8BH3

DNA-PK Ku80 mediated dimer bound to PAXX

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000460	biological_process	maturation of 5.8S rRNA
A	0000723	biological_process	telomere maintenance
A	0000724	biological_process	double-strand break repair via homologous recombination
A	0000781	cellular_component	chromosome, telomeric region
A	0000785	cellular_component	chromatin
A	0001756	biological_process	somitogenesis
A	0001933	biological_process	negative regulation of protein phosphorylation
A	0002218	biological_process	activation of innate immune response
A	0002326	biological_process	B cell lineage commitment
A	0002327	biological_process	immature B cell differentiation
A	0002328	biological_process	pro-B cell differentiation
A	0002360	biological_process	T cell lineage commitment
A	0002376	biological_process	immune system process
A	0003677	molecular_function	DNA binding
A	0003690	molecular_function	double-stranded DNA binding
A	0003723	molecular_function	RNA binding
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004677	molecular_function	DNA-dependent protein kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005667	cellular_component	transcription regulator complex
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
A	0006281	biological_process	DNA repair
A	0006302	biological_process	double-strand break repair
A	0006303	biological_process	double-strand break repair via nonhomologous end joining
A	0006310	biological_process	DNA recombination
A	0006468	biological_process	protein phosphorylation
A	0006974	biological_process	DNA damage response
A	0007420	biological_process	brain development
A	0007507	biological_process	heart development
A	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
A	0010212	biological_process	response to ionizing radiation
A	0010332	biological_process	response to gamma radiation
A	0016020	cellular_component	membrane
A	0016233	biological_process	telomere capping
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0018105	biological_process	peptidyl-serine phosphorylation
A	0018107	biological_process	peptidyl-threonine phosphorylation
A	0019899	molecular_function	enzyme binding
A	0019904	molecular_function	protein domain specific binding
A	0030098	biological_process	lymphocyte differentiation
A	0031297	biological_process	replication fork processing
A	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
A	0031648	biological_process	protein destabilization
A	0032040	cellular_component	small-subunit processome
A	0032869	biological_process	cellular response to insulin stimulus
A	0032991	cellular_component	protein-containing complex
A	0032993	cellular_component	protein-DNA complex
A	0033077	biological_process	T cell differentiation in thymus
A	0033151	biological_process	V(D)J recombination
A	0033152	biological_process	immunoglobulin V(D)J recombination
A	0033153	biological_process	T cell receptor V(D)J recombination
A	0034462	biological_process	small-subunit processome assembly
A	0034511	molecular_function	U3 snoRNA binding
A	0035234	biological_process	ectopic germ cell programmed cell death
A	0035979	molecular_function	histone H2AXS139 kinase activity
A	0036211	biological_process	protein modification process
A	0042254	biological_process	ribosome biogenesis
A	0042752	biological_process	regulation of circadian rhythm
A	0043065	biological_process	positive regulation of apoptotic process
A	0043066	biological_process	negative regulation of apoptotic process
A	0045087	biological_process	innate immune response
A	0045621	biological_process	positive regulation of lymphocyte differentiation
A	0045648	biological_process	positive regulation of erythrocyte differentiation
A	0045727	biological_process	positive regulation of translation
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0048511	biological_process	rhythmic process
A	0048660	biological_process	regulation of smooth muscle cell proliferation
A	0050678	biological_process	regulation of epithelial cell proliferation
A	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
A	0070418	cellular_component	DNA-dependent protein kinase complex
A	0070419	cellular_component	nonhomologous end joining complex
A	0071168	biological_process	protein localization to chromatin
A	0080135	biological_process	regulation of cellular response to stress
A	0097681	biological_process	double-strand break repair via alternative nonhomologous end joining
A	0106310	molecular_function	protein serine kinase activity
A	0140861	biological_process	DNA repair-dependent chromatin remodeling
A	0140896	biological_process	cGAS/STING signaling pathway
A	0160049	biological_process	negative regulation of cGAS/STING signaling pathway
A	1902036	biological_process	regulation of hematopoietic stem cell differentiation
A	1905221	biological_process	positive regulation of platelet formation
A	2001034	biological_process	positive regulation of double-strand break repair via nonhomologous end joining
B	0000166	molecular_function	nucleotide binding
B	0000723	biological_process	telomere maintenance
B	0000725	biological_process	recombinational repair
