8BTT

Structure of human RTCB

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000394	biological_process	RNA splicing, via endonucleolytic cleavage and ligation
A	0000968	biological_process	tRNA exon ligation
A	0001701	biological_process	in utero embryonic development
A	0001890	biological_process	placenta development
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005634	cellular_component	nucleus
A	0005635	cellular_component	nuclear envelope
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005829	cellular_component	cytosol
A	0006388	biological_process	tRNA splicing, via endonucleolytic cleavage and ligation
A	0006396	biological_process	RNA processing
A	0008033	biological_process	tRNA processing
A	0008452	molecular_function	RNA ligase activity
A	0016874	molecular_function	ligase activity
A	0016886	molecular_function	ligase activity, forming phosphoric ester bonds
A	0017166	molecular_function	vinculin binding
A	0036498	biological_process	IRE1-mediated unfolded protein response
A	0044600	molecular_function	protein guanylyltransferase activity
A	0046872	molecular_function	metal ion binding
A	0070054	biological_process	mRNA splicing, via endonucleolytic cleavage and ligation
A	0072669	cellular_component	tRNA-splicing ligase complex
A	0170057	molecular_function	RNA ligase (GTP) activity
A	1902494	cellular_component	catalytic complex
B	0000166	molecular_function	nucleotide binding
B	0000394	biological_process	RNA splicing, via endonucleolytic cleavage and ligation
B	0000968	biological_process	tRNA exon ligation
B	0001701	biological_process	in utero embryonic development
B	0001890	biological_process	placenta development
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005634	cellular_component	nucleus
B	0005635	cellular_component	nuclear envelope
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005829	cellular_component	cytosol
B	0006388	biological_process	tRNA splicing, via endonucleolytic cleavage and ligation
B	0006396	biological_process	RNA processing
B	0008033	biological_process	tRNA processing
B	0008452	molecular_function	RNA ligase activity
B	0016874	molecular_function	ligase activity
B	0016886	molecular_function	ligase activity, forming phosphoric ester bonds
B	0017166	molecular_function	vinculin binding
B	0036498	biological_process	IRE1-mediated unfolded protein response
B	0044600	molecular_function	protein guanylyltransferase activity
B	0046872	molecular_function	metal ion binding
B	0070054	biological_process	mRNA splicing, via endonucleolytic cleavage and ligation
B	0072669	cellular_component	tRNA-splicing ligase complex
B	0170057	molecular_function	RNA ligase (GTP) activity
B	1902494	cellular_component	catalytic complex

Functional Information from PROSITE/UniProt

site_id	PS01288
Number of Residues	30
Details	UPF0027 Uncharacterized protein family UPF0027 signature. QIgNvAaLPgIvhrsigLPDvHsGyGfaIG

Chain	Residue	Details
A	GLN68-GLY97

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"GMP-histidine intermediate","evidences":[{"source":"UniProtKB","id":"O59245","evidenceCode":"ECO:0000250"},{"source":"HAMAP-Rule","id":"MF_03144","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"O59245","evidenceCode":"ECO:0000250"},{"source":"HAMAP-Rule","id":"MF_03144","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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