8CAU

human alpha7 nicotinic receptor in complex with the C4 nanobody and nicotine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001540	molecular_function	amyloid-beta binding
A	0001666	biological_process	response to hypoxia
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0005262	molecular_function	calcium channel activity
A	0005515	molecular_function	protein binding
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005886	cellular_component	plasma membrane
A	0005892	cellular_component	acetylcholine-gated channel complex
A	0006811	biological_process	monoatomic ion transport
A	0006816	biological_process	calcium ion transport
A	0006874	biological_process	intracellular calcium ion homeostasis
A	0007165	biological_process	signal transduction
A	0007268	biological_process	chemical synaptic transmission
A	0007271	biological_process	synaptic transmission, cholinergic
A	0007611	biological_process	learning or memory
A	0007613	biological_process	memory
A	0007614	biological_process	short-term memory
A	0008284	biological_process	positive regulation of cell population proliferation
A	0015464	molecular_function	acetylcholine receptor activity
A	0015643	molecular_function	toxic substance binding
A	0016020	cellular_component	membrane
A	0017081	molecular_function	chloride channel regulator activity
A	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
A	0030425	cellular_component	dendrite
A	0032720	biological_process	negative regulation of tumor necrosis factor production
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0035094	biological_process	response to nicotine
A	0042166	molecular_function	acetylcholine binding
A	0042391	biological_process	regulation of membrane potential
A	0042803	molecular_function	protein homodimerization activity
A	0043005	cellular_component	neuron projection
A	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
A	0043410	biological_process	positive regulation of MAPK cascade
A	0044853	cellular_component	plasma membrane raft
A	0045202	cellular_component	synapse
A	0045211	cellular_component	postsynaptic membrane
A	0045766	biological_process	positive regulation of angiogenesis
A	0050808	biological_process	synapse organization
A	0050890	biological_process	cognition
A	0050893	biological_process	sensory processing
A	0051247	biological_process	positive regulation of protein metabolic process
A	0060079	biological_process	excitatory postsynaptic potential
A	0060084	biological_process	synaptic transmission involved in micturition
A	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
A	0070588	biological_process	calcium ion transmembrane transport
A	0095500	biological_process	acetylcholine receptor signaling pathway
A	0097061	biological_process	dendritic spine organization
A	0098794	cellular_component	postsynapse
A	0098815	biological_process	modulation of excitatory postsynaptic potential
A	0140059	biological_process	dendrite arborization
A	1900016	biological_process	negative regulation of cytokine production involved in inflammatory response
A	1900273	biological_process	positive regulation of long-term synaptic potentiation
A	1902004	biological_process	positive regulation of amyloid-beta formation
A	1902430	biological_process	negative regulation of amyloid-beta formation
A	1902991	biological_process	regulation of amyloid precursor protein catabolic process
A	1904645	biological_process	response to amyloid-beta
A	1905144	biological_process	response to acetylcholine
A	1905906	biological_process	regulation of amyloid fibril formation
A	2000463	biological_process	positive regulation of excitatory postsynaptic potential
B	0001540	molecular_function	amyloid-beta binding
B	0001666	biological_process	response to hypoxia
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0005262	molecular_function	calcium channel activity
B	0005515	molecular_function	protein binding
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005886	cellular_component	plasma membrane
B	0005892	cellular_component	acetylcholine-gated channel complex
B	0006811	biological_process	monoatomic ion transport
B	0006816	biological_process	calcium ion transport
B	0006874	biological_process	intracellular calcium ion homeostasis
B	0007165	biological_process	signal transduction
B	0007268	biological_process	chemical synaptic transmission
B	0007271	biological_process	synaptic transmission, cholinergic
B	0007611	biological_process	learning or memory
B	0007613	biological_process	memory
B	0007614	biological_process	short-term memory
B	0008284	biological_process	positive regulation of cell population proliferation
B	0015464	molecular_function	acetylcholine receptor activity
B	0015643	molecular_function	toxic substance binding
B	0016020	cellular_component	membrane
B	0017081	molecular_function	chloride channel regulator activity
B	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
B	0030425	cellular_component	dendrite
B	0032720	biological_process	negative regulation of tumor necrosis factor production
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0035094	biological_process	response to nicotine
B	0042166	molecular_function	acetylcholine binding
B	0042391	biological_process	regulation of membrane potential
B	0042803	molecular_function	protein homodimerization activity
B	0043005	cellular_component	neuron projection
B	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
B	0043410	biological_process	positive regulation of MAPK cascade
B	0044853	cellular_component	plasma membrane raft
B	0045202	cellular_component	synapse
B	0045211	cellular_component	postsynaptic membrane
B	0045766	biological_process	positive regulation of angiogenesis
B	0050808	biological_process	synapse organization
B	0050890	biological_process	cognition
B	0050893	biological_process	sensory processing
B	0051247	biological_process	positive regulation of protein metabolic process
B	0060079	biological_process	excitatory postsynaptic potential
B	0060084	biological_process	synaptic transmission involved in micturition
B	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
B	0070588	biological_process	calcium ion transmembrane transport
B	0095500	biological_process	acetylcholine receptor signaling pathway
B	0097061	biological_process	dendritic spine organization
B	0098794	cellular_component	postsynapse
B	0098815	biological_process	modulation of excitatory postsynaptic potential
B	0140059	biological_process	dendrite arborization