B	0000781	cellular_component	chromosome, telomeric region
B	0000783	cellular_component	nuclear telomere cap complex
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0002218	biological_process	activation of innate immune response
B	0002376	biological_process	immune system process
B	0002684	biological_process	positive regulation of immune system process
B	0003677	molecular_function	DNA binding
B	0003678	molecular_function	DNA helicase activity
B	0003684	molecular_function	damaged DNA binding
B	0003690	molecular_function	double-stranded DNA binding
B	0003691	molecular_function	double-stranded telomeric DNA binding
B	0003723	molecular_function	RNA binding
B	0003824	molecular_function	catalytic activity
B	0004386	molecular_function	helicase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005667	cellular_component	transcription regulator complex
B	0005694	cellular_component	chromosome
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
B	0006281	biological_process	DNA repair
B	0006303	biological_process	double-strand break repair via nonhomologous end joining
B	0006310	biological_process	DNA recombination
B	0006974	biological_process	DNA damage response
B	0008094	molecular_function	ATP-dependent activity, acting on DNA
B	0010212	biological_process	response to ionizing radiation
B	0010558	biological_process	negative regulation of macromolecule biosynthetic process
B	0016020	cellular_component	membrane
B	0016787	molecular_function	hydrolase activity
B	0016829	molecular_function	lyase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0030332	molecular_function	cyclin binding
B	0032991	cellular_component	protein-containing complex
B	0032993	cellular_component	protein-DNA complex
B	0034774	cellular_component	secretory granule lumen
B	0042162	molecular_function	telomeric DNA binding
B	0043564	cellular_component	Ku70:Ku80 complex
B	0044877	molecular_function	protein-containing complex binding
B	0045027	molecular_function	DNA end binding
B	0045087	biological_process	innate immune response
B	0045621	biological_process	positive regulation of lymphocyte differentiation
B	0045860	biological_process	positive regulation of protein kinase activity
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0048660	biological_process	regulation of smooth muscle cell proliferation
B	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
B	0070418	cellular_component	DNA-dependent protein kinase complex
B	0070419	cellular_component	nonhomologous end joining complex
B	0071475	biological_process	cellular hyperosmotic salinity response
B	0071480	biological_process	cellular response to gamma radiation
B	0071481	biological_process	cellular response to X-ray
B	0097110	molecular_function	scaffold protein binding
B	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
B	1904813	cellular_component	ficolin-1-rich granule lumen
C	0000166	molecular_function	nucleotide binding
C	0000723	biological_process	telomere maintenance
C	0000725	biological_process	recombinational repair
C	0000781	cellular_component	chromosome, telomeric region
C	0000783	cellular_component	nuclear telomere cap complex
C	0000976	molecular_function	transcription cis-regulatory region binding
C	0002218	biological_process	activation of innate immune response
C	0002376	biological_process	immune system process
C	0003677	molecular_function	DNA binding
C	0003678	molecular_function	DNA helicase activity
C	0003684	molecular_function	damaged DNA binding
C	0003690	molecular_function	double-stranded DNA binding
C	0003691	molecular_function	double-stranded telomeric DNA binding
C	0003723	molecular_function	RNA binding
C	0004386	molecular_function	helicase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005694	cellular_component	chromosome
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
C	0006281	biological_process	DNA repair
C	0006302	biological_process	double-strand break repair
C	0006303	biological_process	double-strand break repair via nonhomologous end joining
C	0006310	biological_process	DNA recombination
C	0006974	biological_process	DNA damage response
C	0007004	biological_process	telomere maintenance via telomerase
C	0008047	molecular_function	enzyme activator activity
C	0008094	molecular_function	ATP-dependent activity, acting on DNA
C	0010558	biological_process	negative regulation of macromolecule biosynthetic process
C	0016020	cellular_component	membrane
C	0016787	molecular_function	hydrolase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0022008	biological_process	neurogenesis
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0032040	cellular_component	small-subunit processome
C	0032204	biological_process	regulation of telomere maintenance
C	0032991	cellular_component	protein-containing complex
C	0032993	cellular_component	protein-DNA complex
C	0034462	biological_process	small-subunit processome assembly
C	0034511	molecular_function	U3 snoRNA binding
C	0034774	cellular_component	secretory granule lumen
C	0042162	molecular_function	telomeric DNA binding
C	0042254	biological_process	ribosome biogenesis
C	0043564	cellular_component	Ku70:Ku80 complex
