8CAH

Cryo-EM structure of native Otu2-bound ubiquitinated 43S pre-initiation complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000054	biological_process	ribosomal subunit export from nucleus
A	0000056	biological_process	ribosomal small subunit export from nucleus
A	0002181	biological_process	cytoplasmic translation
A	0003723	molecular_function	RNA binding
A	0003735	molecular_function	structural constituent of ribosome
A	0003906	molecular_function	DNA-(apurinic or apyrimidinic site) endonuclease activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005840	cellular_component	ribosome
A	0006412	biological_process	translation
A	0015935	cellular_component	small ribosomal subunit
A	0022626	cellular_component	cytosolic ribosome
A	0022627	cellular_component	cytosolic small ribosomal subunit
A	0030686	cellular_component	90S preribosome
A	0030688	cellular_component	preribosome, small subunit precursor
A	0070651	biological_process	nonfunctional rRNA decay
A	1990145	biological_process	maintenance of translational fidelity
A	1990904	cellular_component	ribonucleoprotein complex
B	0000028	biological_process	ribosomal small subunit assembly
B	0000054	biological_process	ribosomal subunit export from nucleus
B	0002181	biological_process	cytoplasmic translation
B	0003723	molecular_function	RNA binding
B	0003729	molecular_function	mRNA binding
B	0003735	molecular_function	structural constituent of ribosome
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005840	cellular_component	ribosome
B	0006412	biological_process	translation
B	0006450	biological_process	regulation of translational fidelity
B	0015935	cellular_component	small ribosomal subunit
B	0019843	molecular_function	rRNA binding
B	0022627	cellular_component	cytosolic small ribosomal subunit
B	0030490	biological_process	maturation of SSU-rRNA
B	0030686	cellular_component	90S preribosome
B	1990904	cellular_component	ribonucleoprotein complex
C	0000054	biological_process	ribosomal subunit export from nucleus
C	0002181	biological_process	cytoplasmic translation
C	0003723	molecular_function	RNA binding
C	0003735	molecular_function	structural constituent of ribosome
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005840	cellular_component	ribosome
C	0022627	cellular_component	cytosolic small ribosomal subunit
C	0034198	biological_process	cellular response to amino acid starvation
C	0045860	biological_process	positive regulation of protein kinase activity
C	1990904	cellular_component	ribonucleoprotein complex
D	0000028	biological_process	ribosomal small subunit assembly
D	0002181	biological_process	cytoplasmic translation
D	0003735	molecular_function	structural constituent of ribosome
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005840	cellular_component	ribosome
D	0006364	biological_process	rRNA processing
D	0006412	biological_process	translation
D	0022627	cellular_component	cytosolic small ribosomal subunit
D	0030490	biological_process	maturation of SSU-rRNA
D	0042274	biological_process	ribosomal small subunit biogenesis
D	1990145	biological_process	maintenance of translational fidelity
D	1990904	cellular_component	ribonucleoprotein complex
E	0000028	biological_process	ribosomal small subunit assembly
E	0000054	biological_process	ribosomal subunit export from nucleus
E	0002181	biological_process	cytoplasmic translation
E	0003723	molecular_function	RNA binding
E	0003735	molecular_function	structural constituent of ribosome
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005840	cellular_component	ribosome
E	0006412	biological_process	translation
E	0015935	cellular_component	small ribosomal subunit
E	0022627	cellular_component	cytosolic small ribosomal subunit
E	0042254	biological_process	ribosome biogenesis
E	1990904	cellular_component	ribonucleoprotein complex
F	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F	0003723	molecular_function	RNA binding
F	0003735	molecular_function	structural constituent of ribosome
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005840	cellular_component	ribosome
F	0006412	biological_process	translation
F	0006413	biological_process	translational initiation
F	0022627	cellular_component	cytosolic small ribosomal subunit
F	0030686	cellular_component	90S preribosome
F	1990904	cellular_component	ribonucleoprotein complex
G	0003674	molecular_function	molecular_function
G	0004843	molecular_function	cysteine-type deubiquitinase activity
G	0005737	cellular_component	cytoplasm
G	0008150	biological_process	biological_process
H	0000028	biological_process	ribosomal small subunit assembly
H	0002181	biological_process	cytoplasmic translation
H	0003735	molecular_function	structural constituent of ribosome
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005840	cellular_component	ribosome
H	0006412	biological_process	translation
H	0022627	cellular_component	cytosolic small ribosomal subunit
H	1990904	cellular_component	ribonucleoprotein complex
I	0000054	biological_process	ribosomal subunit export from nucleus
