Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8BMO

Structure of GroEL:GroES complex exhibiting ADP-conformation in trans ring obtained under the continuous turnover conditions

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006457	biological_process	protein folding
A	0009314	biological_process	response to radiation
A	0009408	biological_process	response to heat
A	0016020	cellular_component	membrane
A	0016853	molecular_function	isomerase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0019068	biological_process	virion assembly
A	0042026	biological_process	protein refolding
A	0042802	molecular_function	identical protein binding
A	0051082	molecular_function	unfolded protein binding
A	0051085	biological_process	chaperone cofactor-dependent protein refolding
A	0140662	molecular_function	ATP-dependent protein folding chaperone
A	1990220	cellular_component	GroEL-GroES complex
B	0000287	molecular_function	magnesium ion binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006457	biological_process	protein folding
B	0009314	biological_process	response to radiation
B	0009408	biological_process	response to heat
B	0016020	cellular_component	membrane
B	0016853	molecular_function	isomerase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0019068	biological_process	virion assembly
B	0042026	biological_process	protein refolding
B	0042802	molecular_function	identical protein binding
B	0051082	molecular_function	unfolded protein binding
B	0051085	biological_process	chaperone cofactor-dependent protein refolding
B	0140662	molecular_function	ATP-dependent protein folding chaperone
B	1990220	cellular_component	GroEL-GroES complex
C	0000287	molecular_function	magnesium ion binding
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006457	biological_process	protein folding
C	0009314	biological_process	response to radiation
C	0009408	biological_process	response to heat
C	0016020	cellular_component	membrane
C	0016853	molecular_function	isomerase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0019068	biological_process	virion assembly
C	0042026	biological_process	protein refolding
C	0042802	molecular_function	identical protein binding
C	0051082	molecular_function	unfolded protein binding
C	0051085	biological_process	chaperone cofactor-dependent protein refolding
C	0140662	molecular_function	ATP-dependent protein folding chaperone
C	1990220	cellular_component	GroEL-GroES complex
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006457	biological_process	protein folding
D	0009408	biological_process	response to heat
D	0019068	biological_process	virion assembly
D	0042802	molecular_function	identical protein binding
D	0044183	molecular_function	protein folding chaperone
D	0046872	molecular_function	metal ion binding
D	0051082	molecular_function	unfolded protein binding
D	0051085	biological_process	chaperone cofactor-dependent protein refolding
D	0051087	molecular_function	protein-folding chaperone binding
D	1990220	cellular_component	GroEL-GroES complex
E	0000287	molecular_function	magnesium ion binding
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006457	biological_process	protein folding
E	0009314	biological_process	response to radiation
E	0009408	biological_process	response to heat
E	0016020	cellular_component	membrane
E	0016853	molecular_function	isomerase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0019068	biological_process	virion assembly
E	0042026	biological_process	protein refolding
E	0042802	molecular_function	identical protein binding
E	0051082	molecular_function	unfolded protein binding
E	0051085	biological_process	chaperone cofactor-dependent protein refolding
E	0140662	molecular_function	ATP-dependent protein folding chaperone
E	1990220	cellular_component	GroEL-GroES complex
F	0000287	molecular_function	magnesium ion binding
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006457	biological_process	protein folding
F	0009314	biological_process	response to radiation
F	0009408	biological_process	response to heat
F	0016020	cellular_component	membrane
F	0016853	molecular_function	isomerase activity
F	0016887	molecular_function	ATP hydrolysis activity
F	0019068	biological_process	virion assembly
F	0042026	biological_process	protein refolding
F	0042802	molecular_function	identical protein binding
F	0051082	molecular_function	unfolded protein binding
F	0051085	biological_process	chaperone cofactor-dependent protein refolding
F	0140662	molecular_function	ATP-dependent protein folding chaperone
F	1990220	cellular_component	GroEL-GroES complex
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006457	biological_process	protein folding
G	0009408	biological_process	response to heat
G	0019068	biological_process	virion assembly
G	0042802	molecular_function	identical protein binding
G	0044183	molecular_function	protein folding chaperone
G	0046872	molecular_function	metal ion binding
G	0051082	molecular_function	unfolded protein binding
G	0051085	biological_process	chaperone cofactor-dependent protein refolding
G	0051087	molecular_function	protein-folding chaperone binding
G	1990220	cellular_component	GroEL-GroES complex
H	0000287	molecular_function	magnesium ion binding
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006457	biological_process	protein folding