B	1900016	biological_process	negative regulation of cytokine production involved in inflammatory response
B	1900273	biological_process	positive regulation of long-term synaptic potentiation
B	1902004	biological_process	positive regulation of amyloid-beta formation
B	1902430	biological_process	negative regulation of amyloid-beta formation
B	1902991	biological_process	regulation of amyloid precursor protein catabolic process
B	1904645	biological_process	response to amyloid-beta
B	1905144	biological_process	response to acetylcholine
B	1905906	biological_process	regulation of amyloid fibril formation
B	2000463	biological_process	positive regulation of excitatory postsynaptic potential
C	0001540	molecular_function	amyloid-beta binding
C	0001666	biological_process	response to hypoxia
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0005262	molecular_function	calcium channel activity
C	0005515	molecular_function	protein binding
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005886	cellular_component	plasma membrane
C	0005892	cellular_component	acetylcholine-gated channel complex
C	0006811	biological_process	monoatomic ion transport
C	0006816	biological_process	calcium ion transport
C	0006874	biological_process	intracellular calcium ion homeostasis
C	0007165	biological_process	signal transduction
C	0007268	biological_process	chemical synaptic transmission
C	0007271	biological_process	synaptic transmission, cholinergic
C	0007611	biological_process	learning or memory
C	0007613	biological_process	memory
C	0007614	biological_process	short-term memory
C	0008284	biological_process	positive regulation of cell population proliferation
C	0015464	molecular_function	acetylcholine receptor activity
C	0015643	molecular_function	toxic substance binding
C	0016020	cellular_component	membrane
C	0017081	molecular_function	chloride channel regulator activity
C	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
C	0030425	cellular_component	dendrite
C	0032720	biological_process	negative regulation of tumor necrosis factor production
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0035094	biological_process	response to nicotine
C	0042166	molecular_function	acetylcholine binding
C	0042391	biological_process	regulation of membrane potential
C	0042803	molecular_function	protein homodimerization activity
C	0043005	cellular_component	neuron projection
C	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
C	0043410	biological_process	positive regulation of MAPK cascade
C	0044853	cellular_component	plasma membrane raft
C	0045202	cellular_component	synapse
C	0045211	cellular_component	postsynaptic membrane
C	0045766	biological_process	positive regulation of angiogenesis
C	0050808	biological_process	synapse organization
C	0050890	biological_process	cognition
C	0050893	biological_process	sensory processing
C	0051247	biological_process	positive regulation of protein metabolic process
C	0060079	biological_process	excitatory postsynaptic potential
C	0060084	biological_process	synaptic transmission involved in micturition
C	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
C	0070588	biological_process	calcium ion transmembrane transport
C	0095500	biological_process	acetylcholine receptor signaling pathway
C	0097061	biological_process	dendritic spine organization
C	0098794	cellular_component	postsynapse
C	0098815	biological_process	modulation of excitatory postsynaptic potential
C	0140059	biological_process	dendrite arborization
C	1900016	biological_process	negative regulation of cytokine production involved in inflammatory response
C	1900273	biological_process	positive regulation of long-term synaptic potentiation
C	1902004	biological_process	positive regulation of amyloid-beta formation
C	1902430	biological_process	negative regulation of amyloid-beta formation
C	1902991	biological_process	regulation of amyloid precursor protein catabolic process
C	1904645	biological_process	response to amyloid-beta
C	1905144	biological_process	response to acetylcholine
C	1905906	biological_process	regulation of amyloid fibril formation
C	2000463	biological_process	positive regulation of excitatory postsynaptic potential
D	0001540	molecular_function	amyloid-beta binding
D	0001666	biological_process	response to hypoxia
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0005262	molecular_function	calcium channel activity
D	0005515	molecular_function	protein binding
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005886	cellular_component	plasma membrane
D	0005892	cellular_component	acetylcholine-gated channel complex
D	0006811	biological_process	monoatomic ion transport
D	0006816	biological_process	calcium ion transport
D	0006874	biological_process	intracellular calcium ion homeostasis
D	0007165	biological_process	signal transduction
D	0007268	biological_process	chemical synaptic transmission
D	0007271	biological_process	synaptic transmission, cholinergic
D	0007611	biological_process	learning or memory
D	0007613	biological_process	memory
D	0007614	biological_process	short-term memory
D	0008284	biological_process	positive regulation of cell population proliferation
D	0015464	molecular_function	acetylcholine receptor activity
D	0015643	molecular_function	toxic substance binding
D	0016020	cellular_component	membrane
D	0017081	molecular_function	chloride channel regulator activity
D	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
D	0030425	cellular_component	dendrite
D	0032720	biological_process	negative regulation of tumor necrosis factor production
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0035094	biological_process	response to nicotine
D	0042166	molecular_function	acetylcholine binding
D	0042391	biological_process	regulation of membrane potential
D	0042803	molecular_function	protein homodimerization activity
D	0043005	cellular_component	neuron projection
D	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
D	0043410	biological_process	positive regulation of MAPK cascade
D	0044853	cellular_component	plasma membrane raft
D	0045202	cellular_component	synapse
D	0045211	cellular_component	postsynaptic membrane
D	0045766	biological_process	positive regulation of angiogenesis
D	0050808	biological_process	synapse organization
D	0050890	biological_process	cognition
D	0050893	biological_process	sensory processing
D	0051247	biological_process	positive regulation of protein metabolic process
D	0060079	biological_process	excitatory postsynaptic potential
