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8BYL

Cryo-EM structure of SKP1-SKP2-CKS1 from the SCFSKP2 E3 ligase complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000209biological_processprotein polyubiquitination
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0006338biological_processchromatin remodeling
A0006511biological_processubiquitin-dependent protein catabolic process
A0006513biological_processprotein monoubiquitination
A0008013molecular_functionbeta-catenin binding
A0016567biological_processprotein ubiquitination
A0019005cellular_componentSCF ubiquitin ligase complex
A0019904molecular_functionprotein domain specific binding
A0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
A0031467cellular_componentCul7-RING ubiquitin ligase complex
A0031519cellular_componentPcG protein complex
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0051457biological_processmaintenance of protein location in nucleus
A0070936biological_processprotein K48-linked ubiquitination
A0097602molecular_functioncullin family protein binding
A0140677molecular_functionmolecular function activator activity
A0160072molecular_functionubiquitin ligase complex scaffold activity
A1904668biological_processpositive regulation of ubiquitin protein ligase activity
A1990444molecular_functionF-box domain binding
A1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
B0000082biological_processG1/S transition of mitotic cell cycle
B0000086biological_processG2/M transition of mitotic cell cycle
B0000209biological_processprotein polyubiquitination
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006511biological_processubiquitin-dependent protein catabolic process
B0016567biological_processprotein ubiquitination
B0019005cellular_componentSCF ubiquitin ligase complex
B0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
B0033148biological_processpositive regulation of intracellular estrogen receptor signaling pathway
B0042802molecular_functionidentical protein binding
B0042981biological_processregulation of apoptotic process
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0045087biological_processinnate immune response
B0051607biological_processdefense response to virus
B0051726biological_processregulation of cell cycle
B0070534biological_processprotein K63-linked ubiquitination
B0070936biological_processprotein K48-linked ubiquitination
B1902916biological_processpositive regulation of protein polyubiquitination
B1905168biological_processpositive regulation of double-strand break repair via homologous recombination
B1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
C0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
C0005515molecular_functionprotein binding
C0005654cellular_componentnucleoplasm
C0006355biological_processregulation of DNA-templated transcription
C0007346biological_processregulation of mitotic cell cycle
C0016538molecular_functioncyclin-dependent protein serine/threonine kinase regulator activity
C0019005cellular_componentSCF ubiquitin ligase complex
C0019901molecular_functionprotein kinase binding
C0042393molecular_functionhistone binding
C0043130molecular_functionubiquitin binding
C0044772biological_processmitotic cell cycle phase transition
C0048144biological_processfibroblast proliferation
C0051301biological_processcell division
C0061575molecular_functioncyclin-dependent protein serine/threonine kinase activator activity
D0000079biological_processregulation of cyclin-dependent protein serine/threonine kinase activity
D0000082biological_processG1/S transition of mitotic cell cycle
D0001666biological_processresponse to hypoxia
D0001890biological_processplacenta development
D0001934biological_processpositive regulation of protein phosphorylation
D0004860molecular_functionprotein kinase inhibitor activity
D0004861molecular_functioncyclin-dependent protein serine/threonine kinase inhibitor activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005768cellular_componentendosome
D0005829cellular_componentcytosol
D0006813biological_processpotassium ion transport
D0006915biological_processapoptotic process
D0006977biological_processDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
D0007096biological_processregulation of exit from mitosis
D0007219biological_processNotch signaling pathway
D0007346biological_processregulation of mitotic cell cycle
D0007507biological_processheart development
D0007605biological_processsensory perception of sound
D0008284biological_processpositive regulation of cell population proliferation
D0008285biological_processnegative regulation of cell population proliferation
D0009410biological_processresponse to xenobiotic stimulus
D0009749biological_processresponse to glucose
D0014070biological_processresponse to organic cyclic compound
D0019901molecular_functionprotein kinase binding
D0019903molecular_functionprotein phosphatase binding
D0019914molecular_functioncyclin-dependent protein kinase activating kinase regulator activity
D0030308biological_processnegative regulation of cell growth
D0030332molecular_functioncyclin binding
D0030334biological_processregulation of cell migration
D0030544molecular_functionHsp70 protein binding
D0031116biological_processpositive regulation of microtubule polymerization
D0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
D0031625molecular_functionubiquitin protein ligase binding
D0032355biological_processresponse to estradiol
D0032991cellular_componentprotein-containing complex
D0033673biological_processnegative regulation of kinase activity
D0042326biological_processnegative regulation of phosphorylation
D0043200biological_processresponse to amino acid
D0043231cellular_componentintracellular membrane-bounded organelle
D0043434biological_processresponse to peptide hormone
D0044877molecular_functionprotein-containing complex binding
D0045732biological_processpositive regulation of protein catabolic process
D0045736biological_processnegative regulation of cyclin-dependent protein serine/threonine kinase activity
D0045740biological_processpositive regulation of DNA replication
D0045892biological_processnegative regulation of DNA-templated transcription
D0045930biological_processnegative regulation of mitotic cell cycle
D0046686biological_processresponse to cadmium ion
D0048102biological_processautophagic cell death
D0048839biological_processinner ear development
D0050680biological_processnegative regulation of epithelial cell proliferation
D0051087molecular_functionprotein-folding chaperone binding
D0051168biological_processnuclear export
D0051726biological_processregulation of cell cycle
D0060090molecular_functionmolecular adaptor activity
D0060767biological_processepithelial cell proliferation involved in prostate gland development
D0060770biological_processnegative regulation of epithelial cell proliferation involved in prostate gland development
D0071236biological_processcellular response to antibiotic
D0071285biological_processcellular response to lithium ion
D0071407biological_processcellular response to organic cyclic compound
D0071456biological_processcellular response to hypoxia
D0090398biological_processcellular senescence
D0140678molecular_functionmolecular function inhibitor activity
D1902746biological_processregulation of lens fiber cell differentiation
D1902806biological_processregulation of cell cycle G1/S phase transition
D1904019biological_processepithelial cell apoptotic process
D1904030biological_processnegative regulation of cyclin-dependent protein kinase activity
D1904036biological_processnegative regulation of epithelial cell apoptotic process
D1904706biological_processnegative regulation of vascular associated smooth muscle cell proliferation
D1905179biological_processnegative regulation of cardiac muscle tissue regeneration
D1990757molecular_functionubiquitin ligase activator activity
D2000045biological_processregulation of G1/S transition of mitotic cell cycle
Functional Information from PROSITE/UniProt
site_idPS00944
Number of Residues19
DetailsCKS_1 Cyclin-dependent kinases regulatory subunits signature 1. YSdKYdDEeFEYRHVmLPK
ChainResidueDetails
CTYR3008-LYS3026

