8BE9
Crystal structure of SOS1-HRas-peptidomimetic5
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| R | 0003924 | molecular_function | GTPase activity |
| R | 0005525 | molecular_function | GTP binding |
| R | 0007165 | biological_process | signal transduction |
| R | 0016020 | cellular_component | membrane |
| S | 0005085 | molecular_function | guanyl-nucleotide exchange factor activity |
| S | 0007264 | biological_process | small GTPase-mediated signal transduction |
Functional Information from PROSITE/UniProt
| site_id | PS00720 |
| Number of Residues | 34 |
| Details | RASGEF Ras Guanine-nucleotide exchange factors domain signature. VPFfGiyLtNIlkteegnpevlkrhgkel.................INFsK |
| Chain | Residue | Details |
| S | VAL927-LYS960 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16698776, ECO:0000305|PubMed:35522713 |
| Chain | Residue | Details |
| R | GLY13 | |
| R | VAL29 | |
| R | ALA59 | |
| R | ASN116 | |
| R | SER145 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylmethionine; in GTPase HRas; alternate => ECO:0000269|Ref.12 |
| Chain | Residue | Details |
| R | MET1 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylthreonine; in GTPase HRas, N-terminally processed => ECO:0000269|Ref.12 |
| Chain | Residue | Details |
| R | THR2 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:9020151 |
| Chain | Residue | Details |
| R | CYS118 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CARBOHYD: (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486, ECO:0000269|PubMed:8626575, ECO:0000269|PubMed:8626586, ECO:0000269|PubMed:9632667 |
| Chain | Residue | Details |
| R | THR35 |