C	0044877	molecular_function	protein-containing complex binding
C	0045027	molecular_function	DNA end binding
C	0045087	biological_process	innate immune response
C	0045860	biological_process	positive regulation of protein kinase activity
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0048660	biological_process	regulation of smooth muscle cell proliferation
C	0050769	biological_process	positive regulation of neurogenesis
C	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
C	0060218	biological_process	hematopoietic stem cell differentiation
C	0070198	biological_process	protein localization to chromosome, telomeric region
C	0070418	cellular_component	DNA-dependent protein kinase complex
C	0070419	cellular_component	nonhomologous end joining complex
C	0071425	biological_process	hematopoietic stem cell proliferation
C	0071480	biological_process	cellular response to gamma radiation
C	0090734	cellular_component	site of DNA damage
C	1904430	biological_process	negative regulation of t-circle formation
C	1990830	biological_process	cellular response to leukemia inhibitory factor
C	1990904	cellular_component	ribonucleoprotein complex
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005694	cellular_component	chromosome
D	0005737	cellular_component	cytoplasm
D	0006281	biological_process	DNA repair
D	0006303	biological_process	double-strand break repair via nonhomologous end joining
D	0006974	biological_process	DNA damage response
D	0035861	cellular_component	site of double-strand break
D	0042803	molecular_function	protein homodimerization activity
D	0043564	cellular_component	Ku70:Ku80 complex
D	0060090	molecular_function	molecular adaptor activity
D	0070182	molecular_function	DNA polymerase binding
D	0070419	cellular_component	nonhomologous end joining complex
G	0000793	cellular_component	condensed chromosome
G	0003677	molecular_function	DNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005694	cellular_component	chromosome
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
G	0006281	biological_process	DNA repair
G	0006284	biological_process	base-excision repair
G	0006302	biological_process	double-strand break repair
G	0006303	biological_process	double-strand break repair via nonhomologous end joining
G	0006310	biological_process	DNA recombination
G	0006974	biological_process	DNA damage response
G	0010165	biological_process	response to X-ray
G	0016874	molecular_function	ligase activity
G	0019899	molecular_function	enzyme binding
G	0032807	cellular_component	DNA ligase IV complex
G	0033152	biological_process	immunoglobulin V(D)J recombination
G	0035861	cellular_component	site of double-strand break
G	0042802	molecular_function	identical protein binding
G	0051351	biological_process	positive regulation of ligase activity
G	0070419	cellular_component	nonhomologous end joining complex
G	0070975	molecular_function	FHA domain binding
G	0071285	biological_process	cellular response to lithium ion
G	1990166	biological_process	protein localization to site of double-strand break
H	0000793	cellular_component	condensed chromosome
H	0003677	molecular_function	DNA binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005694	cellular_component	chromosome
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
H	0006281	biological_process	DNA repair
H	0006284	biological_process	base-excision repair
H	0006302	biological_process	double-strand break repair
H	0006303	biological_process	double-strand break repair via nonhomologous end joining
H	0006310	biological_process	DNA recombination
H	0006974	biological_process	DNA damage response
H	0010165	biological_process	response to X-ray
H	0016874	molecular_function	ligase activity
H	0019899	molecular_function	enzyme binding
H	0032807	cellular_component	DNA ligase IV complex
H	0033152	biological_process	immunoglobulin V(D)J recombination
H	0035861	cellular_component	site of double-strand break
H	0042802	molecular_function	identical protein binding
H	0051351	biological_process	positive regulation of ligase activity
H	0070419	cellular_component	nonhomologous end joining complex
H	0070975	molecular_function	FHA domain binding
H	0071285	biological_process	cellular response to lithium ion
H	1990166	biological_process	protein localization to site of double-strand break
I	0000012	biological_process	single strand break repair
I	0000166	molecular_function	nucleotide binding
I	0000287	molecular_function	magnesium ion binding
I	0000781	cellular_component	chromosome, telomeric region
I	0000793	cellular_component	condensed chromosome
I	0001701	biological_process	in utero embryonic development
I	0002328	biological_process	pro-B cell differentiation
I	0003677	molecular_function	DNA binding
I	0003909	molecular_function	DNA ligase activity
I	0003910	molecular_function	DNA ligase (ATP) activity
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
I	0006281	biological_process	DNA repair
I	0006284	biological_process	base-excision repair
I	0006297	biological_process	nucleotide-excision repair, DNA gap filling
I	0006302	biological_process	double-strand break repair
