8BYQ

RNA polymerase II pre-initiation complex with the proximal +1 nucleosome (PIC-Nuc10W)

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
0	0000112	cellular_component	nucleotide-excision repair factor 3 complex
0	0000439	cellular_component	transcription factor TFIIH core complex
0	0000717	biological_process	nucleotide-excision repair, DNA duplex unwinding
0	0001666	biological_process	response to hypoxia
0	0003677	molecular_function	DNA binding
0	0003678	molecular_function	DNA helicase activity
0	0003684	molecular_function	damaged DNA binding
0	0004386	molecular_function	helicase activity
0	0005515	molecular_function	protein binding
0	0005524	molecular_function	ATP binding
0	0005634	cellular_component	nucleus
0	0005654	cellular_component	nucleoplasm
0	0005669	cellular_component	transcription factor TFIID complex
0	0005675	cellular_component	transcription factor TFIIH holo complex
0	0006265	biological_process	DNA topological change
0	0006281	biological_process	DNA repair
0	0006283	biological_process	transcription-coupled nucleotide-excision repair
0	0006289	biological_process	nucleotide-excision repair
0	0006366	biological_process	transcription by RNA polymerase II
0	0006367	biological_process	transcription initiation at RNA polymerase II promoter
0	0006368	biological_process	transcription elongation by RNA polymerase II
0	0006915	biological_process	apoptotic process
0	0006979	biological_process	response to oxidative stress
0	0008104	biological_process	protein localization
0	0009411	biological_process	response to UV
0	0009650	biological_process	UV protection
0	0016787	molecular_function	hydrolase activity
0	0016853	molecular_function	isomerase activity
0	0016887	molecular_function	ATP hydrolysis activity
0	0035315	biological_process	hair cell differentiation
0	0043065	biological_process	positive regulation of apoptotic process
0	0043138	molecular_function	3'-5' DNA helicase activity
0	0048568	biological_process	embryonic organ development
0	0097550	cellular_component	transcription preinitiation complex
0	0140640	molecular_function	catalytic activity, acting on a nucleic acid
0	1901990	biological_process	regulation of mitotic cell cycle phase transition
0	1990841	molecular_function	promoter-specific chromatin binding
1	0000439	cellular_component	transcription factor TFIIH core complex
1	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
1	0001666	biological_process	response to hypoxia
1	0001701	biological_process	in utero embryonic development
1	0003676	molecular_function	nucleic acid binding
1	0003677	molecular_function	DNA binding
1	0003678	molecular_function	DNA helicase activity
1	0003684	molecular_function	damaged DNA binding
1	0004386	molecular_function	helicase activity
1	0005515	molecular_function	protein binding
1	0005524	molecular_function	ATP binding
1	0005634	cellular_component	nucleus
1	0005654	cellular_component	nucleoplasm
1	0005669	cellular_component	transcription factor TFIID complex
1	0005675	cellular_component	transcription factor TFIIH holo complex
1	0005737	cellular_component	cytoplasm
1	0005819	cellular_component	spindle
1	0005829	cellular_component	cytosol
1	0005856	cellular_component	cytoskeleton
1	0006139	biological_process	nucleobase-containing compound metabolic process
1	0006259	biological_process	DNA metabolic process
1	0006281	biological_process	DNA repair
1	0006283	biological_process	transcription-coupled nucleotide-excision repair
1	0006289	biological_process	nucleotide-excision repair
1	0006357	biological_process	regulation of transcription by RNA polymerase II
1	0006362	biological_process	transcription elongation by RNA polymerase I
1	0006366	biological_process	transcription by RNA polymerase II
1	0006367	biological_process	transcription initiation at RNA polymerase II promoter
1	0006915	biological_process	apoptotic process
1	0006974	biological_process	DNA damage response
1	0006979	biological_process	response to oxidative stress
1	0007059	biological_process	chromosome segregation
1	0008340	biological_process	determination of adult lifespan
1	0009411	biological_process	response to UV
1	0009650	biological_process	UV protection
1	0009791	biological_process	post-embryonic development
1	0016787	molecular_function	hydrolase activity
1	0016818	molecular_function	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1	0016853	molecular_function	isomerase activity
1	0016887	molecular_function	ATP hydrolysis activity
1	0021510	biological_process	spinal cord development
1	0022405	biological_process	hair cycle process
1	0030198	biological_process	extracellular matrix organization
1	0030282	biological_process	bone mineralization
1	0030674	molecular_function	protein-macromolecule adaptor activity
1	0032289	biological_process	central nervous system myelin formation
1	0032508	biological_process	DNA duplex unwinding
1	0035264	biological_process	multicellular organism growth
1	0035315	biological_process	hair cell differentiation
1	0040016	biological_process	embryonic cleavage
1	0042274	biological_process	ribosomal small subunit biogenesis
1	0043139	molecular_function	5'-3' DNA helicase activity
1	0043249	biological_process	erythrocyte maturation
1	0043588	biological_process	skin development
1	0045951	biological_process	positive regulation of mitotic recombination
1	0046872	molecular_function	metal ion binding
1	0048009	biological_process	insulin-like growth factor receptor signaling pathway
1	0048568	biological_process	embryonic organ development
1	0048820	biological_process	hair follicle maturation
1	0051539	molecular_function	4 iron, 4 sulfur cluster binding
