8BBK

Crystal structure of human Sirt3 in complex with a fragment of the human AROS protein

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003950	molecular_function	NAD+ poly-ADP-ribosyltransferase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006476	biological_process	protein deacetylation
A	0008270	molecular_function	zinc ion binding
A	0009060	biological_process	aerobic respiration
A	0016740	molecular_function	transferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0017136	molecular_function	histone deacetylase activity, NAD-dependent
A	0019899	molecular_function	enzyme binding
A	0032024	biological_process	positive regulation of insulin secretion
A	0032991	cellular_component	protein-containing complex
A	0033554	biological_process	cellular response to stress
A	0033558	molecular_function	protein lysine deacetylase activity
A	0034979	molecular_function	NAD-dependent protein lysine deacetylase activity
A	0034983	biological_process	peptidyl-lysine deacetylation
A	0043565	molecular_function	sequence-specific DNA binding
A	0046872	molecular_function	metal ion binding
A	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
A	0070403	molecular_function	NAD+ binding
A	0141208	molecular_function	NAD-dependent protein lysine delactylase activity
A	1901671	biological_process	positive regulation of superoxide dismutase activity
A	1902553	biological_process	positive regulation of catalase activity
A	1903862	biological_process	positive regulation of oxidative phosphorylation
A	1990404	molecular_function	NAD+-protein mono-ADP-ribosyltransferase activity
A	2000304	biological_process	positive regulation of ceramide biosynthetic process
A	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
B	0003950	molecular_function	NAD+ poly-ADP-ribosyltransferase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0006476	biological_process	protein deacetylation
B	0008270	molecular_function	zinc ion binding
B	0009060	biological_process	aerobic respiration
B	0016740	molecular_function	transferase activity
B	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
B	0017136	molecular_function	histone deacetylase activity, NAD-dependent
B	0019899	molecular_function	enzyme binding
B	0032024	biological_process	positive regulation of insulin secretion
B	0032991	cellular_component	protein-containing complex
B	0033554	biological_process	cellular response to stress
B	0033558	molecular_function	protein lysine deacetylase activity
B	0034979	molecular_function	NAD-dependent protein lysine deacetylase activity
B	0034983	biological_process	peptidyl-lysine deacetylation
B	0043565	molecular_function	sequence-specific DNA binding
B	0046872	molecular_function	metal ion binding
B	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
B	0070403	molecular_function	NAD+ binding
B	0141208	molecular_function	NAD-dependent protein lysine delactylase activity
B	1901671	biological_process	positive regulation of superoxide dismutase activity
B	1902553	biological_process	positive regulation of catalase activity
B	1903862	biological_process	positive regulation of oxidative phosphorylation
B	1990404	molecular_function	NAD+-protein mono-ADP-ribosyltransferase activity
B	2000304	biological_process	positive regulation of ceramide biosynthetic process
B	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
C	0003950	molecular_function	NAD+ poly-ADP-ribosyltransferase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0006476	biological_process	protein deacetylation
C	0008270	molecular_function	zinc ion binding
C	0009060	biological_process	aerobic respiration
C	0016740	molecular_function	transferase activity
C	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
C	0017136	molecular_function	histone deacetylase activity, NAD-dependent
C	0019899	molecular_function	enzyme binding
C	0032024	biological_process	positive regulation of insulin secretion
C	0032991	cellular_component	protein-containing complex
C	0033554	biological_process	cellular response to stress
C	0033558	molecular_function	protein lysine deacetylase activity
C	0034979	molecular_function	NAD-dependent protein lysine deacetylase activity
C	0034983	biological_process	peptidyl-lysine deacetylation
C	0043565	molecular_function	sequence-specific DNA binding
C	0046872	molecular_function	metal ion binding
C	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
C	0070403	molecular_function	NAD+ binding
C	0141208	molecular_function	NAD-dependent protein lysine delactylase activity
C	1901671	biological_process	positive regulation of superoxide dismutase activity
C	1902553	biological_process	positive regulation of catalase activity
C	1903862	biological_process	positive regulation of oxidative phosphorylation
C	1990404	molecular_function	NAD+-protein mono-ADP-ribosyltransferase activity
C	2000304	biological_process	positive regulation of ceramide biosynthetic process
C	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
D	0003950	molecular_function	NAD+ poly-ADP-ribosyltransferase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0006476	biological_process	protein deacetylation
D	0008270	molecular_function	zinc ion binding
D	0009060	biological_process	aerobic respiration
D	0016740	molecular_function	transferase activity
D	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
D	0017136	molecular_function	histone deacetylase activity, NAD-dependent
D	0019899	molecular_function	enzyme binding
D	0032024	biological_process	positive regulation of insulin secretion
D	0032991	cellular_component	protein-containing complex
D	0033554	biological_process	cellular response to stress
D	0033558	molecular_function	protein lysine deacetylase activity
D	0034979	molecular_function	NAD-dependent protein lysine deacetylase activity
D	0034983	biological_process	peptidyl-lysine deacetylation
D	0043565	molecular_function	sequence-specific DNA binding