I	0000447	biological_process	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I	0002181	biological_process	cytoplasmic translation
I	0003676	molecular_function	nucleic acid binding
I	0003723	molecular_function	RNA binding
I	0003735	molecular_function	structural constituent of ribosome
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005829	cellular_component	cytosol
I	0005840	cellular_component	ribosome
I	0006412	biological_process	translation
I	0015935	cellular_component	small ribosomal subunit
I	0019843	molecular_function	rRNA binding
I	0022627	cellular_component	cytosolic small ribosomal subunit
I	1990904	cellular_component	ribonucleoprotein complex
J	0000028	biological_process	ribosomal small subunit assembly
J	0000054	biological_process	ribosomal subunit export from nucleus
J	0003723	molecular_function	RNA binding
J	0003735	molecular_function	structural constituent of ribosome
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005840	cellular_component	ribosome
J	0006412	biological_process	translation
J	0022627	cellular_component	cytosolic small ribosomal subunit
J	0042254	biological_process	ribosome biogenesis
J	0042274	biological_process	ribosomal small subunit biogenesis
J	1990904	cellular_component	ribonucleoprotein complex
K	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K	0002181	biological_process	cytoplasmic translation
K	0003723	molecular_function	RNA binding
K	0003729	molecular_function	mRNA binding
K	0003735	molecular_function	structural constituent of ribosome
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005840	cellular_component	ribosome
K	0006412	biological_process	translation
K	0015935	cellular_component	small ribosomal subunit
K	0022627	cellular_component	cytosolic small ribosomal subunit
K	1990904	cellular_component	ribonucleoprotein complex
L	0002181	biological_process	cytoplasmic translation
L	0003735	molecular_function	structural constituent of ribosome
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005840	cellular_component	ribosome
L	0022627	cellular_component	cytosolic small ribosomal subunit
L	1990904	cellular_component	ribonucleoprotein complex
M	0002181	biological_process	cytoplasmic translation
M	0003735	molecular_function	structural constituent of ribosome
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0005840	cellular_component	ribosome
M	0006412	biological_process	translation
M	0008270	molecular_function	zinc ion binding
M	0022627	cellular_component	cytosolic small ribosomal subunit
M	0046872	molecular_function	metal ion binding
M	1990904	cellular_component	ribonucleoprotein complex
N	0003735	molecular_function	structural constituent of ribosome
N	0005840	cellular_component	ribosome
N	0006412	biological_process	translation
O	0001965	molecular_function	G-protein alpha-subunit binding
O	0002181	biological_process	cytoplasmic translation
O	0005080	molecular_function	protein kinase C binding
O	0005092	molecular_function	GDP-dissociation inhibitor activity
O	0005634	cellular_component	nucleus
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0005840	cellular_component	ribosome
O	0006521	biological_process	regulation of cellular amino acid metabolic process
O	0007186	biological_process	G protein-coupled receptor signaling pathway
O	0010629	biological_process	negative regulation of gene expression
O	0017148	biological_process	negative regulation of translation
O	0022627	cellular_component	cytosolic small ribosomal subunit
O	0043022	molecular_function	ribosome binding
O	0045182	molecular_function	translation regulator activity
O	0061157	biological_process	mRNA destabilization
O	0070651	biological_process	nonfunctional rRNA decay
O	0072344	biological_process	rescue of stalled ribosome
O	1902660	biological_process	negative regulation of glucose mediated signaling pathway
O	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
O	1990145	biological_process	maintenance of translational fidelity
O	1990904	cellular_component	ribonucleoprotein complex
O	2001125	biological_process	negative regulation of translational frameshifting
P	0000028	biological_process	ribosomal small subunit assembly
P	0000054	biological_process	ribosomal subunit export from nucleus
P	0000447	biological_process	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
P	0000461	biological_process	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
P	0002181	biological_process	cytoplasmic translation
P	0003735	molecular_function	structural constituent of ribosome
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005840	cellular_component	ribosome
P	0006364	biological_process	rRNA processing
P	0006412	biological_process	translation
P	0010494	cellular_component	cytoplasmic stress granule
P	0015935	cellular_component	small ribosomal subunit
P	0022627	cellular_component	cytosolic small ribosomal subunit
P	0030686	cellular_component	90S preribosome
P	0042254	biological_process	ribosome biogenesis
P	1990904	cellular_component	ribonucleoprotein complex
Q	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Q	0002181	biological_process	cytoplasmic translation
Q	0003735	molecular_function	structural constituent of ribosome