H	0009314	biological_process	response to radiation
H	0009408	biological_process	response to heat
H	0016020	cellular_component	membrane
H	0016853	molecular_function	isomerase activity
H	0016887	molecular_function	ATP hydrolysis activity
H	0019068	biological_process	virion assembly
H	0042026	biological_process	protein refolding
H	0042802	molecular_function	identical protein binding
H	0051082	molecular_function	unfolded protein binding
H	0051085	biological_process	chaperone cofactor-dependent protein refolding
H	0140662	molecular_function	ATP-dependent protein folding chaperone
H	1990220	cellular_component	GroEL-GroES complex
I	0000287	molecular_function	magnesium ion binding
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006457	biological_process	protein folding
I	0009314	biological_process	response to radiation
I	0009408	biological_process	response to heat
I	0016020	cellular_component	membrane
I	0016853	molecular_function	isomerase activity
I	0016887	molecular_function	ATP hydrolysis activity
I	0019068	biological_process	virion assembly
I	0042026	biological_process	protein refolding
I	0042802	molecular_function	identical protein binding
I	0051082	molecular_function	unfolded protein binding
I	0051085	biological_process	chaperone cofactor-dependent protein refolding
I	0140662	molecular_function	ATP-dependent protein folding chaperone
I	1990220	cellular_component	GroEL-GroES complex
J	0000287	molecular_function	magnesium ion binding
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006457	biological_process	protein folding
J	0009314	biological_process	response to radiation
J	0009408	biological_process	response to heat
J	0016020	cellular_component	membrane
J	0016853	molecular_function	isomerase activity
J	0016887	molecular_function	ATP hydrolysis activity
J	0019068	biological_process	virion assembly
J	0042026	biological_process	protein refolding
J	0042802	molecular_function	identical protein binding
J	0051082	molecular_function	unfolded protein binding
J	0051085	biological_process	chaperone cofactor-dependent protein refolding
J	0140662	molecular_function	ATP-dependent protein folding chaperone
J	1990220	cellular_component	GroEL-GroES complex
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006457	biological_process	protein folding
K	0009408	biological_process	response to heat
K	0019068	biological_process	virion assembly
K	0042802	molecular_function	identical protein binding
K	0044183	molecular_function	protein folding chaperone
K	0046872	molecular_function	metal ion binding
K	0051082	molecular_function	unfolded protein binding
K	0051085	biological_process	chaperone cofactor-dependent protein refolding
K	0051087	molecular_function	protein-folding chaperone binding
K	1990220	cellular_component	GroEL-GroES complex
L	0000287	molecular_function	magnesium ion binding
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006457	biological_process	protein folding
L	0009314	biological_process	response to radiation
L	0009408	biological_process	response to heat
L	0016020	cellular_component	membrane
L	0016853	molecular_function	isomerase activity
L	0016887	molecular_function	ATP hydrolysis activity
L	0019068	biological_process	virion assembly
L	0042026	biological_process	protein refolding
L	0042802	molecular_function	identical protein binding
L	0051082	molecular_function	unfolded protein binding
L	0051085	biological_process	chaperone cofactor-dependent protein refolding
L	0140662	molecular_function	ATP-dependent protein folding chaperone
L	1990220	cellular_component	GroEL-GroES complex
M	0000287	molecular_function	magnesium ion binding
M	0005515	molecular_function	protein binding
M	0005524	molecular_function	ATP binding
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0006457	biological_process	protein folding
M	0009314	biological_process	response to radiation
M	0009408	biological_process	response to heat
M	0016020	cellular_component	membrane
M	0016853	molecular_function	isomerase activity
M	0016887	molecular_function	ATP hydrolysis activity
M	0019068	biological_process	virion assembly
M	0042026	biological_process	protein refolding
M	0042802	molecular_function	identical protein binding
M	0051082	molecular_function	unfolded protein binding
M	0051085	biological_process	chaperone cofactor-dependent protein refolding
M	0140662	molecular_function	ATP-dependent protein folding chaperone
M	1990220	cellular_component	GroEL-GroES complex
N	0005515	molecular_function	protein binding
N	0005524	molecular_function	ATP binding
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0006457	biological_process	protein folding
N	0009408	biological_process	response to heat
N	0019068	biological_process	virion assembly
N	0042802	molecular_function	identical protein binding
N	0044183	molecular_function	protein folding chaperone
N	0046872	molecular_function	metal ion binding
N	0051082	molecular_function	unfolded protein binding
N	0051085	biological_process	chaperone cofactor-dependent protein refolding
N	0051087	molecular_function	protein-folding chaperone binding
N	1990220	cellular_component	GroEL-GroES complex
O	0000287	molecular_function	magnesium ion binding
O	0005515	molecular_function	protein binding
O	0005524	molecular_function	ATP binding
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0006457	biological_process	protein folding