D	0046872	molecular_function	metal ion binding
D	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
D	0070403	molecular_function	NAD+ binding
D	0141208	molecular_function	NAD-dependent protein lysine delactylase activity
D	1901671	biological_process	positive regulation of superoxide dismutase activity
D	1902553	biological_process	positive regulation of catalase activity
D	1903862	biological_process	positive regulation of oxidative phosphorylation
D	1990404	molecular_function	NAD+-protein mono-ADP-ribosyltransferase activity
D	2000304	biological_process	positive regulation of ceramide biosynthetic process
D	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
E	0003950	molecular_function	NAD+ poly-ADP-ribosyltransferase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0006476	biological_process	protein deacetylation
E	0008270	molecular_function	zinc ion binding
E	0009060	biological_process	aerobic respiration
E	0016740	molecular_function	transferase activity
E	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
E	0017136	molecular_function	histone deacetylase activity, NAD-dependent
E	0019899	molecular_function	enzyme binding
E	0032024	biological_process	positive regulation of insulin secretion
E	0032991	cellular_component	protein-containing complex
E	0033554	biological_process	cellular response to stress
E	0033558	molecular_function	protein lysine deacetylase activity
E	0034979	molecular_function	NAD-dependent protein lysine deacetylase activity
E	0034983	biological_process	peptidyl-lysine deacetylation
E	0043565	molecular_function	sequence-specific DNA binding
E	0046872	molecular_function	metal ion binding
E	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
E	0070403	molecular_function	NAD+ binding
E	0141208	molecular_function	NAD-dependent protein lysine delactylase activity
E	1901671	biological_process	positive regulation of superoxide dismutase activity
E	1902553	biological_process	positive regulation of catalase activity
E	1903862	biological_process	positive regulation of oxidative phosphorylation
E	1990404	molecular_function	NAD+-protein mono-ADP-ribosyltransferase activity
E	2000304	biological_process	positive regulation of ceramide biosynthetic process
E	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
F	0003950	molecular_function	NAD+ poly-ADP-ribosyltransferase activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0006476	biological_process	protein deacetylation
F	0008270	molecular_function	zinc ion binding
F	0009060	biological_process	aerobic respiration
F	0016740	molecular_function	transferase activity
F	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
F	0017136	molecular_function	histone deacetylase activity, NAD-dependent
F	0019899	molecular_function	enzyme binding
F	0032024	biological_process	positive regulation of insulin secretion
F	0032991	cellular_component	protein-containing complex
F	0033554	biological_process	cellular response to stress
F	0033558	molecular_function	protein lysine deacetylase activity
F	0034979	molecular_function	NAD-dependent protein lysine deacetylase activity
F	0034983	biological_process	peptidyl-lysine deacetylation
F	0043565	molecular_function	sequence-specific DNA binding
F	0046872	molecular_function	metal ion binding
F	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
F	0070403	molecular_function	NAD+ binding
F	0141208	molecular_function	NAD-dependent protein lysine delactylase activity
F	1901671	biological_process	positive regulation of superoxide dismutase activity
F	1902553	biological_process	positive regulation of catalase activity
F	1903862	biological_process	positive regulation of oxidative phosphorylation
F	1990404	molecular_function	NAD+-protein mono-ADP-ribosyltransferase activity
F	2000304	biological_process	positive regulation of ceramide biosynthetic process
F	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
G	0003723	molecular_function	RNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005730	cellular_component	nucleolus
G	0005829	cellular_component	cytosol
G	0019899	molecular_function	enzyme binding
G	0032040	cellular_component	small-subunit processome
G	0042274	biological_process	ribosomal small subunit biogenesis
H	0003723	molecular_function	RNA binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005730	cellular_component	nucleolus
H	0005829	cellular_component	cytosol
H	0019899	molecular_function	enzyme binding
H	0032040	cellular_component	small-subunit processome
H	0042274	biological_process	ribosomal small subunit biogenesis
I	0003723	molecular_function	RNA binding
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005730	cellular_component	nucleolus
I	0005829	cellular_component	cytosol
I	0019899	molecular_function	enzyme binding
I	0032040	cellular_component	small-subunit processome
I	0042274	biological_process	ribosomal small subunit biogenesis
J	0003723	molecular_function	RNA binding
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005730	cellular_component	nucleolus
J	0005829	cellular_component	cytosol
J	0019899	molecular_function	enzyme binding
J	0032040	cellular_component	small-subunit processome
J	0042274	biological_process	ribosomal small subunit biogenesis
K	0003723	molecular_function	RNA binding
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005730	cellular_component	nucleolus
K	0005829	cellular_component	cytosol
K	0019899	molecular_function	enzyme binding
K	0032040	cellular_component	small-subunit processome
K	0042274	biological_process	ribosomal small subunit biogenesis
L	0003723	molecular_function	RNA binding
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005730	cellular_component	nucleolus
L	0005829	cellular_component	cytosol
L	0019899	molecular_function	enzyme binding
L	0032040	cellular_component	small-subunit processome
L	0042274	biological_process	ribosomal small subunit biogenesis

