8BY2

Structure of the K+/H+ exchanger KefC with GSH.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006812	biological_process	monoatomic cation transport
A	0006813	biological_process	potassium ion transport
A	0006885	biological_process	regulation of pH
A	0008324	molecular_function	monoatomic cation transmembrane transporter activity
A	0009636	biological_process	response to toxic substance
A	0015079	molecular_function	potassium ion transmembrane transporter activity
A	0015297	molecular_function	antiporter activity
A	0015503	molecular_function	glutathione-regulated potassium exporter activity
A	0015643	molecular_function	toxic substance binding
A	0016020	cellular_component	membrane
A	0019899	molecular_function	enzyme binding
A	0042542	biological_process	response to hydrogen peroxide
A	0042803	molecular_function	protein homodimerization activity
A	0051453	biological_process	regulation of intracellular pH
A	0051454	biological_process	intracellular pH elevation
A	0051595	biological_process	response to methylglyoxal
A	0055085	biological_process	transmembrane transport
A	0071805	biological_process	potassium ion transmembrane transport
A	1902600	biological_process	proton transmembrane transport
B	0000166	molecular_function	nucleotide binding
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006812	biological_process	monoatomic cation transport
B	0006813	biological_process	potassium ion transport
B	0006885	biological_process	regulation of pH
B	0008324	molecular_function	monoatomic cation transmembrane transporter activity
B	0009636	biological_process	response to toxic substance
B	0015079	molecular_function	potassium ion transmembrane transporter activity
B	0015297	molecular_function	antiporter activity
B	0015503	molecular_function	glutathione-regulated potassium exporter activity
B	0015643	molecular_function	toxic substance binding
B	0016020	cellular_component	membrane
B	0019899	molecular_function	enzyme binding
B	0042542	biological_process	response to hydrogen peroxide
B	0042803	molecular_function	protein homodimerization activity
B	0051453	biological_process	regulation of intracellular pH
B	0051454	biological_process	intracellular pH elevation
B	0051595	biological_process	response to methylglyoxal
B	0055085	biological_process	transmembrane transport
B	0071805	biological_process	potassium ion transmembrane transport
B	1902600	biological_process	proton transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	62
Details	Topological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	512
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"HAMAP-Rule","id":"MF_01413","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	134
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	119
Details	Domain: {"description":"RCK N-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00543","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	16
Details	Region: {"description":"Important for the regulation of potassium conductance"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19523906","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	Binding site: {"description":"in other chain"}

Chain

Residue

Details

---