1	0060218	biological_process	hematopoietic stem cell differentiation
1	0070516	cellular_component	CAK-ERCC2 complex
1	0071425	biological_process	hematopoietic stem cell proliferation
1	0071817	cellular_component	MMXD complex
1	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
1	1901990	biological_process	regulation of mitotic cell cycle phase transition
2	0000079	biological_process	regulation of cyclin-dependent protein serine/threonine kinase activity
2	0000439	cellular_component	transcription factor TFIIH core complex
2	0003682	molecular_function	chromatin binding
2	0005515	molecular_function	protein binding
2	0005634	cellular_component	nucleus
2	0005654	cellular_component	nucleoplasm
2	0005675	cellular_component	transcription factor TFIIH holo complex
2	0006281	biological_process	DNA repair
2	0006289	biological_process	nucleotide-excision repair
2	0006351	biological_process	DNA-templated transcription
2	0006360	biological_process	transcription by RNA polymerase I
2	0006366	biological_process	transcription by RNA polymerase II
2	0006367	biological_process	transcription initiation at RNA polymerase II promoter
2	0009755	biological_process	hormone-mediated signaling pathway
2	0045893	biological_process	positive regulation of DNA-templated transcription
2	0046966	molecular_function	nuclear thyroid hormone receptor binding
3	0000438	cellular_component	core TFIIH complex portion of holo TFIIH complex
3	0000439	cellular_component	transcription factor TFIIH core complex
3	0001671	molecular_function	ATPase activator activity
3	0003690	molecular_function	double-stranded DNA binding
3	0005515	molecular_function	protein binding
3	0005634	cellular_component	nucleus
3	0005654	cellular_component	nucleoplasm
3	0005669	cellular_component	transcription factor TFIID complex
3	0005675	cellular_component	transcription factor TFIIH holo complex
3	0006281	biological_process	DNA repair
3	0006289	biological_process	nucleotide-excision repair
3	0006366	biological_process	transcription by RNA polymerase II
3	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
3	0016607	cellular_component	nuclear speck
4	0000438	cellular_component	core TFIIH complex portion of holo TFIIH complex
4	0000439	cellular_component	transcription factor TFIIH core complex
4	0002031	biological_process	G protein-coupled receptor internalization
4	0005515	molecular_function	protein binding
4	0005634	cellular_component	nucleus
4	0005654	cellular_component	nucleoplasm
4	0005669	cellular_component	transcription factor TFIID complex
4	0005675	cellular_component	transcription factor TFIIH holo complex
4	0006281	biological_process	DNA repair
4	0006289	biological_process	nucleotide-excision repair
4	0006351	biological_process	DNA-templated transcription
4	0006357	biological_process	regulation of transcription by RNA polymerase II
4	0006366	biological_process	transcription by RNA polymerase II
4	0006367	biological_process	transcription initiation at RNA polymerase II promoter
4	0008270	molecular_function	zinc ion binding
4	0009411	biological_process	response to UV
4	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
4	0016607	cellular_component	nuclear speck
4	0046872	molecular_function	metal ion binding
5	0000438	cellular_component	core TFIIH complex portion of holo TFIIH complex
5	0000439	cellular_component	transcription factor TFIIH core complex
5	0005515	molecular_function	protein binding
5	0005634	cellular_component	nucleus
5	0005654	cellular_component	nucleoplasm
5	0005669	cellular_component	transcription factor TFIID complex
5	0005675	cellular_component	transcription factor TFIIH holo complex
5	0006281	biological_process	DNA repair
5	0006289	biological_process	nucleotide-excision repair
5	0006355	biological_process	regulation of DNA-templated transcription
5	0006366	biological_process	transcription by RNA polymerase II
5	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
5	0046872	molecular_function	metal ion binding
5	0097550	cellular_component	transcription preinitiation complex
6	0000439	cellular_component	transcription factor TFIIH core complex
6	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
6	0005515	molecular_function	protein binding
6	0005634	cellular_component	nucleus
6	0005654	cellular_component	nucleoplasm
6	0005669	cellular_component	transcription factor TFIID complex
6	0005675	cellular_component	transcription factor TFIIH holo complex
6	0005730	cellular_component	nucleolus
6	0005737	cellular_component	cytoplasm
6	0006281	biological_process	DNA repair
6	0006289	biological_process	nucleotide-excision repair
6	0006294	biological_process	nucleotide-excision repair, preincision complex assembly
6	0006362	biological_process	transcription elongation by RNA polymerase I
6	0006366	biological_process	transcription by RNA polymerase II
6	0006367	biological_process	transcription initiation at RNA polymerase II promoter
6	0071480	biological_process	cellular response to gamma radiation
7	0000082	biological_process	G1/S transition of mitotic cell cycle
7	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
7	0000439	cellular_component	transcription factor TFIIH core complex
7	0005515	molecular_function	protein binding
7	0005634	cellular_component	nucleus
7	0005654	cellular_component	nucleoplasm
7	0005675	cellular_component	transcription factor TFIIH holo complex
7	0006281	biological_process	DNA repair
7	0006289	biological_process	nucleotide-excision repair
7	0006355	biological_process	regulation of DNA-templated transcription
7	0006357	biological_process	regulation of transcription by RNA polymerase II
7	0006367	biological_process	transcription initiation at RNA polymerase II promoter