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	MOD_RES: Citrulline => ECO:0000250

Chain	Residue	Details
G	ARG7
H	ARG7
I	ARG7
J	ARG7
K	ARG7
L	ARG7

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
G	SER84
C	GLN228
C	GLY319
C	ASN344
D	GLY145
D	GLN228
D	GLY319
D	ASN344
E	GLY145
E	GLN228
E	GLY319
H	SER84
E	ASN344
F	GLY145
F	GLN228
F	GLY319
F	ASN344
I	SER84
J	SER84
K	SER84
L	SER84
B	GLY319
B	ASN344
C	GLY145

---

site_id	SWS_FT_FI3
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269|PubMed:19535340, ECO:0000269|PubMed:23897466, ECO:0000269|PubMed:36896611, ECO:0000269|PubMed:37720100

Chain	Residue	Details
A	CYS256
D	CYS256
D	CYS259
D	CYS283
E	CYS256
E	CYS259
E	CYS283
F	CYS256
F	CYS259
F	CYS283
A	CYS259
A	CYS283
B	CYS256
B	CYS259
B	CYS283
C	CYS256
C	CYS259
C	CYS283

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:19535340, ECO:0000269|PubMed:23897466, ECO:0000269|PubMed:36896611

Chain	Residue	Details
A	CYS280
B	CYS280
C	CYS280
D	CYS280
E	CYS280
F	CYS280

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q8R104

Chain	Residue	Details
A	LYS122
B	LYS122
C	LYS122
D	LYS122
E	LYS122
F	LYS122

---