I	0006303	biological_process	double-strand break repair via nonhomologous end joining
I	0006310	biological_process	DNA recombination
I	0006974	biological_process	DNA damage response
I	0007417	biological_process	central nervous system development
I	0008283	biological_process	cell population proliferation
I	0010165	biological_process	response to X-ray
I	0010212	biological_process	response to ionizing radiation
I	0010332	biological_process	response to gamma radiation
I	0016208	molecular_function	AMP binding
I	0016874	molecular_function	ligase activity
I	0022008	biological_process	neurogenesis
I	0032807	cellular_component	DNA ligase IV complex
I	0033077	biological_process	T cell differentiation in thymus
I	0033151	biological_process	V(D)J recombination
I	0033152	biological_process	immunoglobulin V(D)J recombination
I	0033153	biological_process	T cell receptor V(D)J recombination
I	0035019	biological_process	somatic stem cell population maintenance
I	0043524	biological_process	negative regulation of neuron apoptotic process
I	0045190	biological_process	isotype switching
I	0046872	molecular_function	metal ion binding
I	0048144	biological_process	fibroblast proliferation
I	0048146	biological_process	positive regulation of fibroblast proliferation
I	0050769	biological_process	positive regulation of neurogenesis
I	0051276	biological_process	chromosome organization
I	0051301	biological_process	cell division
I	0051402	biological_process	neuron apoptotic process
I	0070419	cellular_component	nonhomologous end joining complex
I	0071285	biological_process	cellular response to lithium ion
I	0071479	biological_process	cellular response to ionizing radiation
I	0071897	biological_process	DNA biosynthetic process
I	0072089	biological_process	stem cell proliferation
I	0075713	biological_process	establishment of integrated proviral latency
I	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
I	1904155	biological_process	DN2 thymocyte differentiation
I	2001252	biological_process	positive regulation of chromosome organization
L	0000166	molecular_function	nucleotide binding
L	0000723	biological_process	telomere maintenance
L	0000725	biological_process	recombinational repair
L	0000781	cellular_component	chromosome, telomeric region
L	0000783	cellular_component	nuclear telomere cap complex
L	0000976	molecular_function	transcription cis-regulatory region binding
L	0002218	biological_process	activation of innate immune response
L	0002376	biological_process	immune system process
L	0003677	molecular_function	DNA binding
L	0003678	molecular_function	DNA helicase activity
L	0003684	molecular_function	damaged DNA binding
L	0003690	molecular_function	double-stranded DNA binding
L	0003691	molecular_function	double-stranded telomeric DNA binding
L	0003723	molecular_function	RNA binding
L	0004386	molecular_function	helicase activity
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0005576	cellular_component	extracellular region
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005694	cellular_component	chromosome
L	0005730	cellular_component	nucleolus
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005886	cellular_component	plasma membrane
L	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
L	0006281	biological_process	DNA repair
L	0006302	biological_process	double-strand break repair
L	0006303	biological_process	double-strand break repair via nonhomologous end joining
L	0006310	biological_process	DNA recombination
L	0006974	biological_process	DNA damage response
L	0007004	biological_process	telomere maintenance via telomerase
L	0008047	molecular_function	enzyme activator activity
L	0008094	molecular_function	ATP-dependent activity, acting on DNA
L	0010558	biological_process	negative regulation of macromolecule biosynthetic process
L	0016020	cellular_component	membrane
L	0016787	molecular_function	hydrolase activity
L	0016887	molecular_function	ATP hydrolysis activity
L	0022008	biological_process	neurogenesis
L	0031625	molecular_function	ubiquitin protein ligase binding
L	0032040	cellular_component	small-subunit processome
L	0032204	biological_process	regulation of telomere maintenance
L	0032991	cellular_component	protein-containing complex
L	0032993	cellular_component	protein-DNA complex
L	0034462	biological_process	small-subunit processome assembly
L	0034511	molecular_function	U3 snoRNA binding
L	0034774	cellular_component	secretory granule lumen
L	0042162	molecular_function	telomeric DNA binding
L	0042254	biological_process	ribosome biogenesis
L	0043564	cellular_component	Ku70:Ku80 complex
L	0044877	molecular_function	protein-containing complex binding
L	0045027	molecular_function	DNA end binding
L	0045087	biological_process	innate immune response
L	0045860	biological_process	positive regulation of protein kinase activity
L	0045892	biological_process	negative regulation of DNA-templated transcription
L	0048660	biological_process	regulation of smooth muscle cell proliferation
L	0050769	biological_process	positive regulation of neurogenesis
L	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
L	0060218	biological_process	hematopoietic stem cell differentiation
