8C9H

AQP7_inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005811	cellular_component	lipid droplet
A	0005886	cellular_component	plasma membrane
A	0005911	cellular_component	cell-cell junction
A	0006833	biological_process	water transport
A	0015204	molecular_function	urea transmembrane transporter activity
A	0015250	molecular_function	water channel activity
A	0015254	molecular_function	glycerol channel activity
A	0015267	molecular_function	channel activity
A	0015793	biological_process	glycerol transmembrane transport
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0030659	cellular_component	cytoplasmic vesicle membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0055085	biological_process	transmembrane transport
A	0071918	biological_process	urea transmembrane transport
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005811	cellular_component	lipid droplet
B	0005886	cellular_component	plasma membrane
B	0005911	cellular_component	cell-cell junction
B	0006833	biological_process	water transport
B	0015204	molecular_function	urea transmembrane transporter activity
B	0015250	molecular_function	water channel activity
B	0015254	molecular_function	glycerol channel activity
B	0015267	molecular_function	channel activity
B	0015793	biological_process	glycerol transmembrane transport
B	0016020	cellular_component	membrane
B	0016323	cellular_component	basolateral plasma membrane
B	0030659	cellular_component	cytoplasmic vesicle membrane
B	0031410	cellular_component	cytoplasmic vesicle
B	0055085	biological_process	transmembrane transport
B	0071918	biological_process	urea transmembrane transport
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005811	cellular_component	lipid droplet
C	0005886	cellular_component	plasma membrane
C	0005911	cellular_component	cell-cell junction
C	0006833	biological_process	water transport
C	0015204	molecular_function	urea transmembrane transporter activity
C	0015250	molecular_function	water channel activity
C	0015254	molecular_function	glycerol channel activity
C	0015267	molecular_function	channel activity
C	0015793	biological_process	glycerol transmembrane transport
C	0016020	cellular_component	membrane
C	0016323	cellular_component	basolateral plasma membrane
C	0030659	cellular_component	cytoplasmic vesicle membrane
C	0031410	cellular_component	cytoplasmic vesicle
C	0055085	biological_process	transmembrane transport
C	0071918	biological_process	urea transmembrane transport
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005811	cellular_component	lipid droplet
D	0005886	cellular_component	plasma membrane
D	0005911	cellular_component	cell-cell junction
D	0006833	biological_process	water transport
D	0015204	molecular_function	urea transmembrane transporter activity
D	0015250	molecular_function	water channel activity
D	0015254	molecular_function	glycerol channel activity
D	0015267	molecular_function	channel activity
D	0015793	biological_process	glycerol transmembrane transport
D	0016020	cellular_component	membrane
D	0016323	cellular_component	basolateral plasma membrane
D	0030659	cellular_component	cytoplasmic vesicle membrane
D	0031410	cellular_component	cytoplasmic vesicle
D	0055085	biological_process	transmembrane transport
D	0071918	biological_process	urea transmembrane transport
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005811	cellular_component	lipid droplet
E	0005886	cellular_component	plasma membrane
E	0005911	cellular_component	cell-cell junction
E	0006833	biological_process	water transport
E	0015204	molecular_function	urea transmembrane transporter activity
E	0015250	molecular_function	water channel activity
E	0015254	molecular_function	glycerol channel activity
E	0015267	molecular_function	channel activity
E	0015793	biological_process	glycerol transmembrane transport
E	0016020	cellular_component	membrane
E	0016323	cellular_component	basolateral plasma membrane
E	0030659	cellular_component	cytoplasmic vesicle membrane
E	0031410	cellular_component	cytoplasmic vesicle
E	0055085	biological_process	transmembrane transport
E	0071918	biological_process	urea transmembrane transport
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005811	cellular_component	lipid droplet
F	0005886	cellular_component	plasma membrane
F	0005911	cellular_component	cell-cell junction
F	0006833	biological_process	water transport
F	0015204	molecular_function	urea transmembrane transporter activity
F	0015250	molecular_function	water channel activity
F	0015254	molecular_function	glycerol channel activity
F	0015267	molecular_function	channel activity
F	0015793	biological_process	glycerol transmembrane transport
F	0016020	cellular_component	membrane
F	0016323	cellular_component	basolateral plasma membrane
F	0030659	cellular_component	cytoplasmic vesicle membrane
F	0031410	cellular_component	cytoplasmic vesicle
F	0055085	biological_process	transmembrane transport
F	0071918	biological_process	urea transmembrane transport
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005811	cellular_component	lipid droplet
G	0005886	cellular_component	plasma membrane
G	0005911	cellular_component	cell-cell junction
G	0006833	biological_process	water transport
G	0015204	molecular_function	urea transmembrane transporter activity
G	0015250	molecular_function	water channel activity
G	0015254	molecular_function	glycerol channel activity
G	0015267	molecular_function	channel activity
G	0015793	biological_process	glycerol transmembrane transport
G	0016020	cellular_component	membrane
G	0016323	cellular_component	basolateral plasma membrane
G	0030659	cellular_component	cytoplasmic vesicle membrane
G	0031410	cellular_component	cytoplasmic vesicle
G	0055085	biological_process	transmembrane transport
G	0071918	biological_process	urea transmembrane transport
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005811	cellular_component	lipid droplet
H	0005886	cellular_component	plasma membrane
H	0005911	cellular_component	cell-cell junction
H	0006833	biological_process	water transport
H	0015204	molecular_function	urea transmembrane transporter activity
H	0015250	molecular_function	water channel activity
H	0015254	molecular_function	glycerol channel activity
H	0015267	molecular_function	channel activity
H	0015793	biological_process	glycerol transmembrane transport
H	0016020	cellular_component	membrane
H	0016323	cellular_component	basolateral plasma membrane
H	0030659	cellular_component	cytoplasmic vesicle membrane
H	0031410	cellular_component	cytoplasmic vesicle
H	0055085	biological_process	transmembrane transport
H	0071918	biological_process	urea transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	976
Details	TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:36737436