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0005840	cellular_component	ribosome
Q	0006412	biological_process	translation
Q	0022627	cellular_component	cytosolic small ribosomal subunit
Q	0030686	cellular_component	90S preribosome
Q	1990904	cellular_component	ribonucleoprotein complex
R	0000054	biological_process	ribosomal subunit export from nucleus
R	0002181	biological_process	cytoplasmic translation
R	0003723	molecular_function	RNA binding
R	0003735	molecular_function	structural constituent of ribosome
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005730	cellular_component	nucleolus
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0005840	cellular_component	ribosome
R	0006364	biological_process	rRNA processing
R	0006412	biological_process	translation
R	0015935	cellular_component	small ribosomal subunit
R	0022627	cellular_component	cytosolic small ribosomal subunit
R	0032040	cellular_component	small-subunit processome
R	0042254	biological_process	ribosome biogenesis
R	0045903	biological_process	positive regulation of translational fidelity
R	0070181	molecular_function	small ribosomal subunit rRNA binding
R	1990904	cellular_component	ribonucleoprotein complex
S	0002181	biological_process	cytoplasmic translation
S	0003723	molecular_function	RNA binding
S	0003735	molecular_function	structural constituent of ribosome
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0005840	cellular_component	ribosome
S	0006412	biological_process	translation
S	0019843	molecular_function	rRNA binding
S	0022627	cellular_component	cytosolic small ribosomal subunit
S	0030686	cellular_component	90S preribosome
S	0043232	cellular_component	intracellular non-membrane-bounded organelle
S	1990904	cellular_component	ribonucleoprotein complex
T	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
T	0003735	molecular_function	structural constituent of ribosome
T	0005634	cellular_component	nucleus
T	0005730	cellular_component	nucleolus
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0005840	cellular_component	ribosome
T	0006364	biological_process	rRNA processing
T	0006412	biological_process	translation
T	0022627	cellular_component	cytosolic small ribosomal subunit
T	0032040	cellular_component	small-subunit processome
T	0042254	biological_process	ribosome biogenesis
T	1990904	cellular_component	ribonucleoprotein complex
U	0002181	biological_process	cytoplasmic translation
U	0003735	molecular_function	structural constituent of ribosome
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005730	cellular_component	nucleolus
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0005840	cellular_component	ribosome
U	0006364	biological_process	rRNA processing
U	0006412	biological_process	translation
U	0022627	cellular_component	cytosolic small ribosomal subunit
U	0030686	cellular_component	90S preribosome
U	0032040	cellular_component	small-subunit processome
U	0042254	biological_process	ribosome biogenesis
U	0042274	biological_process	ribosomal small subunit biogenesis
U	1990904	cellular_component	ribonucleoprotein complex
V	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
V	0003735	molecular_function	structural constituent of ribosome
V	0005737	cellular_component	cytoplasm
V	0005829	cellular_component	cytosol
V	0005840	cellular_component	ribosome
V	0006412	biological_process	translation
V	0022627	cellular_component	cytosolic small ribosomal subunit
V	0030686	cellular_component	90S preribosome
V	1990904	cellular_component	ribonucleoprotein complex
W	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
W	0003723	molecular_function	RNA binding
W	0003735	molecular_function	structural constituent of ribosome
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005730	cellular_component	nucleolus
W	0005737	cellular_component	cytoplasm
W	0005829	cellular_component	cytosol
W	0005840	cellular_component	ribosome
W	0006364	biological_process	rRNA processing
W	0006412	biological_process	translation
W	0015935	cellular_component	small ribosomal subunit
W	0019843	molecular_function	rRNA binding
W	0022627	cellular_component	cytosolic small ribosomal subunit
W	0030686	cellular_component	90S preribosome
W	0032040	cellular_component	small-subunit processome
W	0042254	biological_process	ribosome biogenesis
W	0042274	biological_process	ribosomal small subunit biogenesis
W	0043232	cellular_component	intracellular non-membrane-bounded organelle
W	1990904	cellular_component	ribonucleoprotein complex
X	0000028	biological_process	ribosomal small subunit assembly
X	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
X	0003735	molecular_function	structural constituent of ribosome
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0005840	cellular_component	ribosome
X	0006412	biological_process	translation
X	0019843	molecular_function	rRNA binding
X	0022627	cellular_component	cytosolic small ribosomal subunit
X	0030686	cellular_component	90S preribosome
X	1990904	cellular_component	ribonucleoprotein complex
Y	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Y	0002181	biological_process	cytoplasmic translation