L	0070198	biological_process	protein localization to chromosome, telomeric region
L	0070418	cellular_component	DNA-dependent protein kinase complex
L	0070419	cellular_component	nonhomologous end joining complex
L	0071425	biological_process	hematopoietic stem cell proliferation
L	0071480	biological_process	cellular response to gamma radiation
L	0090734	cellular_component	site of DNA damage
L	1904430	biological_process	negative regulation of t-circle formation
L	1990830	biological_process	cellular response to leukemia inhibitory factor
L	1990904	cellular_component	ribonucleoprotein complex
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005694	cellular_component	chromosome
M	0005737	cellular_component	cytoplasm
M	0006281	biological_process	DNA repair
M	0006303	biological_process	double-strand break repair via nonhomologous end joining
M	0006974	biological_process	DNA damage response
M	0035861	cellular_component	site of double-strand break
M	0042803	molecular_function	protein homodimerization activity
M	0043564	cellular_component	Ku70:Ku80 complex
M	0060090	molecular_function	molecular adaptor activity
M	0070182	molecular_function	DNA polymerase binding
M	0070419	cellular_component	nonhomologous end joining complex
P	0000793	cellular_component	condensed chromosome
P	0003677	molecular_function	DNA binding
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005694	cellular_component	chromosome
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
P	0006281	biological_process	DNA repair
P	0006284	biological_process	base-excision repair
P	0006302	biological_process	double-strand break repair
P	0006303	biological_process	double-strand break repair via nonhomologous end joining
P	0006310	biological_process	DNA recombination
P	0006974	biological_process	DNA damage response
P	0010165	biological_process	response to X-ray
P	0016874	molecular_function	ligase activity
P	0019899	molecular_function	enzyme binding
P	0032807	cellular_component	DNA ligase IV complex
P	0033152	biological_process	immunoglobulin V(D)J recombination
P	0035861	cellular_component	site of double-strand break
P	0042802	molecular_function	identical protein binding
P	0051351	biological_process	positive regulation of ligase activity
P	0070419	cellular_component	nonhomologous end joining complex
P	0070975	molecular_function	FHA domain binding
P	0071285	biological_process	cellular response to lithium ion
P	1990166	biological_process	protein localization to site of double-strand break
Q	0000793	cellular_component	condensed chromosome
Q	0003677	molecular_function	DNA binding
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005694	cellular_component	chromosome
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
Q	0006281	biological_process	DNA repair
Q	0006284	biological_process	base-excision repair
Q	0006302	biological_process	double-strand break repair
Q	0006303	biological_process	double-strand break repair via nonhomologous end joining
Q	0006310	biological_process	DNA recombination
Q	0006974	biological_process	DNA damage response
Q	0010165	biological_process	response to X-ray
Q	0016874	molecular_function	ligase activity
Q	0019899	molecular_function	enzyme binding
Q	0032807	cellular_component	DNA ligase IV complex
Q	0033152	biological_process	immunoglobulin V(D)J recombination
Q	0035861	cellular_component	site of double-strand break
Q	0042802	molecular_function	identical protein binding
Q	0051351	biological_process	positive regulation of ligase activity
Q	0070419	cellular_component	nonhomologous end joining complex
Q	0070975	molecular_function	FHA domain binding
Q	0071285	biological_process	cellular response to lithium ion
Q	1990166	biological_process	protein localization to site of double-strand break
R	0000012	biological_process	single strand break repair
R	0000166	molecular_function	nucleotide binding
R	0000287	molecular_function	magnesium ion binding
R	0000781	cellular_component	chromosome, telomeric region
R	0000793	cellular_component	condensed chromosome
R	0001701	biological_process	in utero embryonic development
R	0002328	biological_process	pro-B cell differentiation
R	0003677	molecular_function	DNA binding
R	0003909	molecular_function	DNA ligase activity
R	0003910	molecular_function	DNA ligase (ATP) activity
R	0005515	molecular_function	protein binding
R	0005524	molecular_function	ATP binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
R	0006281	biological_process	DNA repair
R	0006284	biological_process	base-excision repair
R	0006297	biological_process	nucleotide-excision repair, DNA gap filling
R	0006302	biological_process	double-strand break repair
R	0006303	biological_process	double-strand break repair via nonhomologous end joining
R	0006310	biological_process	DNA recombination
R	0006974	biological_process	DNA damage response
R	0007417	biological_process	central nervous system development
R	0008283	biological_process	cell population proliferation
R	0010165	biological_process	response to X-ray
R	0010212	biological_process	response to ionizing radiation
R	0010332	biological_process	response to gamma radiation