O	0009314	biological_process	response to radiation
O	0009408	biological_process	response to heat
O	0016020	cellular_component	membrane
O	0016853	molecular_function	isomerase activity
O	0016887	molecular_function	ATP hydrolysis activity
O	0019068	biological_process	virion assembly
O	0042026	biological_process	protein refolding
O	0042802	molecular_function	identical protein binding
O	0051082	molecular_function	unfolded protein binding
O	0051085	biological_process	chaperone cofactor-dependent protein refolding
O	0140662	molecular_function	ATP-dependent protein folding chaperone
O	1990220	cellular_component	GroEL-GroES complex
P	0000287	molecular_function	magnesium ion binding
P	0005515	molecular_function	protein binding
P	0005524	molecular_function	ATP binding
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0006457	biological_process	protein folding
P	0009314	biological_process	response to radiation
P	0009408	biological_process	response to heat
P	0016020	cellular_component	membrane
P	0016853	molecular_function	isomerase activity
P	0016887	molecular_function	ATP hydrolysis activity
P	0019068	biological_process	virion assembly
P	0042026	biological_process	protein refolding
P	0042802	molecular_function	identical protein binding
P	0051082	molecular_function	unfolded protein binding
P	0051085	biological_process	chaperone cofactor-dependent protein refolding
P	0140662	molecular_function	ATP-dependent protein folding chaperone
P	1990220	cellular_component	GroEL-GroES complex
Q	0005515	molecular_function	protein binding
Q	0005524	molecular_function	ATP binding
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0006457	biological_process	protein folding
Q	0009408	biological_process	response to heat
Q	0019068	biological_process	virion assembly
Q	0042802	molecular_function	identical protein binding
Q	0044183	molecular_function	protein folding chaperone
Q	0046872	molecular_function	metal ion binding
Q	0051082	molecular_function	unfolded protein binding
Q	0051085	biological_process	chaperone cofactor-dependent protein refolding
Q	0051087	molecular_function	protein-folding chaperone binding
Q	1990220	cellular_component	GroEL-GroES complex
R	0000287	molecular_function	magnesium ion binding
R	0005515	molecular_function	protein binding
R	0005524	molecular_function	ATP binding
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0006457	biological_process	protein folding
R	0009314	biological_process	response to radiation
R	0009408	biological_process	response to heat
R	0016020	cellular_component	membrane
R	0016853	molecular_function	isomerase activity
R	0016887	molecular_function	ATP hydrolysis activity
R	0019068	biological_process	virion assembly
R	0042026	biological_process	protein refolding
R	0042802	molecular_function	identical protein binding
R	0051082	molecular_function	unfolded protein binding
R	0051085	biological_process	chaperone cofactor-dependent protein refolding
R	0140662	molecular_function	ATP-dependent protein folding chaperone
R	1990220	cellular_component	GroEL-GroES complex
S	0000287	molecular_function	magnesium ion binding
S	0005515	molecular_function	protein binding
S	0005524	molecular_function	ATP binding
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0006457	biological_process	protein folding
S	0009314	biological_process	response to radiation
S	0009408	biological_process	response to heat
S	0016020	cellular_component	membrane
S	0016853	molecular_function	isomerase activity
S	0016887	molecular_function	ATP hydrolysis activity
S	0019068	biological_process	virion assembly
S	0042026	biological_process	protein refolding
S	0042802	molecular_function	identical protein binding
S	0051082	molecular_function	unfolded protein binding
S	0051085	biological_process	chaperone cofactor-dependent protein refolding
S	0140662	molecular_function	ATP-dependent protein folding chaperone
S	1990220	cellular_component	GroEL-GroES complex
T	0005515	molecular_function	protein binding
T	0005524	molecular_function	ATP binding
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0006457	biological_process	protein folding
T	0009408	biological_process	response to heat
T	0019068	biological_process	virion assembly
T	0042802	molecular_function	identical protein binding
T	0044183	molecular_function	protein folding chaperone
T	0046872	molecular_function	metal ion binding
T	0051082	molecular_function	unfolded protein binding
T	0051085	biological_process	chaperone cofactor-dependent protein refolding
T	0051087	molecular_function	protein-folding chaperone binding
T	1990220	cellular_component	GroEL-GroES complex
W	0005515	molecular_function	protein binding
W	0005524	molecular_function	ATP binding
W	0005737	cellular_component	cytoplasm
W	0005829	cellular_component	cytosol
W	0006457	biological_process	protein folding
W	0009408	biological_process	response to heat
W	0019068	biological_process	virion assembly
W	0042802	molecular_function	identical protein binding
W	0044183	molecular_function	protein folding chaperone
W	0046872	molecular_function	metal ion binding
W	0051082	molecular_function	unfolded protein binding
W	0051085	biological_process	chaperone cofactor-dependent protein refolding
W	0051087	molecular_function	protein-folding chaperone binding
W	1990220	cellular_component	GroEL-GroES complex

