological_processnegative regulation of tumor necrosis factor production
C0034220biological_processmonoatomic ion transmembrane transport
C0034703cellular_componentcation channel complex
C0035094biological_processresponse to nicotine
C0042166molecular_functionacetylcholine binding
C0042391biological_processregulation of membrane potential
C0042803molecular_functionprotein homodimerization activity
C0043005cellular_componentneuron projection
C0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
C0043410biological_processpositive regulation of MAPK cascade
C0044853cellular_componentplasma membrane raft
C0045202cellular_componentsynapse
C0045211cellular_componentpostsynaptic membrane
C0045766biological_processpositive regulation of angiogenesis
C0050808biological_processsynapse organization
C0050890biological_processcognition
C0050893biological_processsensory processing
C0051247biological_processpositive regulation of protein metabolic process
C0060079biological_processexcitatory postsynaptic potential
C0060084biological_processsynaptic transmission involved in micturition
C0070374biological_processpositive regulation of ERK1 and ERK2 cascade
C0070588biological_processcalcium ion transmembrane transport
C0095500biological_processacetylcholine receptor signaling pathway
C0097061biological_processdendritic spine organization
C0098794cellular_componentpostsynapse
C0098815biological_processmodulation of excitatory postsynaptic potential
C0098878cellular_componentneurotransmitter receptor complex
C0140059biological_processdendrite arborization
C1900016biological_processnegative regulation of cytokine production involved in inflammatory response
C1900273biological_processpositive regulation of long-term synaptic potentiation
C1902004biological_processpositive regulation of amyloid-beta formation
C1902430biological_processnegative regulation of amyloid-beta formation
C1902991biological_processregulation of amyloid precursor protein catabolic process
C1904645biological_processresponse to amyloid-beta
C1905144biological_processresponse to acetylcholine
C1905869biological_processnegative regulation of 3'-UTR-mediated mRNA stabilization
C1905906biological_processregulation of amyloid fibril formation
C1990806biological_processligand-gated ion channel signaling pathway
C2000463biological_processpositive regulation of excitatory postsynaptic potential
D0001540molecular_functionamyloid-beta binding
D0001666biological_processresponse to hypoxia
D0004888molecular_functiontransmembrane signaling receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
D0005262molecular_functioncalcium channel activity
D0005515molecular_functionprotein binding
D0005789cellular_componentendoplasmic reticulum membrane
D0005886cellular_componentplasma membrane
D0005892cellular_componentacetylcholine-gated channel complex
D0006811biological_processmonoatomic ion transport
D0006816biological_processcalcium ion transport
D0006874biological_processintracellular calcium ion homeostasis
D0007165biological_processsignal transduction
D0007249biological_processcanonical NF-kappaB signal transduction
D0007268biological_processchemical synaptic transmission
D0007271biological_processsynaptic transmission, cholinergic
D0007611biological_processlearning or memory
D0007613biological_processmemory
D0007614biological_processshort-term memory
D0008284biological_processpositive regulation of cell population proliferation
D0015464molecular_functionacetylcholine receptor activity
D0015643molecular_functiontoxic substance binding
D0016020cellular_componentmembrane
D0017081molecular_functionchloride channel regulator activity
D0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
D0023019biological_processsignal transduction involved in regulation of gene expression
D0030425cellular_componentdendrite
D0032720biological_processnegative regulation of tumor necrosis factor production
D0034220biological_processmonoatomic ion transmembrane transport
D0034703cellular_componentcation channel complex
D0035094biological_processresponse to nicotine
D0042166molecular_functionacetylcholine binding
D0042391biological_processregulation of membrane potential
D0042803molecular_functionprotein homodimerization activity
D0043005cellular_componentneuron projection
D0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
D0043410biological_processpositive regulation of MAPK cascade
D0044853cellular_componentplasma membrane raft
D0045202cellular_componentsynapse
D0045211cellular_componentpostsynaptic membrane
D0045766biological_processpositive regulation of angiogenesis
D0050808biological_processsynapse organization
D0050890biological_processcognition
D0050893biological_processsensory processing
D0051247biological_processpositive regulation of protein metabolic process
D0060079biological_processexcitatory postsynaptic potential
D0060084biological_processsynaptic transmission involved in micturition
D0070374biological_processpositive regulation of ERK1 and ERK2 cascade
D0070588biological_processcalcium ion transmembrane transport
D0095500biological_processacetylcholine receptor signaling pathway
D0097061biological_processdendritic spine organization