7	0007512	biological_process	adult heart development
7	0008270	molecular_function	zinc ion binding
7	0021591	biological_process	ventricular system development
7	0043066	biological_process	negative regulation of apoptotic process
7	0045737	biological_process	positive regulation of cyclin-dependent protein serine/threonine kinase activity
7	0046872	molecular_function	metal ion binding
7	0048661	biological_process	positive regulation of smooth muscle cell proliferation
7	0051592	biological_process	response to calcium ion
7	0061575	molecular_function	cyclin-dependent protein serine/threonine kinase activator activity
7	0070516	cellular_component	CAK-ERCC2 complex
7	0070985	cellular_component	transcription factor TFIIK complex
7	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
8	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
8	0000439	cellular_component	transcription factor TFIIH core complex
8	0001650	cellular_component	fibrillar center
8	0001673	cellular_component	male germ cell nucleus
8	0004672	molecular_function	protein kinase activity
8	0004674	molecular_function	protein serine/threonine kinase activity
8	0004693	molecular_function	cyclin-dependent protein serine/threonine kinase activity
8	0005515	molecular_function	protein binding
8	0005524	molecular_function	ATP binding
8	0005634	cellular_component	nucleus
8	0005654	cellular_component	nucleoplasm
8	0005675	cellular_component	transcription factor TFIIH holo complex
8	0005737	cellular_component	cytoplasm
8	0005829	cellular_component	cytosol
8	0005886	cellular_component	plasma membrane
8	0006281	biological_process	DNA repair
8	0006366	biological_process	transcription by RNA polymerase II
8	0006367	biological_process	transcription initiation at RNA polymerase II promoter
8	0006468	biological_process	protein phosphorylation
8	0008094	molecular_function	ATP-dependent activity, acting on DNA
8	0008353	molecular_function	RNA polymerase II CTD heptapeptide repeat kinase activity
8	0016301	molecular_function	kinase activity
8	0042795	biological_process	snRNA transcription by RNA polymerase II
8	0045944	biological_process	positive regulation of transcription by RNA polymerase II
8	0048471	cellular_component	perinuclear region of cytoplasm
8	0050821	biological_process	protein stabilization
8	0051301	biological_process	cell division
8	0051726	biological_process	regulation of cell cycle
8	0070516	cellular_component	CAK-ERCC2 complex
8	0070985	cellular_component	transcription factor TFIIK complex
8	0106310	molecular_function	protein serine kinase activity
8	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
9	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
9	0000439	cellular_component	transcription factor TFIIH core complex
9	0005515	molecular_function	protein binding
9	0005634	cellular_component	nucleus
9	0005654	cellular_component	nucleoplasm
9	0005675	cellular_component	transcription factor TFIIH holo complex
9	0006351	biological_process	DNA-templated transcription
9	0006357	biological_process	regulation of transcription by RNA polymerase II
9	0006367	biological_process	transcription initiation at RNA polymerase II promoter
9	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
9	0016538	molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity
9	0050821	biological_process	protein stabilization
9	0070516	cellular_component	CAK-ERCC2 complex
9	0070985	cellular_component	transcription factor TFIIK complex
9	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
a	0000786	cellular_component	nucleosome
a	0003677	molecular_function	DNA binding
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0005694	cellular_component	chromosome
a	0030527	molecular_function	structural constituent of chromatin
a	0046982	molecular_function	protein heterodimerization activity
A	0000428	cellular_component	DNA-directed RNA polymerase complex
A	0001055	molecular_function	RNA polymerase II activity
A	0003677	molecular_function	DNA binding
A	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
A	0005634	cellular_component	nucleus
A	0005665	cellular_component	RNA polymerase II, core complex
A	0006351	biological_process	DNA-templated transcription
A	0006366	biological_process	transcription by RNA polymerase II
A	0016779	molecular_function	nucleotidyltransferase activity
A	0031981	cellular_component	nuclear lumen
A	0032991	cellular_component	protein-containing complex
A	0046872	molecular_function	metal ion binding
b	0000786	cellular_component	nucleosome
b	0003677	molecular_function	DNA binding
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0005694	cellular_component	chromosome
b	0006334	biological_process	nucleosome assembly
b	0030527	molecular_function	structural constituent of chromatin
b	0046982	molecular_function	protein heterodimerization activity
B	0000428	cellular_component	DNA-directed RNA polymerase complex
B	0000781	cellular_component	chromosome, telomeric region
B	0001055	molecular_function	RNA polymerase II activity
B	0001172	biological_process	RNA-templated transcription
B	0003677	molecular_function	DNA binding
B	0003682	molecular_function	chromatin binding
B	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
B	0003968	molecular_function	RNA-dependent RNA polymerase activity
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005665	cellular_component	RNA polymerase II, core complex
B	0006351	biological_process	DNA-templated transcription
B	0006366	biological_process	transcription by RNA polymerase II
B	0016779	molecular_function	nucleotidyltransferase activity
B	0032549	molecular_function	ribonucleoside binding