site_idPS00945
Number of Residues11
DetailsCKS_2 Cyclin-dependent kinases regulatory subunits signature 2. HePEpHILLFR
ChainResidueDetails
CHIS3060-ARG3070

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphoserine; by UHMK1 => ECO:0000269|PubMed:10831586, ECO:0000269|PubMed:12042314, ECO:0000269|PubMed:12093740, ECO:0000269|PubMed:14504289, ECO:0007744|PubMed:23186163
ChainResidueDetails
DSER4010

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphotyrosine; by SRC => ECO:0000269|PubMed:17254967
ChainResidueDetails
DTYR4074
BLYS2071

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphotyrosine; by ABL, LYN, SRC and JAK2 => ECO:0000269|PubMed:16195327, ECO:0000269|PubMed:17254966, ECO:0000269|PubMed:17254967, ECO:0000269|PubMed:21423214
ChainResidueDetails
DTYR4088
BSER2075

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000269|PubMed:16195327
ChainResidueDetails
DTYR4089

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by CaMK1, PKB/AKT1 and PIM1 => ECO:0000269|PubMed:12244301, ECO:0000269|PubMed:12244303, ECO:0000269|PubMed:18593906, ECO:0000269|PubMed:23707388
ChainResidueDetails
DTHR4157

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P46414
ChainResidueDetails
DTHR4170

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by PKB/AKT1, CDK1 and CDK2 => ECO:0000269|PubMed:10323868, ECO:0000269|PubMed:12042314, ECO:0000269|PubMed:16209941, ECO:0000269|PubMed:23478441
ChainResidueDetails
DTPO4187

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by CaMK1, PKB/AKT1, RPS6KA1, RPS6KA3 and PIM1 => ECO:0000269|PubMed:12042314, ECO:0000269|PubMed:14504289, ECO:0000269|PubMed:15280662, ECO:0000269|PubMed:18593906, ECO:0000269|PubMed:23707388
ChainResidueDetails
DTHR4198

222926

PDB entries from 2024-07-24

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