D	0060084	biological_process	synaptic transmission involved in micturition
D	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
D	0070588	biological_process	calcium ion transmembrane transport
D	0095500	biological_process	acetylcholine receptor signaling pathway
D	0097061	biological_process	dendritic spine organization
D	0098794	cellular_component	postsynapse
D	0098815	biological_process	modulation of excitatory postsynaptic potential
D	0140059	biological_process	dendrite arborization
D	1900016	biological_process	negative regulation of cytokine production involved in inflammatory response
D	1900273	biological_process	positive regulation of long-term synaptic potentiation
D	1902004	biological_process	positive regulation of amyloid-beta formation
D	1902430	biological_process	negative regulation of amyloid-beta formation
D	1902991	biological_process	regulation of amyloid precursor protein catabolic process
D	1904645	biological_process	response to amyloid-beta
D	1905144	biological_process	response to acetylcholine
D	1905906	biological_process	regulation of amyloid fibril formation
D	2000463	biological_process	positive regulation of excitatory postsynaptic potential
E	0001540	molecular_function	amyloid-beta binding
E	0001666	biological_process	response to hypoxia
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0005262	molecular_function	calcium channel activity
E	0005515	molecular_function	protein binding
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005886	cellular_component	plasma membrane
E	0005892	cellular_component	acetylcholine-gated channel complex
E	0006811	biological_process	monoatomic ion transport
E	0006816	biological_process	calcium ion transport
E	0006874	biological_process	intracellular calcium ion homeostasis
E	0007165	biological_process	signal transduction
E	0007268	biological_process	chemical synaptic transmission
E	0007271	biological_process	synaptic transmission, cholinergic
E	0007611	biological_process	learning or memory
E	0007613	biological_process	memory
E	0007614	biological_process	short-term memory
E	0008284	biological_process	positive regulation of cell population proliferation
E	0015464	molecular_function	acetylcholine receptor activity
E	0015643	molecular_function	toxic substance binding
E	0016020	cellular_component	membrane
E	0017081	molecular_function	chloride channel regulator activity
E	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
E	0030425	cellular_component	dendrite
E	0032720	biological_process	negative regulation of tumor necrosis factor production
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0035094	biological_process	response to nicotine
E	0042166	molecular_function	acetylcholine binding
E	0042391	biological_process	regulation of membrane potential
E	0042803	molecular_function	protein homodimerization activity
E	0043005	cellular_component	neuron projection
E	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
E	0043410	biological_process	positive regulation of MAPK cascade
E	0044853	cellular_component	plasma membrane raft
E	0045202	cellular_component	synapse
E	0045211	cellular_component	postsynaptic membrane
E	0045766	biological_process	positive regulation of angiogenesis
E	0050808	biological_process	synapse organization
E	0050890	biological_process	cognition
E	0050893	biological_process	sensory processing
E	0051247	biological_process	positive regulation of protein metabolic process
E	0060079	biological_process	excitatory postsynaptic potential
E	0060084	biological_process	synaptic transmission involved in micturition
E	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
E	0070588	biological_process	calcium ion transmembrane transport
E	0095500	biological_process	acetylcholine receptor signaling pathway
E	0097061	biological_process	dendritic spine organization
E	0098794	cellular_component	postsynapse
E	0098815	biological_process	modulation of excitatory postsynaptic potential
E	0140059	biological_process	dendrite arborization
E	1900016	biological_process	negative regulation of cytokine production involved in inflammatory response
E	1900273	biological_process	positive regulation of long-term synaptic potentiation
E	1902004	biological_process	positive regulation of amyloid-beta formation
E	1902430	biological_process	negative regulation of amyloid-beta formation
E	1902991	biological_process	regulation of amyloid precursor protein catabolic process
E	1904645	biological_process	response to amyloid-beta
E	1905144	biological_process	response to acetylcholine
E	1905906	biological_process	regulation of amyloid fibril formation
E	2000463	biological_process	positive regulation of excitatory postsynaptic potential

Functional Information from PROSITE/UniProt

site_id	PS00236
Number of Residues	15
Details	NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CyIdVrwFPfDvqhC

Chain	Residue	Details
A	CYS127-CYS141

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33735609","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38382524","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7KOX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UT1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UZJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V80","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V8A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V8D","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33735609","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38382524","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7KOX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UT1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UZJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V80","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V8A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V8D","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38382524","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UT1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UZJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V80","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V8C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V8D","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38382524","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8V8D","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	15
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---