Y	0003735	molecular_function	structural constituent of ribosome
Y	0005730	cellular_component	nucleolus
Y	0005737	cellular_component	cytoplasm
Y	0005829	cellular_component	cytosol
Y	0005840	cellular_component	ribosome
Y	0006412	biological_process	translation
Y	0022627	cellular_component	cytosolic small ribosomal subunit
Y	0030686	cellular_component	90S preribosome
Y	0070181	molecular_function	small ribosomal subunit rRNA binding
Y	1990904	cellular_component	ribonucleoprotein complex
Z	0000028	biological_process	ribosomal small subunit assembly
Z	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Z	0002181	biological_process	cytoplasmic translation
Z	0003729	molecular_function	mRNA binding
Z	0003735	molecular_function	structural constituent of ribosome
Z	0005634	cellular_component	nucleus
Z	0005654	cellular_component	nucleoplasm
Z	0005730	cellular_component	nucleolus
Z	0005737	cellular_component	cytoplasm
Z	0005829	cellular_component	cytosol
Z	0005840	cellular_component	ribosome
Z	0006364	biological_process	rRNA processing
Z	0006412	biological_process	translation
Z	0022627	cellular_component	cytosolic small ribosomal subunit
Z	0030686	cellular_component	90S preribosome
Z	0032040	cellular_component	small-subunit processome
Z	0042254	biological_process	ribosome biogenesis
Z	1990904	cellular_component	ribonucleoprotein complex
a	0000447	biological_process	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
a	0000461	biological_process	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
a	0003735	molecular_function	structural constituent of ribosome
a	0005737	cellular_component	cytoplasm
a	0005829	cellular_component	cytosol
a	0005840	cellular_component	ribosome
a	0006364	biological_process	rRNA processing
a	0006412	biological_process	translation
a	0022627	cellular_component	cytosolic small ribosomal subunit
a	1990904	cellular_component	ribonucleoprotein complex
b	0002181	biological_process	cytoplasmic translation
b	0003735	molecular_function	structural constituent of ribosome
b	0005737	cellular_component	cytoplasm
b	0005829	cellular_component	cytosol
b	0005840	cellular_component	ribosome
b	0006412	biological_process	translation
b	0022627	cellular_component	cytosolic small ribosomal subunit
b	1990904	cellular_component	ribonucleoprotein complex
c	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
c	0003735	molecular_function	structural constituent of ribosome
c	0005737	cellular_component	cytoplasm
c	0005829	cellular_component	cytosol
c	0005840	cellular_component	ribosome
c	0006412	biological_process	translation
c	0006450	biological_process	regulation of translational fidelity
c	0015935	cellular_component	small ribosomal subunit
c	0022627	cellular_component	cytosolic small ribosomal subunit
c	1990145	biological_process	maintenance of translational fidelity
c	1990904	cellular_component	ribonucleoprotein complex
d	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
d	0002181	biological_process	cytoplasmic translation
d	0003735	molecular_function	structural constituent of ribosome
d	0005737	cellular_component	cytoplasm
d	0005739	cellular_component	mitochondrion
d	0005829	cellular_component	cytosol
d	0005840	cellular_component	ribosome
d	0006412	biological_process	translation
d	0022627	cellular_component	cytosolic small ribosomal subunit
d	1990904	cellular_component	ribonucleoprotein complex
e	0000054	biological_process	ribosomal subunit export from nucleus
e	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
e	0002181	biological_process	cytoplasmic translation
e	0003729	molecular_function	mRNA binding
e	0003735	molecular_function	structural constituent of ribosome
e	0005515	molecular_function	protein binding
e	0005737	cellular_component	cytoplasm
e	0005829	cellular_component	cytosol
e	0005840	cellular_component	ribosome
e	0006412	biological_process	translation
e	0008270	molecular_function	zinc ion binding
e	0022627	cellular_component	cytosolic small ribosomal subunit
e	0030686	cellular_component	90S preribosome
e	0042255	biological_process	ribosome assembly
e	1990904	cellular_component	ribonucleoprotein complex
f	0000028	biological_process	ribosomal small subunit assembly
f	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
f	0003723	molecular_function	RNA binding
f	0003735	molecular_function	structural constituent of ribosome
f	0005737	cellular_component	cytoplasm
f	0005829	cellular_component	cytosol
f	0005840	cellular_component	ribosome
f	0006412	biological_process	translation
f	0008270	molecular_function	zinc ion binding
f	0022627	cellular_component	cytosolic small ribosomal subunit
f	0044391	cellular_component	ribosomal subunit
f	0046872	molecular_function	metal ion binding
f	1990904	cellular_component	ribonucleoprotein complex
g	0002181	biological_process	cytoplasmic translation
g	0003735	molecular_function	structural constituent of ribosome
g	0005737	cellular_component	cytoplasm
g	0005829	cellular_component	cytosol
g	0005840	cellular_component	ribosome
g	0006412	biological_process	translation
g	0010494	cellular_component	cytoplasmic stress granule
