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8BGU

human MDM2-5S RNP

Functional Information from GO Data
ChainGOidnamespacecontents
A0000027biological_processribosomal large subunit assembly
A0002181biological_processcytoplasmic translation
A0003723molecular_functionRNA binding
A0003730molecular_functionmRNA 3'-UTR binding
A0003735molecular_functionstructural constituent of ribosome
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005829cellular_componentcytosol
A0005840cellular_componentribosome
A0005925cellular_componentfocal adhesion
A0006364biological_processrRNA processing
A0006412biological_processtranslation
A0008097molecular_function5S rRNA binding
A0010628biological_processpositive regulation of gene expression
A0016020cellular_componentmembrane
A0019843molecular_functionrRNA binding
A0022625cellular_componentcytosolic large ribosomal subunit
A0022626cellular_componentcytosolic ribosome
A0031625molecular_functionubiquitin protein ligase binding
A0032991cellular_componentprotein-containing complex
A0042273biological_processribosomal large subunit biogenesis
A0045727biological_processpositive regulation of translation
A0048027molecular_functionmRNA 5'-UTR binding
A0050821biological_processprotein stabilization
A0070062cellular_componentextracellular exosome
A1901796biological_processregulation of signal transduction by p53 class mediator
A1904667biological_processnegative regulation of ubiquitin protein ligase activity
A1990904cellular_componentribonucleoprotein complex
A1990948molecular_functionubiquitin ligase inhibitor activity
A2000059biological_processnegative regulation of ubiquitin-dependent protein catabolic process
A2000435biological_processnegative regulation of protein neddylation
B0000027biological_processribosomal large subunit assembly
B0002181biological_processcytoplasmic translation
B0003723molecular_functionRNA binding
B0003735molecular_functionstructural constituent of ribosome
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005840cellular_componentribosome
B0006364biological_processrRNA processing
B0006412biological_processtranslation
B0006605biological_processprotein targeting
B0008097molecular_function5S rRNA binding
B0010628biological_processpositive regulation of gene expression
B0016020cellular_componentmembrane
B0019843molecular_functionrRNA binding
B0022625cellular_componentcytosolic large ribosomal subunit
B0022626cellular_componentcytosolic ribosome
B0031625molecular_functionubiquitin protein ligase binding
B0032092biological_processpositive regulation of protein binding
B0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
B0032991cellular_componentprotein-containing complex
B0034504biological_processprotein localization to nucleus
B0042273biological_processribosomal large subunit biogenesis
B0050821biological_processprotein stabilization
B0070062cellular_componentextracellular exosome
B1901796biological_processregulation of signal transduction by p53 class mediator
B1901798biological_processpositive regulation of signal transduction by p53 class mediator
B1904667biological_processnegative regulation of ubiquitin protein ligase activity
B1990904cellular_componentribonucleoprotein complex
B1990948molecular_functionubiquitin ligase inhibitor activity
B2000059biological_processnegative regulation of ubiquitin-dependent protein catabolic process
B2000435biological_processnegative regulation of protein neddylation
F0000122biological_processnegative regulation of transcription by RNA polymerase II
F0000209biological_processprotein polyubiquitination
F0001568biological_processblood vessel development
F0001974biological_processblood vessel remodeling
F0002027biological_processregulation of heart rate
F0002039molecular_functionp53 binding
F0003170biological_processheart valve development
F0003181biological_processatrioventricular valve morphogenesis
F0003203biological_processendocardial cushion morphogenesis
F0003281biological_processventricular septum development
F0003283biological_processatrial septum development
F0004842molecular_functionubiquitin-protein transferase activity
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005730cellular_componentnucleolus
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0006511biological_processubiquitin-dependent protein catabolic process
F0006915biological_processapoptotic process
F0006977biological_processDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
F0007089biological_processtraversing start control point of mitotic cell cycle
F0007507biological_processheart development
F0008097molecular_function5S rRNA binding
F0008270molecular_functionzinc ion binding
F0008284biological_processpositive regulation of cell population proliferation
F0009410biological_processresponse to xenobiotic stimulus
F0009636biological_processresponse to toxic substance
F0010039biological_processresponse to iron ion
F0010468biological_processregulation of gene expression
F0010628biological_processpositive regulation of gene expression
F0010629biological_processnegative regulation of gene expression
F0010955biological_processnegative regulation of protein processing
F0010977biological_processnegative regulation of neuron projection development