B	0034062	molecular_function	5'-3' RNA polymerase activity
B	0046872	molecular_function	metal ion binding
c	0000786	cellular_component	nucleosome
c	0003677	molecular_function	DNA binding
c	0005634	cellular_component	nucleus
c	0005694	cellular_component	chromosome
c	0030527	molecular_function	structural constituent of chromatin
c	0046982	molecular_function	protein heterodimerization activity
C	0000428	cellular_component	DNA-directed RNA polymerase complex
C	0003677	molecular_function	DNA binding
C	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005665	cellular_component	RNA polymerase II, core complex
C	0005829	cellular_component	cytosol
C	0006351	biological_process	DNA-templated transcription
C	0006366	biological_process	transcription by RNA polymerase II
C	0046983	molecular_function	protein dimerization activity
d	0000786	cellular_component	nucleosome
d	0003677	molecular_function	DNA binding
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005694	cellular_component	chromosome
d	0030527	molecular_function	structural constituent of chromatin
d	0046982	molecular_function	protein heterodimerization activity
D	0000166	molecular_function	nucleotide binding
D	0006352	biological_process	DNA-templated transcription initiation
D	0030880	cellular_component	RNA polymerase complex
D	0044237	biological_process	cellular metabolic process
e	0000786	cellular_component	nucleosome
e	0003677	molecular_function	DNA binding
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005694	cellular_component	chromosome
e	0030527	molecular_function	structural constituent of chromatin
e	0046982	molecular_function	protein heterodimerization activity
E	0001054	molecular_function	RNA polymerase I activity
E	0001055	molecular_function	RNA polymerase II activity
E	0001056	molecular_function	RNA polymerase III activity
E	0003677	molecular_function	DNA binding
E	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005665	cellular_component	RNA polymerase II, core complex
E	0005666	cellular_component	RNA polymerase III complex
E	0005736	cellular_component	RNA polymerase I complex
E	0006351	biological_process	DNA-templated transcription
E	0006362	biological_process	transcription elongation by RNA polymerase I
E	0006366	biological_process	transcription by RNA polymerase II
E	0042797	biological_process	tRNA transcription by RNA polymerase III
f	0000786	cellular_component	nucleosome
f	0003677	molecular_function	DNA binding
f	0005515	molecular_function	protein binding
f	0005634	cellular_component	nucleus
f	0005694	cellular_component	chromosome
f	0006334	biological_process	nucleosome assembly
f	0030527	molecular_function	structural constituent of chromatin
f	0046982	molecular_function	protein heterodimerization activity
F	0000428	cellular_component	DNA-directed RNA polymerase complex
F	0001650	cellular_component	fibrillar center
F	0003677	molecular_function	DNA binding
F	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005665	cellular_component	RNA polymerase II, core complex
F	0005666	cellular_component	RNA polymerase III complex
F	0005736	cellular_component	RNA polymerase I complex
F	0006351	biological_process	DNA-templated transcription
F	0006366	biological_process	transcription by RNA polymerase II
g	0000786	cellular_component	nucleosome
g	0003677	molecular_function	DNA binding
g	0005634	cellular_component	nucleus
g	0005694	cellular_component	chromosome
g	0030527	molecular_function	structural constituent of chromatin
g	0046982	molecular_function	protein heterodimerization activity
G	0000428	cellular_component	DNA-directed RNA polymerase complex
G	0000932	cellular_component	P-body
G	0003676	molecular_function	nucleic acid binding
G	0003697	molecular_function	single-stranded DNA binding
G	0003727	molecular_function	single-stranded RNA binding
G	0005634	cellular_component	nucleus
G	0005665	cellular_component	RNA polymerase II, core complex
G	0006351	biological_process	DNA-templated transcription
G	0006352	biological_process	DNA-templated transcription initiation
G	0006367	biological_process	transcription initiation at RNA polymerase II promoter
G	0031369	molecular_function	translation initiation factor binding
G	0045948	biological_process	positive regulation of translational initiation
G	0060213	biological_process	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
h	0000786	cellular_component	nucleosome
h	0003677	molecular_function	DNA binding
h	0005515	molecular_function	protein binding
h	0005634	cellular_component	nucleus
h	0005694	cellular_component	chromosome
h	0030527	molecular_function	structural constituent of chromatin
h	0046982	molecular_function	protein heterodimerization activity
H	0000428	cellular_component	DNA-directed RNA polymerase complex
H	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
H	0005634	cellular_component	nucleus
H	0005665	cellular_component	RNA polymerase II, core complex
H	0006351	biological_process	DNA-templated transcription
I	0000428	cellular_component	DNA-directed RNA polymerase complex
I	0001193	biological_process	maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II
I	0003676	molecular_function	nucleic acid binding
I	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005665	cellular_component	RNA polymerase II, core complex
I	0005730	cellular_component	nucleolus
I	0006283	biological_process	transcription-coupled nucleotide-excision repair
I	0006351	biological_process	DNA-templated transcription
I	0006366	biological_process	transcription by RNA polymerase II
I	0006367	biological_process	transcription initiation at RNA polymerase II promoter
I	0008270	molecular_function	zinc ion binding