R	0016208	molecular_function	AMP binding
R	0016874	molecular_function	ligase activity
R	0022008	biological_process	neurogenesis
R	0032807	cellular_component	DNA ligase IV complex
R	0033077	biological_process	T cell differentiation in thymus
R	0033151	biological_process	V(D)J recombination
R	0033152	biological_process	immunoglobulin V(D)J recombination
R	0033153	biological_process	T cell receptor V(D)J recombination
R	0035019	biological_process	somatic stem cell population maintenance
R	0043524	biological_process	negative regulation of neuron apoptotic process
R	0045190	biological_process	isotype switching
R	0046872	molecular_function	metal ion binding
R	0048144	biological_process	fibroblast proliferation
R	0048146	biological_process	positive regulation of fibroblast proliferation
R	0050769	biological_process	positive regulation of neurogenesis
R	0051276	biological_process	chromosome organization
R	0051301	biological_process	cell division
R	0051402	biological_process	neuron apoptotic process
R	0070419	cellular_component	nonhomologous end joining complex
R	0071285	biological_process	cellular response to lithium ion
R	0071479	biological_process	cellular response to ionizing radiation
R	0071897	biological_process	DNA biosynthetic process
R	0072089	biological_process	stem cell proliferation
R	0075713	biological_process	establishment of integrated proviral latency
R	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
R	1904155	biological_process	DN2 thymocyte differentiation
R	2001252	biological_process	positive regulation of chromosome organization
S	0000166	molecular_function	nucleotide binding
S	0000460	biological_process	maturation of 5.8S rRNA
S	0000723	biological_process	telomere maintenance
S	0000724	biological_process	double-strand break repair via homologous recombination
S	0000781	cellular_component	chromosome, telomeric region
S	0000785	cellular_component	chromatin
S	0001756	biological_process	somitogenesis
S	0001933	biological_process	negative regulation of protein phosphorylation
S	0002218	biological_process	activation of innate immune response
S	0002326	biological_process	B cell lineage commitment
S	0002327	biological_process	immature B cell differentiation
S	0002328	biological_process	pro-B cell differentiation
S	0002360	biological_process	T cell lineage commitment
S	0002376	biological_process	immune system process
S	0003677	molecular_function	DNA binding
S	0003690	molecular_function	double-stranded DNA binding
S	0003723	molecular_function	RNA binding
S	0004672	molecular_function	protein kinase activity
S	0004674	molecular_function	protein serine/threonine kinase activity
S	0004677	molecular_function	DNA-dependent protein kinase activity
S	0005515	molecular_function	protein binding
S	0005524	molecular_function	ATP binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005667	cellular_component	transcription regulator complex
S	0005730	cellular_component	nucleolus
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
S	0006281	biological_process	DNA repair
S	0006302	biological_process	double-strand break repair
S	0006303	biological_process	double-strand break repair via nonhomologous end joining
S	0006310	biological_process	DNA recombination
S	0006468	biological_process	protein phosphorylation
S	0006974	biological_process	DNA damage response
S	0007420	biological_process	brain development
S	0007507	biological_process	heart development
S	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
S	0010212	biological_process	response to ionizing radiation
S	0010332	biological_process	response to gamma radiation
S	0016020	cellular_component	membrane
S	0016233	biological_process	telomere capping
S	0016301	molecular_function	kinase activity
S	0016740	molecular_function	transferase activity
S	0018105	biological_process	peptidyl-serine phosphorylation
S	0018107	biological_process	peptidyl-threonine phosphorylation
S	0019899	molecular_function	enzyme binding
S	0019904	molecular_function	protein domain specific binding
S	0030098	biological_process	lymphocyte differentiation
S	0031297	biological_process	replication fork processing
S	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
S	0031648	biological_process	protein destabilization
S	0032040	cellular_component	small-subunit processome
S	0032869	biological_process	cellular response to insulin stimulus
S	0032991	cellular_component	protein-containing complex
S	0032993	cellular_component	protein-DNA complex
S	0033077	biological_process	T cell differentiation in thymus
S	0033151	biological_process	V(D)J recombination
S	0033152	biological_process	immunoglobulin V(D)J recombination
S	0033153	biological_process	T cell receptor V(D)J recombination
S	0034462	biological_process	small-subunit processome assembly
S	0034511	molecular_function	U3 snoRNA binding
S	0035234	biological_process	ectopic germ cell programmed cell death
S	0035979	molecular_function	histone H2AXS139 kinase activity
S	0036211	biological_process	protein modification process
S	0042254	biological_process	ribosome biogenesis
S	0042752	biological_process	regulation of circadian rhythm