D0098794cellular_componentpostsynapse
D0098815biological_processmodulation of excitatory postsynaptic potential
D0098878cellular_componentneurotransmitter receptor complex
D0140059biological_processdendrite arborization
D1900016biological_processnegative regulation of cytokine production involved in inflammatory response
D1900273biological_processpositive regulation of long-term synaptic potentiation
D1902004biological_processpositive regulation of amyloid-beta formation
D1902430biological_processnegative regulation of amyloid-beta formation
D1902991biological_processregulation of amyloid precursor protein catabolic process
D1904645biological_processresponse to amyloid-beta
D1905144biological_processresponse to acetylcholine
D1905869biological_processnegative regulation of 3'-UTR-mediated mRNA stabilization
D1905906biological_processregulation of amyloid fibril formation
D1990806biological_processligand-gated ion channel signaling pathway
D2000463biological_processpositive regulation of excitatory postsynaptic potential
E0001540molecular_functionamyloid-beta binding
E0001666biological_processresponse to hypoxia
E0004888molecular_functiontransmembrane signaling receptor activity
E0005216molecular_functionmonoatomic ion channel activity
E0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
E0005262molecular_functioncalcium channel activity
E0005515molecular_functionprotein binding
E0005789cellular_componentendoplasmic reticulum membrane
E0005886cellular_componentplasma membrane
E0005892cellular_componentacetylcholine-gated channel complex
E0006811biological_processmonoatomic ion transport
E0006816biological_processcalcium ion transport
E0006874biological_processintracellular calcium ion homeostasis
E0007165biological_processsignal transduction
E0007249biological_processcanonical NF-kappaB signal transduction
E0007268biological_processchemical synaptic transmission
E0007271biological_processsynaptic transmission, cholinergic
E0007611biological_processlearning or memory
E0007613biological_processmemory
E0007614biological_processshort-term memory
E0008284biological_processpositive regulation of cell population proliferation
E0015464molecular_functionacetylcholine receptor activity
E0015643molecular_functiontoxic substance binding
E0016020cellular_componentmembrane
E0017081molecular_functionchloride channel regulator activity
E0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
E0023019biological_processsignal transduction involved in regulation of gene expression
E0030425cellular_componentdendrite
E0032720biological_processnegative regulation of tumor necrosis factor production
E0034220biological_processmonoatomic ion transmembrane transport
E0034703cellular_componentcation channel complex
E0035094biological_processresponse to nicotine
E0042166molecular_functionacetylcholine binding
E0042391biological_processregulation of membrane potential
E0042803molecular_functionprotein homodimerization activity
E0043005cellular_componentneuron projection
E0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
E0043410biological_processpositive regulation of MAPK cascade
E0044853cellular_componentplasma membrane raft
E0045202cellular_componentsynapse
E0045211cellular_componentpostsynaptic membrane
E0045766biological_processpositive regulation of angiogenesis
E0050808biological_processsynapse organization
E0050890biological_processcognition
E0050893biological_processsensory processing
E0051247biological_processpositive regulation of protein metabolic process
E0060079biological_processexcitatory postsynaptic potential
E0060084biological_processsynaptic transmission involved in micturition
E0070374biological_processpositive regulation of ERK1 and ERK2 cascade
E0070588biological_processcalcium ion transmembrane transport
E0095500biological_processacetylcholine receptor signaling pathway
E0097061biological_processdendritic spine organization
E0098794cellular_componentpostsynapse
E0098815biological_processmodulation of excitatory postsynaptic potential
E0098878cellular_componentneurotransmitter receptor complex
E0140059biological_processdendrite arborization
E1900016biological_processnegative regulation of cytokine production involved in inflammatory response
E1900273biological_processpositive regulation of long-term synaptic potentiation
E1902004biological_processpositive regulation of amyloid-beta formation
E1902430biological_processnegative regulation of amyloid-beta formation
E1902991biological_processregulation of amyloid precursor protein catabolic process
E1904645biological_processresponse to amyloid-beta
E1905144biological_processresponse to acetylcholine
E1905869biological_processnegative regulation of 3'-UTR-mediated mRNA stabilization
E1905906biological_processregulation of amyloid fibril formation
E1990806biological_processligand-gated ion channel signaling pathway
E2000463biological_processpositive regulation of excitatory postsynaptic potential
Functional Information from PROSITE/UniProt
site_idPS00236
Number of Residues15
DetailsNEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CyIdVrwFPfDvqhC
ChainResidueDetails
ACYS127-CYS141