I	0046872	molecular_function	metal ion binding
J	0000428	cellular_component	DNA-directed RNA polymerase complex
J	0001054	molecular_function	RNA polymerase I activity
J	0001055	molecular_function	RNA polymerase II activity
J	0001056	molecular_function	RNA polymerase III activity
J	0003677	molecular_function	DNA binding
J	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
J	0005665	cellular_component	RNA polymerase II, core complex
J	0005666	cellular_component	RNA polymerase III complex
J	0005736	cellular_component	RNA polymerase I complex
J	0006351	biological_process	DNA-templated transcription
J	0006360	biological_process	transcription by RNA polymerase I
J	0006366	biological_process	transcription by RNA polymerase II
J	0008270	molecular_function	zinc ion binding
J	0042797	biological_process	tRNA transcription by RNA polymerase III
J	0046872	molecular_function	metal ion binding
K	0000428	cellular_component	DNA-directed RNA polymerase complex
K	0001055	molecular_function	RNA polymerase II activity
K	0003677	molecular_function	DNA binding
K	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
K	0005634	cellular_component	nucleus
K	0005665	cellular_component	RNA polymerase II, core complex
K	0006351	biological_process	DNA-templated transcription
K	0006366	biological_process	transcription by RNA polymerase II
K	0046983	molecular_function	protein dimerization activity
L	0003677	molecular_function	DNA binding
L	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
L	0005634	cellular_component	nucleus
L	0005665	cellular_component	RNA polymerase II, core complex
L	0005666	cellular_component	RNA polymerase III complex
L	0005736	cellular_component	RNA polymerase I complex
L	0006351	biological_process	DNA-templated transcription
L	0006366	biological_process	transcription by RNA polymerase II
L	0008270	molecular_function	zinc ion binding
L	0046872	molecular_function	metal ion binding
M	0000776	cellular_component	kinetochore
M	0000793	cellular_component	condensed chromosome
M	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
M	0000993	molecular_function	RNA polymerase II complex binding
M	0001174	biological_process	transcriptional start site selection at RNA polymerase II promoter
M	0003677	molecular_function	DNA binding
M	0004402	molecular_function	histone acetyltransferase activity
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005669	cellular_component	transcription factor TFIID complex
M	0005694	cellular_component	chromosome
M	0006338	biological_process	chromatin remodeling
M	0006352	biological_process	DNA-templated transcription initiation
M	0006366	biological_process	transcription by RNA polymerase II
M	0006367	biological_process	transcription initiation at RNA polymerase II promoter
M	0006473	biological_process	protein acetylation
M	0008270	molecular_function	zinc ion binding
M	0010467	biological_process	gene expression
M	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
M	0016407	molecular_function	acetyltransferase activity
M	0016604	cellular_component	nuclear body
M	0016746	molecular_function	acyltransferase activity
M	0017025	molecular_function	TBP-class protein binding
M	0019083	biological_process	viral transcription
M	0032153	cellular_component	cell division site
M	0032993	cellular_component	protein-DNA complex
M	0042585	cellular_component	germinal vesicle
M	0046872	molecular_function	metal ion binding
M	0046966	molecular_function	nuclear thyroid hormone receptor binding
M	0051123	biological_process	RNA polymerase II preinitiation complex assembly
M	0051177	biological_process	meiotic sister chromatid cohesion
M	0051225	biological_process	spindle assembly
M	0051276	biological_process	chromosome organization
M	0061733	molecular_function	peptide-lysine-N-acetyltransferase activity
M	0070897	biological_process	transcription preinitiation complex assembly
M	0090575	cellular_component	RNA polymerase II transcription regulator complex
M	0097550	cellular_component	transcription preinitiation complex
M	0140297	molecular_function	DNA-binding transcription factor binding
M	1904798	biological_process	positive regulation of core promoter binding
M	1990114	biological_process	RNA polymerase II core complex assembly
M	1990841	molecular_function	promoter-specific chromatin binding
O	0000785	cellular_component	chromatin
O	0000791	cellular_component	euchromatin
O	0000976	molecular_function	transcription cis-regulatory region binding
O	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
O	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
O	0000995	molecular_function	RNA polymerase III general transcription initiation factor activity
O	0001046	molecular_function	core promoter sequence-specific DNA binding
O	0001091	molecular_function	RNA polymerase II general transcription initiation factor binding
O	0001093	molecular_function	TFIIB-class transcription factor binding
O	0001164	molecular_function	RNA polymerase I core promoter sequence-specific DNA binding
O	0001188	biological_process	RNA polymerase I preinitiation complex assembly
O	0001673	cellular_component	male germ cell nucleus
O	0001674	cellular_component	female germ cell nucleus
O	0001939	cellular_component	female pronucleus
O	0001940	cellular_component	male pronucleus
O	0003677	molecular_function	DNA binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005668	cellular_component	RNA polymerase transcription factor SL1 complex
O	0005669	cellular_component	transcription factor TFIID complex
O	0005672	cellular_component	transcription factor TFIIA complex
O	0005737	cellular_component	cytoplasm
O	0006352	biological_process	DNA-templated transcription initiation