S	0043065	biological_process	positive regulation of apoptotic process
S	0043066	biological_process	negative regulation of apoptotic process
S	0045087	biological_process	innate immune response
S	0045621	biological_process	positive regulation of lymphocyte differentiation
S	0045648	biological_process	positive regulation of erythrocyte differentiation
S	0045727	biological_process	positive regulation of translation
S	0045944	biological_process	positive regulation of transcription by RNA polymerase II
S	0048511	biological_process	rhythmic process
S	0048660	biological_process	regulation of smooth muscle cell proliferation
S	0050678	biological_process	regulation of epithelial cell proliferation
S	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
S	0070418	cellular_component	DNA-dependent protein kinase complex
S	0070419	cellular_component	nonhomologous end joining complex
S	0071168	biological_process	protein localization to chromatin
S	0080135	biological_process	regulation of cellular response to stress
S	0097681	biological_process	double-strand break repair via alternative nonhomologous end joining
S	0106310	molecular_function	protein serine kinase activity
S	0140861	biological_process	DNA repair-dependent chromatin remodeling
S	0140896	biological_process	cGAS/STING signaling pathway
S	0160049	biological_process	negative regulation of cGAS/STING signaling pathway
S	1902036	biological_process	regulation of hematopoietic stem cell differentiation
S	1905221	biological_process	positive regulation of platelet formation
S	2001034	biological_process	positive regulation of double-strand break repair via nonhomologous end joining
T	0000166	molecular_function	nucleotide binding
T	0000723	biological_process	telomere maintenance
T	0000725	biological_process	recombinational repair
T	0000781	cellular_component	chromosome, telomeric region
T	0000783	cellular_component	nuclear telomere cap complex
T	0000976	molecular_function	transcription cis-regulatory region binding
T	0002218	biological_process	activation of innate immune response
T	0002376	biological_process	immune system process
T	0002684	biological_process	positive regulation of immune system process
T	0003677	molecular_function	DNA binding
T	0003678	molecular_function	DNA helicase activity
T	0003684	molecular_function	damaged DNA binding
T	0003690	molecular_function	double-stranded DNA binding
T	0003691	molecular_function	double-stranded telomeric DNA binding
T	0003723	molecular_function	RNA binding
T	0003824	molecular_function	catalytic activity
T	0004386	molecular_function	helicase activity
T	0005515	molecular_function	protein binding
T	0005524	molecular_function	ATP binding
T	0005576	cellular_component	extracellular region
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005667	cellular_component	transcription regulator complex
T	0005694	cellular_component	chromosome
T	0005730	cellular_component	nucleolus
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
T	0006281	biological_process	DNA repair
T	0006303	biological_process	double-strand break repair via nonhomologous end joining
T	0006310	biological_process	DNA recombination
T	0006974	biological_process	DNA damage response
T	0008094	molecular_function	ATP-dependent activity, acting on DNA
T	0010212	biological_process	response to ionizing radiation
T	0010558	biological_process	negative regulation of macromolecule biosynthetic process
T	0016020	cellular_component	membrane
T	0016787	molecular_function	hydrolase activity
T	0016829	molecular_function	lyase activity
T	0016887	molecular_function	ATP hydrolysis activity
T	0030332	molecular_function	cyclin binding
T	0032991	cellular_component	protein-containing complex
T	0032993	cellular_component	protein-DNA complex
T	0034774	cellular_component	secretory granule lumen
T	0042162	molecular_function	telomeric DNA binding
T	0043564	cellular_component	Ku70:Ku80 complex
T	0044877	molecular_function	protein-containing complex binding
T	0045027	molecular_function	DNA end binding
T	0045087	biological_process	innate immune response
T	0045621	biological_process	positive regulation of lymphocyte differentiation
T	0045860	biological_process	positive regulation of protein kinase activity
T	0045892	biological_process	negative regulation of DNA-templated transcription
T	0045893	biological_process	positive regulation of DNA-templated transcription
T	0045944	biological_process	positive regulation of transcription by RNA polymerase II
T	0048660	biological_process	regulation of smooth muscle cell proliferation
T	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
T	0070418	cellular_component	DNA-dependent protein kinase complex
T	0070419	cellular_component	nonhomologous end joining complex
T	0071475	biological_process	cellular hyperosmotic salinity response
T	0071480	biological_process	cellular response to gamma radiation
T	0071481	biological_process	cellular response to X-ray
T	0097110	molecular_function	scaffold protein binding
T	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
T	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PROSITE/UniProt