Chain	Residue	Details
A	MET1-GLU36
B	ILE276-PHE342
C	MET1-GLU36
C	GLY86-SER89
C	LEU104-LYS111
C	ILE189-GLY200
C	ILE276-PHE342
D	MET1-GLU36
D	GLY86-SER89
D	LEU104-LYS111
D	ILE189-GLY200
A	GLY86-SER89
D	ILE276-PHE342
E	MET1-GLU36
E	GLY86-SER89
E	LEU104-LYS111
E	ILE189-GLY200
E	ILE276-PHE342
F	MET1-GLU36
F	GLY86-SER89
F	LEU104-LYS111
F	ILE189-GLY200
A	LEU104-LYS111
F	ILE276-PHE342
G	MET1-GLU36
G	GLY86-SER89
G	LEU104-LYS111
G	ILE189-GLY200
G	ILE276-PHE342
H	MET1-GLU36
H	GLY86-SER89
H	LEU104-LYS111
H	ILE189-GLY200
A	ILE189-GLY200
H	ILE276-PHE342
A	ILE276-PHE342
B	MET1-GLU36
B	GLY86-SER89
B	LEU104-LYS111
B	ILE189-GLY200

---

site_id	SWS_FT_FI2
Number of Residues	136
Details	TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:36737436, ECO:0007744|PDB:8AMW, ECO:0007744|PDB:8AMX

Chain	Residue	Details
A	PHE37-SER54
B	PHE37-SER54
C	PHE37-SER54
D	PHE37-SER54
E	PHE37-SER54
F	PHE37-SER54
G	PHE37-SER54
H	PHE37-SER54

---

site_id	SWS_FT_FI3
Number of Residues	552
Details	TOPO_DOM: Extracellular => ECO:0000305|PubMed:36737436

Chain	Residue	Details
A	VAL55-TYR67
C	LEU133-ARG170
C	GLY218-THR221
C	PHE236-TRP253
D	VAL55-TYR67
D	LEU133-ARG170
D	GLY218-THR221
D	PHE236-TRP253
E	VAL55-TYR67
E	LEU133-ARG170
E	GLY218-THR221
A	LEU133-ARG170
E	PHE236-TRP253
F	VAL55-TYR67
F	LEU133-ARG170
F	GLY218-THR221
F	PHE236-TRP253
G	VAL55-TYR67
G	LEU133-ARG170
G	GLY218-THR221
G	PHE236-TRP253
H	VAL55-TYR67
A	GLY218-THR221
H	LEU133-ARG170
H	GLY218-THR221
H	PHE236-TRP253
A	PHE236-TRP253
B	VAL55-TYR67
B	LEU133-ARG170
B	GLY218-THR221
B	PHE236-TRP253
C	VAL55-TYR67