O	0006366	biological_process	transcription by RNA polymerase II
O	0006367	biological_process	transcription initiation at RNA polymerase II promoter
O	0006383	biological_process	transcription by RNA polymerase III
O	0007283	biological_process	spermatogenesis
O	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
O	0017162	molecular_function	aryl hydrocarbon receptor binding
O	0019899	molecular_function	enzyme binding
O	0032991	cellular_component	protein-containing complex
O	0042789	biological_process	mRNA transcription by RNA polymerase II
O	0045120	cellular_component	pronucleus
O	0045893	biological_process	positive regulation of DNA-templated transcription
O	0051123	biological_process	RNA polymerase II preinitiation complex assembly
O	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
O	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
O	0140297	molecular_function	DNA-binding transcription factor binding
Q	0001091	molecular_function	RNA polymerase II general transcription initiation factor binding
Q	0001096	molecular_function	TFIIF-class transcription factor complex binding
Q	0003677	molecular_function	DNA binding
Q	0003723	molecular_function	RNA binding
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005669	cellular_component	transcription factor TFIID complex
Q	0005674	cellular_component	transcription factor TFIIF complex
Q	0006366	biological_process	transcription by RNA polymerase II
Q	0006367	biological_process	transcription initiation at RNA polymerase II promoter
Q	0006368	biological_process	transcription elongation by RNA polymerase II
Q	0009615	biological_process	response to virus
Q	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
Q	0019211	molecular_function	phosphatase activator activity
Q	0019903	molecular_function	protein phosphatase binding
Q	0019904	molecular_function	protein domain specific binding
Q	0030054	cellular_component	cell junction
Q	0032091	biological_process	negative regulation of protein binding
Q	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
Q	0032991	cellular_component	protein-containing complex
Q	0043231	cellular_component	intracellular membrane-bounded organelle
Q	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Q	1990841	molecular_function	promoter-specific chromatin binding
R	0003677	molecular_function	DNA binding
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005674	cellular_component	transcription factor TFIIF complex
R	0006366	biological_process	transcription by RNA polymerase II
R	0006367	biological_process	transcription initiation at RNA polymerase II promoter
R	0006368	biological_process	transcription elongation by RNA polymerase II
R	0015630	cellular_component	microtubule cytoskeleton
R	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
R	0045944	biological_process	positive regulation of transcription by RNA polymerase II
U	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
U	0001091	molecular_function	RNA polymerase II general transcription initiation factor binding
U	0003677	molecular_function	DNA binding
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005669	cellular_component	transcription factor TFIID complex
U	0005672	cellular_component	transcription factor TFIIA complex
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0006366	biological_process	transcription by RNA polymerase II
U	0006367	biological_process	transcription initiation at RNA polymerase II promoter
U	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
U	0017025	molecular_function	TBP-class protein binding
U	0045944	biological_process	positive regulation of transcription by RNA polymerase II
U	0046982	molecular_function	protein heterodimerization activity
U	0051123	biological_process	RNA polymerase II preinitiation complex assembly
U	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
U	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
U	0097550	cellular_component	transcription preinitiation complex
V	0001091	molecular_function	RNA polymerase II general transcription initiation factor binding
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005669	cellular_component	transcription factor TFIID complex
V	0005672	cellular_component	transcription factor TFIIA complex
V	0006366	biological_process	transcription by RNA polymerase II
V	0006367	biological_process	transcription initiation at RNA polymerase II promoter
V	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
V	0017025	molecular_function	TBP-class protein binding
V	0030054	cellular_component	cell junction
V	0042803	molecular_function	protein homodimerization activity
V	0045944	biological_process	positive regulation of transcription by RNA polymerase II
V	0046982	molecular_function	protein heterodimerization activity
V	0051123	biological_process	RNA polymerase II preinitiation complex assembly
V	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
V	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
W	0006367	biological_process	transcription initiation at RNA polymerase II promoter
X	0001097	molecular_function	TFIIH-class transcription factor complex binding
X	0003677	molecular_function	DNA binding
X	0003723	molecular_function	RNA binding
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005669	cellular_component	transcription factor TFIID complex
X	0005673	cellular_component	transcription factor TFIIE complex
X	0005829	cellular_component	cytosol
X	0006366	biological_process	transcription by RNA polymerase II
X	0006367	biological_process	transcription initiation at RNA polymerase II promoter
X	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DNDPSDYVEqdDI

