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8BP6

Structure of MHC-class I related molecule MR1 with bound M3Ade

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0001913biological_processT cell mediated cytotoxicity
A0001916biological_processpositive regulation of T cell mediated cytotoxicity
A0002237biological_processresponse to molecule of bacterial origin
A0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
A0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
A0002502biological_processpeptide antigen assembly with MHC class I protein complex
A0002503biological_processpeptide antigen assembly with MHC class II protein complex
A0002726biological_processpositive regulation of T cell cytokine production
A0005198molecular_functionstructural molecule activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005765cellular_componentlysosomal membrane
A0005783cellular_componentendoplasmic reticulum
A0005788cellular_componentendoplasmic reticulum lumen
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0006826biological_processiron ion transport
A0006879biological_processintracellular iron ion homeostasis
A0006955biological_processimmune response
A0007608biological_processsensory perception of smell
A0007611biological_processlearning or memory
A0009897cellular_componentexternal side of plasma membrane
A0009986cellular_componentcell surface
A0010977biological_processnegative regulation of neuron projection development
A0012507cellular_componentER to Golgi transport vesicle membrane
A0016020cellular_componentmembrane
A0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
A0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
A0023026molecular_functionMHC class II protein complex binding
A0030670cellular_componentphagocytic vesicle membrane
A0031901cellular_componentearly endosome membrane
A0031902cellular_componentlate endosome membrane
A0031905cellular_componentearly endosome lumen
A0032092biological_processpositive regulation of protein binding
A0033077biological_processT cell differentiation in thymus
A0034756biological_processregulation of iron ion transport
A0035580cellular_componentspecific granule lumen
A0042026biological_processprotein refolding
A0042605molecular_functionpeptide antigen binding
A0042612cellular_componentMHC class I protein complex
A0042613cellular_componentMHC class II protein complex
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0042824cellular_componentMHC class I peptide loading complex
A0045646biological_processregulation of erythrocyte differentiation
A0048260biological_processpositive regulation of receptor-mediated endocytosis
A0050680biological_processnegative regulation of epithelial cell proliferation
A0050768biological_processnegative regulation of neurogenesis
A0050778biological_processpositive regulation of immune response
A0050870biological_processpositive regulation of T cell activation
A0051289biological_processprotein homotetramerization
A0055038cellular_componentrecycling endosome membrane
A0060586biological_processmulticellular organismal-level iron ion homeostasis
A0070062cellular_componentextracellular exosome
A0071281biological_processcellular response to iron ion
A0071283biological_processcellular response to iron(III) ion
A0071316biological_processcellular response to nicotine
A1900121biological_processnegative regulation of receptor binding
A1900122biological_processpositive regulation of receptor binding
A1904434biological_processpositive regulation of ferrous iron binding
A1904437biological_processpositive regulation of transferrin receptor binding
A1904724cellular_componenttertiary granule lumen
A1990000biological_processamyloid fibril formation
A1990712cellular_componentHFE-transferrin receptor complex
A2000774biological_processpositive regulation of cellular senescence
A2000978biological_processnegative regulation of forebrain neuron differentiation
B0000139cellular_componentGolgi membrane
B0001913biological_processT cell mediated cytotoxicity
B0001916biological_processpositive regulation of T cell mediated cytotoxicity
B0002237biological_processresponse to molecule of bacterial origin
B0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
B0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B0002502biological_processpeptide antigen assembly with MHC class I protein complex
B0002503biological_processpeptide antigen assembly with MHC class II protein complex
B0002726biological_processpositive regulation of T cell cytokine production
B0005198molecular_functionstructural molecule activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005765cellular_componentlysosomal membrane
B0005783cellular_componentendoplasmic reticulum
B0005788cellular_componentendoplasmic reticulum lumen
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0006826biological_processiron ion transport
B0006879biological_processintracellular iron ion homeostasis
B0006955biological_processimmune response
B0007608biological_processsensory perception of smell
B0007611biological_processlearning or memory
B0009897cellular_componentexternal side of plasma membrane
B0009986cellular_componentcell surface
B0010977biological_processnegative regulation of neuron projection development
B0012507cellular_componentER to Golgi transport vesicle membrane
B0016020cellular_componentmembrane
B0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
B0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
B0023026molecular_functionMHC class II protein complex binding
B0030670cellular_componentphagocytic vesicle membrane
B0031901cellular_componentearly endosome membrane
B0031902cellular_componentlate endosome membrane
B0031905cellular_componentearly endosome lumen
B0032092biological_processpositive regulation of protein binding
B0033077biological_processT cell differentiation in thymus
B0034756biological_processregulation of iron ion transport
B0035580cellular_componentspecific granule lumen
B0042026biological_processprotein refolding
B0042605molecular_functionpeptide antigen binding
B0042612cellular_componentMHC class I protein complex
B0042613cellular_componentMHC class II protein complex
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0042824cellular_componentMHC class I peptide loading complex
B0045646biological_processregulation of erythrocyte differentiation
B0048260biological_processpositive regulation of receptor-mediated endocytosis
B0050680biological_processnegative regulation of epithelial cell proliferation
B0050768biological_processnegative regulation of neurogenesis
B0050778biological_processpositive regulation of immune response
B0050870biological_processpositive regulation of T cell activation
B0051289biological_processprotein homotetramerization
B0055038cellular_componentrecycling endosome membrane
B0060586biological_processmulticellular organismal-level iron ion homeostasis
B0070062cellular_componentextracellular exosome
B0071281biological_processcellular response to iron ion
B0071283biological_processcellular response to iron(III) ion
B0071316biological_processcellular response to nicotine
B1900121biological_processnegative regulation of receptor binding
B1900122biological_processpositive regulation of receptor binding
B1904434biological_processpositive regulation of ferrous iron binding
B1904437biological_processpositive regulation of transferrin receptor binding
B1904724cellular_componenttertiary granule lumen
B1990000biological_processamyloid fibril formation
B1990712cellular_componentHFE-transferrin receptor complex
B2000774biological_processpositive regulation of cellular senescence
B2000978biological_processnegative regulation of forebrain neuron differentiation
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH
ChainResidueDetails
ATYR78-HIS84
ATYR369-HIS375

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
ChainResidueDetails
AGLN2
BGLN2

site_idSWS_FT_FI2
Number of Residues2
DetailsCARBOHYD: N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269|PubMed:7918443
ChainResidueDetails
AILE1
BILE1

site_idSWS_FT_FI3
Number of Residues12
DetailsCARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
ChainResidueDetails
ALYS19
BLYS58
BLYS91
BLYS94
ALYS41
ALYS48
ALYS58
ALYS91
ALYS94
BLYS19
BLYS41
BLYS48

site_idSWS_FT_FI4
Number of Residues10
DetailsBINDING: BINDING => ECO:0000269|PubMed:24695216, ECO:0000269|PubMed:26795251, ECO:0007744|PDB:4NQC, ECO:0007744|PDB:5D5M
ChainResidueDetails
AARG124
BGLN268
ASER139
AARG209
ATYR267
AGLN268
BARG124
BSER139
BARG209
BTYR267

site_idSWS_FT_FI5
Number of Residues2
DetailsBINDING: covalent => ECO:0000269|PubMed:24695216, ECO:0000269|PubMed:26795251, ECO:0007744|PDB:4NQC, ECO:0007744|PDB:5D5M
ChainResidueDetails
ALYS158
BLYS158

site_idSWS_FT_FI6
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12794138
ChainResidueDetails
AASN200
BASN200

222415

PDB entries from 2024-07-10

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