8BI5

Crystal structure of human Choline Kinase A in complex with UNC0737

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004103	molecular_function	choline kinase activity
A	0004305	molecular_function	ethanolamine kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005811	cellular_component	lipid droplet
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006646	biological_process	phosphatidylethanolamine biosynthetic process
A	0006656	biological_process	phosphatidylcholine biosynthetic process
A	0006657	biological_process	CDP-choline pathway
A	0006869	biological_process	lipid transport
A	0008654	biological_process	phospholipid biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
B	0000166	molecular_function	nucleotide binding
B	0004103	molecular_function	choline kinase activity
B	0004305	molecular_function	ethanolamine kinase activity
B	0004713	molecular_function	protein tyrosine kinase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005811	cellular_component	lipid droplet
B	0005829	cellular_component	cytosol
B	0006629	biological_process	lipid metabolic process
B	0006646	biological_process	phosphatidylethanolamine biosynthetic process
B	0006656	biological_process	phosphatidylcholine biosynthetic process
B	0006657	biological_process	CDP-choline pathway
B	0006869	biological_process	lipid transport
B	0008654	biological_process	phospholipid biosynthetic process
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17007874","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20299452","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2CKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3G15","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17007874","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2CKQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"34077757","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"34077757","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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