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues425
DetailsTRANSMEM: Helical => ECO:0000269|PubMed:33735609, ECO:0007744|PDB:7KOO
ChainResidueDetails
AGLY211-LEU231
CGLY236-VAL256
CLEU269-LEU292
CVAL444-SER466
DGLY211-LEU231
DGLY236-VAL256
DLEU269-LEU292
DVAL444-SER466
EGLY211-LEU231
EGLY236-VAL256
ELEU269-LEU292
AGLY236-VAL256
EVAL444-SER466
ALEU269-LEU292
AVAL444-SER466
BGLY211-LEU231
BGLY236-VAL256
BLEU269-LEU292
BVAL444-SER466
CGLY211-LEU231

site_idSWS_FT_FI2
Number of Residues750
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AGLN293-VAL443
BGLN293-VAL443
CGLN293-VAL443
DGLN293-VAL443
EGLN293-VAL443

site_idSWS_FT_FI3
Number of Residues5
DetailsBINDING: BINDING => ECO:0000269|PubMed:33735609, ECO:0000269|PubMed:38382524, ECO:0007744|PDB:7KOX, ECO:0007744|PDB:8UT1, ECO:0007744|PDB:8UZJ, ECO:0007744|PDB:8V80, ECO:0007744|PDB:8V88, ECO:0007744|PDB:8V8A, ECO:0007744|PDB:8V8D
ChainResidueDetails
AARG19
BARG19
CARG19
DARG19
EARG19

site_idSWS_FT_FI4
Number of Residues5
DetailsBINDING: BINDING => ECO:0000269|PubMed:33735609, ECO:0000269|PubMed:38382524, ECO:0007744|PDB:7KOX, ECO:0007744|PDB:8UT1, ECO:0007744|PDB:8UZJ, ECO:0007744|PDB:8V80, ECO:0007744|PDB:8V82, ECO:0007744|PDB:8V8A, ECO:0007744|PDB:8V8D
ChainResidueDetails
AVAL21
BVAL21
CVAL21
DVAL21
EVAL21

site_idSWS_FT_FI5
Number of Residues5
DetailsBINDING: BINDING => ECO:0000269|PubMed:38382524, ECO:0007744|PDB:8UT1, ECO:0007744|PDB:8UZJ, ECO:0007744|PDB:8V80, ECO:0007744|PDB:8V82, ECO:0007744|PDB:8V88, ECO:0007744|PDB:8V8C, ECO:0007744|PDB:8V8D
ChainResidueDetails
ASER149
BSER149
CSER149
DSER149
ESER149

site_idSWS_FT_FI6
Number of Residues5
DetailsBINDING: BINDING => ECO:0000269|PubMed:38382524, ECO:0007744|PDB:8V8D
ChainResidueDetails
ATYR187
BTYR187
CTYR187
DTYR187
ETYR187

site_idSWS_FT_FI7
Number of Residues15
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN23
DASN23
DASN67
DASN110
EASN23
EASN67
EASN110
AASN67
AASN110
BASN23
BASN67
BASN110
CASN23
CASN67
CASN110

238268

PDB entries from 2025-07-02

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