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8BWO

Cryo-EM structure of nanodisc-reconstituted human MRP4 with E1202Q mutation (outward-facing occluded conformation)

Functional Information from GO Data
ChainGOidnamespacecontents
A0001409molecular_functionguanine nucleotide transmembrane transporter activity
A0002576biological_processplatelet degranulation
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005730cellular_componentnucleolus
A0005794cellular_componentGolgi apparatus
A0005886cellular_componentplasma membrane
A0006805biological_processxenobiotic metabolic process
A0006855biological_processxenobiotic transmembrane transport
A0006869biological_processlipid transport
A0008559molecular_functionABC-type xenobiotic transporter activity
A0015132molecular_functionprostaglandin transmembrane transporter activity
A0015143molecular_functionurate transmembrane transporter activity
A0015216molecular_functionpurine nucleotide transmembrane transporter activity
A0015431molecular_functionABC-type glutathione S-conjugate transporter activity
A0015432molecular_functionABC-type bile acid transporter activity
A0015562molecular_functionefflux transmembrane transporter activity
A0015721biological_processbile acid and bile salt transport
A0015732biological_processprostaglandin transport
A0015747biological_processurate transport
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0016324cellular_componentapical plasma membrane
A0016404molecular_function15-hydroxyprostaglandin dehydrogenase (NAD+) activity
A0016887molecular_functionATP hydrolysis activity
A0031088cellular_componentplatelet dense granule membrane
A0032310biological_processprostaglandin secretion
A0034634molecular_functionglutathione transmembrane transporter activity
A0034775biological_processglutathione transmembrane transport
A0042626molecular_functionATPase-coupled transmembrane transporter activity
A0042910molecular_functionxenobiotic transmembrane transporter activity
A0043225molecular_functionATPase-coupled inorganic anion transmembrane transporter activity
A0055085biological_processtransmembrane transport
A0060271biological_processcilium assembly
A0070730biological_processcAMP transport
A0071716biological_processleukotriene transport
A0098591cellular_componentexternal side of apical plasma membrane
A0098656biological_processmonoatomic anion transmembrane transport
A0140115biological_processexport across plasma membrane
A0140359molecular_functionABC-type transporter activity
A0150104biological_processtransport across blood-brain barrier
A1903790biological_processguanine nucleotide transmembrane transport
Functional Information from PROSITE/UniProt
site_idPS00211
Number of Residues15
DetailsABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKARVNLARAV
ChainResidueDetails
ALEU535-VAL549
APHE1177-ILE1191

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues280
DetailsTRANSMEM: Helical => ECO:0000255|PROSITE-ProRule:PRU00441
ChainResidueDetails
ALEU93-LEU113
AALA136-PHE156
AGLN207-ALA227
ALEU228-LEU248
ASER328-ALA348
AVAL351-SER371
ALEU440-GLY460
AHIS710-LEU730
ALEU771-VAL791
ALEU836-VAL856
AVAL858-LEU878
AALA954-LEU974
AGLY977-VAL997
AGLU1038-LEU1058

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434
ChainResidueDetails
AGLY445
AGLY1075

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
ATHR646

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ATHR648

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER664
ASER668

site_idSWS_FT_FI6
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:26721430
ChainResidueDetails
AASN746
AASN754

221051

PDB entries from 2024-06-12

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