---

site_id	SWS_FT_FI4
Number of Residues	136
Details	TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:36737436, ECO:0007744|PDB:8AMW, ECO:0007744|PDB:8AMX

Chain	Residue	Details
A	LEU68-ALA85
B	LEU68-ALA85
C	LEU68-ALA85
D	LEU68-ALA85
E	LEU68-ALA85
F	LEU68-ALA85
G	LEU68-ALA85
H	LEU68-ALA85

---

site_id	SWS_FT_FI5
Number of Residues	208
Details	INTRAMEM: Discontinuously helical => ECO:0000269|PubMed:36737436, ECO:0007744|PDB:8AMW, ECO:0007744|PDB:8AMX

Chain	Residue	Details
A	GLY90-ALA103
E	GLY222-ILE235
F	GLY90-ALA103
F	GLY222-ILE235
G	GLY90-ALA103
G	GLY222-ILE235
H	GLY90-ALA103
H	GLY222-ILE235
A	GLY222-ILE235
B	GLY90-ALA103
B	GLY222-ILE235
C	GLY90-ALA103
C	GLY222-ILE235
D	GLY90-ALA103
D	GLY222-ILE235
E	GLY90-ALA103

---

site_id	SWS_FT_FI6
Number of Residues	160
Details	TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:36737436, ECO:0007744|PDB:8AMW, ECO:0007744|PDB:8AMX

Chain	Residue	Details
A	PHE112-SER132
B	PHE112-SER132
C	PHE112-SER132
D	PHE112-SER132
E	PHE112-SER132
F	PHE112-SER132
G	PHE112-SER132
H	PHE112-SER132

---

site_id	SWS_FT_FI7
Number of Residues	136
Details	TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:36737436, ECO:0007744|PDB:8AMW, ECO:0007744|PDB:8AMX

Chain	Residue	Details
A	GLY171-ALA188
B	GLY171-ALA188
C	GLY171-ALA188
D	GLY171-ALA188
E	GLY171-ALA188
F	GLY171-ALA188
G	GLY171-ALA188
H	GLY171-ALA188

---

site_id	SWS_FT_FI8
Number of Residues	128
Details	TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:36737436, ECO:0007744|PDB:8AMW, ECO:0007744|PDB:8AMX

Chain	Residue	Details
A	THR201-LEU217
B	THR201-LEU217
C	THR201-LEU217
D	THR201-LEU217
E	THR201-LEU217
F	THR201-LEU217
G	THR201-LEU217
H	THR201-LEU217

---

site_id	SWS_FT_FI9
Number of Residues	168
Details	TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:36737436, ECO:0007744|PDB:8AMW, ECO:0007744|PDB:8AMX

Chain	Residue	Details
A	TRP254-PHE275
B	TRP254-PHE275
C	TRP254-PHE275
D	TRP254-PHE275
E	TRP254-PHE275
F	TRP254-PHE275
G	TRP254-PHE275
H	TRP254-PHE275

---

site_id	SWS_FT_FI10
Number of Residues	24
Details	SITE: Selectivity filter => ECO:0000305|PubMed:36737436

Chain	Residue	Details
A	PHE74
D	PHE74
D	TYR223
D	ARG229
E	PHE74
E	TYR223
E	ARG229
F	PHE74
F	TYR223
F	ARG229
G	PHE74
A	TYR223
G	TYR223
G	ARG229
H	PHE74
H	TYR223
H	ARG229
A	ARG229
B	PHE74
B	TYR223
B	ARG229
C	PHE74
C	TYR223
C	ARG229

---

site_id	SWS_FT_FI11
Number of Residues	8
Details	SITE: Important for permeability to glycerol => ECO:0000269|PubMed:30423801

Chain	Residue	Details
A	TYR135
B	TYR135
C	TYR135
D	TYR135
E	TYR135
F	TYR135
G	TYR135
H	TYR135

---

site_id	SWS_FT_FI12
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P56403

Chain	Residue	Details
A	SER20
B	SER20
C	SER20
D	SER20
E	SER20
F	SER20
G	SER20
H	SER20

---