Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8C9H

AQP7_inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005811	cellular_component	lipid droplet
A	0005886	cellular_component	plasma membrane
A	0005911	cellular_component	cell-cell junction
A	0006833	biological_process	water transport
A	0015204	molecular_function	urea transmembrane transporter activity
A	0015250	molecular_function	water channel activity
A	0015254	molecular_function	glycerol channel activity
A	0015267	molecular_function	channel activity
A	0015793	biological_process	glycerol transmembrane transport
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0030659	cellular_component	cytoplasmic vesicle membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0055085	biological_process	transmembrane transport
A	0071918	biological_process	urea transmembrane transport
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005811	cellular_component	lipid droplet
B	0005886	cellular_component	plasma membrane
B	0005911	cellular_component	cell-cell junction
B	0006833	biological_process	water transport
B	0015204	molecular_function	urea transmembrane transporter activity
B	0015250	molecular_function	water channel activity
B	0015254	molecular_function	glycerol channel activity
B	0015267	molecular_function	channel activity
B	0015793	biological_process	glycerol transmembrane transport
B	0016020	cellular_component	membrane
B	0016323	cellular_component	basolateral plasma membrane
B	0030659	cellular_component	cytoplasmic vesicle membrane
B	0031410	cellular_component	cytoplasmic vesicle
B	0055085	biological_process	transmembrane transport
B	0071918	biological_process	urea transmembrane transport
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005811	cellular_component	lipid droplet
C	0005886	cellular_component	plasma membrane
C	0005911	cellular_component	cell-cell junction
C	0006833	biological_process	water transport
C	0015204	molecular_function	urea transmembrane transporter activity
C	0015250	molecular_function	water channel activity
C	0015254	molecular_function	glycerol channel activity
C	0015267	molecular_function	channel activity
C	0015793	biological_process	glycerol transmembrane transport
C	0016020	cellular_component	membrane
C	0016323	cellular_component	basolateral plasma membrane
C	0030659	cellular_component	cytoplasmic vesicle membrane
C	0031410	cellular_component	cytoplasmic vesicle
C	0055085	biological_process	transmembrane transport
C	0071918	biological_process	urea transmembrane transport
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005811	cellular_component	lipid droplet
D	0005886	cellular_component	plasma membrane
D	0005911	cellular_component	cell-cell junction
D	0006833	biological_process	water transport
D	0015204	molecular_function	urea transmembrane transporter activity
D	0015250	molecular_function	water channel activity
D	0015254	molecular_function	glycerol channel activity
D	0015267	molecular_function	channel activity
D	0015793	biological_process	glycerol transmembrane transport
D	0016020	cellular_component	membrane
D	0016323	cellular_component	basolateral plasma membrane
D	0030659	cellular_component	cytoplasmic vesicle membrane
D	0031410	cellular_component	cytoplasmic vesicle
D	0055085	biological_process	transmembrane transport
D	0071918	biological_process	urea transmembrane transport
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005811	cellular_component	lipid droplet
E	0005886	cellular_component	plasma membrane
E	0005911	cellular_component	cell-cell junction
E	0006833	biological_process	water transport
E	0015204	molecular_function	urea transmembrane transporter activity
E	0015250	molecular_function	water channel activity
E	0015254	molecular_function	glycerol channel activity
E	0015267	molecular_function	channel activity
E	0015793	biological_process	glycerol transmembrane transport
E	0016020	cellular_component	membrane
E	0016323	cellular_component	basolateral plasma membrane
E	0030659	cellular_component	cytoplasmic vesicle membrane
E	0031410	cellular_component	cytoplasmic vesicle
E	0055085	biological_process	transmembrane transport
E	0071918	biological_process	urea transmembrane transport
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005811	cellular_component	lipid droplet
F	0005886	cellular_component	plasma membrane
F	0005911	cellular_component	cell-cell junction
F	0006833	biological_process	water transport
F	0015204	molecular_function	urea transmembrane transporter activity
F	0015250	molecular_function	water channel activity
F	0015254	molecular_function	glycerol channel activity
F	0015267	molecular_function	channel activity
F	0015793	biological_process	glycerol transmembrane transport
F	0016020	cellular_component	membrane
F	0016323	cellular_component	basolateral plasma membrane
F	0030659	cellular_component	cytoplasmic vesicle membrane
F	0031410	cellular_component	cytoplasmic vesicle
F	0055085	biological_process	transmembrane transport
F	0071918	biological_process	urea transmembrane transport
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005811	cellular_component	lipid droplet
G	0005886	cellular_component	plasma membrane
G	0005911	cellular_component	cell-cell junction
G	0006833	biological_process	water transport
G	0015204	molecular_function	urea transmembrane transporter activity
G	0015250	molecular_function	water channel activity
G	0015254	molecular_function	glycerol channel activity
G	0015267	molecular_function	channel activity
G	0015793	biological_process	glycerol transmembrane transport
G	0016020	cellular_component	membrane
G	0016323	cellular_component	basolateral plasma membrane
G	0030659	cellular_component	cytoplasmic vesicle membrane
G	0031410	cellular_component	cytoplasmic vesicle
G	0055085	biological_process	transmembrane transport
G	0071918	biological_process	urea transmembrane transport
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005811	cellular_component	lipid droplet
H	0005886	cellular_component	plasma membrane
H	0005911	cellular_component	cell-cell junction
H	0006833	biological_process	water transport
H	0015204	molecular_function	urea transmembrane transporter activity
H	0015250	molecular_function	water channel activity
H	0015254	molecular_function	glycerol channel activity
H	0015267	molecular_function	channel activity
H	0015793	biological_process	glycerol transmembrane transport
H	0016020	cellular_component	membrane
H	0016323	cellular_component	basolateral plasma membrane
H	0030659	cellular_component	cytoplasmic vesicle membrane
H	0031410	cellular_component	cytoplasmic vesicle
H	0055085	biological_process	transmembrane transport
H	0071918	biological_process	urea transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	136
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AMX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	552
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	136
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AMX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	168
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	208
Details	Intramembrane: {"description":"Discontinuously helical","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AMX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	160
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AMX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	136
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AMX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	128
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AMX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	168
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AMX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	16
Details	Motif: {"description":"NPA 1","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	16
Details	Motif: {"description":"NPA 2","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	24
Details	Site: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	8
Details	Site: {"description":"Important for permeability to glycerol","evidences":[{"source":"PubMed","id":"30423801","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)