g	0022627	cellular_component	cytosolic small ribosomal subunit
g	1990904	cellular_component	ribonucleoprotein complex
h	0000028	biological_process	ribosomal small subunit assembly
h	0000054	biological_process	ribosomal subunit export from nucleus
h	0003735	molecular_function	structural constituent of ribosome
h	0005737	cellular_component	cytoplasm
h	0005829	cellular_component	cytosol
h	0005840	cellular_component	ribosome
h	0006412	biological_process	translation
h	0022627	cellular_component	cytosolic small ribosomal subunit
h	0030490	biological_process	maturation of SSU-rRNA
h	1900153	biological_process	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
h	1990904	cellular_component	ribonucleoprotein complex
i	0001677	biological_process	formation of translation initiation ternary complex
i	0001731	biological_process	formation of translation preinitiation complex
i	0001732	biological_process	formation of cytoplasmic translation initiation complex
i	0002188	biological_process	translation reinitiation
i	0003723	molecular_function	RNA binding
i	0003725	molecular_function	double-stranded RNA binding
i	0003743	molecular_function	translation initiation factor activity
i	0005515	molecular_function	protein binding
i	0005737	cellular_component	cytoplasm
i	0006412	biological_process	translation
i	0006413	biological_process	translational initiation
i	0010494	cellular_component	cytoplasmic stress granule
i	0016282	cellular_component	eukaryotic 43S preinitiation complex
i	0019901	molecular_function	protein kinase binding
i	0031369	molecular_function	translation initiation factor binding
i	0033290	cellular_component	eukaryotic 48S preinitiation complex
i	0043024	molecular_function	ribosomal small subunit binding
l	0001732	biological_process	formation of cytoplasmic translation initiation complex
l	0002183	biological_process	cytoplasmic translational initiation
l	0002188	biological_process	translation reinitiation
l	0003723	molecular_function	RNA binding
l	0003743	molecular_function	translation initiation factor activity
l	0005515	molecular_function	protein binding
l	0005737	cellular_component	cytoplasm
l	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
l	0006412	biological_process	translation
l	0006413	biological_process	translational initiation
l	0010494	cellular_component	cytoplasmic stress granule
l	0016282	cellular_component	eukaryotic 43S preinitiation complex
l	0033290	cellular_component	eukaryotic 48S preinitiation complex
l	0043614	cellular_component	multi-eIF complex
l	0071541	cellular_component	eukaryotic translation initiation factor 3 complex, eIF3m
m	0001731	biological_process	formation of translation preinitiation complex
m	0003723	molecular_function	RNA binding
m	0003743	molecular_function	translation initiation factor activity
m	0005515	molecular_function	protein binding
m	0006412	biological_process	translation
m	0006413	biological_process	translational initiation
m	0006417	biological_process	regulation of translation
m	0006450	biological_process	regulation of translational fidelity
m	0016282	cellular_component	eukaryotic 43S preinitiation complex
m	0031369	molecular_function	translation initiation factor binding
m	0043024	molecular_function	ribosomal small subunit binding
m	0043614	cellular_component	multi-eIF complex
m	1990145	biological_process	maintenance of translational fidelity
n	0002181	biological_process	cytoplasmic translation
n	0003735	molecular_function	structural constituent of ribosome
n	0005737	cellular_component	cytoplasm
n	0005829	cellular_component	cytosol
n	0005840	cellular_component	ribosome
n	0006412	biological_process	translation
n	0022625	cellular_component	cytosolic large ribosomal subunit
n	1990904	cellular_component	ribonucleoprotein complex
o	0000131	cellular_component	incipient cellular bud site
o	0001732	biological_process	formation of cytoplasmic translation initiation complex
o	0002183	biological_process	cytoplasmic translational initiation
o	0002188	biological_process	translation reinitiation
o	0003723	molecular_function	RNA binding
o	0003729	molecular_function	mRNA binding
o	0003743	molecular_function	translation initiation factor activity
o	0005515	molecular_function	protein binding
o	0005737	cellular_component	cytoplasm
o	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
o	0006412	biological_process	translation
o	0006413	biological_process	translational initiation
o	0010494	cellular_component	cytoplasmic stress granule
o	0016282	cellular_component	eukaryotic 43S preinitiation complex
o	0033290	cellular_component	eukaryotic 48S preinitiation complex
o	0043614	cellular_component	multi-eIF complex
o	0071540	cellular_component	eukaryotic translation initiation factor 3 complex, eIF3e
o	0071541	cellular_component	eukaryotic translation initiation factor 3 complex, eIF3m
p	0001732	biological_process	formation of cytoplasmic translation initiation complex
p	0002183	biological_process	cytoplasmic translational initiation
p	0003676	molecular_function	nucleic acid binding
p	0003723	molecular_function	RNA binding
