8C7H
Cryo-EM Map of the latTGF-beta LHG-10 Fab complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005160 | molecular_function | transforming growth factor beta receptor binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| B | 0005576 | cellular_component | extracellular region |
| B | 0008083 | molecular_function | growth factor activity |
| C | 0005160 | molecular_function | transforming growth factor beta receptor binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005615 | cellular_component | extracellular space |
| D | 0005576 | cellular_component | extracellular region |
| D | 0008083 | molecular_function | growth factor activity |
| I | 0001818 | biological_process | negative regulation of cytokine production |
| I | 0005515 | molecular_function | protein binding |
| I | 0005654 | cellular_component | nucleoplasm |
| I | 0005886 | cellular_component | plasma membrane |
| I | 0007179 | biological_process | transforming growth factor beta receptor signaling pathway |
| I | 0009986 | cellular_component | cell surface |
| I | 0010628 | biological_process | positive regulation of gene expression |
| I | 0016020 | cellular_component | membrane |
| I | 0019838 | molecular_function | growth factor binding |
| I | 0030512 | biological_process | negative regulation of transforming growth factor beta receptor signaling pathway |
| I | 0035592 | biological_process | establishment of protein localization to extracellular region |
| I | 0038023 | molecular_function | signaling receptor activity |
| I | 0046007 | biological_process | negative regulation of activated T cell proliferation |
| I | 0050431 | molecular_function | transforming growth factor beta binding |
| I | 0062009 | biological_process | secondary palate development |
| I | 0141069 | molecular_function | receptor ligand inhibitor activity |
Functional Information from PROSITE/UniProt
| site_id | PS00250 |
| Number of Residues | 16 |
| Details | TGF_BETA_1 TGF-beta family signature. IhePkgYhanfClGpC |
| Chain | Residue | Details |
| B | ILE311-CYS326 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH |
| Chain | Residue | Details |
| L | TYR220-HIS226 | |
| K | TYR212-HIS218 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16263699","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28117447","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5FFO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 23 |
| Details | Repeat: {"description":"LRR 1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | Repeat: {"description":"LRR 4","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 5","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 6","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 7","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 20 |
| Details | Repeat: {"description":"LRR 8","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 9","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 23 |
| Details | Repeat: {"description":"LRR 11","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 23 |
| Details | Repeat: {"description":"LRR 12","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 13","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 14","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 16","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 17","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 18","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