Chain	Residue	Details
C	ASP136-ILE148

---

site_id	PS00028
Number of Residues	21
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cav..CqnvFcvdcdvfvHdsl..H

Chain	Residue	Details
4	CYS360-HIS380

---

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
c	ALA22-VAL28

---

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
b	GLY15-HIS19

---

site_id	PS00107
Number of Residues	25
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGQFATVYkArdkntnqiv.........AIKK

Chain	Residue	Details
8	LEU18-LYS42

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IlHrDLKpnNLLL

Chain	Residue	Details
8	ILE133-LEU145

---

site_id	PS00115
Number of Residues	7
Details	RNA_POL_II_REPEAT Eukaryotic RNA polymerase II heptapeptide repeat. YSPTSPA

Chain	Residue	Details
A	TYR1593-ALA1599
A	TYR1671-SER1677
A	TYR1678-SER1684
A	TYR1685-SER1691
A	TYR1692-SER1698
A	TYR1699-SER1705
A	TYR1706-SER1712
A	TYR1713-SER1719
A	TYR1720-SER1726
A	TYR1727-SER1733
A	TYR1734-SER1740
A	TYR1615-SER1621
A	TYR1741-ASN1747
A	TYR1748-ASN1754
A	TYR1755-SER1761
A	TYR1762-SER1768
A	TYR1769-ASN1775
A	TYR1776-ASN1782
A	TYR1783-SER1789
A	TYR1790-SER1796
A	TYR1797-SER1803
A	TYR1818-SER1824
A	TYR1622-SER1628
A	TYR1825-SER1831
A	TYR1832-LYS1838
A	TYR1839-SER1845
A	TYR1853-LYS1859
A	TYR1860-LYS1866
A	TYR1867-LYS1873
A	TYR1874-THR1880
A	TYR1888-THR1894
A	TYR1902-LYS1908
A	TYR1909-THR1915
A	TYR1629-ASN1635
A	TYR1916-LYS1922
A	TYR1923-THR1929
A	TYR1930-LYS1936
A	TYR1947-THR1953
A	TYR1636-SER1642
A	TYR1643-SER1649
A	TYR1650-SER1656
A	TYR1657-SER1663
A	TYR1664-SER1670

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YVCTAPH

Chain	Residue	Details
I	TYR112-HIS118

---

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
a	LYS15-LEU21

---

site_id	PS00351
Number of Residues	50
Details	TFIID Transcription factor TFIID repeat signature. YnPkrFaaVImRirePRttaLIFsSGKMvctGAKseeqsrlAarkyarvV