p	0003743	molecular_function	translation initiation factor activity
p	0005515	molecular_function	protein binding
p	0005737	cellular_component	cytoplasm
p	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
p	0006412	biological_process	translation
p	0006413	biological_process	translational initiation
p	0010494	cellular_component	cytoplasmic stress granule
p	0016282	cellular_component	eukaryotic 43S preinitiation complex
p	0031369	molecular_function	translation initiation factor binding
p	0033290	cellular_component	eukaryotic 48S preinitiation complex
p	0042802	molecular_function	identical protein binding
p	0043614	cellular_component	multi-eIF complex
q	0001732	biological_process	formation of cytoplasmic translation initiation complex
q	0002183	biological_process	cytoplasmic translational initiation
q	0003723	molecular_function	RNA binding
q	0003729	molecular_function	mRNA binding
q	0003743	molecular_function	translation initiation factor activity
q	0005515	molecular_function	protein binding
q	0005737	cellular_component	cytoplasm
q	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
q	0006412	biological_process	translation
q	0006413	biological_process	translational initiation
q	0010494	cellular_component	cytoplasmic stress granule
q	0016282	cellular_component	eukaryotic 43S preinitiation complex
q	0031369	molecular_function	translation initiation factor binding
q	0033290	cellular_component	eukaryotic 48S preinitiation complex
q	0043614	cellular_component	multi-eIF complex
r	0001732	biological_process	formation of cytoplasmic translation initiation complex
r	0002183	biological_process	cytoplasmic translational initiation
r	0002188	biological_process	translation reinitiation
r	0003676	molecular_function	nucleic acid binding
r	0003723	molecular_function	RNA binding
r	0003743	molecular_function	translation initiation factor activity
r	0005515	molecular_function	protein binding
r	0005737	cellular_component	cytoplasm
r	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
r	0006412	biological_process	translation
r	0006413	biological_process	translational initiation
r	0006415	biological_process	translational termination
r	0008270	molecular_function	zinc ion binding
r	0010494	cellular_component	cytoplasmic stress granule
r	0016282	cellular_component	eukaryotic 43S preinitiation complex
r	0033290	cellular_component	eukaryotic 48S preinitiation complex
r	0043614	cellular_component	multi-eIF complex
x	0000054	biological_process	ribosomal subunit export from nucleus
x	0003743	molecular_function	translation initiation factor activity
x	0005506	molecular_function	iron ion binding
x	0005515	molecular_function	protein binding
x	0005524	molecular_function	ATP binding
x	0005634	cellular_component	nucleus
x	0005737	cellular_component	cytoplasm
x	0005829	cellular_component	cytosol
x	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
x	0006364	biological_process	rRNA processing
x	0006412	biological_process	translation
x	0006413	biological_process	translational initiation
x	0006415	biological_process	translational termination
x	0016887	molecular_function	ATP hydrolysis activity
x	0032790	biological_process	ribosome disassembly
x	0042254	biological_process	ribosome biogenesis
x	0042273	biological_process	ribosomal large subunit biogenesis
x	0043024	molecular_function	ribosomal small subunit binding
x	0045727	biological_process	positive regulation of translation
y	0000184	biological_process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
y	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
y	0001732	biological_process	formation of cytoplasmic translation initiation complex
y	0002181	biological_process	cytoplasmic translation
y	0002183	biological_process	cytoplasmic translational initiation
y	0003743	molecular_function	translation initiation factor activity
y	0005515	molecular_function	protein binding
y	0005737	cellular_component	cytoplasm
y	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
y	0006412	biological_process	translation
y	0006413	biological_process	translational initiation
y	0010494	cellular_component	cytoplasmic stress granule
y	0016282	cellular_component	eukaryotic 43S preinitiation complex
y	0033290	cellular_component	eukaryotic 48S preinitiation complex
z	0000184	biological_process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
z	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
z	0001732	biological_process	formation of cytoplasmic translation initiation complex
z	0002181	biological_process	cytoplasmic translation
z	0002183	biological_process	cytoplasmic translational initiation
z	0003743	molecular_function	translation initiation factor activity
z	0005515	molecular_function	protein binding
z	0005737	cellular_component	cytoplasm
z	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
z	0006412	biological_process	translation
z	0006413	biological_process	translational initiation
z	0010494	cellular_component	cytoplasmic stress granule
z	0016282	cellular_component	eukaryotic 43S preinitiation complex
z	0033290	cellular_component	eukaryotic 48S preinitiation complex