site_id	PS00333
Number of Residues	25
Details	DNA_LIGASE_A2 ATP-dependent DNA ligase signature 2. EGIMVKqplsi...YKpdk...RgegwlKIK

Chain	Residue	Details
I	GLU427-LYS451

---

site_id	PS00697
Number of Residues	9
Details	DNA_LIGASE_A1 ATP-dependent DNA ligase AMP-binding site. ETKLDGERM

Chain	Residue	Details
I	GLU271-MET279

---

site_id	PS00915
Number of Residues	15
Details	PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. VKgg.EDLRQDqrveQ

Chain	Residue	Details
A	VAL3752-GLN3766

---

site_id	PS00916
Number of Residues	21
Details	PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ShAlicIshWILgIgDRHlnN

Chain	Residue	Details
A	SER3907-ASN3927

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: N6-AMP-lysine intermediate => ECO:0000255|PROSITE-ProRule:PRU10135, ECO:0000269|PubMed:23523427, ECO:0000269|PubMed:29980672, ECO:0007744|PDB:3W1B

Chain	Residue	Details
I	LYS273
L	LYS665
R	LYS273
P	ASP265
Q	ASP265
C	LYS665
L	LYS144
L	LYS265
L	LYS332
L	LYS660

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P18858

Chain	Residue	Details
I	GLU271
A	LYS3642
S	LYS117
S	LYS828
S	LYS1209
S	LYS1970
S	LYS2259
S	LYS3241
S	LYS3260
S	LYS3621
S	LYS3638
R	GLU271
S	LYS3642
P	SER53
Q	SER53
L	SER258
L	SER318
T	SER306
T	SER560
A	LYS3638

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	BINDING: BINDING => ECO:0000269|PubMed:23523427, ECO:0007744|PDB:3W1G, ECO:0007744|PDB:3W5O

Chain	Residue	Details
I	THR272
R	LYS451
S	SER1065
S	SER2789
S	SER3731
S	SER3821
I	LYS273
I	LEU274
I	LYS449
I	LYS451
R	THR272
R	LYS273
R	LEU274
R	LYS449

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:23523427, ECO:0007744|PDB:3W5O

Chain	Residue	Details
I	ARG278
I	LYS345
I	PHE367
I	LYS432
R	ARG278
R	LYS345
R	PHE367
R	LYS432

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
I	GLU331
I	GLU427
R	GLU331
R	GLU427

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by CK2 => ECO:0000269|PubMed:15385968, ECO:0000269|PubMed:20852255, ECO:0000269|PubMed:28453785, ECO:0007744|PubMed:24275569

Chain	Residue	Details
G	THR233
T	LYS544
T	LYS553
T	LYS556
H	THR233
P	THR233
Q	THR233
B	LYS553
B	LYS556
T	LYS317
T	LYS539
T	LYS542

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
G	SER237
H	SER237
P	SER237
Q	SER237

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
G	SER256
L	LYS532
L	LYS534
L	LYS566
L	LYS669
L	LYS688
H	SER256
P	SER256
Q	SER256
C	LYS566
C	LYS669
C	LYS688
L	LYS195

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PRKDC => ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:28500754, ECO:0000269|PubMed:30247612, ECO:0007744|PubMed:23186163

Chain	Residue	Details
G	SER260
H	SER260
P	SER260
Q	SER260

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PRKDC => ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:22228831

Chain	Residue	Details
G	SER303
H	SER303
P	SER303
Q	SER303

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PRKDC => ECO:0000269|PubMed:28500754, ECO:0007744|PubMed:23186163

Chain	Residue	Details
G	SER304
H	SER304
P	SER304
Q	SER304

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PRKDC => ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28500754, ECO:0007744|PubMed:23186163

Chain	Residue	Details
G	SER320
H	SER320
P	SER320
Q	SER320

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by PRKDC => ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:28500754

Chain	Residue	Details
G	THR323
H	THR323
P	THR323
Q	THR323

---

site_id	SWS_FT_FI14
Number of Residues	8
Details	MOD_RES: Phosphoserine; by PRKDC => ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:28500754, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332

Chain	Residue	Details
G	SER327
G	SER328
H	SER327
H	SER328
P	SER327
P	SER328
Q	SER327
Q	SER328

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:16478998

Chain	Residue	Details
G	LYS210
H	LYS210
P	LYS210
Q	LYS210

---

site_id	SWS_FT_FI16
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:26774286

Chain	Residue	Details
G	LYS296
H	LYS296
P	LYS296
Q	LYS296

---