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8BV5

Focus refinement of soluble domain of Adenylyl cyclase 8 bound to stimulatory G protein, Forskolin, ATPalphaS, and Ca2+/Calmodulin in lipid nanodisc conditions

Functional Information from GO Data
ChainGOidnamespacecontents
A0004016molecular_functionadenylate cyclase activity
A0005524molecular_functionATP binding
A0005886cellular_componentplasma membrane
A0006171biological_processcAMP biosynthetic process
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0007613biological_processmemory
A0007616biological_processlong-term memory
A0007626biological_processlocomotory behavior
A0008294molecular_functioncalcium- and calmodulin-responsive adenylate cyclase activity
A0009190biological_processcyclic nucleotide biosynthetic process
A0010255biological_processglucose mediated signaling pathway
A0014069cellular_componentpostsynaptic density
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0016324cellular_componentapical plasma membrane
A0016829molecular_functionlyase activity
A0016849molecular_functionphosphorus-oxygen lyase activity
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0031915biological_processpositive regulation of synaptic plasticity
A0032024biological_processpositive regulation of insulin secretion
A0032809cellular_componentneuronal cell body membrane
A0035556biological_processintracellular signal transduction
A0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
A0042593biological_processglucose homeostasis
A0042734cellular_componentpresynaptic membrane
A0046872molecular_functionmetal ion binding
A0048786cellular_componentpresynaptic active zone
A0050804biological_processmodulation of chemical synaptic transmission
A0051480biological_processregulation of cytosolic calcium ion concentration
A0060076cellular_componentexcitatory synapse
A0071315biological_processcellular response to morphine
A0071377biological_processcellular response to glucagon stimulus
A0080135biological_processregulation of cellular response to stress
A0098685cellular_componentSchaffer collateral - CA1 synapse
A0098686cellular_componenthippocampal mossy fiber to CA3 synapse
A0098978cellular_componentglutamatergic synapse
A0150076biological_processneuroinflammatory response
A1900273biological_processpositive regulation of long-term synaptic potentiation
A1900454biological_processpositive regulation of long-term synaptic depression
B0003924molecular_functionGTPase activity
B0005525molecular_functionGTP binding
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0019001molecular_functionguanyl nucleotide binding
B0031683molecular_functionG-protein beta/gamma-subunit complex binding
Functional Information from PROSITE/UniProt
site_idPS00137
Number of Residues11
DetailsSUBTILASE_HIS Serine proteases, subtilase family, histidine active site. HGSvVAGvIGA
ChainResidueDetails
AHIS1095-ALA1105

site_idPS00452
Number of Residues24
DetailsGUANYLATE_CYCLASE_1 Guanylate cyclase signature. GVL.GlrkwqFdVWSWDVDianklE
ChainResidueDetails
AGLY520-GLU543
AGLY1101-ASP1124

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues5
DetailsBINDING: BINDING => ECO:0000305|PubMed:10427002, ECO:0000305|PubMed:11087399, ECO:0000305|PubMed:15591060, ECO:0000305|PubMed:16766715, ECO:0000305|PubMed:19243146, ECO:0000305|PubMed:9395396, ECO:0000305|PubMed:9417641
ChainResidueDetails
BGLY47
BLEU197
BASP223
BASN292
BALA366

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:10427002, ECO:0000269|PubMed:11087399, ECO:0000269|PubMed:15591060, ECO:0000269|PubMed:19243146, ECO:0000269|PubMed:9395396, ECO:0000269|PubMed:9417641, ECO:0000305|PubMed:16766715
ChainResidueDetails
BSER54
BTHR204

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P63092
ChainResidueDetails
BSER352

site_idSWS_FT_FI4
Number of Residues1
DetailsLIPID: N-palmitoyl glycine => ECO:0000269|PubMed:12574119
ChainResidueDetails
BGLY2

site_idSWS_FT_FI5
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:12574119
ChainResidueDetails
BCYS3

site_idSWS_FT_FI6
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P63092
ChainResidueDetails
BLYS300

222036

PDB entries from 2024-07-03

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