Functional Information from PROSITE/UniProt

site_id	PS00052
Number of Residues	27
Details	RIBOSOMAL_S7 Ribosomal protein S7 signature. ErLtnsLMmngrnnGKKlkavrIIkhT

Chain	Residue	Details
B	GLU91-THR117

---

site_id	PS00053
Number of Residues	18
Details	RIBOSOMAL_S8 Ribosomal protein S8 signature. GyvILTTSaGIMdheeAR

Chain	Residue	Details
b	GLY100-ARG117

---

site_id	PS00054
Number of Residues	23
Details	RIBOSOMAL_S11 Ribosomal protein S11 signature. LrALarS.GLrIgrieDvTPvPSD

Chain	Residue	Details
Z	LEU102-ASP124

---

site_id	PS00055
Number of Residues	8
Details	RIBOSOMAL_S12 Ribosomal protein S12 signature. KqPNSAiR

Chain	Residue	Details
c	LYS62-ARG69

---

site_id	PS00056
Number of Residues	13
Details	RIBOSOMAL_S17 Ribosomal protein S17 signature. GDiVtVgQcRPIS

Chain	Residue	Details
X	GLY120-SER132

---

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiGCGiCVkKCP

Chain	Residue	Details
x	CYS55-PRO66

---

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGELQRVAIVLAL

Chain	Residue	Details
x	LEU468-LEU482

---

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
k	LYS27-ASP52

---

site_id	PS00323
Number of Residues	25
Details	RIBOSOMAL_S19 Ribosomal protein S19 signature. NGKafnqveIrpemLGhyLGEFsiT

Chain	Residue	Details
E	ASN98-THR122

---

site_id	PS00360
Number of Residues	19
Details	RIBOSOMAL_S9 Ribosomal protein S9 signature. GGGhvSQvyAirqAiAKGL

Chain	Residue	Details
F	GLY71-LEU89

---

site_id	PS00361
Number of Residues	16
Details	RIBOSOMAL_S10 Ribosomal protein S10 signature. AeqhNLvkkGPVrLPT

Chain	Residue	Details
K	ALA45-THR60

---

site_id	PS00362
Number of Residues	31
Details	RIBOSOMAL_S15 Ribosomal protein S15 signature. VrkHLernRkDkdAkfrLilIesrihrLarY

Chain	Residue	Details
Y	VAL98-TYR128

---

site_id	PS00527
Number of Residues	23
Details	RIBOSOMAL_S14 Ribosomal protein S14 signature. RvCsshtglirkyg.LNICRqCFR

Chain	Residue	Details
M	ARG22-ARG44

---

site_id	PS00528
Number of Residues	15
Details	RIBOSOMAL_S4E Ribosomal protein S4e signature. HlKRLAaPhhWlLdK

Chain	Residue	Details
S	HIS8-LYS22

---

site_id	PS00529
Number of Residues	23
Details	RIBOSOMAL_S24E Ribosomal protein S24e signature. FGggKSvGFGlVYNSvaeakkfE

Chain	Residue	Details
d	PHE64-GLU86

---

site_id	PS00548
Number of Residues	37
Details	RIBOSOMAL_S3 Ribosomal protein S3 signature. AKamkfadGfLihSgqpVndfIDtatrhvlMrqGvlG

Chain	Residue	Details
A	ALA147-GLY183

---

site_id	PS00578
Number of Residues	12
Details	RIBOSOMAL_S6E Ribosomal protein S6e signature. ISGGnDkqGfPM

Chain	Residue	Details
T	ILE52-MET63

---

site_id	PS00585
Number of Residues	33
Details	RIBOSOMAL_S5 Ribosomal protein S5 signature. GQrtrFkAvvVVGDsn.GhVGlGiktak.EVag.AI

Chain	Residue	Details
R	GLY93-ILE125

---

site_id	PS00628
Number of Residues	20
Details	RIBOSOMAL_S19E Ribosomal protein S19e signature. PykhidaSgsInRkVLQaLE

Chain	Residue	Details
J	PRO90-GLU109

---

site_id	PS00632
Number of Residues	25
Details	RIBOSOMAL_S4 Ribosomal protein S4 signature. LErRLqtqVYKlglAkSvhhARvLI