Chain	Residue	Details
O	TYR192-VAL241
O	TYR283-LEU332

---

site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG

Chain	Residue	Details
d	ARG93-GLY115

---

site_id	PS00446
Number of Residues	41
Details	RNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NSIRRvfiaevpiiAidwVqidaNsSvlhDEfIAhRLGLIP

Chain	Residue	Details
C	ASN32-PRO72

---

site_id	PS00466
Number of Residues	38
Details	ZF_TFIIS_1 Zinc finger TFIIS-type signature. CqkCghkeavffqSHSARaEDAmrlyyvCtaph.CghrW

Chain	Residue	Details
I	CYS86-TRP123

---

site_id	PS00518
Number of Residues	10
Details	ZF_RING_1 Zinc finger RING-type signature. CgHtLCesCV

Chain	Residue	Details
7	CYS26-VAL35

---

site_id	PS00690
Number of Residues	10
Details	DEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. AvVVFDEAHN

Chain	Residue	Details
1	ALA229-ASN238

---

site_id	PS00782
Number of Residues	16
Details	TFIIB Transcription factor TFIIB repeat signature. GRandAIASACLYIAC

Chain	Residue	Details
M	GLY153-CYS168
M	GLY247-SER262

---

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
a	PRO67-ILE75

---

site_id	PS01030
Number of Residues	27
Details	RNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FCQECNNMLypkedkenrillyaCrnC

Chain	Residue	Details
I	PHE16-CYS42

---

site_id	PS01110
Number of Residues	14
Details	RNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HELVPEHvvMtkEE

Chain	Residue	Details
E	HIS142-GLU155

---

site_id	PS01111
Number of Residues	15
Details	RNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARvLGtRAlQ

Chain	Residue	Details
F	THR58-GLN72

---

site_id	PS01112
Number of Residues	10
Details	RNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IIPVrCFTCG

Chain	Residue	Details
J	ILE2-GLY11

---

site_id	PS01154
Number of Residues	32
Details	RNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. InkEdHTLgNiIksqLlkdpqVlfagYkvpHP

Chain	Residue	Details
K	ILE35-PRO66

---

site_id	PS01166
Number of Residues	13
Details	RNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT

Chain	Residue	Details
B	GLY932-THR944

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027, ECO:0000269|PubMed:15530371

Chain	Residue	Details
8	ASP137
d	LYS13
d	LYS16
d	LYS21
h	LYS6
h	LYS13
h	LYS16
h	LYS21

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:15530371

Chain	Residue	Details
8	LEU18
8	LYS41
W	CYS154
W	CYS157

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N-acetylalanine => ECO:0007744|PubMed:22814378

Chain	Residue	Details
8	ALA2
h	SER113
g	LYS10
g	LYS96

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976

Chain	Residue	Details
8	SER7
M	THR284
M	ARG286
M	ARG290
g	LYS37
h	LYS121
M	ARG154
M	LYS189
M	LYS196
M	ARG248
M	LYS272
M	ALA281

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine; by CDK1 and CDK2 => ECO:0000269|PubMed:11113184, ECO:0000269|PubMed:9832506, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:23186163

Chain	Residue	Details
8	SER164
c	LYS76
g	LYS75
g	LYS76
f	LYS9
f	LYS17
f	LYS45
f	LYS80

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by CDK2 => ECO:0000269|PubMed:11113184, ECO:0000269|PubMed:15530371, ECO:0000269|PubMed:9832506, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
8	THR170
g	GLN105
f	LYS13
f	LYS21

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231

Chain	Residue	Details
8	SER321
g	LYS119
f	LYS32
f	LYS92

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250

Chain	Residue	Details
c	LYS14
f	SER48
c	LYS16
c	LYS120
g	LYS14
g	LYS16
g	LYS120

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
b	TYR52
b	TYR89
f	TYR52
f	TYR89

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
b	LYS60
e	LYS65
f	LYS60
a	LYS28
a	LYS37
a	LYS65
e	LYS19
e	LYS24
e	LYS28
e	LYS37

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
b	LYS78
f	LYS78

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
b	LYS32
f	LYS32

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
a	LYS38
b	LYS92
f	LYS92

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
a	TYR42
e	TYR42

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P84228

Chain	Residue	Details
a	LYS57
a	LYS80
e	LYS57
e	LYS80

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
a	SER58
e	SER58

---

site_id	SWS_FT_FI17
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
a	THR81
a	THR108
e	THR81
e	THR108

---

site_id	SWS_FT_FI18
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P84243

Chain	Residue	Details
a	SER87
e	SER87

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
a	LYS116
e	LYS116

---

site_id	SWS_FT_FI20
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
a	LYS123
e	LYS123

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	LIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
a	CYS111
e	CYS111

---