Functional Information from PROSITE/UniProt

site_id	PS00296
Number of Residues	12
Details	CHAPERONINS_CPN60 Chaperonins cpn60 signature. AAVEEGVVaGGG

Chain	Residue	Details
C	ALA405-GLY416

site_id	PS00681
Number of Residues	25
Details	CHAPERONINS_CPN10 Chaperonins cpn10 signature. IrPLhDRVIVKrkevetksaGgIVL

Chain	Residue	Details
W	ILE3-LEU27

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	MOD_RES: N6-succinyllysine => ECO:0000269\|PubMed:21151122

Chain	Residue	Details
W	LYS34
I	ASP495
A	THR30
A	ASP87
A	GLY415
A	ASN479
A	ASP495
B	THR30
B	ASP87
B	GLY415
B	ASN479
D	LYS34
B	ASP495
E	THR30
E	ASP87
E	GLY415
E	ASN479
E	ASP495
F	THR30
F	ASP87
F	GLY415
F	ASN479
G	LYS34
F	ASP495
H	THR30
H	ASP87
H	GLY415
H	ASN479
H	ASP495
J	THR30
J	ASP87
J	GLY415
J	ASN479
K	LYS34
J	ASP495
L	THR30
L	ASP87
L	GLY415
L	ASN479
L	ASP495
M	THR30
M	ASP87
M	GLY415
M	ASN479
N	LYS34
M	ASP495
O	THR30
O	ASP87
O	GLY415
O	ASN479
O	ASP495
P	THR30
P	ASP87
P	GLY415
P	ASN479
Q	LYS34
P	ASP495
R	THR30
R	ASP87
R	GLY415
R	ASN479
R	ASP495
S	THR30
S	ASP87
S	GLY415
S	ASN479
T	LYS34
S	ASP495
I	GLY415
I	ASN479

site_id	SWS_FT_FI2
Number of Residues	14
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00600, ECO:0000269\|PubMed:25174333, ECO:0000305\|PubMed:14517228, ECO:0000305\|PubMed:9285585, ECO:0007744\|PDB:1AON, ECO:0007744\|PDB:1PF9, ECO:0007744\|PDB:3WVL

Chain	Residue	Details
C	LYS51
M	LYS51
O	LYS51
P	LYS51
R	LYS51
S	LYS51
I	LYS51
A	LYS51
B	LYS51
E	LYS51
F	LYS51
H	LYS51
J	LYS51
L	LYS51

site_id	SWS_FT_FI3
Number of Residues	70
Details	MOD_RES: N6-succinyllysine => ECO:0000269\|PubMed:21151122

Chain	Residue	Details
C	LYS34
I	LYS390
A	LYS34
A	LYS51
A	LYS277
A	LYS321
A	LYS390
B	LYS34
B	LYS51
B	LYS277
B	LYS321
C	LYS51
B	LYS390
E	LYS34
E	LYS51
E	LYS277
E	LYS321
E	LYS390
F	LYS34
F	LYS51
F	LYS277
F	LYS321
C	LYS277
F	LYS390
H	LYS34
H	LYS51
H	LYS277
H	LYS321
H	LYS390
J	LYS34
J	LYS51
J	LYS277
J	LYS321
C	LYS321
J	LYS390
L	LYS34
L	LYS51
L	LYS277
L	LYS321
L	LYS390
M	LYS34
M	LYS51
M	LYS277
M	LYS321
C	LYS390
M	LYS390
O	LYS34
O	LYS51
O	LYS277
O	LYS321
O	LYS390
P	LYS34
P	LYS51
P	LYS277
P	LYS321
I	LYS34
P	LYS390
R	LYS34
R	LYS51
R	LYS277
R	LYS321
R	LYS390
S	LYS34
S	LYS51
S	LYS277
S	LYS321
I	LYS51
S	LYS390
I	LYS277
I	LYS321

site_id	SWS_FT_FI4
Number of Residues	14
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269\|PubMed:21151122

Chain	Residue	Details
C	LYS117
M	LYS117
O	LYS117
P	LYS117
R	LYS117
S	LYS117
I	LYS117
A	LYS117
B	LYS117
E	LYS117
F	LYS117
H	LYS117
J	LYS117
L	LYS117

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)