F0016567biological_processprotein ubiquitination
F0016604cellular_componentnuclear body
F0016740molecular_functiontransferase activity
F0016874molecular_functionligase activity
F0016925biological_processprotein sumoylation
F0017053cellular_componenttranscription repressor complex
F0019789molecular_functionSUMO transferase activity
F0019899molecular_functionenzyme binding
F0019904molecular_functionprotein domain specific binding
F0030666cellular_componentendocytic vesicle membrane
F0031625molecular_functionubiquitin protein ligase binding
F0031648biological_processprotein destabilization
F0032026biological_processresponse to magnesium ion
F0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
F0032991cellular_componentprotein-containing complex
F0033612molecular_functionreceptor serine/threonine kinase binding
F0034504biological_processprotein localization to nucleus
F0042176biological_processregulation of protein catabolic process
F0042220biological_processresponse to cocaine
F0042802molecular_functionidentical protein binding
F0042975molecular_functionperoxisome proliferator activated receptor binding
F0043021molecular_functionribonucleoprotein complex binding
F0043066biological_processnegative regulation of apoptotic process
F0043130molecular_functionubiquitin binding
F0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
F0043518biological_processnegative regulation of DNA damage response, signal transduction by p53 class mediator
F0045184biological_processestablishment of protein localization
F0045472biological_processresponse to ether
F0045787biological_processpositive regulation of cell cycle
F0045892biological_processnegative regulation of DNA-templated transcription
F0045931biological_processpositive regulation of mitotic cell cycle
F0046677biological_processresponse to antibiotic
F0046827biological_processpositive regulation of protein export from nucleus
F0046872molecular_functionmetal ion binding
F0048545biological_processresponse to steroid hormone
F0051149biological_processpositive regulation of muscle cell differentiation
F0051603biological_processproteolysis involved in protein catabolic process
F0051726biological_processregulation of cell cycle
F0051865biological_processprotein autoubiquitination
F0060411biological_processcardiac septum morphogenesis
F0061630molecular_functionubiquitin protein ligase activity
F0061663molecular_functionNEDD8 ligase activity
F0065003biological_processprotein-containing complex assembly
F0065008biological_processregulation of biological quality
F0070301biological_processcellular response to hydrogen peroxide
F0071236biological_processcellular response to antibiotic
F0071301biological_processcellular response to vitamin B1
F0071310biological_processobsolete cellular response to organic substance
F0071312biological_processcellular response to alkaloid
F0071363biological_processcellular response to growth factor stimulus
F0071375biological_processcellular response to peptide hormone stimulus
F0071391biological_processcellular response to estrogen stimulus
F0071407biological_processcellular response to organic cyclic compound
F0071456biological_processcellular response to hypoxia
F0071480biological_processcellular response to gamma radiation
F0071494biological_processcellular response to UV-C
F0072537biological_processfibroblast activation
F0072717biological_processcellular response to actinomycin D
F0097718molecular_functiondisordered domain specific binding
F1901797biological_processnegative regulation of signal transduction by p53 class mediator
F1902254biological_processnegative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
F1904404biological_processresponse to formaldehyde
F1904707biological_processpositive regulation of vascular associated smooth muscle cell proliferation
F1904754biological_processpositive regulation of vascular associated smooth muscle cell migration
F1990000biological_processamyloid fibril formation
F1990785biological_processresponse to water-immersion restraint stress
Functional Information from PROSITE/UniProt
site_idPS00358
Number of Residues17
DetailsRIBOSOMAL_L5 Ribosomal protein L5 signature. LeqLTGQtpVfSkARyT
ChainResidueDetails
BLEU40-THR56

site_idPS01358
Number of Residues20
DetailsZF_RANBP2_1 Zinc finger RanBP2-type signature. WkCts..CnemNpplpshCnrC
ChainResidueDetails
FTRP303-CYS322

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0000269|PubMed:12962325, ECO:0000269|Ref.5, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712
ChainResidueDetails
BALA2

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976
ChainResidueDetails
BTHR44
ALYS48

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BTHR47

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
ChainResidueDetails
BLYS52

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
BLYS85
FSER242
FSER246
FSER260
FSER262

site_idSWS_FT_FI6
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
BLYS38
FSER395
BLYS154
FSER425
FSER429

site_idSWS_FT_FI7
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733
ChainResidueDetails
BLYS52

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PDB entries from 2024-07-17

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