Chain	Residue	Details
W	LEU105-ILE129

---

site_id	PS00646
Number of Residues	14
Details	RIBOSOMAL_S13_1 Ribosomal protein S13 signature. RGiRHfwGlrVRGQ

Chain	Residue	Details
I	ARG123-GLN136

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. CVTGsaDySIKLWDV

Chain	Residue	Details
l	CYS67-VAL81
O	ALA80-VAL94
O	ILE169-LEU183
O	ILE211-LEU225

---

site_id	PS00712
Number of Residues	16
Details	RIBOSOMAL_S17E Ribosomal protein S17e signature. IqSKrLRNkIAGYtTH

Chain	Residue	Details
H	ILE41-HIS56

---

site_id	PS00733
Number of Residues	8
Details	RIBOSOMAL_S26E Ribosomal protein S26e signature. YCVSCAIH

Chain	Residue	Details
e	TYR73-HIS80

---

site_id	PS00948
Number of Residues	14
Details	RIBOSOMAL_S7E Ribosomal protein S7e signature. KLtRELEKKFQdRH

Chain	Residue	Details
U	LYS76-HIS89

---

site_id	PS00961
Number of Residues	9
Details	RIBOSOMAL_S28E Ribosomal protein S28e signature. ESEREARrL

Chain	Residue	Details
h	GLU58-LEU66

---

site_id	PS00962
Number of Residues	12
Details	RIBOSOMAL_S2_1 Ribosomal protein S2 signature 1. AqLLLAANTHLG

Chain	Residue	Details
P	ALA14-GLY25

---

site_id	PS00963
Number of Residues	25
Details	RIBOSOMAL_S2_2 Ribosomal protein S2 signature 2. PrlVIVtDprsDaqaIkEasyvNIP

Chain	Residue	Details
P	PRO118-PRO142

---

site_id	PS00996
Number of Residues	9
Details	RIBOSOMAL_S21E Ribosomal protein S21e signature. LYVPRKCSA

Chain	Residue	Details
a	LEU11-ALA19

---

site_id	PS01168
Number of Residues	33
Details	RIBOSOMAL_S27E Ribosomal protein S27e signature. KCpgClnittvFShAqtavtCesCStiLctPtG

Chain	Residue	Details
f	LYS36-GLY68

---

site_id	PS01189
Number of Residues	19
Details	RIBOSOMAL_S12E Ribosomal protein S12e signature. ALKvvLrtAlvhDGLarGL

Chain	Residue	Details
D	ALA27-LEU45

---

site_id	PS01191
Number of Residues	13
Details	RIBOSOMAL_S3AE Ribosomal protein S3Ae signature. LkGRVvEvCLaDL

Chain	Residue	Details
Q	LEU61-LEU73

---

site_id	PS01193
Number of Residues	20
Details	RIBOSOMAL_S8E Ribosomal protein S8e signature. RsaTGAkraqf.RkKrKfELG

Chain	Residue	Details
V	ARG11-GLY30

---

site_id	PS01262
Number of Residues	23
Details	IF1A Eukaryotic initiation factor 1A signature. MlGnGRveasCfDGnkRmaHIrG

Chain	Residue	Details
i	MET41-GLY63

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:33856219

Chain	Residue	Details
z	SER65
y	SER65
q	SER103
D	LYS114

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:33856219, ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198

Chain	Residue	Details
z	THR75
X	LYS141
X	LYS148
y	THR75
E	LYS35
E	LYS64
X	LYS57
X	LYS79
X	LYS96
X	LYS105
X	LYS133

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198

Chain	Residue	Details
z	SER92
y	SER92
K	LYS32
K	LYS101
I	LYS96

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Omega-N-methylarginine => ECO:0000269|PubMed:33856219

Chain	Residue	Details
z	ARG220
y	ARG220
O	LYS53
O	LYS107
O	LYS137
O	LYS161
S	LYS179
S	LYS211
S	LYS233

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047

Chain	Residue	Details
F	LYS30
F	LYS47
F	LYS59

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17287358, ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198

Chain	Residue	Details
A	SER221

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19779198

Chain	Residue	Details
A	THR231

---

site_id	SWS_FT_FI8
Number of Residues	5
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047

Chain	Residue	Details
A	LYS106
A	LYS132
A	LYS141
A	LYS151
A	LYS200

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:28757607, ECO:0000269|PubMed:30718516, ECO:0000269|PubMed:30893611, ECO:0000269|PubMed:31819057, ECO:0007744|PubMed:22106047

Chain	Residue	Details
A	LYS212

---