8BI6

Crystal structure of human Choline Kinase A in complex with UNC0638

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004103	molecular_function	choline kinase activity
A	0004104	molecular_function	cholinesterase activity
A	0004305	molecular_function	ethanolamine kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005811	cellular_component	lipid droplet
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006646	biological_process	phosphatidylethanolamine biosynthetic process
A	0006656	biological_process	phosphatidylcholine biosynthetic process
A	0006657	biological_process	CDP-choline pathway
A	0006869	biological_process	lipid transport
A	0008654	biological_process	phospholipid biosynthetic process
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
B	0004103	molecular_function	choline kinase activity
B	0004104	molecular_function	cholinesterase activity
B	0004305	molecular_function	ethanolamine kinase activity
B	0004713	molecular_function	protein tyrosine kinase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005811	cellular_component	lipid droplet
B	0005829	cellular_component	cytosol
B	0006629	biological_process	lipid metabolic process
B	0006646	biological_process	phosphatidylethanolamine biosynthetic process
B	0006656	biological_process	phosphatidylcholine biosynthetic process
B	0006657	biological_process	CDP-choline pathway
B	0006869	biological_process	lipid transport
B	0008654	biological_process	phospholipid biosynthetic process
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:17007874, ECO:0000269|PubMed:20299452, ECO:0007744|PDB:2CKP, ECO:0007744|PDB:3G15

Chain	Residue	Details
A	ARG117
A	ARG146
A	GLN207
A	ASP330
B	ARG117
B	ARG146
B	GLN207
B	ASP330

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:17007874, ECO:0007744|PDB:2CKQ

Chain	Residue	Details
A	GLY119
B	GLY119

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
A	GLN308
B	GLN308

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:34077757

Chain	Residue	Details
A	LYS247
B	LYS247

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site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:34077757

Chain	Residue	Details
A	SER279
B	SER279

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